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Protein

Zinc finger protein 44

Gene

ZNF44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri189 – 21123C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri245 – 26723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri273 – 29523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri301 – 32323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 37923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri385 – 40723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 43523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri441 – 46323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri469 – 49123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51822C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri524 – 54623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri552 – 57423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri580 – 60223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri608 – 63023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri636 – 65823C2H2-type 17PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 44
Alternative name(s):
Gonadotropin-inducible ovary transcription repressor 2
Short name:
GIOT-2
Zinc finger protein 55
Zinc finger protein 58
Zinc finger protein KOX7
Gene namesi
Name:ZNF44
Synonyms:GIOT2, KOX7, ZNF55, ZNF58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13110. ZNF44.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37685.

Polymorphism and mutation databases

BioMutaiZNF44.
DMDMi215274197.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 663663Zinc finger protein 44PRO_0000047377Add
BLAST

Proteomic databases

MaxQBiP15621.
PaxDbiP15621.
PRIDEiP15621.

PTM databases

PhosphoSiteiP15621.

Expressioni

Gene expression databases

BgeeiP15621.
CleanExiHS_ZNF44.
ExpressionAtlasiP15621. baseline and differential.
GenevisibleiP15621. HS.

Organism-specific databases

HPAiHPA003146.

Interactioni

Protein-protein interaction databases

BioGridi119691. 1 interaction.
IntActiP15621. 1 interaction.
STRINGi9606.ENSP00000348419.

Structurei

3D structure databases

ProteinModelPortaliP15621.
SMRiP15621. Positions 52-102, 187-658.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 13887KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 17 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri189 – 21123C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri245 – 26723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri273 – 29523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri301 – 32323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 37923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri385 – 40723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 43523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri441 – 46323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri469 – 49123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51822C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri524 – 54623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri552 – 57423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri580 – 60223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri608 – 63023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri636 – 65823C2H2-type 17PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP15621.
KOiK09228.
OMAiARIHEGT.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP15621.
TreeFamiTF338854.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P15621-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALCYGTFWG YPKMLEAANL MEGLVDIGPW VTLPRGQPEV LEWGLPKDQD
60 70 80 90 100
SVAFEDVAVN FTHEEWALLG PSQKNLYRDV MRETIRNLNC IGMKWENQNI
110 120 130 140 150
DDQHQNLRRN PRCDVVERFG KSKDGSQCGE TLSQIRNSIV NKNTPARVDA
160 170 180 190 200
CGSSVNGEVI MGHSSLNCYI RVDTGHKHRE CHEYAEKSYT HKQCGKGLSY
210 220 230 240 250
RHSFQTCERP HTGKKPYDCK ECGKTFSSPG NLRRHMVVKG GDGPYKCELC
260 270 280 290 300
GKAFFWPSLL RMHERTHTGE KPYECKQCSK AFPVYSSYLR HEKIHTGEKP
310 320 330 340 350
YECKQCSKAF PDYSSYLRHE RTHTGEKPYK CKQCGKAFSV SGSLRVHERI
360 370 380 390 400
HTGEKPYTCK QCGKAFCHLG SFQRHMIMHS GDGPHKCKIC GKGFDFPGSA
410 420 430 440 450
RIHEGTHTLE KPYECKQCGK LLSHRSSFRR HMMAHTGDGP HKCTVCGKAF
460 470 480 490 500
DSPSVFQRHE RTHTGEKPYE CKQCGKAFRT SSSLRKHETT HTGEQPYKCK
510 520 530 540 550
CGKAFSDLFS FQSHETTHSE EEPYECKECG KAFSSFKYFC RHERTHSEEK
560 570 580 590 600
SYECQICGKA FSRFSYLKTH ERTHTAEKPY ECKQCRKAFF WPSFLLRHER
610 620 630 640 650
THTGERPYEC KHCGKAFSRS SFCREHERTH TGEKPYECKE CGKAFSSLSS
660
FNRHKRTHWK DIL
Length:663
Mass (Da):76,524
Last modified:November 25, 2008 - v3
Checksum:i6B66F4715A972432
GO
Isoform 2 (identifier: P15621-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     49-49: Q → M
     638-663: Missing.

Show »
Length:589
Mass (Da):68,089
Checksum:iCDEA5A84ACE31162
GO
Isoform 3 (identifier: P15621-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     638-663: Missing.

Show »
Length:637
Mass (Da):73,462
Checksum:i6A73DE76DBA740AA
GO

Sequence cautioni

The sequence CAA34357.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti389 – 3891I → R in BAA86988 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921G → A.
Corresponds to variant rs11882046 [ dbSNP | Ensembl ].
VAR_047425
Natural varianti212 – 2121T → A.1 Publication
Corresponds to variant rs11879168 [ dbSNP | Ensembl ].
VAR_047426

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4848Missing in isoform 2. 1 PublicationVSP_035757Add
BLAST
Alternative sequencei49 – 491Q → M in isoform 2. 1 PublicationVSP_035758
Alternative sequencei638 – 66326Missing in isoform 2 and isoform 3. 2 PublicationsVSP_035759Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021642 mRNA. Translation: BAA86988.1.
AK297528 mRNA. Translation: BAG59931.1.
AC012618 Genomic DNA. No translation available.
BC136502 mRNA. Translation: AAI36503.1.
X16281 mRNA. Translation: CAA34357.1. Frameshift.
X52338 mRNA. Translation: CAA36564.1.
CCDSiCCDS54223.1. [P15621-1]
PIRiD56409. S06779.
RefSeqiNP_001157748.1. NM_001164276.1. [P15621-1]
UniGeneiHs.296731.
Hs.693933.

Genome annotation databases

EnsembliENST00000356109; ENSP00000348419; ENSG00000197857.
ENST00000393337; ENSP00000377008; ENSG00000197857. [P15621-3]
ENST00000397742; ENSP00000380850; ENSG00000197857. [P15621-2]
GeneIDi51710.
KEGGihsa:51710.
UCSCiuc010xmj.2. human. [P15621-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021642 mRNA. Translation: BAA86988.1.
AK297528 mRNA. Translation: BAG59931.1.
AC012618 Genomic DNA. No translation available.
BC136502 mRNA. Translation: AAI36503.1.
X16281 mRNA. Translation: CAA34357.1. Frameshift.
X52338 mRNA. Translation: CAA36564.1.
CCDSiCCDS54223.1. [P15621-1]
PIRiD56409. S06779.
RefSeqiNP_001157748.1. NM_001164276.1. [P15621-1]
UniGeneiHs.296731.
Hs.693933.

3D structure databases

ProteinModelPortaliP15621.
SMRiP15621. Positions 52-102, 187-658.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119691. 1 interaction.
IntActiP15621. 1 interaction.
STRINGi9606.ENSP00000348419.

PTM databases

PhosphoSiteiP15621.

Polymorphism and mutation databases

BioMutaiZNF44.
DMDMi215274197.

Proteomic databases

MaxQBiP15621.
PaxDbiP15621.
PRIDEiP15621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356109; ENSP00000348419; ENSG00000197857.
ENST00000393337; ENSP00000377008; ENSG00000197857. [P15621-3]
ENST00000397742; ENSP00000380850; ENSG00000197857. [P15621-2]
GeneIDi51710.
KEGGihsa:51710.
UCSCiuc010xmj.2. human. [P15621-1]

Organism-specific databases

CTDi51710.
GeneCardsiGC19M012336.
HGNCiHGNC:13110. ZNF44.
HPAiHPA003146.
MIMi194542. gene.
neXtProtiNX_P15621.
PharmGKBiPA37685.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP15621.
KOiK09228.
OMAiARIHEGT.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP15621.
TreeFamiTF338854.

Miscellaneous databases

ChiTaRSiZNF44. human.
GeneWikiiZNF44.
GenomeRNAii51710.
NextBioi55752.
PROiP15621.
SOURCEiSearch...

Gene expression databases

BgeeiP15621.
CleanExiHS_ZNF44.
ExpressionAtlasiP15621. baseline and differential.
GenevisibleiP15621. HS.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of novel zinc finger proteins in the human ovary."
    Okada T., Mizutani T., Miyamoto K.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ALA-212.
    Tissue: Ovary.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  5. Ammendola S., Ciliberto G.
    Submitted (AUG-1989) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 403-663 (ISOFORM 1).
  6. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 413-468.
    Tissue: Lymphoid tissue.

Entry informationi

Entry nameiZNF44_HUMAN
AccessioniPrimary (citable) accession number: P15621
Secondary accession number(s): B4DML9
, B9EGJ5, B9ZVM2, P17018, Q9ULZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 25, 2008
Last modified: July 22, 2015
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.