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P15621

- ZNF44_HUMAN

UniProt

P15621 - ZNF44_HUMAN

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Protein
Zinc finger protein 44
Gene
ZNF44, GIOT2, KOX7, ZNF55, ZNF58
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri189 – 21123C2H2-type 1; atypical
Add
BLAST
Zinc fingeri217 – 23923C2H2-type 2; degenerate
Add
BLAST
Zinc fingeri245 – 26723C2H2-type 3
Add
BLAST
Zinc fingeri273 – 29523C2H2-type 4
Add
BLAST
Zinc fingeri301 – 32323C2H2-type 5
Add
BLAST
Zinc fingeri329 – 35123C2H2-type 6
Add
BLAST
Zinc fingeri357 – 37923C2H2-type 7
Add
BLAST
Zinc fingeri385 – 40723C2H2-type 8
Add
BLAST
Zinc fingeri413 – 43523C2H2-type 9
Add
BLAST
Zinc fingeri441 – 46323C2H2-type 10
Add
BLAST
Zinc fingeri469 – 49123C2H2-type 11
Add
BLAST
Zinc fingeri497 – 51822C2H2-type 12
Add
BLAST
Zinc fingeri524 – 54623C2H2-type 13
Add
BLAST
Zinc fingeri552 – 57423C2H2-type 14
Add
BLAST
Zinc fingeri580 – 60223C2H2-type 15
Add
BLAST
Zinc fingeri608 – 63023C2H2-type 16
Add
BLAST
Zinc fingeri636 – 65823C2H2-type 17
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 44
Alternative name(s):
Gonadotropin-inducible ovary transcription repressor 2
Short name:
GIOT-2
Zinc finger protein 55
Zinc finger protein 58
Zinc finger protein KOX7
Gene namesi
Name:ZNF44
Synonyms:GIOT2, KOX7, ZNF55, ZNF58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13110. ZNF44.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 663663Zinc finger protein 44
PRO_0000047377Add
BLAST

Proteomic databases

MaxQBiP15621.
PaxDbiP15621.
PRIDEiP15621.

PTM databases

PhosphoSiteiP15621.

Expressioni

Gene expression databases

ArrayExpressiP15621.
BgeeiP15621.
CleanExiHS_ZNF44.
GenevestigatoriP15621.

Organism-specific databases

HPAiHPA003146.

Interactioni

Protein-protein interaction databases

BioGridi119691. 2 interactions.
IntActiP15621. 1 interaction.
STRINGi9606.ENSP00000347910.

Structurei

3D structure databases

ProteinModelPortaliP15621.
SMRiP15621. Positions 52-102, 149-662.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 13887KRAB
Add
BLAST

Sequence similaritiesi

Contains 17 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
KOiK09228.
OMAiERFPNIL.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP15621.
TreeFamiTF338854.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P15621-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALCYGTFWG YPKMLEAANL MEGLVDIGPW VTLPRGQPEV LEWGLPKDQD    50
SVAFEDVAVN FTHEEWALLG PSQKNLYRDV MRETIRNLNC IGMKWENQNI 100
DDQHQNLRRN PRCDVVERFG KSKDGSQCGE TLSQIRNSIV NKNTPARVDA 150
CGSSVNGEVI MGHSSLNCYI RVDTGHKHRE CHEYAEKSYT HKQCGKGLSY 200
RHSFQTCERP HTGKKPYDCK ECGKTFSSPG NLRRHMVVKG GDGPYKCELC 250
GKAFFWPSLL RMHERTHTGE KPYECKQCSK AFPVYSSYLR HEKIHTGEKP 300
YECKQCSKAF PDYSSYLRHE RTHTGEKPYK CKQCGKAFSV SGSLRVHERI 350
HTGEKPYTCK QCGKAFCHLG SFQRHMIMHS GDGPHKCKIC GKGFDFPGSA 400
RIHEGTHTLE KPYECKQCGK LLSHRSSFRR HMMAHTGDGP HKCTVCGKAF 450
DSPSVFQRHE RTHTGEKPYE CKQCGKAFRT SSSLRKHETT HTGEQPYKCK 500
CGKAFSDLFS FQSHETTHSE EEPYECKECG KAFSSFKYFC RHERTHSEEK 550
SYECQICGKA FSRFSYLKTH ERTHTAEKPY ECKQCRKAFF WPSFLLRHER 600
THTGERPYEC KHCGKAFSRS SFCREHERTH TGEKPYECKE CGKAFSSLSS 650
FNRHKRTHWK DIL 663
Length:663
Mass (Da):76,524
Last modified:November 25, 2008 - v3
Checksum:i6B66F4715A972432
GO
Isoform 2 (identifier: P15621-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     49-49: Q → M
     638-663: Missing.

Show »
Length:589
Mass (Da):68,089
Checksum:iCDEA5A84ACE31162
GO
Isoform 3 (identifier: P15621-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     638-663: Missing.

Show »
Length:637
Mass (Da):73,462
Checksum:i6A73DE76DBA740AA
GO

Sequence cautioni

The sequence CAA34357.1 differs from that shown. Reason: Frameshift at several positions.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921G → A.
Corresponds to variant rs11882046 [ dbSNP | Ensembl ].
VAR_047425
Natural varianti212 – 2121T → A.1 Publication
Corresponds to variant rs11879168 [ dbSNP | Ensembl ].
VAR_047426

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4848Missing in isoform 2.
VSP_035757Add
BLAST
Alternative sequencei49 – 491Q → M in isoform 2.
VSP_035758
Alternative sequencei638 – 66326Missing in isoform 2 and isoform 3.
VSP_035759Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti389 – 3891I → R in BAA86988. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB021642 mRNA. Translation: BAA86988.1.
AK297528 mRNA. Translation: BAG59931.1.
AC012618 Genomic DNA. No translation available.
BC136502 mRNA. Translation: AAI36503.1.
X16281 mRNA. Translation: CAA34357.1. Frameshift.
X52338 mRNA. Translation: CAA36564.1.
CCDSiCCDS54223.1. [P15621-1]
PIRiD56409. S06779.
RefSeqiNP_001157748.1. NM_001164276.1. [P15621-1]
UniGeneiHs.296731.
Hs.693933.

Genome annotation databases

EnsembliENST00000356109; ENSP00000348419; ENSG00000197857. [P15621-1]
ENST00000393337; ENSP00000377008; ENSG00000197857. [P15621-3]
ENST00000397742; ENSP00000380850; ENSG00000197857. [P15621-2]
GeneIDi51710.
KEGGihsa:51710.
UCSCiuc010xmj.2. human. [P15621-1]

Polymorphism databases

DMDMi215274197.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB021642 mRNA. Translation: BAA86988.1 .
AK297528 mRNA. Translation: BAG59931.1 .
AC012618 Genomic DNA. No translation available.
BC136502 mRNA. Translation: AAI36503.1 .
X16281 mRNA. Translation: CAA34357.1 . Frameshift.
X52338 mRNA. Translation: CAA36564.1 .
CCDSi CCDS54223.1. [P15621-1 ]
PIRi D56409. S06779.
RefSeqi NP_001157748.1. NM_001164276.1. [P15621-1 ]
UniGenei Hs.296731.
Hs.693933.

3D structure databases

ProteinModelPortali P15621.
SMRi P15621. Positions 52-102, 149-662.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119691. 2 interactions.
IntActi P15621. 1 interaction.
STRINGi 9606.ENSP00000347910.

PTM databases

PhosphoSitei P15621.

Polymorphism databases

DMDMi 215274197.

Proteomic databases

MaxQBi P15621.
PaxDbi P15621.
PRIDEi P15621.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356109 ; ENSP00000348419 ; ENSG00000197857 . [P15621-1 ]
ENST00000393337 ; ENSP00000377008 ; ENSG00000197857 . [P15621-3 ]
ENST00000397742 ; ENSP00000380850 ; ENSG00000197857 . [P15621-2 ]
GeneIDi 51710.
KEGGi hsa:51710.
UCSCi uc010xmj.2. human. [P15621-1 ]

Organism-specific databases

CTDi 51710.
GeneCardsi GC19M012354.
HGNCi HGNC:13110. ZNF44.
HPAi HPA003146.
MIMi 194542. gene.
neXtProti NX_P15621.
PharmGKBi PA37685.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
KOi K09228.
OMAi ERFPNIL.
OrthoDBi EOG7KSX7Q.
PhylomeDBi P15621.
TreeFami TF338854.

Miscellaneous databases

GeneWikii ZNF44.
GenomeRNAii 51710.
NextBioi 55752.
PROi P15621.
SOURCEi Search...

Gene expression databases

ArrayExpressi P15621.
Bgeei P15621.
CleanExi HS_ZNF44.
Genevestigatori P15621.

Family and domain databases

Gene3Di 3.30.160.60. 17 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of novel zinc finger proteins in the human ovary."
    Okada T., Mizutani T., Miyamoto K.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ALA-212.
    Tissue: Ovary.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  5. Ammendola S., Ciliberto G.
    Submitted (AUG-1989) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 403-663 (ISOFORM 1).
  6. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 413-468.
    Tissue: Lymphoid tissue.

Entry informationi

Entry nameiZNF44_HUMAN
AccessioniPrimary (citable) accession number: P15621
Secondary accession number(s): B4DML9
, B9EGJ5, B9ZVM2, P17018, Q9ULZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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