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Protein

Zinc finger protein 271

Gene

Znf271

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May act to control gene activity during the pachytene stage of meiotic prophase. May function as a transcription activator.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri78 – 10023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri104 – 12623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri132 – 15423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri160 – 18223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri496 – 51823C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri524 – 54522C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri551 – 57323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • inflammatory response to antigenic stimulus Source: MGI
  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of T-helper 2 cell differentiation Source: MGI
  • negative regulation of type 2 immune response Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • spermatogenesis Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 271
Alternative name(s):
Zinc finger protein 35
Short name:
Zfp-35
Gene namesi
Name:Znf271
Synonyms:Zfp-35, Zfp35
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:99179. Zfp35.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Zinc finger protein 271PRO_0000047497Add
BLAST

Proteomic databases

PaxDbiP15620.
PRIDEiP15620.

PTM databases

iPTMnetiP15620.

Expressioni

Tissue specificityi

Selectively expressed in adult testis.1 Publication

Gene expression databases

BgeeiP15620.
CleanExiMM_ZFP35.
ExpressionAtlasiP15620. baseline and differential.
GenevisibleiP15620. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074475.

Structurei

3D structure databases

ProteinModelPortaliP15620.
SMRiP15620. Positions 76-577.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 7777Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri78 – 10023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri104 – 12623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri132 – 15423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri160 – 18223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri496 – 51823C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri524 – 54522C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri551 – 57323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP15620.
OMAiFCEFGDK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP15620.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 18 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 8 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 18 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15620-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIQFSYESQ DHHFLSDGET KIKIGEPATE EEMTGKIGTV TEESGSLEED
60 70 80 90 100
VPHDSRGKEF REFGEELNDQ MLFRRRQYNC DECDQSFAWS TGLIRHQRTH
110 120 130 140 150
WKPYECEECG KAFRMSSALV LHQRIHTGEK PYPCSWCIKS FSRSSDLIKH
160 170 180 190 200
QRVHTGEKPY KCDECGKAFS QSSDLMIHQR IHTGEKPYQC SHCSKSFSQH
210 220 230 240 250
SGMVKHLRIH TGEKPYMCNH CYKHFSQSSD LIKHQRIHTG EKPYKCDVCG
260 270 280 290 300
KAFSQSSDRI LHQRIHTGEK PYPCAQCNKS FSQNSDLIKH RRIHTGEKPY
310 320 330 340 350
KCSECGKAFN QSSVLILHQR IHTGEKPYPC NQCTKSFSRL SDLINHQRIH
360 370 380 390 400
TGEKPYPCSQ CSKMFSRRSD LVKHYRIHTG EKPYECDKCG KTFSQSSNLI
410 420 430 440 450
LHQRIHTGEK PYPCNSCSKS FSRGSDLIKH QRVHTGEKPY TCNLCSKSFS
460 470 480 490 500
QSSDLTKHQR VHSGEKPYHC SSCNKAFRQS SDLILHHRVH TGERPYACTQ
510 520 530 540 550
CPRSFSQKSD LIKHQRIHTG EKPYKCMCGK AFSQCSAFTL HQRIHTGEKP
560 570 580
YPCAQCGKSF SQRSDLVNHQ RVHADQKLQM
Length:580
Mass (Da):67,036
Last modified:April 1, 1990 - v1
Checksum:i11AA449913562B4C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti370 – 3701D → H in AAA40583 (PubMed:2249852).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17617 mRNA. Translation: CAA35618.1.
M36146, M36145 Genomic DNA. Translation: AAA40583.1.
CCDSiCCDS29097.1.
PIRiA37107.
RefSeqiNP_035885.2. NM_011755.2.
UniGeneiMm.290596.

Genome annotation databases

EnsembliENSMUST00000074941; ENSMUSP00000074475; ENSMUSG00000063281.
GeneIDi22694.
KEGGimmu:22694.
UCSCiuc008egk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17617 mRNA. Translation: CAA35618.1.
M36146, M36145 Genomic DNA. Translation: AAA40583.1.
CCDSiCCDS29097.1.
PIRiA37107.
RefSeqiNP_035885.2. NM_011755.2.
UniGeneiMm.290596.

3D structure databases

ProteinModelPortaliP15620.
SMRiP15620. Positions 76-577.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074475.

PTM databases

iPTMnetiP15620.

Proteomic databases

PaxDbiP15620.
PRIDEiP15620.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074941; ENSMUSP00000074475; ENSMUSG00000063281.
GeneIDi22694.
KEGGimmu:22694.
UCSCiuc008egk.1. mouse.

Organism-specific databases

CTDi22694.
MGIiMGI:99179. Zfp35.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP15620.
OMAiFCEFGDK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP15620.
TreeFamiTF341817.

Miscellaneous databases

PROiP15620.
SOURCEiSearch...

Gene expression databases

BgeeiP15620.
CleanExiMM_ZFP35.
ExpressionAtlasiP15620. baseline and differential.
GenevisibleiP15620. MM.

Family and domain databases

Gene3Di3.30.160.60. 18 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 8 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 18 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A mouse zinc finger gene which is transiently expressed during spermatogenesis."
    Cunliffe V.T., Koopman P., McLaren A., Trowsdale J.
    EMBO J. 9:197-205(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: MF1.
    Tissue: Testis.
  2. "Genomic analysis of a mouse zinc finger gene, Zfp-35, that is up-regulated during spermatogenesis."
    Cunliffe V., Williams S., Trowsdale J.
    Genomics 8:331-339(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiZN271_MOUSE
AccessioniPrimary (citable) accession number: P15620
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 8, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.