Reviewed, UniProtKB/Swiss-Prot P15601 (NDUS3_PARPR)

Names and origin

Protein names

Recommended name:
    NADH-ubiquinone oxidoreductase subunit 9
    EC=1.6.5.3
    EC=1.6.99.3
Alternative name(s):
    Protein P1

Gene names

Name:

NAD9

Encoded on

Mitochondrion

Organism

Paramecium primaurelia

Taxonomic identifier

5886 [NCBI]

Taxonomic lineage

Eukaryota › Alveolata › Ciliophora › Intramacronucleata › Oligohymenophorea › Peniculida › Parameciidae › Paramecium

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol. NADH + acceptor = NAD+ + reduced acceptor.
Subunit structure	Complex I is composed of about 30 different subunits.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the complex I 30 kDa subunit family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	NADH-ubiquinone oxidoreductase subunit 9		PRO_0000118646

Sequences

	Sequence		Length	Mass (Da)
	P15601-1 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: B138B325711DAB43	FASTA	209	23,655
	10 20 30 40 50 60 MSPQRPQRAF FCSEGAKKKK KPKYRFGFPM ALYFFFEKLN FSYWTSTTVS PNHYVCVLPA 70 80 90 100 110 120 AASQALASVL GGELFLGKSQ LVEATAFDLT GQEVAAGDFL VFLKNNGIVL SYSFYFFLLK 130 140 150 160 170 180 KRITFFLHGG EKVCSVEAFY SNANWLEREI SEMFGVSYLL KKDSRNLLLD YGSSFNPFLK 190 200 KFPSTGHTEV VFNSFLKTTA YVQNASVEL

References

[1]	"Paramecium mitochondrial DNA sequences and RNA transcripts for cytochrome oxidase subunit I, URF1, and three ORFs adjacent to the replication origin." Pritchard A.E., Seilhamer J.J., Cummings D.J. Gene 44:243-253(1986) [PubMed: 3023187] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M15276 Genomic DNA. Translation: AAA79263.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.6.5.3. 286605. 1.6.99.3. 286605.
Family and domain databases
InterPro	IPR001268. NADH_UbQ_OxRdtase_30kDa_su. [Graphical view]
Pfam	PF00329. Complex1_30kDa. 1 hit. [Graphical view]
ProDom	PD001581. Complex1_30K. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00542. COMPLEX1_30K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDUS3_PARPR

Accession

Primary (citable) accession number: P15601

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)