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P15597 (VIRF_AGRT9) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein virF
Gene names
Name:virF
Encoded onPlasmid pTi15955
OrganismAgrobacterium tumefaciens (strain 15955)
Taxonomic identifier190386 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium

Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

In the host plant, component of SCF(virF) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins such as the host VIP1, after its implication in T-DNA translocation to the host nucleus By similarity. Required for the formation of tumors of a wild-type size on certain plant species only.

Subunit structure

Component of SCF(virF) E3 ubiquitin ligase complexes. Interacts with host VIP1 and SKP1A By similarity.

Sequence similarities

Contains 1 F-box domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
Virulence
   DiseaseCrown gall tumor
   Technical termPlasmid
Gene Ontology (GO)
   Biological processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ASK10Q9C5T54EBI-605118,EBI-607786From a different organism.
SKP1AQ392556EBI-605118,EBI-532357From a different organism.
SKP1BQ9FHW75EBI-605118,EBI-604076From a different organism.
VIP1Q9MA753EBI-605118,EBI-606057From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 202202Protein virF
PRO_0000065870

Regions

Domain20 – 6647F-box

Sequences

Sequence LengthMass (Da)Tools
P15597 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 3B0E33E157C1ADD1

FASTA20222,437
        10         20         30         40         50         60 
MRNSSLRDAS GSNDAQVPHK TELLNLPDHV LTEVAKRLAT NNPVESAENI ANFSKSHRFT 

        70         80         90        100        110        120 
RDAVRTEPLE KFSSRLKILS RNAKLLSHAV RHAATLPDGE QLSEAQLSQM RSEVATRPVL 

       130        140        150        160        170        180 
GVAYTHQDGQ PEERLSGNHL DHKINNIPNL VFNVAEPIMF NEISALEVMA EVRPIARSIK 

       190        200 
TAHDDARAEL MSADRPRSTR GL 

« Hide

References

[1]"Octopine and nopaline strains of Agrobacterium tumefaciens differ in virulence; molecular characterization of the virF locus."
Melchers L.S., Maroney M.J., den Dulk-Ras A., Thompson D.V., van Vuuren H.A.J., Schilperoort R.A., Hooykaas P.J.J.
Plant Mol. Biol. 14:249-259(1990) [PubMed: 2101693] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13981 Genomic DNA. Translation: CAA32163.1.
PIRS07979. S15915.
RefSeqNP_059824.1. NC_002377.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActP15597. 8 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1224343.

Phylogenomic databases

ProtClustDBCLSK539983.

Family and domain databases

PROSITEPS50181. FBOX. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVIRF_AGRT9
AccessionPrimary (citable) accession number: P15597
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 21, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families