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Protein

Steryl-sulfatase

Gene

Sts

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conversion of sulfated steroid precursors to estrogens during pregnancy.

Catalytic activityi

3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi34CalciumBy similarity1
Metal bindingi35CalciumBy similarity1
Active sitei74NucleophileBy similarity1
Metal bindingi74Calcium; via 3-oxoalanineBy similarity1
Active sitei135By similarity1
Metal bindingi341CalciumBy similarity1
Metal bindingi342CalciumBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • steryl-sulfatase activity Source: RGD

GO - Biological processi

  • female pregnancy Source: UniProtKB-KW
  • learning or memory Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • response to estrogen Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD
  • response to pH Source: RGD
  • skin development Source: RGD
  • steroid metabolic process Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism, Pregnancy, Steroid metabolism
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Steryl-sulfatase (EC:3.1.6.2)
Alternative name(s):
Arylsulfatase C
Short name:
ASC
Steroid sulfatase
Steryl-sulfate sulfohydrolase
Gene namesi
Name:Sts
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3783 Sts

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 183LumenalBy similarityAdd BLAST163
Transmembranei184 – 207HelicalBy similarityAdd BLAST24
Topological domaini208 – 211CytoplasmicBy similarity4
Transmembranei212 – 233HelicalBy similarityAdd BLAST22
Topological domaini234 – 577LumenalBy similarityAdd BLAST344

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3531

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000003341620 – 577Steryl-sulfataseAdd BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei743-oxoalanine (Cys)By similarity1
Disulfide bondi140 ↔ 147By similarity
Disulfide bondi169 ↔ 241By similarity
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi445 ↔ 488By similarity
Glycosylationi458N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi480 ↔ 486By similarity
Disulfide bondi561 ↔ 571By similarity

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP15589
PRIDEiP15589

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043915

Chemistry databases

BindingDBiP15589

Structurei

3D structure databases

ProteinModelPortaliP15589
SMRiP15589
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3867 Eukaryota
COG3119 LUCA
HOGENOMiHOG000135352
HOVERGENiHBG004283
InParanoidiP15589
KOiK01131
PhylomeDBiP15589

Family and domain databases

Gene3Di3.40.720.10, 3 hits
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR024607 Sulfatase_CS
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00523 SULFATASE_1, 1 hit
PS00149 SULFATASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWPCLLALL LSQLNFLCAA RPGPGPNFLL IMADDLGIGD LGCYGNRTLR
60 70 80 90 100
TPHIDRLALE GVKLTQHLAA APLCTPSRAA FLTGRYPVRS GMASHGRLGV
110 120 130 140 150
FLFSASSGGL PPNEVTFAKL LKGQGYTTGL VGKWHLGLSC QAASDFCHHP
160 170 180 190 200
GRHGFDRFLG TPTTNLRDCK PGGGTVFGSA QQVFVVLPMN ILGAVLLAMA
210 220 230 240 250
LARWAGLARP PGWVFGVTVA AMAAVGGAYV AFLYHFRPAN CFLMADFTIT
260 270 280 290 300
QQPTDYKGLT QRLASEAGDF LRRNRDTPFL LFLSFMHVHT AHFANPEFAG
310 320 330 340 350
QSLHGAYGDA VEEMDWAVGQ VLATLDKLGL ANNTLVYLTS DHGAHVEELG
360 370 380 390 400
PNGERHGGSN GIYRGGKANT WEGGIRVPGL VRWPGVIVPG QEVEEPTSNM
410 420 430 440 450
DVFPTVARLA GAELPTDRVI DGRDLMPLLL GHVQHSEHEF LFHYCNAYLS
460 470 480 490 500
AVAWRPHNSS SVWKAFYFTP NFDPPGSNGC FSTHVCMCHG HHVTHHDPPL
510 520 530 540 550
LFDIARDPRE RHPLTPETEP RHGEILRNMD AAARAHVATL EEAPNQLSMS
560 570
NVAWKPWLQL CLPSKPHPLA CRCAGDG
Length:577
Mass (Da):62,679
Last modified:October 1, 1996 - v2
Checksum:i07562EADEDCDB716
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37138 mRNA Translation: AAC53097.1
PIRiS05414
RefSeqiNP_036793.1, NM_012661.1
UniGeneiRn.6312

Genome annotation databases

GeneIDi24800
KEGGirno:24800

Similar proteinsi

Entry informationi

Entry nameiSTS_RAT
AccessioniPrimary (citable) accession number: P15589
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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