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P15588

- G6PD_DIDVI

UniProt

P15588 - G6PD_DIDVI

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

G6PD

Organism
Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei86 – 861NADP 1By similarity
    Binding sitei101 – 1011SubstratePROSITE-ProRule annotation
    Active sitei106 – 1061Proton acceptorBy similarity
    Binding sitei163 – 1631NADP 2By similarity
    Binding sitei179 – 1791NADP 2By similarity
    Binding sitei185 – 1851NADP 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi38 – 458NADP 1By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. glucose 6-phosphate metabolic process Source: UniProtKB
    2. NADP metabolic process Source: UniProtKB
    3. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
    Short name:
    G6PD
    Gene namesi
    Name:G6PD
    OrganismiDidelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)
    Taxonomic identifieri9267 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeDidelphis

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 191190Glucose-6-phosphate 1-dehydrogenasePRO_0000068082Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei173 – 1731N6-acetyllysineBy similarity

    Post-translational modificationi

    Acetylated by ELP3; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2; deacetylation stimulates its enzyme activity By similarity.By similarity

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Homotetramer; dimer of dimers. Interacts with SIRT2; the interaction is enhanced by H2O2 treatment By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP15588.
    SMRiP15588. Positions 27-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR001282. G6P_DH.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 2 hits.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragments.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15588-1 [UniParc]FASTAAdd to Basket

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    MAEQVALSRT QVCGILREEL YQGDAFHQSD THIFIIMGAS GDLAKKKIYP    50
    TIEPASFQRL NTHMNSLHHG AQANRLFYLA LPPIVYEAVT KNIKETCMSQ 100
    DVMQNHLLQM LCLVAMEKPA STNSDDVRDE KDELQEAWRI FTPLLHHIER 150
    EKTQPIPYVY GSRGPPEADE LMKRVGFQYE GTYKWVNPHK L 191
    Length:191
    Mass (Da):21,941
    Last modified:April 1, 1990 - v1
    Checksum:iE838F22AA83F4AFD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-adjacent residuesi52 – 532Curated
    Non-adjacent residuesi100 – 1012Curated
    Non-adjacent residuesi131 – 1322Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M19637, M19636 Genomic DNA. Translation: AAA30971.1.
    M19642 Genomic DNA. Translation: AAA30972.1. Sequence problems.
    M19638 Genomic DNA. Translation: AAA30973.1.
    M19639 Genomic DNA. Translation: AAA30974.1.
    M19641, M19640 Genomic DNA. Translation: AAA30975.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M19637 , M19636 Genomic DNA. Translation: AAA30971.1 .
    M19642 Genomic DNA. Translation: AAA30972.1 . Sequence problems.
    M19638 Genomic DNA. Translation: AAA30973.1 .
    M19639 Genomic DNA. Translation: AAA30974.1 .
    M19641 , M19640 Genomic DNA. Translation: AAA30975.1 .

    3D structure databases

    ProteinModelPortali P15588.
    SMRi P15588. Positions 27-191.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR001282. G6P_DH.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 2 hits.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular studies of marsupial X chromosomes reveal limited sequence homology of mammalian X-linked genes."
      Kaslow D.C., Migeon B.R., Persico M.G., Zollo M., Vandeberg J.L., Samollow P.B.
      Genomics 1:19-28(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiG6PD_DIDVI
    AccessioniPrimary (citable) accession number: P15588
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3