Reviewed, UniProtKB/Swiss-Prot P15588 (G6PD_DIDMA)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:

G6PD

Organism

Didelphis marsupialis virginiana (North American opossum)

Taxonomic identifier

9267 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Metatheria › Didelphimorphia › Didelphidae › Didelphis

Protein attributes

Sequence length	191 AA.
Sequence status	Fragments.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068082
Sites
	Active site	106	1	Proton acceptor By similarity
	Binding site	40	1	NADP By similarity
Amino acid modifications
	Modified residue	179	1	Phosphotyrosine By similarity
	Modified residue	183	1	Phosphotyrosine By similarity
Experimental info
	Non-adjacent residues	52 – 53	2
	Non-adjacent residues	100 – 101	2
	Non-adjacent residues	131 – 132	2

Sequences

	Sequence		Length	Mass (Da)
	P15588-1 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: E838F22AA83F4AFD	FASTA	191	21,941
	10 20 30 40 50 60 MAEQVALSRT QVCGILREEL YQGDAFHQSD THIFIIMGAS GDLAKKKIYP TIEPASFQRL 70 80 90 100 110 120 NTHMNSLHHG AQANRLFYLA LPPIVYEAVT KNIKETCMSQ DVMQNHLLQM LCLVAMEKPA 130 140 150 160 170 180 STNSDDVRDE KDELQEAWRI FTPLLHHIER EKTQPIPYVY GSRGPPEADE LMKRVGFQYE 190 GTYKWVNPHK L

References

[1]	"Molecular studies of marsupial X chromosomes reveal limited sequence homology of mammalian X-linked genes." Kaslow D.C., Migeon B.R., Persico M.G., Zollo M., Vandeberg J.L., Samollow P.B. Genomics 1:19-28(1987) [PubMed: 2822568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M19637, M19636 Genomic DNA. Translation: AAA30971.1. M19642 Genomic DNA. Translation: AAA30972.1. Sequence problems. M19638 Genomic DNA. Translation: AAA30973.1. M19639 Genomic DNA. Translation: AAA30974.1. M19641, M19640 Genomic DNA. Translation: AAA30975.1.
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
SMR	P15588. Positions 53-100, 132-191.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P15588.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 2 hits. [Graphical view]
PROSITE	PS00069. G6P_DEHYDROGENASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_DIDMA

Accession

Primary (citable) accession number: P15588

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	November 25, 2008
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)