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P15588 (G6PD_DIDVI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase

Short name=G6PD
EC=1.1.1.49
Gene names
Name:G6PD
OrganismDidelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)
Taxonomic identifier9267 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeDidelphis

Protein attributes

Sequence length191 AA.
Sequence statusFragments.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.

Subunit structure

Homotetramer; dimer of dimers By similarity.

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 191190Glucose-6-phosphate 1-dehydrogenase
PRO_0000068082

Regions

Nucleotide binding38 – 458NADP 1 By similarity

Sites

Active site1061Proton acceptor By similarity
Binding site861NADP 1 By similarity
Binding site1011Substrate By similarity
Binding site1631NADP 2 By similarity
Binding site1791NADP 2 By similarity
Binding site1851NADP 2 By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue1731N6-acetyllysine By similarity

Experimental info

Non-adjacent residues52 – 532
Non-adjacent residues100 – 1012
Non-adjacent residues131 – 1322

Sequences

Sequence LengthMass (Da)Tools
P15588 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: E838F22AA83F4AFD

FASTA19121,941
        10         20         30         40         50         60 
MAEQVALSRT QVCGILREEL YQGDAFHQSD THIFIIMGAS GDLAKKKIYP TIEPASFQRL 

        70         80         90        100        110        120 
NTHMNSLHHG AQANRLFYLA LPPIVYEAVT KNIKETCMSQ DVMQNHLLQM LCLVAMEKPA 

       130        140        150        160        170        180 
STNSDDVRDE KDELQEAWRI FTPLLHHIER EKTQPIPYVY GSRGPPEADE LMKRVGFQYE 

       190 
GTYKWVNPHK L 

« Hide

References

[1]"Molecular studies of marsupial X chromosomes reveal limited sequence homology of mammalian X-linked genes."
Kaslow D.C., Migeon B.R., Persico M.G., Zollo M., Vandeberg J.L., Samollow P.B.
Genomics 1:19-28(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M19637, M19636 Genomic DNA. Translation: AAA30971.1.
M19642 Genomic DNA. Translation: AAA30972.1. Sequence problems.
M19638 Genomic DNA. Translation: AAA30973.1.
M19639 Genomic DNA. Translation: AAA30974.1.
M19641, M19640 Genomic DNA. Translation: AAA30975.1.

3D structure databases

ProteinModelPortalP15588.
SMRP15588. Positions 27-191.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 2 hits.
PF00479. G6PD_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_DIDVI
AccessionPrimary (citable) accession number: P15588
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways