Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P15588

- G6PD_DIDVI

UniProt

P15588 - G6PD_DIDVI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

G6PD

Organism
Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861NADP 1By similarity
Binding sitei101 – 1011SubstratePROSITE-ProRule annotation
Active sitei106 – 1061Proton acceptorBy similarity
Binding sitei163 – 1631NADP 2By similarity
Binding sitei179 – 1791NADP 2By similarity
Binding sitei185 – 1851NADP 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 458NADP 1By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB
  2. NADP binding Source: InterPro

GO - Biological processi

  1. glucose 6-phosphate metabolic process Source: UniProtKB
  2. NADP metabolic process Source: UniProtKB
  3. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:G6PD
OrganismiDidelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)
Taxonomic identifieri9267 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeDidelphis

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 191190Glucose-6-phosphate 1-dehydrogenasePRO_0000068082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei173 – 1731N6-acetyllysineBy similarity

Post-translational modificationi

Acetylated by ELP3; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2; deacetylation stimulates its enzyme activity By similarity.By similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Homotetramer; dimer of dimers. Interacts with SIRT2; the interaction is enhanced by H2O2 treatment By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliP15588.
SMRiP15588. Positions 27-191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 2 hits.
PF00479. G6PD_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragments.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15588-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEQVALSRT QVCGILREEL YQGDAFHQSD THIFIIMGAS GDLAKKKIYP
60 70 80 90 100
TIEPASFQRL NTHMNSLHHG AQANRLFYLA LPPIVYEAVT KNIKETCMSQ
110 120 130 140 150
DVMQNHLLQM LCLVAMEKPA STNSDDVRDE KDELQEAWRI FTPLLHHIER
160 170 180 190
EKTQPIPYVY GSRGPPEADE LMKRVGFQYE GTYKWVNPHK L
Length:191
Mass (Da):21,941
Last modified:April 1, 1990 - v1
Checksum:iE838F22AA83F4AFD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-adjacent residuesi52 – 532Curated
Non-adjacent residuesi100 – 1012Curated
Non-adjacent residuesi131 – 1322Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19637, M19636 Genomic DNA. Translation: AAA30971.1.
M19642 Genomic DNA. Translation: AAA30972.1. Sequence problems.
M19638 Genomic DNA. Translation: AAA30973.1.
M19639 Genomic DNA. Translation: AAA30974.1.
M19641, M19640 Genomic DNA. Translation: AAA30975.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19637 , M19636 Genomic DNA. Translation: AAA30971.1 .
M19642 Genomic DNA. Translation: AAA30972.1 . Sequence problems.
M19638 Genomic DNA. Translation: AAA30973.1 .
M19639 Genomic DNA. Translation: AAA30974.1 .
M19641 , M19640 Genomic DNA. Translation: AAA30975.1 .

3D structure databases

ProteinModelPortali P15588.
SMRi P15588. Positions 27-191.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 2 hits.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular studies of marsupial X chromosomes reveal limited sequence homology of mammalian X-linked genes."
    Kaslow D.C., Migeon B.R., Persico M.G., Zollo M., Vandeberg J.L., Samollow P.B.
    Genomics 1:19-28(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiG6PD_DIDVI
AccessioniPrimary (citable) accession number: P15588
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 1, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3