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P15575

- B3AT_CHICK

UniProt

P15575 - B3AT_CHICK

Protein

Band 3 anion transport protein

Gene

SLC4A1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney By similarity.By similarity

    GO - Molecular functioni

    1. bicarbonate transmembrane transporter activity Source: UniProtKB
    2. inorganic anion exchanger activity Source: UniProtKB

    GO - Biological processi

    1. bicarbonate transport Source: UniProtKB

    Keywords - Biological processi

    Anion exchange, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Band 3 anion transport protein
    Alternative name(s):
    Solute carrier family 4 member 1
    Gene namesi
    Name:SLC4A1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Basolateral cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Detected in the erythrocyte cell membrane and on the basolateral membrane of alpha-intercalated cells in the collecting duct in the kidney.By similarity

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 922922Band 3 anion transport proteinPRO_0000079212Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi653 – 6531N-linked (GlcNAc...)Curated

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Erythrocytes.

    Interactioni

    Subunit structurei

    A dimer in solution, it spans the membrane asymmetrically and appears to be tetrameric.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP15575.
    SMRiP15575. Positions 402-443, 814-845.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 416416CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini555 – 57925ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini600 – 61415CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini636 – 67136ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei417 – 43721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei450 – 46920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei473 – 49220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei504 – 52320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei536 – 55419HelicalSequence AnalysisAdd
    BLAST
    Transmembranei580 – 59920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei615 – 63521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei672 – 69120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei710 – 73021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei774 – 79118HelicalSequence AnalysisAdd
    BLAST
    Transmembranei796 – 81722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei855 – 87622HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni417 – 922506Membrane (anion exchange)Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004326.
    PhylomeDBiP15575.

    Family and domain databases

    Gene3Di3.40.1100.10. 1 hit.
    InterProiIPR001717. Anion_exchange.
    IPR002977. Anion_exchange_1.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view]
    PANTHERiPTHR11453. PTHR11453. 1 hit.
    PfamiPF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 2 hits.
    [Graphical view]
    PRINTSiPR00165. ANIONEXCHNGR.
    PR01187. ANIONEXHNGR1.
    PR01231. HCO3TRNSPORT.
    SUPFAMiSSF55804. SSF55804. 1 hit.
    TIGRFAMsiTIGR00834. ae. 1 hit.
    PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15575-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGPGQDTED ALRRSLDPEG YEDTKGSRTS LGTMSNPLVS DVDLEAAGSR    50
    QPTAHRDTYE GYVELHELVL DSRKDPCWME AGRWLHLEES MEPGGAWGSH 100
    LPLLTYHSLL ELHRAFAKGV VLLDVAANSL AAVAHVLLDQ LIYEGQLKPQ 150
    HRDDVLRALL LRHKHPSEAE SVWTLPAAQL QCSDGEQKDA DERALLRDQR 200
    AVEMRELHGA GQSPSRAQLG PQLHQQLPED TEATLVLVAC AAFLEQPLLA 250
    LVRLGAPCPD AVLAVPLPVR FVLTVLGPDS PRLSYHEIRR AAATVMADRV 300
    FRRDAYLCGG RAELLGGLQG FLEASIVLPP QEVPSEQHLH ALIPLQRHAV 350
    RRRYQHPDTV RSPGGPTAPK DTGDKGQAPQ DDDPLLRTRR PFGGLVRDIR 400
    RRYPKYLSDI RDALNPQCLA AVIFIYFAAL SPAITFGGLL GEKTRGMMGV 450
    SELLLSTSVQ CLLFSLLSAQ PLLVVGFSGP LLVFEEAFFR FCEDHGLEYI 500
    VGRVWIGFWL ILLVLLVVAC EGTVLVRYLS RYTQEIFSFL ISLIFIYETF 550
    AKLVTIFEAH PLQQSYDTDV STEPSVPKPN TALLSLVLMA GTFFLALFLR 600
    QFKNSVFLPG KVRRLIGDFG VPISIFVMAL ADFFIKDTYT QKLKVPRGLE 650
    VTNGTARGWF IHPMGSATPF PIWMMFASPV PALLVFILIF LETQITTLIV 700
    SKPERKLVKG SGFHLDLLLI VAMGGLAALF GMPWLSATTV RTITHANALT 750
    VVGKSAVPGE RAHIVEVKEQ RLSGLLVAVL IGVSILMEPI LKYIPLAVLF 800
    GIFLYMGVTS LFGIQLFDRI LLLLMPPKYH PKEPYVTRVK TWRITSSPLT 850
    QILVVALLWG VKVSPASLRC PFVLVLTVPL RRLLLPRIFS EIELKCLDTD 900
    DAVVTFEEAE GQDVYNEVQM PS 922
    Length:922
    Mass (Da):102,223
    Last modified:April 1, 1990 - v1
    Checksum:iFF4ECAD6D60CF0CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23404 mRNA. Translation: AAA48753.1.
    PIRiA30816.
    RefSeqiNP_001277483.1. NM_001290554.1.
    UniGeneiGga.29570.
    Gga.49168.
    Gga.4952.

    Genome annotation databases

    GeneIDi396532.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23404 mRNA. Translation: AAA48753.1 .
    PIRi A30816.
    RefSeqi NP_001277483.1. NM_001290554.1.
    UniGenei Gga.29570.
    Gga.49168.
    Gga.4952.

    3D structure databases

    ProteinModelPortali P15575.
    SMRi P15575. Positions 402-443, 814-845.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396532.

    Phylogenomic databases

    HOVERGENi HBG004326.
    PhylomeDBi P15575.

    Family and domain databases

    Gene3Di 3.40.1100.10. 1 hit.
    InterProi IPR001717. Anion_exchange.
    IPR002977. Anion_exchange_1.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view ]
    PANTHERi PTHR11453. PTHR11453. 1 hit.
    Pfami PF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 2 hits.
    [Graphical view ]
    PRINTSi PR00165. ANIONEXCHNGR.
    PR01187. ANIONEXHNGR1.
    PR01231. HCO3TRNSPORT.
    SUPFAMi SSF55804. SSF55804. 1 hit.
    TIGRFAMsi TIGR00834. ae. 1 hit.
    PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two different mRNAs are transcribed from a single genomic locus encoding the chicken erythrocyte anion transport proteins (band 3)."
      Kim H.R.C., Yew N.S., Ansorge W., Voss H., Schwager C., Vennstroem B., Zenke M., Engel J.D.
      Mol. Cell. Biol. 8:4416-4424(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiB3AT_CHICK
    AccessioniPrimary (citable) accession number: P15575
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3