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P15575

- B3AT_CHICK

UniProt

P15575 - B3AT_CHICK

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Protein

Band 3 anion transport protein

Gene
SLC4A1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney By similarity.

GO - Molecular functioni

  1. bicarbonate transmembrane transporter activity Source: UniProtKB
  2. inorganic anion exchanger activity Source: UniProtKB

GO - Biological processi

  1. bicarbonate transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Band 3 anion transport protein
Alternative name(s):
Solute carrier family 4 member 1
Gene namesi
Name:SLC4A1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity. Basolateral cell membrane; Multi-pass membrane protein By similarity
Note: Detected in the erythrocyte cell membrane and on the basolateral membrane of alpha-intercalated cells in the collecting duct in the kidney By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 416416Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei417 – 43721Helical; Reviewed predictionAdd
BLAST
Transmembranei450 – 46920Helical; Reviewed predictionAdd
BLAST
Transmembranei473 – 49220Helical; Reviewed predictionAdd
BLAST
Transmembranei504 – 52320Helical; Reviewed predictionAdd
BLAST
Transmembranei536 – 55419Helical; Reviewed predictionAdd
BLAST
Topological domaini555 – 57925Extracellular Reviewed predictionAdd
BLAST
Transmembranei580 – 59920Helical; Reviewed predictionAdd
BLAST
Topological domaini600 – 61415Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei615 – 63521Helical; Reviewed predictionAdd
BLAST
Topological domaini636 – 67136Extracellular Reviewed predictionAdd
BLAST
Transmembranei672 – 69120Helical; Reviewed predictionAdd
BLAST
Transmembranei710 – 73021Helical; Reviewed predictionAdd
BLAST
Transmembranei774 – 79118Helical; Reviewed predictionAdd
BLAST
Transmembranei796 – 81722Helical; Reviewed predictionAdd
BLAST
Transmembranei855 – 87622Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 922922Band 3 anion transport proteinPRO_0000079212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi653 – 6531N-linked (GlcNAc...) Inferred

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Erythrocytes.

Interactioni

Subunit structurei

A dimer in solution, it spans the membrane asymmetrically and appears to be tetrameric By similarity.

Structurei

3D structure databases

ProteinModelPortaliP15575.
SMRiP15575. Positions 402-443, 814-845.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni417 – 922506Membrane (anion exchange)Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004326.
PhylomeDBiP15575.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002977. Anion_exchange_1.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01187. ANIONEXHNGR1.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15575-1 [UniParc]FASTAAdd to Basket

« Hide

MEGPGQDTED ALRRSLDPEG YEDTKGSRTS LGTMSNPLVS DVDLEAAGSR    50
QPTAHRDTYE GYVELHELVL DSRKDPCWME AGRWLHLEES MEPGGAWGSH 100
LPLLTYHSLL ELHRAFAKGV VLLDVAANSL AAVAHVLLDQ LIYEGQLKPQ 150
HRDDVLRALL LRHKHPSEAE SVWTLPAAQL QCSDGEQKDA DERALLRDQR 200
AVEMRELHGA GQSPSRAQLG PQLHQQLPED TEATLVLVAC AAFLEQPLLA 250
LVRLGAPCPD AVLAVPLPVR FVLTVLGPDS PRLSYHEIRR AAATVMADRV 300
FRRDAYLCGG RAELLGGLQG FLEASIVLPP QEVPSEQHLH ALIPLQRHAV 350
RRRYQHPDTV RSPGGPTAPK DTGDKGQAPQ DDDPLLRTRR PFGGLVRDIR 400
RRYPKYLSDI RDALNPQCLA AVIFIYFAAL SPAITFGGLL GEKTRGMMGV 450
SELLLSTSVQ CLLFSLLSAQ PLLVVGFSGP LLVFEEAFFR FCEDHGLEYI 500
VGRVWIGFWL ILLVLLVVAC EGTVLVRYLS RYTQEIFSFL ISLIFIYETF 550
AKLVTIFEAH PLQQSYDTDV STEPSVPKPN TALLSLVLMA GTFFLALFLR 600
QFKNSVFLPG KVRRLIGDFG VPISIFVMAL ADFFIKDTYT QKLKVPRGLE 650
VTNGTARGWF IHPMGSATPF PIWMMFASPV PALLVFILIF LETQITTLIV 700
SKPERKLVKG SGFHLDLLLI VAMGGLAALF GMPWLSATTV RTITHANALT 750
VVGKSAVPGE RAHIVEVKEQ RLSGLLVAVL IGVSILMEPI LKYIPLAVLF 800
GIFLYMGVTS LFGIQLFDRI LLLLMPPKYH PKEPYVTRVK TWRITSSPLT 850
QILVVALLWG VKVSPASLRC PFVLVLTVPL RRLLLPRIFS EIELKCLDTD 900
DAVVTFEEAE GQDVYNEVQM PS 922
Length:922
Mass (Da):102,223
Last modified:April 1, 1990 - v1
Checksum:iFF4ECAD6D60CF0CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23404 mRNA. Translation: AAA48753.1.
PIRiA30816.
RefSeqiNP_001277483.1. NM_001290554.1.
UniGeneiGga.29570.
Gga.49168.
Gga.4952.

Genome annotation databases

GeneIDi396532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23404 mRNA. Translation: AAA48753.1 .
PIRi A30816.
RefSeqi NP_001277483.1. NM_001290554.1.
UniGenei Gga.29570.
Gga.49168.
Gga.4952.

3D structure databases

ProteinModelPortali P15575.
SMRi P15575. Positions 402-443, 814-845.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396532.

Phylogenomic databases

HOVERGENi HBG004326.
PhylomeDBi P15575.

Family and domain databases

Gene3Di 3.40.1100.10. 1 hit.
InterProi IPR001717. Anion_exchange.
IPR002977. Anion_exchange_1.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view ]
PANTHERi PTHR11453. PTHR11453. 1 hit.
Pfami PF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view ]
PRINTSi PR00165. ANIONEXCHNGR.
PR01187. ANIONEXHNGR1.
PR01231. HCO3TRNSPORT.
SUPFAMi SSF55804. SSF55804. 1 hit.
TIGRFAMsi TIGR00834. ae. 1 hit.
PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two different mRNAs are transcribed from a single genomic locus encoding the chicken erythrocyte anion transport proteins (band 3)."
    Kim H.R.C., Yew N.S., Ansorge W., Voss H., Schwager C., Vennstroem B., Zenke M., Engel J.D.
    Mol. Cell. Biol. 8:4416-4424(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiB3AT_CHICK
AccessioniPrimary (citable) accession number: P15575
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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