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Protein

Band 3 anion transport protein

Gene

SLC4A1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Anion exchange, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Band 3 anion transport protein
Alternative name(s):
Solute carrier family 4 member 1
Gene namesi
Name:SLC4A1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity
  • Basolateral cell membrane By similarity; Multi-pass membrane protein By similarity

  • Note: Detected in the erythrocyte cell membrane and on the basolateral membrane of alpha-intercalated cells in the collecting duct in the kidney.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 416CytoplasmicBy similarityAdd BLAST416
Transmembranei417 – 440Helical; Name=1By similarityAdd BLAST24
Topological domaini441 – 448ExtracellularBy similarity8
Transmembranei449 – 469Helical; Name=2By similarityAdd BLAST21
Topological domaini470 – 472CytoplasmicBy similarity3
Transmembranei473 – 489Discontinuously helical; Name=3By similarityAdd BLAST17
Topological domaini490 – 498ExtracellularBy similarity9
Transmembranei499 – 519Helical; Name=4By similarityAdd BLAST21
Topological domaini520 – 531CytoplasmicBy similarityAdd BLAST12
Transmembranei532 – 554Helical; Name=5By similarityAdd BLAST23
Topological domaini555 – 581ExtracellularBy similarityAdd BLAST27
Transmembranei582 – 602Helical; Name=6By similarityAdd BLAST21
Topological domaini603 – 613CytoplasmicBy similarityAdd BLAST11
Transmembranei614 – 634Helical; Name=7By similarityAdd BLAST21
Topological domaini635 – 674ExtracellularBy similarityAdd BLAST40
Transmembranei675 – 695Helical; Name=8By similarityAdd BLAST21
Topological domaini696 – 711CytoplasmicBy similarityAdd BLAST16
Transmembranei712 – 730Helical; Name=9By similarityAdd BLAST19
Transmembranei731 – 748Discontinuously helical; Name=10By similarityAdd BLAST18
Topological domaini749 – 771CytoplasmicBy similarityAdd BLAST23
Transmembranei772 – 792Helical; Name=11By similarityAdd BLAST21
Transmembranei793 – 811Helical; Name=12By similarityAdd BLAST19
Topological domaini812 – 849CytoplasmicBy similarityAdd BLAST38
Intramembranei850 – 880Discontinuously helicalBy similarityAdd BLAST31
Topological domaini881 – 922CytoplasmicBy similarityAdd BLAST42

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000792121 – 922Band 3 anion transport proteinAdd BLAST922

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi653N-linked (GlcNAc...)Curated1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP15575.

Expressioni

Tissue specificityi

Erythrocytes.

Interactioni

Subunit structurei

A dimer in solution, it spans the membrane asymmetrically and appears to be tetrameric.By similarity

Structurei

3D structure databases

ProteinModelPortaliP15575.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004326.
InParanoidiP15575.
KOiK06573.
PhylomeDBiP15575.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002977. Anion_exchange_1.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01187. ANIONEXHNGR1.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15575-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPGQDTED ALRRSLDPEG YEDTKGSRTS LGTMSNPLVS DVDLEAAGSR
60 70 80 90 100
QPTAHRDTYE GYVELHELVL DSRKDPCWME AGRWLHLEES MEPGGAWGSH
110 120 130 140 150
LPLLTYHSLL ELHRAFAKGV VLLDVAANSL AAVAHVLLDQ LIYEGQLKPQ
160 170 180 190 200
HRDDVLRALL LRHKHPSEAE SVWTLPAAQL QCSDGEQKDA DERALLRDQR
210 220 230 240 250
AVEMRELHGA GQSPSRAQLG PQLHQQLPED TEATLVLVAC AAFLEQPLLA
260 270 280 290 300
LVRLGAPCPD AVLAVPLPVR FVLTVLGPDS PRLSYHEIRR AAATVMADRV
310 320 330 340 350
FRRDAYLCGG RAELLGGLQG FLEASIVLPP QEVPSEQHLH ALIPLQRHAV
360 370 380 390 400
RRRYQHPDTV RSPGGPTAPK DTGDKGQAPQ DDDPLLRTRR PFGGLVRDIR
410 420 430 440 450
RRYPKYLSDI RDALNPQCLA AVIFIYFAAL SPAITFGGLL GEKTRGMMGV
460 470 480 490 500
SELLLSTSVQ CLLFSLLSAQ PLLVVGFSGP LLVFEEAFFR FCEDHGLEYI
510 520 530 540 550
VGRVWIGFWL ILLVLLVVAC EGTVLVRYLS RYTQEIFSFL ISLIFIYETF
560 570 580 590 600
AKLVTIFEAH PLQQSYDTDV STEPSVPKPN TALLSLVLMA GTFFLALFLR
610 620 630 640 650
QFKNSVFLPG KVRRLIGDFG VPISIFVMAL ADFFIKDTYT QKLKVPRGLE
660 670 680 690 700
VTNGTARGWF IHPMGSATPF PIWMMFASPV PALLVFILIF LETQITTLIV
710 720 730 740 750
SKPERKLVKG SGFHLDLLLI VAMGGLAALF GMPWLSATTV RTITHANALT
760 770 780 790 800
VVGKSAVPGE RAHIVEVKEQ RLSGLLVAVL IGVSILMEPI LKYIPLAVLF
810 820 830 840 850
GIFLYMGVTS LFGIQLFDRI LLLLMPPKYH PKEPYVTRVK TWRITSSPLT
860 870 880 890 900
QILVVALLWG VKVSPASLRC PFVLVLTVPL RRLLLPRIFS EIELKCLDTD
910 920
DAVVTFEEAE GQDVYNEVQM PS
Length:922
Mass (Da):102,223
Last modified:April 1, 1990 - v1
Checksum:iFF4ECAD6D60CF0CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23404 mRNA. Translation: AAA48753.1.
PIRiA30816.
RefSeqiNP_001277483.1. NM_001290554.1.
UniGeneiGga.29570.
Gga.49168.
Gga.4952.
Gga.51423.

Genome annotation databases

GeneIDi396532.
KEGGigga:396532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23404 mRNA. Translation: AAA48753.1.
PIRiA30816.
RefSeqiNP_001277483.1. NM_001290554.1.
UniGeneiGga.29570.
Gga.49168.
Gga.4952.
Gga.51423.

3D structure databases

ProteinModelPortaliP15575.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP15575.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396532.
KEGGigga:396532.

Organism-specific databases

CTDi6521.

Phylogenomic databases

HOVERGENiHBG004326.
InParanoidiP15575.
KOiK06573.
PhylomeDBiP15575.

Miscellaneous databases

PROiP15575.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002977. Anion_exchange_1.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01187. ANIONEXHNGR1.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3AT_CHICK
AccessioniPrimary (citable) accession number: P15575
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.