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P15575 (B3AT_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Band 3 anion transport protein
Alternative name(s):
Solute carrier family 4 member 1
Gene names
Name:SLC4A1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length922 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin.

Subunit structure

A dimer in solution, it spans the membrane asymmetrically and appears to be tetrameric.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Erythrocytes.

Sequence similarities

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]

Ontologies

Keywords
   Biological processAnion exchange
Ion transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioninorganic anion exchanger activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 922922Band 3 anion transport protein
PRO_0000079212

Regions

Topological domain1 – 416416Cytoplasmic Potential
Transmembrane417 – 43721Helical; Potential
Transmembrane450 – 46920Helical; Potential
Transmembrane473 – 49220Helical; Potential
Transmembrane504 – 52320Helical; Potential
Transmembrane536 – 55419Helical; Potential
Topological domain555 – 57925Extracellular Potential
Transmembrane580 – 59920Helical; Potential
Topological domain600 – 61415Cytoplasmic Potential
Transmembrane615 – 63521Helical; Potential
Topological domain636 – 67136Extracellular Potential
Transmembrane672 – 69120Helical; Potential
Transmembrane710 – 73021Helical; Potential
Transmembrane774 – 79118Helical; Potential
Transmembrane796 – 81722Helical; Potential
Transmembrane855 – 87622Helical; Potential
Region417 – 922506Membrane (anion exchange)

Amino acid modifications

Glycosylation6531N-linked (GlcNAc...) Probable

Sequences

Sequence LengthMass (Da)Tools
P15575 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: FF4ECAD6D60CF0CF

FASTA922102,223
        10         20         30         40         50         60 
MEGPGQDTED ALRRSLDPEG YEDTKGSRTS LGTMSNPLVS DVDLEAAGSR QPTAHRDTYE 

        70         80         90        100        110        120 
GYVELHELVL DSRKDPCWME AGRWLHLEES MEPGGAWGSH LPLLTYHSLL ELHRAFAKGV 

       130        140        150        160        170        180 
VLLDVAANSL AAVAHVLLDQ LIYEGQLKPQ HRDDVLRALL LRHKHPSEAE SVWTLPAAQL 

       190        200        210        220        230        240 
QCSDGEQKDA DERALLRDQR AVEMRELHGA GQSPSRAQLG PQLHQQLPED TEATLVLVAC 

       250        260        270        280        290        300 
AAFLEQPLLA LVRLGAPCPD AVLAVPLPVR FVLTVLGPDS PRLSYHEIRR AAATVMADRV 

       310        320        330        340        350        360 
FRRDAYLCGG RAELLGGLQG FLEASIVLPP QEVPSEQHLH ALIPLQRHAV RRRYQHPDTV 

       370        380        390        400        410        420 
RSPGGPTAPK DTGDKGQAPQ DDDPLLRTRR PFGGLVRDIR RRYPKYLSDI RDALNPQCLA 

       430        440        450        460        470        480 
AVIFIYFAAL SPAITFGGLL GEKTRGMMGV SELLLSTSVQ CLLFSLLSAQ PLLVVGFSGP 

       490        500        510        520        530        540 
LLVFEEAFFR FCEDHGLEYI VGRVWIGFWL ILLVLLVVAC EGTVLVRYLS RYTQEIFSFL 

       550        560        570        580        590        600 
ISLIFIYETF AKLVTIFEAH PLQQSYDTDV STEPSVPKPN TALLSLVLMA GTFFLALFLR 

       610        620        630        640        650        660 
QFKNSVFLPG KVRRLIGDFG VPISIFVMAL ADFFIKDTYT QKLKVPRGLE VTNGTARGWF 

       670        680        690        700        710        720 
IHPMGSATPF PIWMMFASPV PALLVFILIF LETQITTLIV SKPERKLVKG SGFHLDLLLI 

       730        740        750        760        770        780 
VAMGGLAALF GMPWLSATTV RTITHANALT VVGKSAVPGE RAHIVEVKEQ RLSGLLVAVL 

       790        800        810        820        830        840 
IGVSILMEPI LKYIPLAVLF GIFLYMGVTS LFGIQLFDRI LLLLMPPKYH PKEPYVTRVK 

       850        860        870        880        890        900 
TWRITSSPLT QILVVALLWG VKVSPASLRC PFVLVLTVPL RRLLLPRIFS EIELKCLDTD 

       910        920 
DAVVTFEEAE GQDVYNEVQM PS

« Hide

References

[1]"Two different mRNAs are transcribed from a single genomic locus encoding the chicken erythrocyte anion transport proteins (band 3)."
Kim H.R.C., Yew N.S., Ansorge W., Voss H., Schwager C., Vennstroem B., Zenke M., Engel J.D.
Mol. Cell. Biol. 8:4416-4424(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M23404 mRNA. Translation: AAA48753.1.
IPIIPI00603414.
PIRA30816.
UniGeneGga.29570.
Gga.49168.
Gga.4952.

3D structure databases

ProteinModelPortalP15575.
SMRP15575. Positions 402-443, 814-845.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG004326.

Family and domain databases

Gene3D3.40.1100.10. 1 hit.
InterProIPR001717. Anion_exchange.
IPR002977. Anion_exchange_1.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERPTHR11453. PTHR11453. 1 hit.
PfamPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view]
PRINTSPR00165. ANIONEXCHNGR.
PR01187. ANIONEXHNGR1.
PR01231. HCO3TRNSPORT.
SUPFAMSSF55804. PTrfase/Anion_transptr. 1 hit.
TIGRFAMsTIGR00834. ae. 1 hit.
PROSITEPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB3AT_CHICK
AccessionPrimary (citable) accession number: P15575
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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