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Protein

Band 3 anion transport protein

Gene

SLC4A1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney (By similarity).By similarity

GO - Molecular functioni

  1. bicarbonate transmembrane transporter activity Source: UniProtKB
  2. inorganic anion exchanger activity Source: UniProtKB

GO - Biological processi

  1. anion transmembrane transport Source: GOC
  2. bicarbonate transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Band 3 anion transport protein
Alternative name(s):
Solute carrier family 4 member 1
Gene namesi
Name:SLC4A1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

  1. Cell membrane By similarity; Multi-pass membrane protein By similarity
  2. Basolateral cell membrane By similarity; Multi-pass membrane protein By similarity

  3. Note: Detected in the erythrocyte cell membrane and on the basolateral membrane of alpha-intercalated cells in the collecting duct in the kidney.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 416416CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei417 – 43721HelicalSequence AnalysisAdd
BLAST
Transmembranei450 – 46920HelicalSequence AnalysisAdd
BLAST
Transmembranei473 – 49220HelicalSequence AnalysisAdd
BLAST
Transmembranei504 – 52320HelicalSequence AnalysisAdd
BLAST
Transmembranei536 – 55419HelicalSequence AnalysisAdd
BLAST
Topological domaini555 – 57925ExtracellularSequence AnalysisAdd
BLAST
Transmembranei580 – 59920HelicalSequence AnalysisAdd
BLAST
Topological domaini600 – 61415CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei615 – 63521HelicalSequence AnalysisAdd
BLAST
Topological domaini636 – 67136ExtracellularSequence AnalysisAdd
BLAST
Transmembranei672 – 69120HelicalSequence AnalysisAdd
BLAST
Transmembranei710 – 73021HelicalSequence AnalysisAdd
BLAST
Transmembranei774 – 79118HelicalSequence AnalysisAdd
BLAST
Transmembranei796 – 81722HelicalSequence AnalysisAdd
BLAST
Transmembranei855 – 87622HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 922922Band 3 anion transport proteinPRO_0000079212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi653 – 6531N-linked (GlcNAc...)Curated

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Erythrocytes.

Interactioni

Subunit structurei

A dimer in solution, it spans the membrane asymmetrically and appears to be tetrameric.By similarity

Structurei

3D structure databases

ProteinModelPortaliP15575.
SMRiP15575. Positions 402-443, 814-845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni417 – 922506Membrane (anion exchange)Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004326.
InParanoidiP15575.
PhylomeDBiP15575.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002977. Anion_exchange_1.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01187. ANIONEXHNGR1.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15575-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPGQDTED ALRRSLDPEG YEDTKGSRTS LGTMSNPLVS DVDLEAAGSR
60 70 80 90 100
QPTAHRDTYE GYVELHELVL DSRKDPCWME AGRWLHLEES MEPGGAWGSH
110 120 130 140 150
LPLLTYHSLL ELHRAFAKGV VLLDVAANSL AAVAHVLLDQ LIYEGQLKPQ
160 170 180 190 200
HRDDVLRALL LRHKHPSEAE SVWTLPAAQL QCSDGEQKDA DERALLRDQR
210 220 230 240 250
AVEMRELHGA GQSPSRAQLG PQLHQQLPED TEATLVLVAC AAFLEQPLLA
260 270 280 290 300
LVRLGAPCPD AVLAVPLPVR FVLTVLGPDS PRLSYHEIRR AAATVMADRV
310 320 330 340 350
FRRDAYLCGG RAELLGGLQG FLEASIVLPP QEVPSEQHLH ALIPLQRHAV
360 370 380 390 400
RRRYQHPDTV RSPGGPTAPK DTGDKGQAPQ DDDPLLRTRR PFGGLVRDIR
410 420 430 440 450
RRYPKYLSDI RDALNPQCLA AVIFIYFAAL SPAITFGGLL GEKTRGMMGV
460 470 480 490 500
SELLLSTSVQ CLLFSLLSAQ PLLVVGFSGP LLVFEEAFFR FCEDHGLEYI
510 520 530 540 550
VGRVWIGFWL ILLVLLVVAC EGTVLVRYLS RYTQEIFSFL ISLIFIYETF
560 570 580 590 600
AKLVTIFEAH PLQQSYDTDV STEPSVPKPN TALLSLVLMA GTFFLALFLR
610 620 630 640 650
QFKNSVFLPG KVRRLIGDFG VPISIFVMAL ADFFIKDTYT QKLKVPRGLE
660 670 680 690 700
VTNGTARGWF IHPMGSATPF PIWMMFASPV PALLVFILIF LETQITTLIV
710 720 730 740 750
SKPERKLVKG SGFHLDLLLI VAMGGLAALF GMPWLSATTV RTITHANALT
760 770 780 790 800
VVGKSAVPGE RAHIVEVKEQ RLSGLLVAVL IGVSILMEPI LKYIPLAVLF
810 820 830 840 850
GIFLYMGVTS LFGIQLFDRI LLLLMPPKYH PKEPYVTRVK TWRITSSPLT
860 870 880 890 900
QILVVALLWG VKVSPASLRC PFVLVLTVPL RRLLLPRIFS EIELKCLDTD
910 920
DAVVTFEEAE GQDVYNEVQM PS
Length:922
Mass (Da):102,223
Last modified:April 1, 1990 - v1
Checksum:iFF4ECAD6D60CF0CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23404 mRNA. Translation: AAA48753.1.
PIRiA30816.
RefSeqiNP_001277483.1. NM_001290554.1.
UniGeneiGga.29570.
Gga.49168.
Gga.4952.

Genome annotation databases

GeneIDi396532.
KEGGigga:396532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23404 mRNA. Translation: AAA48753.1.
PIRiA30816.
RefSeqiNP_001277483.1. NM_001290554.1.
UniGeneiGga.29570.
Gga.49168.
Gga.4952.

3D structure databases

ProteinModelPortaliP15575.
SMRiP15575. Positions 402-443, 814-845.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396532.
KEGGigga:396532.

Organism-specific databases

CTDi6521.

Phylogenomic databases

HOVERGENiHBG004326.
InParanoidiP15575.
PhylomeDBiP15575.

Miscellaneous databases

PROiP15575.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002977. Anion_exchange_1.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01187. ANIONEXHNGR1.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Two different mRNAs are transcribed from a single genomic locus encoding the chicken erythrocyte anion transport proteins (band 3)."
    Kim H.R.C., Yew N.S., Ansorge W., Voss H., Schwager C., Vennstroem B., Zenke M., Engel J.D.
    Mol. Cell. Biol. 8:4416-4424(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiB3AT_CHICK
AccessioniPrimary (citable) accession number: P15575
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 29, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.