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Protein

Phosphoribosylaminoimidazole carboxylase

Gene

ade6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route).
Proteins known to be involved in this subpathway in this organism are:
  1. Phosphoribosylaminoimidazole carboxylase (ade6)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi134 – 18956ATPPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi4.1.1.21. 5613.
UniPathwayiUPA00074; UER00130.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole carboxylase (EC:4.1.1.21)
Alternative name(s):
AIR carboxylase
Short name:
AIRC
Gene namesi
Name:ade6
Synonyms:min1
ORF Names:SPCC1322.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1322.13.
PomBaseiSPCC1322.13. ade6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552Phosphoribosylaminoimidazole carboxylasePRO_0000075027Add
BLAST

Proteomic databases

MaxQBiP15567.

Interactioni

Protein-protein interaction databases

BioGridi275318. 4 interactions.
MINTiMINT-4687373.

Structurei

3D structure databases

ProteinModelPortaliP15567.
SMRiP15567. Positions 386-550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 295188ATP-graspPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.Curated
Contains 1 ATP-grasp domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000034027.
InParanoidiP15567.
KOiK11808.
OMAiACETSQY.
OrthoDBiEOG7FJH8G.
PhylomeDBiP15567.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.40.50.7700. 1 hit.
HAMAPiMF_01928. PurK.
MF_01929. PurE_classI.
InterProiIPR016301. AIR_COase.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR000031. PurE_dom.
IPR005875. PurK.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF00731. AIRC. 1 hit.
PF02222. ATP-grasp. 1 hit.
[Graphical view]
PIRSFiPIRSF001340. AIR_carboxylase. 1 hit.
SMARTiSM01001. AIRC. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52255. SSF52255. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01162. purE. 1 hit.
TIGR01161. purK. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKQVVGIL GGGQLGRMMV EAAHRLNIKC IILDAANSPA KQIDGGREHI
60 70 80 90 100
DASFTDPDAI VELSKKCTLL TTEIEHINTD ALAAVTKSVA VEPSPATLRC
110 120 130 140 150
IQDKYLQKQH LQVFKIALPE FCDAPDQESV EKAGQEFGYP FVLKSKTLAY
160 170 180 190 200
DGRGNYVVHQ PSEIPTAIKA LGDRPLYVEK FVPFSMEIAV MVVRSLDGKV
210 220 230 240 250
YAYPTTETIQ KDNVCHLVYA PARLPFSIQQ RAQTLAMDAV RTFEGAGIYG
260 270 280 290 300
VEMFVLQDGE TILLNEIAPR PHNSGHYTIE ACPTSQFEAH LRAICGLPFS
310 320 330 340 350
EINTQLSTST THALMVNILG TDDPDYVSKI AKRSLSIPGA TLHLYGKAES
360 370 380 390 400
RKGRKMGHVT IISDSPQECE RRYQMLLDVK DPVESPVVGI IMGSDSDLSK
410 420 430 440 450
MKDAAVILDE FKVPYELTIV SAHRTPDRMV TYARTAASRG LRVIIAGAGG
460 470 480 490 500
AAHLPGMVAA MTPLPVIGVP VKGSTLDGVD SLHSIVQMPR GVPVATVAIN
510 520 530 540 550
NSQNAGILAC RILATFQPSL LAAMESFMDN MKEIVLEKAD KLEKVGWKNY

SA
Length:552
Mass (Da):60,013
Last modified:April 1, 1990 - v1
Checksum:i2C10AF7C4349808F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37264 Genomic DNA. Translation: AAA35285.1.
X14488 Genomic DNA. Translation: CAA32650.1.
CU329672 Genomic DNA. Translation: CAA22866.1.
PIRiS02159. DEZPP.
RefSeqiNP_588141.1. NM_001023131.2.

Genome annotation databases

EnsemblFungiiSPCC1322.13.1; SPCC1322.13.1:pep; SPCC1322.13.
GeneIDi2538734.
KEGGispo:SPCC1322.13.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37264 Genomic DNA. Translation: AAA35285.1.
X14488 Genomic DNA. Translation: CAA32650.1.
CU329672 Genomic DNA. Translation: CAA22866.1.
PIRiS02159. DEZPP.
RefSeqiNP_588141.1. NM_001023131.2.

3D structure databases

ProteinModelPortaliP15567.
SMRiP15567. Positions 386-550.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275318. 4 interactions.
MINTiMINT-4687373.

Proteomic databases

MaxQBiP15567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1322.13.1; SPCC1322.13.1:pep; SPCC1322.13.
GeneIDi2538734.
KEGGispo:SPCC1322.13.

Organism-specific databases

EuPathDBiFungiDB:SPCC1322.13.
PomBaseiSPCC1322.13. ade6.

Phylogenomic databases

HOGENOMiHOG000034027.
InParanoidiP15567.
KOiK11808.
OMAiACETSQY.
OrthoDBiEOG7FJH8G.
PhylomeDBiP15567.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00130.
BRENDAi4.1.1.21. 5613.

Miscellaneous databases

PROiP15567.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.40.50.7700. 1 hit.
HAMAPiMF_01928. PurK.
MF_01929. PurE_classI.
InterProiIPR016301. AIR_COase.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR000031. PurE_dom.
IPR005875. PurK.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF00731. AIRC. 1 hit.
PF02222. ATP-grasp. 1 hit.
[Graphical view]
PIRSFiPIRSF001340. AIR_carboxylase. 1 hit.
SMARTiSM01001. AIRC. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52255. SSF52255. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01162. purE. 1 hit.
TIGR01161. purK. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence analysis of the ade6 gene of Schizosaccharomyces pombe. Wild-type and mutant alleles including the recombination host spot allele ade6-M26."
    Szankasi P., Heyer W.-D., Schuchert P., Kohli J.
    J. Mol. Biol. 204:917-925(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPUR6_SCHPO
AccessioniPrimary (citable) accession number: P15567
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 8, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.