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P15545

- COX2_STRPU

UniProt

P15545 - COX2_STRPU

Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi161 – 1611Copper ACurated
    Metal bindingi196 – 1961Copper ACurated
    Metal bindingi200 – 2001Copper ACurated
    Metal bindingi204 – 2041Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:COII
    Encoded oniMitochondrion
    OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
    Taxonomic identifieri7668 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
    ProteomesiUP000007110: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229Cytochrome c oxidase subunit 2PRO_0000183697Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7668.P15545.

    Structurei

    3D structure databases

    ProteinModelPortaliP15545.
    SMRiP15545. Positions 6-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini48 – 6215Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini85 – 229145Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8422HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    InParanoidiP15545.
    KOiK02261.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15545-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTWAQFGLQ DASSPLMEEL TYFHDYALIV LTLITILVFY GLVSLLVSSN    50
    TNRFFFEGQE LETIWTVIPA LILILIALPS LQLLYLMDEV NDPFLTIKAF 100
    GHQWYWSYEY TDFNDLEFDS YMVPTSDVSF GNPRLLEVDN RLVLPMQNPI 150
    RVLVSSADVL HSWAVPSLGT KMDAVPGRLN QTTFFAARTG VFYGQCSEIC 200
    GANHSFMPIV IESVPFNTFE NWVTQYLEE 229
    Length:229
    Mass (Da):26,111
    Last modified:April 1, 1990 - v1
    Checksum:iFF5C6BBF46EED403
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12631 Genomic DNA. Translation: CAA31155.1.
    PIRiS01503.
    RefSeqiNP_006969.1. NC_001453.1.

    Genome annotation databases

    GeneIDi2652720.
    KEGGispu:2652720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12631 Genomic DNA. Translation: CAA31155.1 .
    PIRi S01503.
    RefSeqi NP_006969.1. NC_001453.1.

    3D structure databases

    ProteinModelPortali P15545.
    SMRi P15545. Positions 6-227.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7668.P15545.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2652720.
    KEGGi spu:2652720.

    Organism-specific databases

    CTDi 4513.

    Phylogenomic databases

    eggNOGi COG1622.
    InParanoidi P15545.
    KOi K02261.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and gene organization of sea urchin mitochondrial DNA."
      Jacobs H.T., Elliott D.J., Math V.B., Farquharson A.
      J. Mol. Biol. 202:185-217(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX2_STRPU
    AccessioniPrimary (citable) accession number: P15545
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3