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P15544

- COX1_STRPU

UniProt

P15544 - COX1_STRPU

Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi61 – 611Iron (heme A axial ligand)Curated
    Metal bindingi240 – 2401Copper BCurated
    Metal bindingi244 – 2441Copper BCurated
    Metal bindingi290 – 2901Copper BCurated
    Metal bindingi291 – 2911Copper BCurated
    Metal bindingi376 – 3761Iron (heme A3 axial ligand)Curated
    Metal bindingi378 – 3781Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COI
    Encoded oniMitochondrion
    OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
    Taxonomic identifieri7668 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
    ProteomesiUP000007110: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517Cytochrome c oxidase subunit 1PRO_0000183423Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi7668.P15544.

    Structurei

    3D structure databases

    ProteinModelPortaliP15544.
    SMRiP15544. Positions 3-508.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei305 – 32521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei338 – 35821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei414 – 43421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    InParanoidiP15544.
    KOiK02256.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15544-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLSRWLFST NHKDIGTLYL IFGAWAGMVG TAMSVIIRAE LAQPGSLLND    50
    DQIYNVVVTA HALVMIFFMV MPIMIGGFGN WLIPLMIGAP DMAFPRMNNM 100
    SFWLIPPSFI LLLASAGVEN GAGTGWTIYP PLSSNITHAG SSVDLAIFSL 150
    HLAGASSILG LINFITTIIN MRTPGMSLDR LPLFVWSVFV TAFLLLLSLP 200
    VLAGAITMLL TDRNINTTFF DPAGGGDPIL FQHLFWLFGH PEVYILILPG 250
    FGMISHVIAH YSGKREPFGY LGLVYAMIAI GVLGFLVWAH HMFTVGMDVD 300
    TRAYFTAATM IIAVPTGLKV FSWMAKLQGS NLQWSLPLLW TLGIVFLFTL 350
    GGLTGIVLAN SSIDFVLHDT YYVVAHFHYV LSMGAVFAIF AGFTHWFPLF 400
    SGYSLHPLWG KVHFFIMFVG VNLTFFPQHF LGLAGMPRRY SDYPDAYTLW 450
    NTISSIGSTI SVVAMLFFLF LIWEAFASQR EGITPEFSHA SLEWQYTSFP 500
    PSHHTFDETP STIIIVK 517
    Length:517
    Mass (Da):57,306
    Last modified:April 1, 1990 - v1
    Checksum:iA3FBC0A23C9042FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12631 Genomic DNA. Translation: CAA31153.1.
    PIRiS01501.
    RefSeqiNP_006967.1. NC_001453.1.

    Genome annotation databases

    GeneIDi2652718.
    KEGGispu:2652718.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12631 Genomic DNA. Translation: CAA31153.1 .
    PIRi S01501.
    RefSeqi NP_006967.1. NC_001453.1.

    3D structure databases

    ProteinModelPortali P15544.
    SMRi P15544. Positions 3-508.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7668.P15544.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2652718.
    KEGGi spu:2652718.

    Organism-specific databases

    CTDi 4512.

    Phylogenomic databases

    eggNOGi COG0843.
    InParanoidi P15544.
    KOi K02256.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and gene organization of sea urchin mitochondrial DNA."
      Jacobs H.T., Elliott D.J., Math V.B., Farquharson A.
      J. Mol. Biol. 202:185-217(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Egg.
    2. Erratum
      Jacobs H.T., Elliott D.J., Math V.B., Farquharson A.
      J. Mol. Biol. 211:663-663(1990)
      Cited for: SEQUENCE REVISION TO 61-62.

    Entry informationi

    Entry nameiCOX1_STRPU
    AccessioniPrimary (citable) accession number: P15544
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3