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P15539

- C11B2_MOUSE

UniProt

P15539 - C11B2_MOUSE

Protein

Cytochrome P450 11B2, mitochondrial

Gene

Cyp11b2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Forms corticosterone from 11-deoxycorticosterone.

    Catalytic activityi

    A steroid + reduced adrenodoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenodoxin + H2O.
    Corticosterone + reduced adrenodoxin + O2 = 18-hydroxycorticosterone + oxidized adrenodoxin + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. corticosterone 18-monooxygenase activity Source: UniProtKB-EC
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro
    4. steroid 11-beta-monooxygenase activity Source: MGI

    GO - Biological processi

    1. aldosterone biosynthetic process Source: MGI
    2. drinking behavior Source: MGI
    3. ion homeostasis Source: MGI
    4. regulation of blood volume by renal aldosterone Source: MGI
    5. regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: MGI

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Steroidogenesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_204887. Mineralocorticoid biosynthesis.
    REACT_207160. Glucocorticoid biosynthesis.
    REACT_227038. Endogenous sterols.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 11B2, mitochondrial
    Alternative name(s):
    Aldosterone synthase
    CYPXIB2
    Cytochrome P450C11
    Steroid 11-beta-hydroxylase (EC:1.14.15.4, EC:1.14.15.5)
    Gene namesi
    Name:Cyp11b2
    Synonyms:Cyp11b-2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:88584. Cyp11b2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB-SubCell
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2424MitochondrionAdd
    BLAST
    Chaini25 – 500476Cytochrome P450 11B2, mitochondrialPRO_0000003600Add
    BLAST

    Proteomic databases

    MaxQBiP15539.
    PRIDEiP15539.

    Expressioni

    Gene expression databases

    BgeeiP15539.
    GenevestigatoriP15539.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000023253.

    Structurei

    3D structure databases

    ProteinModelPortaliP15539.
    SMRiP15539. Positions 34-499.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000013161.
    HOVERGENiHBG051098.
    InParanoidiQ14AB5.
    KOiK00497.
    PhylomeDBiP15539.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002399. Cyt_P450_mitochondrial.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00408. MITP450.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15539-1 [UniParc]FASTAAdd to Basket

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    MALRVTADVW LARPWQCLHR TRALGTTATL APKTLQPFEA IPQYSRNKWL    50
    KMIQILREQG QENLHLEMHQ VFRELGPIFR HSVGKTQIVS VMLPEDAEKL 100
    HQVESMLPRR MHLEPWVAHR ELRGLRRGVF LLNGPEWRLN RLRLNRNVLS 150
    PKAVQKFVPM VDMVARDFLE TLKEKVLQNA RGSLTMDVQQ SLFNYTIEAS 200
    NFALFGERLG LLGHDLSPGS LKFIHALHSM FKSTSQLLFL PKSLTRWTST 250
    RVWKEHFDAW DVISEYANRC IWKVHQELRL GSSQTYSGIV AELISQGSLP 300
    LDAIKANSME LTAGSVDTTA IPLVMTLFEL ARNPDVQKAL RQESLAAEAS 350
    IAANPQKAMS DLPLLRAALK ETLRLYPVGG FLERILSSDL VLQNYHVPAG 400
    TLVLLYLYSM GRNPAVFPRP ERYMPQRWLE RKRSFQHLAF GFGVRQCLGR 450
    RLAEVEMMLL LHHILKTFQV ETLRQEDVQM AYRFVLMPSS SPVLTFRPVS 500
    Length:500
    Mass (Da):57,373
    Last modified:July 27, 2011 - v3
    Checksum:iDCAFFF3EF2663195
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti491 – 4911S → E in AAB21517. (PubMed:1686470)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S85260 Genomic DNA. Translation: AAB21517.2.
    BC116908 mRNA. Translation: AAI16909.1.
    BC119321 mRNA. Translation: AAI19322.1.
    J04451 Genomic DNA. Translation: AAA50299.1.
    PIRiA41552.
    RefSeqiNP_034121.3. NM_009991.3.
    UniGeneiMm.377079.

    Genome annotation databases

    GeneIDi13072.
    KEGGimmu:13072.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S85260 Genomic DNA. Translation: AAB21517.2 .
    BC116908 mRNA. Translation: AAI16909.1 .
    BC119321 mRNA. Translation: AAI19322.1 .
    J04451 Genomic DNA. Translation: AAA50299.1 .
    PIRi A41552.
    RefSeqi NP_034121.3. NM_009991.3.
    UniGenei Mm.377079.

    3D structure databases

    ProteinModelPortali P15539.
    SMRi P15539. Positions 34-499.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000023253.

    Proteomic databases

    MaxQBi P15539.
    PRIDEi P15539.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 13072.
    KEGGi mmu:13072.

    Organism-specific databases

    CTDi 1585.
    MGIi MGI:88584. Cyp11b2.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000013161.
    HOVERGENi HBG051098.
    InParanoidi Q14AB5.
    KOi K00497.
    PhylomeDBi P15539.

    Enzyme and pathway databases

    Reactomei REACT_204887. Mineralocorticoid biosynthesis.
    REACT_207160. Glucocorticoid biosynthesis.
    REACT_227038. Endogenous sterols.

    Miscellaneous databases

    NextBioi 283008.
    PROi P15539.
    SOURCEi Search...

    Gene expression databases

    Bgeei P15539.
    Genevestigatori P15539.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002399. Cyt_P450_mitochondrial.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00408. MITP450.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids."
      Domalik L.J., Chaplin D.D., Kirkman M.S., Wu R.C., Liu W., Howard T.A., Seldin M.F., Parker K.L.
      Mol. Endocrinol. 5:1853-1861(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase."
      Mouw A.R., Rice D.A., Meade J.C., Chua S.C., White P.C., Schimmer B.P., Parker K.L.
      J. Biol. Chem. 264:1305-1309(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.

    Entry informationi

    Entry nameiC11B2_MOUSE
    AccessioniPrimary (citable) accession number: P15539
    Secondary accession number(s): Q14AB5, Q64661
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 129 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3