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P15530

- CD79B_MOUSE

UniProt

P15530 - CD79B_MOUSE

Protein

B-cell antigen receptor complex-associated protein beta chain

Gene

Cd79b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.4 Publications

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. B cell receptor signaling pathway Source: MGI

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_188194. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B-cell antigen receptor complex-associated protein beta chain
    Alternative name(s):
    B-cell-specific glycoprotein B29
    Ig-beta
    Immunoglobulin-associated B29 protein
    CD_antigen: CD79b
    Gene namesi
    Name:Cd79b
    Synonyms:Igb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96431. Cd79b.

    Subcellular locationi

    Cell membrane 3 Publications; Single-pass type I membrane protein 3 Publications
    Note: Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.

    GO - Cellular componenti

    1. B cell receptor complex Source: MGI
    2. external side of plasma membrane Source: MGI
    3. Golgi apparatus Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. nucleus Source: Ensembl
    6. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Add
    BLAST
    Chaini26 – 228203B-cell antigen receptor complex-associated protein beta chainPRO_0000014561Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 1241 PublicationPROSITE-ProRule annotation
    Disulfide bondi65 ↔ 1201 PublicationPROSITE-ProRule annotation
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi135 – 135Interchain (with C-113 in alpha chain)1 PublicationPROSITE-ProRule annotation
    Modified residuei195 – 1951Phosphotyrosine; by SRC-type Tyr-kinases2 PublicationsPROSITE-ProRule annotation
    Modified residuei206 – 2061Phosphotyrosine; by SRC-type Tyr-kinases2 PublicationsPROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP15530.
    PRIDEiP15530.

    PTM databases

    PhosphoSiteiP15530.

    Expressioni

    Tissue specificityi

    B-cells.

    Gene expression databases

    ArrayExpressiP15530.
    BgeeiP15530.
    CleanExiMM_CD79B.
    GenevestigatoriP15530.

    Interactioni

    Subunit structurei

    Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts with LYN.4 Publications

    Protein-protein interaction databases

    BioGridi200546. 1 interaction.
    DIPiDIP-59498N.
    STRINGi10090.ENSMUSP00000048239.

    Structurei

    Secondary structure

    1
    228
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi45 – 495
    Beta strandi51 – 566
    Beta strandi61 – 7111
    Beta strandi73 – 786
    Beta strandi84 – 863
    Turni90 – 934
    Beta strandi94 – 996
    Beta strandi102 – 1076
    Helixi112 – 1143
    Beta strandi116 – 1249
    Beta strandi131 – 1344
    Beta strandi137 – 1426

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3KHOX-ray3.11A/B27-159[»]
    3KHQX-ray1.70A27-159[»]
    ProteinModelPortaliP15530.
    SMRiP15530. Positions 43-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP15530.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 158133ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini181 – 22848CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei159 – 18022HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 13292Ig-like V-typeAdd
    BLAST
    Domaini184 – 21229ITAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ITAM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46934.
    GeneTreeiENSGT00510000048811.
    HOVERGENiHBG050855.
    InParanoidiP15530.
    KOiK06507.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR003110. Phos_immunorcpt_sig_ITAM.
    [Graphical view]
    PfamiPF02189. ITAM. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00077. ITAM. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51055. ITAM_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15530-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATLVLSSMP CHWLLFLLLL FSGEPVPAMT SSDLPLNFQG SPCSQIWQHP    50
    RFAAKKRSSM VKFHCYTNHS GALTWFRKRG SQQPQELVSE EGRIVQTQNG 100
    SVYTLTIQNI QYEDNGIYFC KQKCDSANHN VTDSCGTELL VLGFSTLDQL 150
    KRRNTLKDGI ILIQTLLIIL FIIVPIFLLL DKDDGKAGME EDHTYEGLNI 200
    DQTATYEDIV TLRTGEVKWS VGEHPGQE 228
    Length:228
    Mass (Da):25,726
    Last modified:April 1, 1990 - v1
    Checksum:i9A3A2008648E8307
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03857 mRNA. Translation: AAA37274.1.
    AK143573 mRNA. Translation: BAE25444.1.
    CT010358 mRNA. Translation: CAJ18566.1.
    BC012226 mRNA. Translation: AAH12226.1.
    AF002279 Genomic DNA. Translation: AAB93965.1.
    CCDSiCCDS48960.1.
    PIRiB60228.
    RefSeqiNP_032365.1. NM_008339.2.
    UniGeneiMm.2987.

    Genome annotation databases

    EnsembliENSMUST00000167143; ENSMUSP00000129029; ENSMUSG00000040592.
    GeneIDi15985.
    KEGGimmu:15985.
    UCSCiuc007lyt.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03857 mRNA. Translation: AAA37274.1 .
    AK143573 mRNA. Translation: BAE25444.1 .
    CT010358 mRNA. Translation: CAJ18566.1 .
    BC012226 mRNA. Translation: AAH12226.1 .
    AF002279 Genomic DNA. Translation: AAB93965.1 .
    CCDSi CCDS48960.1.
    PIRi B60228.
    RefSeqi NP_032365.1. NM_008339.2.
    UniGenei Mm.2987.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3KHO X-ray 3.11 A/B 27-159 [» ]
    3KHQ X-ray 1.70 A 27-159 [» ]
    ProteinModelPortali P15530.
    SMRi P15530. Positions 43-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200546. 1 interaction.
    DIPi DIP-59498N.
    STRINGi 10090.ENSMUSP00000048239.

    PTM databases

    PhosphoSitei P15530.

    Proteomic databases

    PaxDbi P15530.
    PRIDEi P15530.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000167143 ; ENSMUSP00000129029 ; ENSMUSG00000040592 .
    GeneIDi 15985.
    KEGGi mmu:15985.
    UCSCi uc007lyt.2. mouse.

    Organism-specific databases

    CTDi 974.
    MGIi MGI:96431. Cd79b.

    Phylogenomic databases

    eggNOGi NOG46934.
    GeneTreei ENSGT00510000048811.
    HOVERGENi HBG050855.
    InParanoidi P15530.
    KOi K06507.

    Enzyme and pathway databases

    Reactomei REACT_188194. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

    Miscellaneous databases

    EvolutionaryTracei P15530.
    NextBioi 288780.
    PROi P15530.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P15530.
    Bgeei P15530.
    CleanExi MM_CD79B.
    Genevestigatori P15530.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR003110. Phos_immunorcpt_sig_ITAM.
    [Graphical view ]
    Pfami PF02189. ITAM. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00077. ITAM. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51055. ITAM_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells."
      Hermanson G.G., Eisenberg D., Kincade P.W., Wall R.
      Proc. Natl. Acad. Sci. U.S.A. 85:6890-6894(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: B-cell.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Spleen.
    3. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
      Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.
    5. "Immunoglobulin enhancer and promoter motifs 5' of the B29 B-cell-specific gene."
      Hermanson G.G., Briskin M., Sigman D., Wall R.
      Proc. Natl. Acad. Sci. U.S.A. 86:7341-7345(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.
    6. "The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases."
      Lin J., Justement L.B.
      J. Immunol. 149:1548-1555(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BLK.
    7. "B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn."
      Law D.A., Chan V.W., Datta S.K., DeFranco A.L.
      Curr. Biol. 3:645-657(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LYN, PHOSPHORYLATION.
    8. "Activation of B- and T-cells by the cytoplasmic domains of the B-cell antigen receptor proteins Ig-alpha and Ig-beta."
      Taddie J.A., Hurley T.R., Hardwick B.S., Sefton B.M.
      J. Biol. Chem. 269:13529-13535(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Reconstitution of the B cell antigen receptor signaling components in COS cells."
      Saouaf S.J., Kut S.A., Fargnoli J., Rowley R.B., Bolen J.B., Mahajan S.
      J. Biol. Chem. 270:27072-27078(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BLK, PHOSPHORYLATION AT TYR-195 AND TYR-206.
    10. "A role for lipid rafts in B cell antigen receptor signaling and antigen targeting."
      Cheng P.C., Dykstra M.L., Mitchell R.N., Pierce S.K.
      J. Exp. Med. 190:1549-1560(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    11. "Ig alpha and Ig beta are required for efficient trafficking to late endosomes and to enhance antigen presentation."
      Siemasko K., Eisfelder B.J., Stebbins C., Kabak S., Sant A.J., Song W., Clark M.R.
      J. Immunol. 162:6518-6525(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling."
      Cheng P.C., Brown B.K., Song W., Pierce S.K.
      J. Immunol. 166:3693-3701(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    13. "Cooperative interaction of Ig(alpha) and Ig(beta) of the BCR regulates the kinetics and specificity of antigen targeting."
      Li C., Siemasko K., Clark M.R., Song W.
      Int. Immunol. 14:1179-1191(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    14. "Ig alpha/Ig beta complexes generate signals for B cell development independent of selective plasma membrane compartmentalization."
      Fuentes-Panana E.M., Bannish G., van der Voort D., King L.B., Monroe J.G.
      J. Immunol. 174:1245-1252(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    15. "Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor."
      Radaev S., Zou Z., Tolar P., Nguyen K., Nguyen A., Krueger P.D., Stutzman N., Pierce S., Sun P.D.
      Structure 18:934-943(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 27-159, SUBUNIT, DISULFIDE BONDS.

    Entry informationi

    Entry nameiCD79B_MOUSE
    AccessioniPrimary (citable) accession number: P15530
    Secondary accession number(s): Q4FJP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3