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P15515

- HIS1_HUMAN

UniProt

P15515 - HIS1_HUMAN

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Protein

Histatin-1

Gene
HTN1, HIS1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities.

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. biomineral tissue development Source: UniProtKB-KW
  2. defense response to bacterium Source: UniProtKB
  3. defense response to fungus Source: UniProtKB-KW
  4. killing of cells of other organism Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Fungicide

Keywords - Biological processi

Biomineralization

Names & Taxonomyi

Protein namesi
Recommended name:
Histatin-1
Alternative name(s):
Histidine-rich protein 1
Post-PB protein
Short name:
PPB
Cleaved into the following chain:
His1-(31-57)-peptide
Short name:
His1 31/57
Alternative name(s):
His1-(12-38)-peptide
Short name:
His1 12/38
Histatin-2
Gene namesi
Name:HTN1
Synonyms:HIS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:5283. HTN1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29546.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19193 PublicationsAdd
BLAST
Peptidei20 – 5738Histatin-13 PublicationsPRO_0000021416Add
BLAST
Peptidei31 – 5727His1-(31-57)-peptidePRO_0000021417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211Phosphoserine2 Publications
Modified residuei46 – 461Sulfotyrosine; in submandibular gland form1 Publication
Modified residuei49 – 491Sulfotyrosine; in submandibular gland form1 Publication
Modified residuei53 – 531Sulfotyrosine; in submandibular gland form1 Publication
Modified residuei55 – 551Sulfotyrosine; in submandibular gland form1 Publication

Post-translational modificationi

Depending on the authors, the form called histatin-2 is alternatively a proteolytic product, or the non-phosphorylated form of histatin-1.2 Publications

Keywords - PTMi

Phosphoprotein, Sulfation

Proteomic databases

PaxDbiP15515.
PeptideAtlasiP15515.
PRIDEiP15515.

PTM databases

PhosphoSiteiP15515.

Expressioni

Tissue specificityi

Submandibular and parotid glands.1 Publication

Gene expression databases

BgeeiP15515.
CleanExiHS_HTN1.
GenevestigatoriP15515.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MUC7Q8TAX72EBI-738638,EBI-738582

Protein-protein interaction databases

BioGridi109578. 1 interaction.
IntActiP15515. 1 interaction.
STRINGi9606.ENSP00000246896.

Structurei

3D structure databases

ProteinModelPortaliP15515.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG249966.
HOGENOMiHOG000112905.
HOVERGENiHBG005970.
InParanoidiP15515.
KOiK13913.
OMAiDYGSNYL.
OrthoDBiEOG7TTQBV.
PhylomeDBiP15515.
TreeFamiTF341637.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15515-1 [UniParc]FASTAAdd to Basket

« Hide

MKFFVFALVL ALMISMISAD SHEKRHHGYR RKFHEKHHSH REFPFYGDYG   50
SNYLYDN 57
Length:57
Mass (Da):6,963
Last modified:February 1, 1991 - v2
Checksum:iF3532BD1DCE23D83
GO

Mass spectrometryi

Molecular mass is 4848.2±0.5 Da from positions 20 - 50. Determined by ESI. Not post-translationally modified.1 Publication
Molecular mass is 4928.2±0.5 Da from positions 20 - 50. Determined by ESI. with 1 phosphate group.1 Publication
Molecular mass is 5008.6±0.5 Da from positions 20 - 50. Determined by ESI. with 1 phosphate group and 1 sulfate group.1 Publication
Molecular mass is 5088.4±0.5 Da from positions 20 - 50. Determined by ESI. with 1 phosphate group and 2 sulfate groups.1 Publication
Molecular mass is 5168.2±0.5 Da from positions 20 - 50. Determined by ESI. with 1 phosphate group and 3 sulfate groups.1 Publication
Molecular mass is 5247.7±0.5 Da from positions 20 - 50. Determined by ESI. with 1 phosphate group and 4 sulfate groups.1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26664 mRNA. Translation: AAA58645.1.
L04132 Genomic DNA. Translation: AAA02745.1.
BC017835 mRNA. Translation: AAH17835.1.
CCDSiCCDS3534.1.
PIRiI57425. A32541.
RefSeqiNP_002150.1. NM_002159.2.
UniGeneiHs.250959.

Genome annotation databases

EnsembliENST00000246896; ENSP00000246896; ENSG00000126550.
ENST00000511674; ENSP00000424501; ENSG00000126550.
GeneIDi3346.
KEGGihsa:3346.
UCSCiuc003hex.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26664 mRNA. Translation: AAA58645.1 .
L04132 Genomic DNA. Translation: AAA02745.1 .
BC017835 mRNA. Translation: AAH17835.1 .
CCDSi CCDS3534.1.
PIRi I57425. A32541.
RefSeqi NP_002150.1. NM_002159.2.
UniGenei Hs.250959.

3D structure databases

ProteinModelPortali P15515.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109578. 1 interaction.
IntActi P15515. 1 interaction.
STRINGi 9606.ENSP00000246896.

PTM databases

PhosphoSitei P15515.

Proteomic databases

PaxDbi P15515.
PeptideAtlasi P15515.
PRIDEi P15515.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000246896 ; ENSP00000246896 ; ENSG00000126550 .
ENST00000511674 ; ENSP00000424501 ; ENSG00000126550 .
GeneIDi 3346.
KEGGi hsa:3346.
UCSCi uc003hex.3. human.

Organism-specific databases

CTDi 3346.
GeneCardsi GC04P070916.
HGNCi HGNC:5283. HTN1.
MIMi 142701. gene.
neXtProti NX_P15515.
PharmGKBi PA29546.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG249966.
HOGENOMi HOG000112905.
HOVERGENi HBG005970.
InParanoidi P15515.
KOi K13913.
OMAi DYGSNYL.
OrthoDBi EOG7TTQBV.
PhylomeDBi P15515.
TreeFami TF341637.

Miscellaneous databases

ChiTaRSi HTN1. human.
GeneWikii HTN1.
GenomeRNAii 3346.
NextBioi 13236.
PROi P15515.
SOURCEi Search...

Gene expression databases

Bgeei P15515.
CleanExi HS_HTN1.
Genevestigatori P15515.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2)."
    Sabatini L.M., Azen E.A.
    Biochem. Biophys. Res. Commun. 160:495-502(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family."
    Chen Z.W.
    Mol. Biol. Evol. 10:497-511(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  4. "Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans."
    Oppenheim F.G., Xu T., McMillian F.M., Levitz S.M., Diamond R.D., Offner G.D., Troxler R.F.
    J. Biol. Chem. 263:7472-7477(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-57, PHOSPHORYLATION AT SER-21.
    Tissue: Parotid gland.
  5. "The primary structure and functional characterization of the neutral histidine-rich polypeptide from human parotid secretion."
    Oppenheim F.G., Yang Y.C., Diamond R.D., Hyslop D., Offner G.D., Troxler R.F.
    J. Biol. Chem. 261:1177-1182(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-57.
    Tissue: Parotid gland.
  6. "Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva."
    Sugiyama K., Ogino T., Ogata K.
    Arch. Oral Biol. 35:415-419(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-57.
    Tissue: Saliva.
  7. "Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs."
    Vanderspek J.C., Wyandt H.E., Skare J.C., Milunsky A., Oppenheim F.G., Troxler R.F.
    Am. J. Hum. Genet. 45:381-387(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-57.
  8. "Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of the submandibular gland."
    Cabras T., Fanali C., Monteiro J.A., Amado F., Inzitari R., Desiderio C., Scarano E., Giardina B., Castagnola M., Messana I.
    J. Proteome Res. 6:2472-2480(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, SULFATION AT TYR-46; TYR-49; TYR-53 AND TYR-55, TISSUE SPECIFICITY, MASS SPECTROMETRY.
  9. Cited for: PEPTIDE NOMENCLATURE.

Entry informationi

Entry nameiHIS1_HUMAN
AccessioniPrimary (citable) accession number: P15515
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: February 1, 1991
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The recommended nomenclature of salivary peptides follows published guidelines (1 Publication). In agreement with the authors, it has been decided to indicate the boundaries of the peptides according to the positions within the precursor, and not in the mature protein, as has formerly been proposed.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi