Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Amphiregulin

Gene

AREG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

Miscellaneous

AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII (Coat Protein 2) Mediated Vesicle Transport
R-HSA-5694530 Cargo concentration in the ER
SignaLinkiP15514
SIGNORiP15514

Names & Taxonomyi

Protein namesi
Recommended name:
Amphiregulin1 Publication
Short name:
AR1 Publication
Alternative name(s):
Colorectum cell-derived growth factor1 Publication
Short name:
CRDGF1 Publication
Gene namesi
Name:AREGImported
Synonyms:AREGBImported, SDGFImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109321.10
HGNCiHGNC:651 AREG
MIMi104640 gene
neXtProtiNX_P15514

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei199 – 221HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi374
OpenTargetsiENSG00000109321
PharmGKBiPA162376851

Chemistry databases

ChEMBLiCHEMBL3731

Polymorphism and mutation databases

BioMutaiAREG
DMDMi113754

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000000747320 – 100Add BLAST81
ChainiPRO_0000007474101 – 187AmphiregulinAdd BLAST87
PropeptideiPRO_0000007475188 – 252Add BLAST65

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagine1
Disulfide bondi146 ↔ 159PROSITE-ProRule annotation1 Publication
Disulfide bondi154 ↔ 170PROSITE-ProRule annotation1 Publication
Disulfide bondi172 ↔ 181PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP15514
PeptideAtlasiP15514
PRIDEiP15514

PTM databases

iPTMnetiP15514
PhosphoSitePlusiP15514

Miscellaneous databases

PMAP-CutDBiP15514

Expressioni

Inductioni

By phorbol 12-myristate 13-acetate (PMA).

Gene expression databases

BgeeiENSG00000109321
CleanExiHS_AREG
ExpressionAtlasiP15514 baseline and differential
GenevisibleiP15514 HS

Organism-specific databases

HPAiCAB023519
HPA008720

Interactioni

Subunit structurei

The immature precursor interacts with CNIH.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
S100A4P264474EBI-953674,EBI-717058

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106869, 11 interactors
DIPiDIP-5766N
IntActiP15514, 13 interactors
MINTiP15514
STRINGi9606.ENSP00000370227

Chemistry databases

BindingDBiP15514

Structurei

Secondary structure

1252
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni145 – 149Combined sources5
Helixi150 – 152Combined sources3
Beta strandi155 – 162Combined sources8
Turni163 – 166Combined sources4
Beta strandi167 – 171Combined sources5
Beta strandi178 – 180Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RNLNMR-A142-184[»]
ProteinModelPortaliP15514
SMRiP15514
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15514

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 182EGF-likePROSITE-ProRule annotationAdd BLAST41

Sequence similaritiesi

Belongs to the amphiregulin family.Curated

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXZG Eukaryota
ENOG4112CXY LUCA
GeneTreeiENSGT00530000063708
HOGENOMiHOG000034038
HOVERGENiHBG060279
InParanoidiP15514
KOiK09782
OMAiCKCHQDY
PhylomeDBiP15514
TreeFamiTF332773

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR015497 EGF_rcpt_ligand
PANTHERiPTHR10740 PTHR10740, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15514-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAPLLPPAP VVLSLLILGS GHYAAGLDLN DTYSGKREPF SGDHSADGFE
60 70 80 90 100
VTSRSEMSSG SEISPVSEMP SSSEPSSGAD YDYSEEYDNE PQIPGYIVDD
110 120 130 140 150
SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF
160 170 180 190 200
QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSKIA
210 220 230 240 250
LAAIAAFMSA VILTAVAVIT VQLRRQYVRK YEGEAEERKK LRQENGNVHA

IA
Length:252
Mass (Da):27,895
Last modified:February 1, 1991 - v2
Checksum:i68C1FA6BCD4D2BED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01891880D → V1 PublicationCorresponds to variant dbSNP:rs373527160Ensembl.1
Natural variantiVAR_01891981Y → C1 PublicationCorresponds to variant dbSNP:rs28364979Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30704 mRNA Translation: AAA51781.1
M30702
, M30698, M30699, M30700, M30701 Genomic DNA Translation: AAA51773.1
AY442340 Genomic DNA Translation: AAR05438.1
BT019866 mRNA Translation: AAV38669.1
AC021180 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05710.1
BC009799 mRNA Translation: AAH09799.1
BC146953 mRNA Translation: AAI46954.1
BC146967 mRNA Translation: AAI46968.1
CCDSiCCDS3565.1
PIRiA34702
RefSeqiNP_001648.1, NM_001657.3
UniGeneiHs.270833
Hs.645475

Genome annotation databases

EnsembliENST00000395748; ENSP00000379097; ENSG00000109321
GeneIDi374
KEGGihsa:374
UCSCiuc032tme.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAREG_HUMAN
AccessioniPrimary (citable) accession number: P15514
Secondary accession number(s): Q5U026
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: February 1, 1991
Last modified: February 28, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health