Reviewed, UniProtKB/Swiss-Prot P15502 (ELN_HUMAN)

Names and origin

Protein names

Recommended name:
    Elastin
Alternative name(s):
    Tropoelastin

Gene names

Name:

ELN

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	786 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle By similarity.
Subunit structure	The polymeric elastin chains are cross-linked together into an extensible 3D network. Forms a ternary complex with BGN and MFAP2. Interacts with MFAP2 via divalent cations (calcium > magnesium > manganese) in a dose-dependent and saturating manner.
Subcellular location	Secreted › extracellular space › extracellular matrix. Note: Extracellular matrix of elastic fibers.
Tissue specificity	Expressed within the outer myometrial smooth muscle and throughout the arteriolar tree of uterus (at protein level). Also expressed in the large arteries, lung and skin. Ref.12
Post-translational modification	Elastin is formed through the cross-linking of its soluble precursor tropoelastin. Cross-linking is initiated through the action of lysyl oxidase on exposed lysines to form allysine. Subsequent spontaneous condensation reactions with other allysine or unmodified lysine residues result in various bi-, tri-, and tetrafunctional cross-links. The most abundant cross-links in mature elastin fibers are lysinonorleucine, allysine aldol, desmosine, and isodesmosine. Hydroxylation on proline residues within the sequence motif, GXPG, is most likely 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates By similarity.
Involvement in disease	Defects in ELN are a cause of autosomal dominant cutis laxa [MIM:123700]. Cutis laxa is a rare connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. The skin changes are often accompanied by extracutaneous manifestations, including pulmonary emphysema, bladder diverticula, pulmonary artery stenosis and pyloric stenosis. Haploinsufficiency of ELN may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder and a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23. Defects in ELN are the cause of supravalvular aortic stenosis (SVAS) [MIM:185500]. SVAS is a congenital narrowing of the ascending aorta which can occur sporadically, as an autosomal dominant condition, or as one component of Williams-Beuren syndrome. Ref.15
Sequence similarities	Belongs to the elastin family.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Williams-Beuren syndrome
Domain	Repeat Signal
PTM	Disulfide bond Hydroxylation
Gene Ontology (GO)
Biological process	blood circulation Ref.14 Traceable author statement. Source: ProtInc cell proliferation Traceable author statement. Source: ProtInc organ morphogenesis Traceable author statement. Source: ProtInc respiratory gaseous exchange Ref.14 Traceable author statement. Source: ProtInc
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell proteinaceous extracellular matrix Non-traceable author statement. Source: UniProtKB
Molecular function	extracellular matrix constituent conferring elasticity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 3 (identifier: P15502-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: P15502-1)

The sequence of this isoform differs from the canonical sequence as follows:
     453-481: Missing.
     500-500: F → FALLNLA
     612-644: Missing.

Isoform 2 (identifier: P15502-2)

The sequence of this isoform differs from the canonical sequence as follows:
     453-481: Missing.
     612-644: Missing.

Isoform 4 (identifier: P15502-4)

The sequence of this isoform differs from the canonical sequence as follows:
     453-481: Missing.

Isoform 5 (identifier: P15502-5)

The sequence of this isoform differs from the canonical sequence as follows:
     125-125: A → AAPSVP
     453-481: Missing.
     612-644: Missing.
     740-757: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: P15502-6)

The sequence of this isoform differs from the canonical sequence as follows:
     453-500: Missing.
     612-644: Missing.
     740-757: Missing.

Isoform 7 (identifier: P15502-7)

The sequence of this isoform differs from the canonical sequence as follows:
     45-54: Missing.
     453-500: Missing.
     612-644: Missing.
     740-757: Missing.

Note: No experimental confirmation available.

Isoform 8 (identifier: P15502-8)

The sequence of this isoform differs from the canonical sequence as follows:
     215-228: Missing.
     453-500: Missing.
     555-570: AAAKSAAKVAAKAQLR → G
     612-644: Missing.
     740-757: Missing.

Note: No experimental confirmation available.

Isoform 9 (identifier: P15502-9)

The sequence of this isoform differs from the canonical sequence as follows:
     500-500: F → FALLNLA

Note: No experimental confirmation available.

Isoform 10 (identifier: P15502-10)

The sequence of this isoform differs from the canonical sequence as follows:
     500-500: F → FALLNLA
     612-644: Missing.

Note: No experimental confirmation available.

Isoform 11 (identifier: P15502-11)

The sequence of this isoform differs from the canonical sequence as follows:
     78-180: Missing.
     215-228: Missing.
     453-500: Missing.
     612-644: Missing.
     740-757: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	By similarity
	Chain	27 – 786	760	Elastin		PRO_0000021163
Regions
	Compositional bias	97 – 102	6	Poly-Ala
	Compositional bias	236 – 742	507	Ala-rich
Amino acid modifications
	Modified residue	34	1	Hydroxyproline
	Modified residue	65	1	Hydroxyproline; partial
	Modified residue	67	1	Hydroxyproline; partial
	Modified residue	88	1	Hydroxyproline; partial
	Modified residue	104	1	Allysine By similarity
	Modified residue	116	1	4-hydroxyproline; partial Ref.16
	Modified residue	156	1	Hydroxyproline; partial
	Modified residue	167	1	Hydroxyproline; partial
	Modified residue	170	1	Hydroxyproline; partial
	Modified residue	177	1	Hydroxyproline; partial
	Modified residue	190	1	4-hydroxyproline; partial Ref.16 Ref.17
	Modified residue	241	1	Allysine By similarity
	Modified residue	261	1	Allysine By similarity
	Modified residue	265	1	Allysine By similarity
	Modified residue	283	1	4-hydroxyproline; partial Ref.17
	Modified residue	286	1	4-hydroxyproline; partial Ref.16 Ref.17
	Modified residue	290	1	Hydroxyproline; partial
	Modified residue	312	1	Allysine By similarity
	Modified residue	315	1	Allysine By similarity
	Modified residue	327	1	4-hydroxyproline; partial Ref.17
	Modified residue	342	1	4-hydroxyproline; partial Ref.17
	Modified residue	347	1	4-hydroxyproline; partial Ref.17
	Modified residue	352	1	Hydroxyproline; partial
	Modified residue	355	1	Hydroxyproline; partial
	Modified residue	360	1	4-hydroxyproline; partial Ref.17
	Modified residue	375	1	Allysine By similarity
	Modified residue	379	1	Allysine By similarity
	Modified residue	382	1	Allysine By similarity
	Modified residue	415	1	4-hydroxyproline; partial Ref.16
	Modified residue	421	1	Hydroxyproline; partial
	Modified residue	427	1	4-hydroxyproline; partial Ref.16 Ref.17
	Modified residue	451	1	Allysine By similarity
	Modified residue	465	1	Hydroxyproline; partial
	Modified residue	467	1	Hydroxyproline; partial
	Modified residue	481	1	4-hydroxyproline; partial Ref.16
	Modified residue	492	1	Allysine By similarity
	Modified residue	496	1	Allysine By similarity
	Modified residue	522	1	Hydroxyproline; partial
	Modified residue	550	1	Hydroxyproline; partial
	Modified residue	558	1	Allysine By similarity
	Modified residue	562	1	Allysine By similarity
	Modified residue	566	1	Allysine By similarity
	Modified residue	580	1	4-hydroxyproline; partial Ref.16 Ref.17
	Modified residue	589	1	4-hydroxyproline Probable
	Modified residue	598	1	4-hydroxyproline Probable
	Modified residue	607	1	4-hydroxyproline; partial Ref.16
	Modified residue	646	1	Hydroxyproline; partial
	Modified residue	653	1	Allysine By similarity
	Modified residue	656	1	Allysine By similarity
	Modified residue	677	1	4-hydroxyproline; partial Ref.16 Ref.17
	Modified residue	693	1	Allysine By similarity
	Modified residue	697	1	Allysine By similarity
	Modified residue	735	1	Allysine By similarity
	Modified residue	738	1	Allysine By similarity
	Modified residue	769	1	Hydroxyproline; partial
	Modified residue	772	1	Hydroxyproline; partial
	Disulfide bond	776 ↔ 781		By similarity
Natural variations
	Alternative sequence	45 – 54	10	Missing in isoform 7.		VSP_012479
	Alternative sequence	78 – 180	103	Missing in isoform 11.		VSP_012480
	Alternative sequence	125	1	A → AAPSVP in isoform 5.		VSP_012481
	Alternative sequence	215 – 228	14	Missing in isoform 8 and isoform 11.		VSP_012482
	Alternative sequence	453 – 500	48	Missing in isoform 6, isoform 7, isoform 8 and isoform 11.		VSP_012483
	Alternative sequence	453 – 481	29	Missing in isoform 1, isoform 2, isoform 4 and isoform 5.		VSP_012484
	Alternative sequence	500	1	F → FALLNLA in isoform 1, isoform 9 and isoform 10.		VSP_012485
	Alternative sequence	555 – 570	16	AAAKS…KAQLR → G in isoform 8.		VSP_012486
	Alternative sequence	612 – 644	33	Missing in isoform 1, isoform 2, isoform 5, isoform 6, isoform 7, isoform 8, isoform 10 and isoform 11.		VSP_012487
	Alternative sequence	740 – 757	18	Missing in isoform 5, isoform 6, isoform 7, isoform 8 and isoform 11.		VSP_012488
	Natural variant	422	1	S → G: dbSNP rs2071307. Ref.3 Ref.5		VAR_020882
	Natural variant	610	1	G → R: dbSNP rs17855988.		VAR_056869
Experimental info
	Sequence conflict	317	1	G → E in CAD97910. Ref.4
	Sequence conflict	467 – 469	3	PQA → APG in AAB65620. Ref.10
	Sequence conflict	467 – 469	3	PQA → APG in AAB65621. Ref.10
	Sequence conflict	553	1	V → I in BAC85506. Ref.3
	Sequence conflict	691	1	A → T in CAD98065. Ref.4
	Sequence conflict	773	1	G → D in CAD97910. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 [UniParc]. Last modified January 4, 2005. Version 2. Checksum: 1E06FD2C692820F8	FASTA	786	68,499
	10 20 30 40 50 60 MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPGAGLGA LGGGALGPGG 70 80 90 100 110 120 KPLKPVPGGL AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG 130 140 150 160 170 180 LGVSAGAVVP QPGAGVKPGK VPGVGLPGVY PGGVLPGARF PGVGVLPGVP TGAGVKPKAP 190 200 210 220 230 240 GVGGAFAGIP GVGPFGGPQP GVPLGYPIKA PKLPGGYGLP YTTGKLPYGY GPGGVAGAAG 250 260 270 280 290 300 KAGYPTGTGV GPQAAAAAAA KAAAKFGAGA AGVLPGVGGA GVPGVPGAIP GIGGIAGVGT 310 320 330 340 350 360 PAAAAAAAAA AKAAKYGAAA GLVPGGPGFG PGVVGVPGAG VPGVGVPGAG IPVVPGAGIP 370 380 390 400 410 420 GAAVPGVVSP EAAAKAAAKA AKYGARPGVG VGGIPTYGVG AGGFPGFGVG VGGIPGVAGV 430 440 450 460 470 480 PSVGGVPGVG GVPGVGISPE AQAAAAAKAA KYGAAGAGVL GGLVPGPQAA VPGVPGTGGV 490 500 510 520 530 540 PGVGTPAAAA AKAAAKAAQF GLVPGVGVAP GVGVAPGVGV APGVGLAPGV GVAPGVGVAP 550 560 570 580 590 600 GVGVAPGIGP GGVAAAAKSA AKVAAKAQLR AAAGLGAGIP GLGVGVGVPG LGVGAGVPGL 610 620 630 640 650 660 GVGAGVPGFG AGADEGVRRS LSPELREGDP SSSQHLPSTP SSPRVPGALA AAKAAKYGAA 670 680 690 700 710 720 VPGVLGGLGA LGGVGIPGGV VGAGPAAAAA AAKAAAKAAQ FGLVGAAGLG GLGVGGLGVP 730 740 750 760 770 780 GVGGLGGIPP AAAAKAAKYG AAGLGGVLGG AGQFPLGGVA ARPGFGLSPI FPGGACLGKA CGRKRK
	Isoform 1. Checksum: AB06D15BA567AE46	FASTA	730	63,260
	10 20 30 40 50 60 MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPGAGLGA LGGGALGPGG 70 80 90 100 110 120 KPLKPVPGGL AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG 130 140 150 160 170 180 LGVSAGAVVP QPGAGVKPGK VPGVGLPGVY PGGVLPGARF PGVGVLPGVP TGAGVKPKAP 190 200 210 220 230 240 GVGGAFAGIP GVGPFGGPQP GVPLGYPIKA PKLPGGYGLP YTTGKLPYGY GPGGVAGAAG 250 260 270 280 290 300 KAGYPTGTGV GPQAAAAAAA KAAAKFGAGA AGVLPGVGGA GVPGVPGAIP GIGGIAGVGT 310 320 330 340 350 360 PAAAAAAAAA AKAAKYGAAA GLVPGGPGFG PGVVGVPGAG VPGVGVPGAG IPVVPGAGIP 370 380 390 400 410 420 GAAVPGVVSP EAAAKAAAKA AKYGARPGVG VGGIPTYGVG AGGFPGFGVG VGGIPGVAGV 430 440 450 460 470 480 PSVGGVPGVG GVPGVGISPE AQAAAAAKAA KYGVGTPAAA AAKAAAKAAQ FALLNLAGLV 490 500 510 520 530 540 PGVGVAPGVG VAPGVGVAPG VGLAPGVGVA PGVGVAPGVG VAPGIGPGGV AAAAKSAAKV 550 560 570 580 590 600 AAKAQLRAAA GLGAGIPGLG VGVGVPGLGV GAGVPGLGVG AGVPGFGAVP GALAAAKAAK 610 620 630 640 650 660 YGAAVPGVLG GLGALGGVGI PGGVVGAGPA AAAAAAKAAA KAAQFGLVGA AGLGGLGVGG 670 680 690 700 710 720 LGVPGVGGLG GIPPAAAAKA AKYGAAGLGG VLGGAGQFPL GGVAARPGFG LSPIFPGGAC 730 LGKACGRKRK
	Isoform 2. Checksum: 61155686228EDF3D	FASTA	724	62,664
	10 20 30 40 50 60 MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPGAGLGA LGGGALGPGG 70 80 90 100 110 120 KPLKPVPGGL AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG 130 140 150 160 170 180 LGVSAGAVVP QPGAGVKPGK VPGVGLPGVY PGGVLPGARF PGVGVLPGVP TGAGVKPKAP 190 200 210 220 230 240 GVGGAFAGIP GVGPFGGPQP GVPLGYPIKA PKLPGGYGLP YTTGKLPYGY GPGGVAGAAG 250 260 270 280 290 300 KAGYPTGTGV GPQAAAAAAA KAAAKFGAGA AGVLPGVGGA GVPGVPGAIP GIGGIAGVGT 310 320 330 340 350 360 PAAAAAAAAA AKAAKYGAAA GLVPGGPGFG PGVVGVPGAG VPGVGVPGAG IPVVPGAGIP 370 380 390 400 410 420 GAAVPGVVSP EAAAKAAAKA AKYGARPGVG VGGIPTYGVG AGGFPGFGVG VGGIPGVAGV 430 440 450 460 470 480 PSVGGVPGVG GVPGVGISPE AQAAAAAKAA KYGVGTPAAA AAKAAAKAAQ FGLVPGVGVA 490 500 510 520 530 540 PGVGVAPGVG VAPGVGLAPG VGVAPGVGVA PGVGVAPGIG PGGVAAAAKS AAKVAAKAQL 550 560 570 580 590 600 RAAAGLGAGI PGLGVGVGVP GLGVGAGVPG LGVGAGVPGF GAVPGALAAA KAAKYGAAVP 610 620 630 640 650 660 GVLGGLGALG GVGIPGGVVG AGPAAAAAAA KAAAKAAQFG LVGAAGLGGL GVGGLGVPGV 670 680 690 700 710 720 GGLGGIPPAA AAKAAKYGAA GLGGVLGGAG QFPLGGVAAR PGFGLSPIFP GGACLGKACG RKRK
	Isoform 4. Checksum: 23B7FE5B8AF85CA8	FASTA	757	66,136
	10 20 30 40 50 60 MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPGAGLGA LGGGALGPGG 70 80 90 100 110 120 KPLKPVPGGL AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG 130 140 150 160 170 180 LGVSAGAVVP QPGAGVKPGK VPGVGLPGVY PGGVLPGARF PGVGVLPGVP TGAGVKPKAP 190 200 210 220 230 240 GVGGAFAGIP GVGPFGGPQP GVPLGYPIKA PKLPGGYGLP YTTGKLPYGY GPGGVAGAAG 250 260 270 280 290 300 KAGYPTGTGV GPQAAAAAAA KAAAKFGAGA AGVLPGVGGA GVPGVPGAIP GIGGIAGVGT 310 320 330 340 350 360 PAAAAAAAAA AKAAKYGAAA GLVPGGPGFG PGVVGVPGAG VPGVGVPGAG IPVVPGAGIP 370 380 390 400 410 420 GAAVPGVVSP EAAAKAAAKA AKYGARPGVG VGGIPTYGVG AGGFPGFGVG VGGIPGVAGV 430 440 450 460 470 480 PSVGGVPGVG GVPGVGISPE AQAAAAAKAA KYGVGTPAAA AAKAAAKAAQ FGLVPGVGVA 490 500 510 520 530 540 PGVGVAPGVG VAPGVGLAPG VGVAPGVGVA PGVGVAPGIG PGGVAAAAKS AAKVAAKAQL 550 560 570 580 590 600 RAAAGLGAGI PGLGVGVGVP GLGVGAGVPG LGVGAGVPGF GAGADEGVRR SLSPELREGD 610 620 630 640 650 660 PSSSQHLPST PSSPRVPGAL AAAKAAKYGA AVPGVLGGLG ALGGVGIPGG VVGAGPAAAA 670 680 690 700 710 720 AAAKAAAKAA QFGLVGAAGL GGLGVGGLGV PGVGGLGGIP PAAAAKAAKY GAAGLGGVLG 730 740 750 GAGQFPLGGV AARPGFGLSP IFPGGACLGK ACGRKRK
	Isoform 5. Checksum: 19568E8A0D8B2B58	FASTA	711	61,635
	10 20 30 40 50 60 MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPGAGLGA LGGGALGPGG 70 80 90 100 110 120 KPLKPVPGGL AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG 130 140 150 160 170 180 LGVSAAPSVP GAVVPQPGAG VKPGKVPGVG LPGVYPGGVL PGARFPGVGV LPGVPTGAGV 190 200 210 220 230 240 KPKAPGVGGA FAGIPGVGPF GGPQPGVPLG YPIKAPKLPG GYGLPYTTGK LPYGYGPGGV 250 260 270 280 290 300 AGAAGKAGYP TGTGVGPQAA AAAAAKAAAK FGAGAAGVLP GVGGAGVPGV PGAIPGIGGI 310 320 330 340 350 360 AGVGTPAAAA AAAAAAKAAK YGAAAGLVPG GPGFGPGVVG VPGAGVPGVG VPGAGIPVVP 370 380 390 400 410 420 GAGIPGAAVP GVVSPEAAAK AAAKAAKYGA RPGVGVGGIP TYGVGAGGFP GFGVGVGGIP 430 440 450 460 470 480 GVAGVPSVGG VPGVGGVPGV GISPEAQAAA AAKAAKYGVG TPAAAAAKAA AKAAQFGLVP 490 500 510 520 530 540 GVGVAPGVGV APGVGVAPGV GLAPGVGVAP GVGVAPGVGV APGIGPGGVA AAAKSAAKVA 550 560 570 580 590 600 AKAQLRAAAG LGAGIPGLGV GVGVPGLGVG AGVPGLGVGA GVPGFGAVPG ALAAAKAAKY 610 620 630 640 650 660 GAAVPGVLGG LGALGGVGIP GGVVGAGPAA AAAAAKAAAK AAQFGLVGAA GLGGLGVGGL 670 680 690 700 710 GVPGVGGLGG IPPAAAAKAA KYGVAARPGF GLSPIFPGGA CLGKACGRKR K
	Isoform 6. Checksum: 864068C4C8E9F88F	FASTA	687	59,530
	10 20 30 40 50 60 MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPGAGLGA LGGGALGPGG 70 80 90 100 110 120 KPLKPVPGGL AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG 130 140 150 160 170 180 LGVSAGAVVP QPGAGVKPGK VPGVGLPGVY PGGVLPGARF PGVGVLPGVP TGAGVKPKAP 190 200 210 220 230 240 GVGGAFAGIP GVGPFGGPQP GVPLGYPIKA PKLPGGYGLP YTTGKLPYGY GPGGVAGAAG 250 260 270 280 290 300 KAGYPTGTGV GPQAAAAAAA KAAAKFGAGA AGVLPGVGGA GVPGVPGAIP GIGGIAGVGT 310 320 330 340 350 360 PAAAAAAAAA AKAAKYGAAA GLVPGGPGFG PGVVGVPGAG VPGVGVPGAG IPVVPGAGIP 370 380 390 400 410 420 GAAVPGVVSP EAAAKAAAKA AKYGARPGVG VGGIPTYGVG AGGFPGFGVG VGGIPGVAGV 430 440 450 460 470 480 PSVGGVPGVG GVPGVGISPE AQAAAAAKAA KYGLVPGVGV APGVGVAPGV GVAPGVGLAP 490 500 510 520 530 540 GVGVAPGVGV APGVGVAPGI GPGGVAAAAK SAAKVAAKAQ LRAAAGLGAG IPGLGVGVGV 550 560 570 580 590 600 PGLGVGAGVP GLGVGAGVPG FGAVPGALAA AKAAKYGAAV PGVLGGLGAL GGVGIPGGVV 610 620 630 640 650 660 GAGPAAAAAA AKAAAKAAQF GLVGAAGLGG LGVGGLGVPG VGGLGGIPPA AAAKAAKYGV 670 680 AARPGFGLSP IFPGGACLGK ACGRKRK
	Isoform 7. Checksum: C50C284800A88E7A	FASTA	677	58,819
	10 20 30 40 50 60 MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPALGPGG KPLKPVPGGL 70 80 90 100 110 120 AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG LGVSAGAVVP 130 140 150 160 170 180 QPGAGVKPGK VPGVGLPGVY PGGVLPGARF PGVGVLPGVP TGAGVKPKAP GVGGAFAGIP 190 200 210 220 230 240 GVGPFGGPQP GVPLGYPIKA PKLPGGYGLP YTTGKLPYGY GPGGVAGAAG KAGYPTGTGV 250 260 270 280 290 300 GPQAAAAAAA KAAAKFGAGA AGVLPGVGGA GVPGVPGAIP GIGGIAGVGT PAAAAAAAAA 310 320 330 340 350 360 AKAAKYGAAA GLVPGGPGFG PGVVGVPGAG VPGVGVPGAG IPVVPGAGIP GAAVPGVVSP 370 380 390 400 410 420 EAAAKAAAKA AKYGARPGVG VGGIPTYGVG AGGFPGFGVG VGGIPGVAGV PSVGGVPGVG 430 440 450 460 470 480 GVPGVGISPE AQAAAAAKAA KYGLVPGVGV APGVGVAPGV GVAPGVGLAP GVGVAPGVGV 490 500 510 520 530 540 APGVGVAPGI GPGGVAAAAK SAAKVAAKAQ LRAAAGLGAG IPGLGVGVGV PGLGVGAGVP 550 560 570 580 590 600 GLGVGAGVPG FGAVPGALAA AKAAKYGAAV PGVLGGLGAL GGVGIPGGVV GAGPAAAAAA 610 620 630 640 650 660 AKAAAKAAQF GLVGAAGLGG LGVGGLGVPG VGGLGGIPPA AAAKAAKYGV AARPGFGLSP 670 IFPGGACLGK ACGRKRK
	Isoform 8. Checksum: 5DAFC01166AB895B	FASTA	658	56,581
	10 20 30 40 50 60 MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPGAGLGA LGGGALGPGG 70 80 90 100 110 120 KPLKPVPGGL AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG 130 140 150 160 170 180 LGVSAGAVVP QPGAGVKPGK VPGVGLPGVY PGGVLPGARF PGVGVLPGVP TGAGVKPKAP 190 200 210 220 230 240 GVGGAFAGIP GVGPFGGPQP GVPLGYPIKA PKLPGYGPGG VAGAAGKAGY PTGTGVGPQA 250 260 270 280 290 300 AAAAAAKAAA KFGAGAAGVL PGVGGAGVPG VPGAIPGIGG IAGVGTPAAA AAAAAAAKAA 310 320 330 340 350 360 KYGAAAGLVP GGPGFGPGVV GVPGAGVPGV GVPGAGIPVV PGAGIPGAAV PGVVSPEAAA 370 380 390 400 410 420 KAAAKAAKYG ARPGVGVGGI PTYGVGAGGF PGFGVGVGGI PGVAGVPSVG GVPGVGGVPG 430 440 450 460 470 480 VGISPEAQAA AAAKAAKYGL VPGVGVAPGV GVAPGVGVAP GVGLAPGVGV APGVGVAPGV 490 500 510 520 530 540 GVAPGIGPGG VAGAAAGLGA GIPGLGVGVG VPGLGVGAGV PGLGVGAGVP GFGAVPGALA 550 560 570 580 590 600 AAKAAKYGAA VPGVLGGLGA LGGVGIPGGV VGAGPAAAAA AAKAAAKAAQ FGLVGAAGLG 610 620 630 640 650 GLGVGGLGVP GVGGLGGIPP AAAAKAAKYG VAARPGFGLS PIFPGGACLG KACGRKRK
	Isoform 9. Checksum: 392ECBA04B6AF306	FASTA	792	69,094
	10 20 30 40 50 60 MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPGAGLGA LGGGALGPGG 70 80 90 100 110 120 KPLKPVPGGL AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG 130 140 150 160 170 180 LGVSAGAVVP QPGAGVKPGK VPGVGLPGVY PGGVLPGARF PGVGVLPGVP TGAGVKPKAP 190 200 210 220 230 240 GVGGAFAGIP GVGPFGGPQP GVPLGYPIKA PKLPGGYGLP YTTGKLPYGY GPGGVAGAAG 250 260 270 280 290 300 KAGYPTGTGV GPQAAAAAAA KAAAKFGAGA AGVLPGVGGA GVPGVPGAIP GIGGIAGVGT 310 320 330 340 350 360 PAAAAAAAAA AKAAKYGAAA GLVPGGPGFG PGVVGVPGAG VPGVGVPGAG IPVVPGAGIP 370 380 390 400 410 420 GAAVPGVVSP EAAAKAAAKA AKYGARPGVG VGGIPTYGVG AGGFPGFGVG VGGIPGVAGV 430 440 450 460 470 480 PSVGGVPGVG GVPGVGISPE AQAAAAAKAA KYGAAGAGVL GGLVPGPQAA VPGVPGTGGV 490 500 510 520 530 540 PGVGTPAAAA AKAAAKAAQF ALLNLAGLVP GVGVAPGVGV APGVGVAPGV GLAPGVGVAP 550 560 570 580 590 600 GVGVAPGVGV APGIGPGGVA AAAKSAAKVA AKAQLRAAAG LGAGIPGLGV GVGVPGLGVG 610 620 630 640 650 660 AGVPGLGVGA GVPGFGAGAD EGVRRSLSPE LREGDPSSSQ HLPSTPSSPR VPGALAAAKA 670 680 690 700 710 720 AKYGAAVPGV LGGLGALGGV GIPGGVVGAG PAAAAAAAKA AAKAAQFGLV GAAGLGGLGV 730 740 750 760 770 780 GGLGVPGVGG LGGIPPAAAA KAAKYGAAGL GGVLGGAGQF PLGGVAARPG FGLSPIFPGG 790 ACLGKACGRK RK
	Isoform 10. Checksum: 9077C3510A0CF34B	FASTA	759	65,623
	10 20 30 40 50 60 MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPGAGLGA LGGGALGPGG 70 80 90 100 110 120 KPLKPVPGGL AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG 130 140 150 160 170 180 LGVSAGAVVP QPGAGVKPGK VPGVGLPGVY PGGVLPGARF PGVGVLPGVP TGAGVKPKAP 190 200 210 220 230 240 GVGGAFAGIP GVGPFGGPQP GVPLGYPIKA PKLPGGYGLP YTTGKLPYGY GPGGVAGAAG 250 260 270 280 290 300 KAGYPTGTGV GPQAAAAAAA KAAAKFGAGA AGVLPGVGGA GVPGVPGAIP GIGGIAGVGT 310 320 330 340 350 360 PAAAAAAAAA AKAAKYGAAA GLVPGGPGFG PGVVGVPGAG VPGVGVPGAG IPVVPGAGIP 370 380 390 400 410 420 GAAVPGVVSP EAAAKAAAKA AKYGARPGVG VGGIPTYGVG AGGFPGFGVG VGGIPGVAGV 430 440 450 460 470 480 PSVGGVPGVG GVPGVGISPE AQAAAAAKAA KYGAAGAGVL GGLVPGPQAA VPGVPGTGGV 490 500 510 520 530 540 PGVGTPAAAA AKAAAKAAQF ALLNLAGLVP GVGVAPGVGV APGVGVAPGV GLAPGVGVAP 550 560 570 580 590 600 GVGVAPGVGV APGIGPGGVA AAAKSAAKVA AKAQLRAAAG LGAGIPGLGV GVGVPGLGVG 610 620 630 640 650 660 AGVPGLGVGA GVPGFGAVPG ALAAAKAAKY GAAVPGVLGG LGALGGVGIP GGVVGAGPAA 670 680 690 700 710 720 AAAAAKAAAK AAQFGLVGAA GLGGLGVGGL GVPGVGGLGG IPPAAAAKAA KYGAAGLGGV 730 740 750 LGGAGQFPLG GVAARPGFGL SPIFPGGACL GKACGRKRK
	Isoform 11. Checksum: 6C952DA7D0724770	FASTA	570	48,927
	10 20 30 40 50 60 MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPGAGLGA LGGGALGPGG 70 80 90 100 110 120 KPLKPVPGGL AGAGLGAGVG GAFAGIPGVG PFGGPQPGVP LGYPIKAPKL PGYGPGGVAG 130 140 150 160 170 180 AAGKAGYPTG TGVGPQAAAA AAAKAAAKFG AGAAGVLPGV GGAGVPGVPG AIPGIGGIAG 190 200 210 220 230 240 VGTPAAAAAA AAAAKAAKYG AAAGLVPGGP GFGPGVVGVP GAGVPGVGVP GAGIPVVPGA 250 260 270 280 290 300 GIPGAAVPGV VSPEAAAKAA AKAAKYGARP GVGVGGIPTY GVGAGGFPGF GVGVGGIPGV 310 320 330 340 350 360 AGVPSVGGVP GVGGVPGVGI SPEAQAAAAA KAAKYGLVPG VGVAPGVGVA PGVGVAPGVG 370 380 390 400 410 420 LAPGVGVAPG VGVAPGVGVA PGIGPGGVAA AAKSAAKVAA KAQLRAAAGL GAGIPGLGVG 430 440 450 460 470 480 VGVPGLGVGA GVPGLGVGAG VPGFGAVPGA LAAAKAAKYG AAVPGVLGGL GALGGVGIPG 490 500 510 520 530 540 GVVGAGPAAA AAAAKAAAKA AQFGLVGAAG LGGLGVGGLG VPGVGGLGGI PPAAAAKAAK 550 560 570 YGVAARPGFG LSPIFPGGAC LGKACGRKRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Alternative splicing of human elastin mRNA indicated by sequence analysis of cloned genomic and complementary DNA." Indik Z., Yeh H., Ornstein-Goldstein N., Sheppard P., Anderson N., Rosenbloom J.C., Peltonen L., Rosenbloom J. Proc. Natl. Acad. Sci. U.S.A. 84:5680-5684(1987) [PubMed: 3039501] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2; 3; 4 AND 6).
[2]	"Cloning of full-length elastin cDNAs from a human skin fibroblast recombinant cDNA library: further elucidation of alternative splicing utilizing exon-specific oligonucleotides." Fazio M.J., Olsen D.R., Kauh E.A., Baldwin C.T., Indik Z., Ornstein-Goldstein N., Yeh H., Rosenbloom J., Uitto J. J. Invest. Dermatol. 91:458-464(1988) [PubMed: 3171221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Skin fibroblast.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 11).
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7), VARIANT GLY-422. Tissue: Fetal kidney.
[5]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-422.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8), VARIANT ARG-610. Tissue: Eye.
[7]	"Characterization of the complete human elastin gene. Delineation of unusual features in the 5'-flanking region." Bashir M.M., Indik Z., Yeh H., Ornstein-Goldstein N., Rosenbloom J.C., Abrams W., Fazio M., Uitto J., Rosenbloom J. J. Biol. Chem. 264:8887-8891(1989) [PubMed: 2722804] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 1-27.
[8]	Bressan G.M. Submitted (JUN-1989) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-27.
[9]	Bressan G.M. Submitted (OCT-1991) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[10]	"Elastin point mutations cause an obstructive vascular disease, supravalvular aortic stenosis." Li D.Y., Toland A.E., Boak B.B., Atkinson D.L., Ensing G.J., Morris C.A., Keating M.T. Hum. Mol. Genet. 6:1021-1028(1997) [PubMed: 9215670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-657 (ISOFORMS 9 AND 10), VARIANT ARG-610.
[11]	"Isolation and characterization of human elastin cDNAs, and age-associated variation in elastin gene expression in cultured skin fibroblasts." Fazio M.J., Olsen D.R., Kuivaniemi H., Chu M.L., Davidson J.M., Rosenbloom J., Uitto J. Lab. Invest. 58:270-277(1988) [PubMed: 2831431] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 164-724 (ISOFORM 2). Tissue: Placenta.
[12]	"Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients." Osborne L.R., Martindale D.W., Scherer S.W., Shi X.-M., Huizenga J., Heng H.H.Q., Costa T., Pober B., Lew L., Brinkman J., Rommens J., Koop B.F., Tsui L.-C. Genomics 36:328-336(1996) [PubMed: 8812460] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 500-786, TISSUE SPECIFICITY.
[13]	"LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition." Frangiskakis J.M., Ewart A.K., Morris C.A., Mervis C.B., Bertrand J., Robinson B.F., Klein B.P., Ensing G.J., Everett L.A., Green E.D., Proeschel C., Gutowski N.J., Noble M., Atkinson D.L., Odelberg S.J., Keating M.T. Cell 86:59-69(1996) [PubMed: 8689688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 659-786. Tissue: Hippocampus and Placenta.
[14]	"Cutis laxa arising from frameshift mutations in exon 30 of the elastin gene (ELN)." Zhang M.-C., He L., Giro M., Yong S.L., Tiller G.E., Davidson J.M. J. Biol. Chem. 274:981-986(1999) [PubMed: 9873040] [Abstract] Cited for: INVOLVEMENT IN CUTIS LAXA.
[15]	"Isolated supravalvular aortic stenosis: functional haploinsufficiency of the elastin gene as a result of nonsense-mediated decay." Urban Z., Michels V.V., Thibodeau S.N., Davis E.C., Bonnefont J.-P., Munnich A., Eyskens B., Gewillig M., Devriendt K., Boyd C.D. Hum. Genet. 106:577-588(2000) [PubMed: 10942104] [Abstract] Cited for: INVOLVEMENT IN SVAS.
[16]	"Mass spectrometric characterization of human skin elastin peptides produced by proteolytic digestion with pepsin and thermitase." Schmelzer C.E.H., Getie M., Neubert R.H.H. J. Chromatogr. A 1083:120-126(2005) [PubMed: 16078697] [Abstract] Cited for: HYDROXYLATION AT PRO-65; PRO-67; PRO-88; PRO-116; PRO-156; PRO-177; PRO-190; PRO-286; PRO-290; PRO-415; PRO-427; PRO-465; PRO-467; PRO-481; PRO-522; PRO-580; PRO-607; PRO-646; PRO-677; PRO-769 AND PRO-772, MASS SPECTROMETRY.
[17]	"Characterization of peptides resulting from digestion of human skin elastin with elastase." Getie M., Schmelzer C.E.H., Neubert R.H.H. Proteins 61:649-657(2005) [PubMed: 16161116] [Abstract] Cited for: HYDROXYLATION AT PRO-34; PRO-167; PRO-170; PRO-190; PRO-283; PRO-286; PRO-327; PRO-342; PRO-347; PRO-352; PRO-355; PRO-360; PRO-421; PRO-427; PRO-550; PRO-580; PRO-589; PRO-598 AND PRO-677, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

GeneReviews

Wikipedia

Elastin entry

Cross-references

Sequence databases
EMBLGenBankDDBJ	M17282 , M16983, M17265, M17266, M17267, M17268, M17271, M17272, M17273, M17275, M17276, M17277, M17278, M17279, M17281 Genomic DNA. Translation: AAC98393.1. M17282 , M16983, M17265, M17266, M17267, M17268, M17270, M17271, M17272, M17273, M17275, M17276, M17277, M17278, M17279, M17280, M17281 Genomic DNA. Translation: AAC98394.1. M17282 , M16983, M17265, M17266, M17267, M17268, M17270, M17271, M17272, M17273, M17274, M17275, M17276, M17277, M17278, M17279, M17280, M17281 Genomic DNA. Translation: AAC98395.1. M36860 mRNA. Translation: AAA52382.1. AK122731 mRNA. Translation: BAC85506.1. BX537939 mRNA. Translation: CAD97910.1. BX538199 mRNA. Translation: CAD98065.1. Different initiation. AC005056 Genomic DNA. Translation: AAS07435.1. BC065566 mRNA. Translation: AAH65566.1. X15603 Genomic DNA. Translation: CAA33627.1. U93037 , U93034, U93035, U93036 Genomic DNA. Translation: AAB65620.1. U93037 , U93034, U93035, U93036 Genomic DNA. Translation: AAB65621.1. M24782 mRNA. Translation: AAA53190.1. U63721 Genomic DNA. Translation: AAC13884.1. Different initiation. U62292 Genomic DNA. Translation: AAB17544.1.
IPI	IPI00163202. IPI00177942. IPI00446835. IPI00472548. IPI00513726. IPI00514114. IPI00514196. IPI00514508. IPI00514851. IPI00515021. IPI00925620.
PIR	EAHU. A32707.
RefSeq	NP_001075221.1.
UniGene	Hs.647061
3D structure databases
HSSP	HSSP built from PDB template 1ZFJ based on UniProtKB P50099.
ModBase	Search...
PTM databases
PhosphoSite	P15502.
Proteomic databases
PRIDE	P15502.
Genome annotation databases
Ensembl	ENSG00000049540. Homo sapiens. [Contig view]
GeneID	2006.
Organism-specific databases
GeneCards	GC07P073080.
H-InvDB	HIX0006761. HIX0019421.
HGNC	HGNC:3327. ELN.
HPA	CAB010750. HPA018111.
MIM	123700. phenotype. 130160. gene. 185500. phenotype. 194050. phenotype.
Orphanet	209. Cutis laxa. 90348. Cutis laxa, dominant type. 3193. Supravalvar aortic stenosis. 904. Williams syndrome.
PharmGKB	PA27757.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P15502.
Gene expression databases
ArrayExpress	P15502.
Bgee	P15502.
GermOnline	ENSG00000049540. Homo sapiens.
Family and domain databases
InterPro	IPR003979. Tropoelastin. [Graphical view]
PRINTS	PR01500. TROPOELASTIN.
ProtoNet	Search...
Other Resources
DrugBank	DB00533. Rofecoxib.
NextBio	8119.
PMAP-CutDB	P15502.
SOURCE	Search...

Entry information

Entry name

ELN_HUMAN

Accession

Primary (citable) accession number: P15502
Secondary accession number(s): O15336 , O15337, Q14233, Q14234, Q14235, Q14238, Q6P0L4, Q6ZWJ6, Q75MU5, Q7Z316, Q7Z3F5, Q9UMF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	January 4, 2005
Last modified:	June 16, 2009
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)