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Protein

Peripherin-2

Gene

Prph2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • retina development in camera-type eye Source: MGI
  • visual perception Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Peripherin-2
Alternative name(s):
Retinal degeneration slow protein
Gene namesi
Name:Prph2
Synonyms:Rds
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:102791. Prph2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei25 – 4319HelicalSequence AnalysisAdd
BLAST
Topological domaini44 – 6118LumenalSequence AnalysisAdd
BLAST
Transmembranei62 – 8019HelicalSequence AnalysisAdd
BLAST
Topological domaini81 – 9919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei100 – 12324HelicalSequence AnalysisAdd
BLAST
Topological domaini124 – 264141LumenalSequence AnalysisAdd
BLAST
Transmembranei265 – 29026HelicalSequence AnalysisAdd
BLAST
Topological domaini291 – 34656CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • photoreceptor outer segment Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Responsible for retinal degeneration slow (Rds).

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Peripherin-2PRO_0000168106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP15499.

PTM databases

PhosphoSiteiP15499.

Expressioni

Tissue specificityi

Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.

Gene expression databases

BgeeiP15499.
CleanExiMM_PRPH2.
ExpressionAtlasiP15499. baseline and differential.
GenevisibleiP15499. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Probably forms a complex with a ROM1 homodimer. Other proteins could associate with this complex in rods. Interacts with MREG.1 Publication

Protein-protein interaction databases

MINTiMINT-8401204.
STRINGi10090.ENSMUSP00000024773.

Structurei

3D structure databases

ProteinModelPortaliP15499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni341 – 3466Interaction with MREG

Sequence similaritiesi

Belongs to the PRPH2/ROM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237707.
GeneTreeiENSGT00390000016192.
HOGENOMiHOG000026780.
HOVERGENiHBG004964.
InParanoidiP15499.
KOiK17343.
OMAiCCFLMRG.
OrthoDBiEOG7T1RBG.
PhylomeDBiP15499.
TreeFamiTF331684.

Family and domain databases

InterProiIPR000830. Peripherin/rom-1.
IPR018498. Peripherin/rom-1_CS.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSiPR00218. PERIPHERNRDS.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00930. RDS_ROM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLKVKFDQ KKRVKLAQGL WLMNWLSVLA GIVLFSLGLF LKIELRKRSE
60 70 80 90 100
VMNNSESHFV PNSLIGVGVL SCVFNSLAGK ICYDALDPAK YAKWKPWLKP
110 120 130 140 150
YLAVCIFFNV ILFLVALCCF LLRGSLESTL AYGLKNGMKY YRDTDTPGRC
160 170 180 190 200
FMKKTIDMLQ IEFKCCGNNG FRDWFEIQWI SNRYLDFSSK EVKDRIKSNV
210 220 230 240 250
DGRYLVDGVP FSCCNPSSPR PCIQYQLTNN SAHYSYDHQT EELNLWLRGC
260 270 280 290 300
RAALLNYYSS LMNSMGVVTL LVWLFEVSIT AGLRYLHTAL ESVSNPEDPE
310 320 330 340
CESEGWLLEK SVPETWKAFL ESFKKLGKSN QVEAEGADAG PAPEAG
Length:346
Mass (Da):39,260
Last modified:April 1, 1990 - v1
Checksum:iF9B80C14F2867BDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14770 mRNA. Translation: CAA32878.1.
BC028958 mRNA. Translation: AAH28958.1.
BC085266 mRNA. Translation: AAH85266.1.
L42167 Genomic DNA. Translation: AAC37674.1.
CCDSiCCDS28844.1.
PIRiS03347.
RefSeqiNP_032964.1. NM_008938.1.
UniGeneiMm.291370.

Genome annotation databases

EnsembliENSMUST00000024773; ENSMUSP00000024773; ENSMUSG00000023978.
GeneIDi19133.
KEGGimmu:19133.
UCSCiuc008cun.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14770 mRNA. Translation: CAA32878.1.
BC028958 mRNA. Translation: AAH28958.1.
BC085266 mRNA. Translation: AAH85266.1.
L42167 Genomic DNA. Translation: AAC37674.1.
CCDSiCCDS28844.1.
PIRiS03347.
RefSeqiNP_032964.1. NM_008938.1.
UniGeneiMm.291370.

3D structure databases

ProteinModelPortaliP15499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-8401204.
STRINGi10090.ENSMUSP00000024773.

PTM databases

PhosphoSiteiP15499.

Proteomic databases

PRIDEiP15499.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024773; ENSMUSP00000024773; ENSMUSG00000023978.
GeneIDi19133.
KEGGimmu:19133.
UCSCiuc008cun.1. mouse.

Organism-specific databases

CTDi5961.
MGIiMGI:102791. Prph2.

Phylogenomic databases

eggNOGiNOG237707.
GeneTreeiENSGT00390000016192.
HOGENOMiHOG000026780.
HOVERGENiHBG004964.
InParanoidiP15499.
KOiK17343.
OMAiCCFLMRG.
OrthoDBiEOG7T1RBG.
PhylomeDBiP15499.
TreeFamiTF331684.

Miscellaneous databases

ChiTaRSiPrph2. mouse.
NextBioi295758.
PROiP15499.
SOURCEiSearch...

Gene expression databases

BgeeiP15499.
CleanExiMM_PRPH2.
ExpressionAtlasiP15499. baseline and differential.
GenevisibleiP15499. MM.

Family and domain databases

InterProiIPR000830. Peripherin/rom-1.
IPR018498. Peripherin/rom-1_CS.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSiPR00218. PERIPHERNRDS.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00930. RDS_ROM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds)."
    Travis G.H., Brennan M.B., Danielson P.E., Kozak C.A., Sutcliffe J.G.
    Nature 338:70-73(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Retina.
  2. "Photoreceptor peripherin is the normal product of the gene responsible for retinal degeneration in the rds mouse."
    Connell G., Bascom R., Molday L., Reid D., McInnes R.R., Molday R.S.
    Proc. Natl. Acad. Sci. U.S.A. 88:723-726(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Retina.
  4. "Retinal degeneration slow (rds) in mouse results from simple insertion of a t haplotype-specific element into protein-coding exon II."
    Ma J., Norton J.C., Allen A.C., Burns J.B., Hasel K.W., Burns J.L., Sutcliffe J.G., Travis G.H.
    Genomics 28:212-219(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-229.
  5. Cited for: INTERACTION WITH MREG.

Entry informationi

Entry nameiPRPH2_MOUSE
AccessioniPrimary (citable) accession number: P15499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 22, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.