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Protein

Peripherin-2

Gene

Prph2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cell surface receptor signaling pathway Source: GO_Central
  • retina development in camera-type eye Source: MGI
  • visual perception Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Peripherin-2
Alternative name(s):
Retinal degeneration slow protein
Gene namesi
Name:Prph2
Synonyms:Rds
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:102791. Prph2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 43HelicalSequence analysisAdd BLAST19
Topological domaini44 – 61LumenalSequence analysisAdd BLAST18
Transmembranei62 – 80HelicalSequence analysisAdd BLAST19
Topological domaini81 – 99CytoplasmicSequence analysisAdd BLAST19
Transmembranei100 – 123HelicalSequence analysisAdd BLAST24
Topological domaini124 – 264LumenalSequence analysisAdd BLAST141
Transmembranei265 – 290HelicalSequence analysisAdd BLAST26
Topological domaini291 – 346CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • photoreceptor outer segment Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Responsible for retinal degeneration slow (Rds) (PubMed:8530028).

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001681061 – 346Peripherin-2Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...)Sequence analysis1
Glycosylationi229N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP15499.
PRIDEiP15499.

PTM databases

PhosphoSitePlusiP15499.

Expressioni

Tissue specificityi

Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.

Gene expression databases

BgeeiENSMUSG00000023978.
CleanExiMM_PRPH2.
ExpressionAtlasiP15499. baseline and differential.
GenevisibleiP15499. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Probably forms a complex with a ROM1 homodimer. Other proteins could associate with this complex in rods. Interacts with MREG.1 Publication

Protein-protein interaction databases

MINTiMINT-8401204.
STRINGi10090.ENSMUSP00000024773.

Structurei

3D structure databases

ProteinModelPortaliP15499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni341 – 346Interaction with MREG1 Publication6

Sequence similaritiesi

Belongs to the PRPH2/ROM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00390000016192.
HOGENOMiHOG000026780.
HOVERGENiHBG004964.
InParanoidiP15499.
KOiK17343.
OMAiCCFLMRG.
OrthoDBiEOG091G0956.
PhylomeDBiP15499.
TreeFamiTF331684.

Family and domain databases

InterProiIPR000830. Peripherin/rom-1.
IPR018498. Peripherin/rom-1_CS.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSiPR00218. PERIPHERNRDS.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00930. RDS_ROM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLKVKFDQ KKRVKLAQGL WLMNWLSVLA GIVLFSLGLF LKIELRKRSE
60 70 80 90 100
VMNNSESHFV PNSLIGVGVL SCVFNSLAGK ICYDALDPAK YAKWKPWLKP
110 120 130 140 150
YLAVCIFFNV ILFLVALCCF LLRGSLESTL AYGLKNGMKY YRDTDTPGRC
160 170 180 190 200
FMKKTIDMLQ IEFKCCGNNG FRDWFEIQWI SNRYLDFSSK EVKDRIKSNV
210 220 230 240 250
DGRYLVDGVP FSCCNPSSPR PCIQYQLTNN SAHYSYDHQT EELNLWLRGC
260 270 280 290 300
RAALLNYYSS LMNSMGVVTL LVWLFEVSIT AGLRYLHTAL ESVSNPEDPE
310 320 330 340
CESEGWLLEK SVPETWKAFL ESFKKLGKSN QVEAEGADAG PAPEAG
Length:346
Mass (Da):39,260
Last modified:April 1, 1990 - v1
Checksum:iF9B80C14F2867BDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14770 mRNA. Translation: CAA32878.1.
BC028958 mRNA. Translation: AAH28958.1.
BC085266 mRNA. Translation: AAH85266.1.
L42167 Genomic DNA. Translation: AAC37674.1.
CCDSiCCDS28844.1.
PIRiS03347.
RefSeqiNP_032964.1. NM_008938.1.
UniGeneiMm.291370.

Genome annotation databases

EnsembliENSMUST00000024773; ENSMUSP00000024773; ENSMUSG00000023978.
GeneIDi19133.
KEGGimmu:19133.
UCSCiuc008cun.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14770 mRNA. Translation: CAA32878.1.
BC028958 mRNA. Translation: AAH28958.1.
BC085266 mRNA. Translation: AAH85266.1.
L42167 Genomic DNA. Translation: AAC37674.1.
CCDSiCCDS28844.1.
PIRiS03347.
RefSeqiNP_032964.1. NM_008938.1.
UniGeneiMm.291370.

3D structure databases

ProteinModelPortaliP15499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-8401204.
STRINGi10090.ENSMUSP00000024773.

PTM databases

PhosphoSitePlusiP15499.

Proteomic databases

PaxDbiP15499.
PRIDEiP15499.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024773; ENSMUSP00000024773; ENSMUSG00000023978.
GeneIDi19133.
KEGGimmu:19133.
UCSCiuc008cun.1. mouse.

Organism-specific databases

CTDi5961.
MGIiMGI:102791. Prph2.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00390000016192.
HOGENOMiHOG000026780.
HOVERGENiHBG004964.
InParanoidiP15499.
KOiK17343.
OMAiCCFLMRG.
OrthoDBiEOG091G0956.
PhylomeDBiP15499.
TreeFamiTF331684.

Miscellaneous databases

ChiTaRSiPrph2. mouse.
PROiP15499.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023978.
CleanExiMM_PRPH2.
ExpressionAtlasiP15499. baseline and differential.
GenevisibleiP15499. MM.

Family and domain databases

InterProiIPR000830. Peripherin/rom-1.
IPR018498. Peripherin/rom-1_CS.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSiPR00218. PERIPHERNRDS.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00930. RDS_ROM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRPH2_MOUSE
AccessioniPrimary (citable) accession number: P15499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.