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P15499

- PRPH2_MOUSE

UniProt

P15499 - PRPH2_MOUSE

Protein

Peripherin-2

Gene

Prph2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. retina development in camera-type eye Source: MGI
    3. visual perception Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peripherin-2
    Alternative name(s):
    Retinal degeneration slow protein
    Gene namesi
    Name:Prph2
    Synonyms:Rds
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:102791. Prph2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Responsible for retinal degeneration slow (Rds).

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Peripherin-2PRO_0000168106Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP15499.

    PTM databases

    PhosphoSiteiP15499.

    Expressioni

    Tissue specificityi

    Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.

    Gene expression databases

    BgeeiP15499.
    CleanExiMM_PRPH2.
    GenevestigatoriP15499.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Probably forms a complex with a ROM1 homodimer. Other proteins could associate with this complex in rods. Interacts with MREG.1 Publication

    Protein-protein interaction databases

    MINTiMINT-8401204.
    STRINGi10090.ENSMUSP00000024773.

    Structurei

    3D structure databases

    ProteinModelPortaliP15499.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini44 – 6118LumenalSequence AnalysisAdd
    BLAST
    Topological domaini81 – 9919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini124 – 264141LumenalSequence AnalysisAdd
    BLAST
    Topological domaini291 – 34656CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4319HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8019HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12324HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 29026HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni341 – 3466Interaction with MREG

    Sequence similaritiesi

    Belongs to the PRPH2/ROM1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG237707.
    HOGENOMiHOG000026780.
    HOVERGENiHBG004964.
    InParanoidiP15499.
    KOiK17343.
    OMAiKVKFDQK.
    OrthoDBiEOG7T1RBG.
    PhylomeDBiP15499.
    TreeFamiTF331684.

    Family and domain databases

    InterProiIPR000830. Peripherin/rom-1.
    IPR018498. Peripherin/rom-1_CS.
    IPR018499. Tetraspanin/Peripherin.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PRINTSiPR00218. PERIPHERNRDS.
    SUPFAMiSSF48652. SSF48652. 2 hits.
    PROSITEiPS00930. RDS_ROM1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15499-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALLKVKFDQ KKRVKLAQGL WLMNWLSVLA GIVLFSLGLF LKIELRKRSE    50
    VMNNSESHFV PNSLIGVGVL SCVFNSLAGK ICYDALDPAK YAKWKPWLKP 100
    YLAVCIFFNV ILFLVALCCF LLRGSLESTL AYGLKNGMKY YRDTDTPGRC 150
    FMKKTIDMLQ IEFKCCGNNG FRDWFEIQWI SNRYLDFSSK EVKDRIKSNV 200
    DGRYLVDGVP FSCCNPSSPR PCIQYQLTNN SAHYSYDHQT EELNLWLRGC 250
    RAALLNYYSS LMNSMGVVTL LVWLFEVSIT AGLRYLHTAL ESVSNPEDPE 300
    CESEGWLLEK SVPETWKAFL ESFKKLGKSN QVEAEGADAG PAPEAG 346
    Length:346
    Mass (Da):39,260
    Last modified:April 1, 1990 - v1
    Checksum:iF9B80C14F2867BDE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14770 mRNA. Translation: CAA32878.1.
    BC028958 mRNA. Translation: AAH28958.1.
    BC085266 mRNA. Translation: AAH85266.1.
    L42167 Genomic DNA. Translation: AAC37674.1.
    CCDSiCCDS28844.1.
    PIRiS03347.
    RefSeqiNP_032964.1. NM_008938.1.
    UniGeneiMm.291370.

    Genome annotation databases

    EnsembliENSMUST00000024773; ENSMUSP00000024773; ENSMUSG00000023978.
    GeneIDi19133.
    KEGGimmu:19133.
    UCSCiuc008cun.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14770 mRNA. Translation: CAA32878.1 .
    BC028958 mRNA. Translation: AAH28958.1 .
    BC085266 mRNA. Translation: AAH85266.1 .
    L42167 Genomic DNA. Translation: AAC37674.1 .
    CCDSi CCDS28844.1.
    PIRi S03347.
    RefSeqi NP_032964.1. NM_008938.1.
    UniGenei Mm.291370.

    3D structure databases

    ProteinModelPortali P15499.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-8401204.
    STRINGi 10090.ENSMUSP00000024773.

    PTM databases

    PhosphoSitei P15499.

    Proteomic databases

    PRIDEi P15499.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000024773 ; ENSMUSP00000024773 ; ENSMUSG00000023978 .
    GeneIDi 19133.
    KEGGi mmu:19133.
    UCSCi uc008cun.1. mouse.

    Organism-specific databases

    CTDi 5961.
    MGIi MGI:102791. Prph2.

    Phylogenomic databases

    eggNOGi NOG237707.
    HOGENOMi HOG000026780.
    HOVERGENi HBG004964.
    InParanoidi P15499.
    KOi K17343.
    OMAi KVKFDQK.
    OrthoDBi EOG7T1RBG.
    PhylomeDBi P15499.
    TreeFami TF331684.

    Miscellaneous databases

    ChiTaRSi PRPH2. mouse.
    NextBioi 295758.
    PROi P15499.
    SOURCEi Search...

    Gene expression databases

    Bgeei P15499.
    CleanExi MM_PRPH2.
    Genevestigatori P15499.

    Family and domain databases

    InterProi IPR000830. Peripherin/rom-1.
    IPR018498. Peripherin/rom-1_CS.
    IPR018499. Tetraspanin/Peripherin.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PRINTSi PR00218. PERIPHERNRDS.
    SUPFAMi SSF48652. SSF48652. 2 hits.
    PROSITEi PS00930. RDS_ROM1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds)."
      Travis G.H., Brennan M.B., Danielson P.E., Kozak C.A., Sutcliffe J.G.
      Nature 338:70-73(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Retina.
    2. "Photoreceptor peripherin is the normal product of the gene responsible for retinal degeneration in the rds mouse."
      Connell G., Bascom R., Molday L., Reid D., McInnes R.R., Molday R.S.
      Proc. Natl. Acad. Sci. U.S.A. 88:723-726(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Retina.
    4. "Retinal degeneration slow (rds) in mouse results from simple insertion of a t haplotype-specific element into protein-coding exon II."
      Ma J., Norton J.C., Allen A.C., Burns J.B., Hasel K.W., Burns J.L., Sutcliffe J.G., Travis G.H.
      Genomics 28:212-219(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-229.
    5. Cited for: INTERACTION WITH MREG.

    Entry informationi

    Entry nameiPRPH2_MOUSE
    AccessioniPrimary (citable) accession number: P15499
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3