Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proto-oncogene vav

Gene

VAV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri515 – 56450Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1433557. Signaling by SCF-KIT.
R-HSA-193648. NRAGE signals death through JNK.
R-HSA-194840. Rho GTPase cycle.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-389359. CD28 dependent Vav1 pathway.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-4420097. VEGFA-VEGFR2 Pathway.
R-HSA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-HSA-5218920. VEGFR2 mediated vascular permeability.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-HSA-912631. Regulation of signaling by CBL.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
SignaLinkiP15498.
SIGNORiP15498.

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene vav
Gene namesi
Name:VAV1
Synonyms:VAV
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12657. VAV1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi529 – 5291C → R: Abolishes transforming activity. 1 Publication
Mutagenesisi696 – 6961R → L: Loss of interaction with SYK. 1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA37280.

Chemistry

ChEMBLiCHEMBL3259472.

Polymorphism and mutation databases

BioMutaiVAV1.
DMDMi13124807.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 845845Proto-oncogene vavPRO_0000080980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei826 – 8261PhosphotyrosineCombined sources
Modified residuei844 – 8441PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity). Phosphorylated by FYN.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP15498.
MaxQBiP15498.
PaxDbiP15498.
PeptideAtlasiP15498.
PRIDEiP15498.

PTM databases

iPTMnetiP15498.
PhosphoSiteiP15498.

Miscellaneous databases

PMAP-CutDBP15498.

Expressioni

Tissue specificityi

Widely expressed in hematopoietic cells but not in other cell types.

Gene expression databases

BgeeiENSG00000141968.
CleanExiHS_VAV1.
ExpressionAtlasiP15498. baseline and differential.
GenevisibleiP15498. HS.

Organism-specific databases

HPAiHPA001864.

Interactioni

Subunit structurei

Interacts with SHB (PubMed:12084069). Interacts with APS, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK (PubMed:12393632, PubMed:12400014, PubMed:15558030). Interacts with SIAH2; without leading to its degradation (PubMed:10207103). Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion (PubMed:9697839). Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity (PubMed:9399639). May interact with CCPG1. Interacts with CLNK. Interacts with THEMIS2 (By similarity). Interacts with NEK3 and this interaction is prolactin-dependent (PubMed:15618286). Interacts with ITK (PubMed:15661896). Interacts with PTK2B/PYK2 (By similarity). Interacts with HCK. Interacts with PTK2B/PYK2 (PubMed:19207108). Interacts (via SH2 domain) with SYK (PubMed:8986718). Interacts with ANKRD54. Interacts with CD6 (By similarity).By similarity11 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI1Q8IZP02EBI-625518,EBI-375446
ABL1P005195EBI-625518,EBI-375543
GAB1Q134802EBI-625518,EBI-517684
GRB2P629932EBI-625518,EBI-401755
KHDRBS1Q076663EBI-625518,EBI-1364
LCP2Q130949EBI-625518,EBI-346946
PLCG1P084874EBI-625518,EBI-8013886From a different organism.
RAC1P630002EBI-625518,EBI-413628
SH3BP2P783148EBI-625518,EBI-727062
ZNF655Q8N7205EBI-625518,EBI-625509

Protein-protein interaction databases

BioGridi113252. 85 interactions.
DIPiDIP-1061N.
IntActiP15498. 28 interactions.
MINTiMINT-1211643.
STRINGi9606.ENSP00000472929.

Chemistry

BindingDBiP15498.

Structurei

Secondary structure

1
845
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1311Combined sources
Turni22 – 243Combined sources
Helixi30 – 378Combined sources
Helixi41 – 5010Combined sources
Helixi57 – 593Combined sources
Helixi68 – 8417Combined sources
Helixi96 – 1005Combined sources
Helixi105 – 11713Combined sources
Turni119 – 1213Combined sources
Helixi122 – 1243Combined sources
Helixi145 – 1495Combined sources
Helixi159 – 1624Combined sources
Helixi168 – 17811Combined sources
Helixi191 – 21828Combined sources
Helixi221 – 2244Combined sources
Turni225 – 2273Combined sources
Helixi230 – 2378Combined sources
Helixi240 – 25920Combined sources
Turni260 – 2623Combined sources
Helixi267 – 2737Combined sources
Helixi276 – 2783Combined sources
Helixi279 – 30022Combined sources
Helixi302 – 31615Combined sources
Beta strandi317 – 3193Combined sources
Helixi322 – 3265Combined sources
Helixi328 – 3336Combined sources
Helixi336 – 3449Combined sources
Helixi351 – 38838Combined sources
Helixi397 – 4004Combined sources
Beta strandi403 – 41210Combined sources
Beta strandi420 – 43516Combined sources
Beta strandi442 – 4487Combined sources
Helixi449 – 4513Combined sources
Beta strandi452 – 4565Combined sources
Beta strandi469 – 47911Combined sources
Beta strandi481 – 4888Combined sources
Helixi489 – 50618Combined sources
Turni509 – 5124Combined sources
Helixi513 – 5153Combined sources
Beta strandi518 – 5214Combined sources
Turni530 – 5323Combined sources
Beta strandi538 – 5403Combined sources
Beta strandi543 – 5464Combined sources
Turni547 – 5493Combined sources
Helixi555 – 5606Combined sources
Helixi666 – 6683Combined sources
Beta strandi669 – 6724Combined sources
Helixi678 – 6847Combined sources
Turni685 – 6873Combined sources
Beta strandi692 – 6965Combined sources
Beta strandi700 – 7023Combined sources
Beta strandi706 – 7116Combined sources
Beta strandi714 – 7196Combined sources
Beta strandi721 – 7233Combined sources
Beta strandi726 – 7305Combined sources
Beta strandi735 – 7373Combined sources
Helixi738 – 7458Combined sources
Helixi750 – 7523Combined sources
Beta strandi754 – 7563Combined sources
Beta strandi763 – 7664Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CRHNMR-A629-775[»]
2LCTNMR-A664-767[»]
2MC1NMR-A664-767[»]
2RORNMR-A629-775[»]
3BJIX-ray2.60A/B189-565[»]
3KY9X-ray2.73A/B2-584[»]
ProteinModelPortaliP15498.
SMRiP15498. Positions 2-565, 583-780, 784-844.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15498.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 119119CHPROSITE-ProRule annotationAdd
BLAST
Domaini194 – 373180DHPROSITE-ProRule annotationAdd
BLAST
Domaini402 – 504103PHPROSITE-ProRule annotationAdd
BLAST
Domaini617 – 66044SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini671 – 76595SH2PROSITE-ProRule annotationAdd
BLAST
Domaini782 – 84261SH3 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 9967Leu-richAdd
BLAST

Domaini

The DH domain is involved in interaction with CCPG1.By similarity

Sequence similaritiesi

Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri515 – 56450Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, SH2 domain, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiKOG2996. Eukaryota.
ENOG410XPH6. LUCA.
GeneTreeiENSGT00800000124085.
HOGENOMiHOG000234364.
HOVERGENiHBG018066.
InParanoidiP15498.
KOiK05730.
OMAiEKDNKKW.
OrthoDBiEOG091G01O3.
PhylomeDBiP15498.
TreeFamiTF316171.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR022613. CAMSAP_CH.
IPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR003096. SM22_calponin.
IPR028530. Vav.
[Graphical view]
PANTHERiPTHR22826:SF97. PTHR22826:SF97. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF11971. CAMSAP_CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00888. SM22CALPONIN.
SMARTiSM00109. C1. 1 hit.
SM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P15498-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL
60 70 80 90 100
LPHAINLREV NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF
110 120 130 140 150
DVQDFGKVIY TLSALSWTPI AQNRGIMPFP TEEESVGDED IYSGLSDQID
160 170 180 190 200
DTVEEDEDLY DCVENEEAEG DEIYEDLMRS EPVSMPPKMT EYDKRCCCLR
210 220 230 240 250
EIQQTEEKYT DTLGSIQQHF LKPLQRFLKP QDIEIIFINI EDLLRVHTHF
260 270 280 290 300
LKEMKEALGT PGAANLYQVF IKYKERFLVY GRYCSQVESA SKHLDRVAAA
310 320 330 340 350
REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQEA
360 370 380 390 400
MEKENLRLAL DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLAHY
410 420 430 440 450
GRPKIDGELK ITSVERRSKM DRYAFLLDKA LLICKRRGDS YDLKDFVNLH
460 470 480 490 500
SFQVRDDSSG DRDNKKWSHM FLLIEDQGAQ GYELFFKTRE LKKKWMEQFE
510 520 530 540 550
MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF YQGYRCHRCR
560 570 580 590 600
ASAHKECLGR VPPCGRHGQD FPGTMKKDKL HRRAQDKKRN ELGLPKMEVF
610 620 630 640 650
QEYYGLPPPP GAIGPFLRLN PGDIVELTKA EAEQNWWEGR NTSTNEIGWF
660 670 680 690 700
PCNRVKPYVH GPPQDLSVHL WYAGPMERAG AESILANRSD GTFLVRQRVK
710 720 730 740 750
DAAEFAISIK YNVEVKHIKI MTAEGLYRIT EKKAFRGLTE LVEFYQQNSL
760 770 780 790 800
KDCFKSLDTT LQFPFKEPEK RTISRPAVGS TKYFGTAKAR YDFCARDRSE
810 820 830 840
LSLKEGDIIK ILNKKGQQGW WRGEIYGRVG WFPANYVEED YSEYC
Length:845
Mass (Da):98,314
Last modified:February 21, 2001 - v4
Checksum:iAC3BC9736FD2F138
GO
Isoform 2 (identifier: P15498-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-218: Missing.

Note: No experimental confirmation available.
Show »
Length:813
Mass (Da):94,493
Checksum:i2DD711DA5E0A8403
GO

Sequence cautioni

The sequence BAG62721 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA34383 differs from that shown. Reason: Frameshift at positions 322 and 355. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti264 – 2641A → P in CAA34383 (PubMed:2477241).Curated
Sequence conflicti368 – 3681Q → R in BAG62721 (PubMed:14702039).Curated
Sequence conflicti718 – 7181I → TV (PubMed:2477241).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti739 – 7391T → M.
Corresponds to variant rs36097961 [ dbSNP | Ensembl ].
VAR_051997

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei187 – 21832Missing in isoform 2. 1 PublicationVSP_047563Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030227
, AF030201, AF030202, AF030203, AF030204, AF030205, AF030206, AF030207, AF030208, AF030209, AF030210, AF030211, AF030212, AF030213, AF030214, AF030215, AF030216, AF030217, AF030218, AF030219, AF030220, AF030221, AF030222, AF030223, AF030224, AF030225, AF030226 Genomic DNA. Translation: AAC25011.1.
AC010647 Genomic DNA. No translation available.
AC020895 Genomic DNA. No translation available.
AC020954 Genomic DNA. No translation available.
AC022156 Genomic DNA. No translation available.
M59834 Genomic DNA. Translation: AAA63267.1.
AK301128 mRNA. Translation: BAG62721.1. Different initiation.
X16316 mRNA. Translation: CAA34383.1. Frameshift.
X83931 mRNA. Translation: CAA58783.1.
CCDSiCCDS12174.1. [P15498-1]
CCDS59342.1. [P15498-2]
PIRiB39576. TVHUVV.
RefSeqiNP_001245136.1. NM_001258207.1. [P15498-2]
NP_005419.2. NM_005428.3. [P15498-1]
UniGeneiHs.116237.

Genome annotation databases

EnsembliENST00000596764; ENSP00000469450; ENSG00000141968. [P15498-2]
ENST00000602142; ENSP00000472929; ENSG00000141968. [P15498-1]
GeneIDi7409.
KEGGihsa:7409.
UCSCiuc002mfu.3. human. [P15498-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030227
, AF030201, AF030202, AF030203, AF030204, AF030205, AF030206, AF030207, AF030208, AF030209, AF030210, AF030211, AF030212, AF030213, AF030214, AF030215, AF030216, AF030217, AF030218, AF030219, AF030220, AF030221, AF030222, AF030223, AF030224, AF030225, AF030226 Genomic DNA. Translation: AAC25011.1.
AC010647 Genomic DNA. No translation available.
AC020895 Genomic DNA. No translation available.
AC020954 Genomic DNA. No translation available.
AC022156 Genomic DNA. No translation available.
M59834 Genomic DNA. Translation: AAA63267.1.
AK301128 mRNA. Translation: BAG62721.1. Different initiation.
X16316 mRNA. Translation: CAA34383.1. Frameshift.
X83931 mRNA. Translation: CAA58783.1.
CCDSiCCDS12174.1. [P15498-1]
CCDS59342.1. [P15498-2]
PIRiB39576. TVHUVV.
RefSeqiNP_001245136.1. NM_001258207.1. [P15498-2]
NP_005419.2. NM_005428.3. [P15498-1]
UniGeneiHs.116237.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CRHNMR-A629-775[»]
2LCTNMR-A664-767[»]
2MC1NMR-A664-767[»]
2RORNMR-A629-775[»]
3BJIX-ray2.60A/B189-565[»]
3KY9X-ray2.73A/B2-584[»]
ProteinModelPortaliP15498.
SMRiP15498. Positions 2-565, 583-780, 784-844.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113252. 85 interactions.
DIPiDIP-1061N.
IntActiP15498. 28 interactions.
MINTiMINT-1211643.
STRINGi9606.ENSP00000472929.

Chemistry

BindingDBiP15498.
ChEMBLiCHEMBL3259472.

PTM databases

iPTMnetiP15498.
PhosphoSiteiP15498.

Polymorphism and mutation databases

BioMutaiVAV1.
DMDMi13124807.

Proteomic databases

EPDiP15498.
MaxQBiP15498.
PaxDbiP15498.
PeptideAtlasiP15498.
PRIDEiP15498.

Protocols and materials databases

DNASUi7409.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000596764; ENSP00000469450; ENSG00000141968. [P15498-2]
ENST00000602142; ENSP00000472929; ENSG00000141968. [P15498-1]
GeneIDi7409.
KEGGihsa:7409.
UCSCiuc002mfu.3. human. [P15498-1]

Organism-specific databases

CTDi7409.
GeneCardsiVAV1.
H-InvDBHIX0202828.
HGNCiHGNC:12657. VAV1.
HPAiHPA001864.
MIMi164875. gene.
neXtProtiNX_P15498.
PharmGKBiPA37280.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2996. Eukaryota.
ENOG410XPH6. LUCA.
GeneTreeiENSGT00800000124085.
HOGENOMiHOG000234364.
HOVERGENiHBG018066.
InParanoidiP15498.
KOiK05730.
OMAiEKDNKKW.
OrthoDBiEOG091G01O3.
PhylomeDBiP15498.
TreeFamiTF316171.

Enzyme and pathway databases

ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1433557. Signaling by SCF-KIT.
R-HSA-193648. NRAGE signals death through JNK.
R-HSA-194840. Rho GTPase cycle.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-389359. CD28 dependent Vav1 pathway.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-4420097. VEGFA-VEGFR2 Pathway.
R-HSA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-HSA-5218920. VEGFR2 mediated vascular permeability.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-HSA-912631. Regulation of signaling by CBL.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
SignaLinkiP15498.
SIGNORiP15498.

Miscellaneous databases

ChiTaRSiVAV1. human.
EvolutionaryTraceiP15498.
GenomeRNAii7409.
PMAP-CutDBP15498.
PROiP15498.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141968.
CleanExiHS_VAV1.
ExpressionAtlasiP15498. baseline and differential.
GenevisibleiP15498. HS.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR022613. CAMSAP_CH.
IPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR003096. SM22_calponin.
IPR028530. Vav.
[Graphical view]
PANTHERiPTHR22826:SF97. PTHR22826:SF97. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF11971. CAMSAP_CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00888. SM22CALPONIN.
SMARTiSM00109. C1. 1 hit.
SM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVAV_HUMAN
AccessioniPrimary (citable) accession number: P15498
Secondary accession number(s): B4DVK9, M0QXX6, Q15860
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: February 21, 2001
Last modified: September 7, 2016
This is version 197 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Vav' stands for the sixth letter of the Hebrew alphabet.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.