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Reviewed, UniProtKB/Swiss-Prot P15494 (BEV1A_BETVE)

Last modified November 25, 2008. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Major pollen allergen Bet v 1-A
Alternative name(s):
    Allergen Bet v I-A
    Allergen=Bet v 1-A
Gene names
Name: BETVIA
Synonyms: BETVI
OrganismBetula verrucosa (White birch) (Betula pendula)
Taxonomic identifier3505 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsrosidseurosids IFagalesBetulaceaeBetula

Protein attributes

Sequence length160 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May be a general steroid carrier protein By similarity.

Subcellular location

Cytoplasm.

Allergenic properties

Causes an allergic reaction in human. Is a cause of type I allergic reactions in Europe, North America and USSR.

Sequence similarities

Belongs to the BetVI family.

Ontologies

Keywords

   Biological processPlant defense
   Cellular componentCytoplasm
   DiseaseAllergen
   Molecular functionPathogenesis-related protein
   Technical term3D-structure
Direct protein sequencing

Gene Ontology (GO)

   Biological processdefense response

Inferred from electronic annotation. Source: InterPro

response to biotic stimulus

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 160159Major pollen allergen Bet v 1-A
PRO_0000154174

Sites

Binding site701Substrate By similarity
Binding site951Substrate By similarity
Binding site1211Substrate By similarity
Binding site1271Substrate By similarity

Natural variations

Natural variant631F → L

Experimental info

Mutagenesis291N → T: Slightly reduced interaction with BV16; when associated with N-33
Mutagenesis331K → N: Slightly reduced interaction with BV16; when associated with T-29
Mutagenesis461E → S: Strongly reduced interaction with BV16, hypoallergenic
Mutagenesis481N → S: Slightly reduced interaction with BV16
Mutagenesis611E → S: Slightly reduced interaction with BV16
Mutagenesis1091P → G: Slightly reduced interaction with BV16

Secondary structure

......................... 160
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P15494-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 69B44110BBDA1AC6

FASTA16017,571
        10         20         30         40         50         60 
MGVFNYETET TSVIPAARLF KAFILDGDNL FPKVAPQAIS SVENIEGNGG PGTIKKISFP 

        70         80         90        100        110        120 
EGFPFKYVKD RVDEVDHTNF KYNYSVIEGG PIGDTLEKIS NEIKIVATPD GGSILKISNK 

       130        140        150        160 
YHTKGDHEVK AEQVKASKEM GETLLRAVES YLLAHSDAYN 

« Hide

References

[1]"The gene coding for the major birch pollen allergen Betv1, is highly homologous to a pea disease resistance response gene."
Breiteneder H., Pettenburger K., Bito A., Valenta R., Kraft D., Rumpold H., Scheiner O., Breitenbach M.
EMBO J. 8:1935-1938(1989) [PubMed: 2571499] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-35.
Tissue: Pollen.
[2]Larsen J.N.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pollen.
[3]"Isoforms of Bet v 1, the major birch pollen allergen, analyzed by liquid chromatography, mass spectrometry, and cDNA cloning."
Swoboda I., Jilek A., Ferreira F., Engel E., Hoffman-Sommergruber K., Scheiner O., Kraft D., Breiteneder H., Pittenauer E., Schmid E., Vicente O., Heberle-Bors E., Ahorn H., Breitenbach M.
J. Biol. Chem. 270:2607-2613(1995) [PubMed: 7852325] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-160.
Tissue: Pollen.
[4]"Purification and N-terminal amino acid sequence of two birch pollen isoallergens (Bet v I and Bet v II)."
Elsayed S., Vik H.
Int. Arch. Allergy Appl. Immunol. 93:378-384(1990) [PubMed: 2101127] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE.
[5]"Secondary structure and tertiary fold of the birch pollen allergen Bet v 1 in solution."
Faber C., Lindemann A., Sticht H., Ejchart A., Kungl A., Susani M., Frank R.W., Kraft D., Breitenbach M., Roesch P.
J. Biol. Chem. 271:19243-19250(1996) [PubMed: 8702605] [Abstract]
Cited for: STRUCTURE BY NMR.
[6]"X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy."
Gajhede M., Osmark P., Poulsen F.M., Ipsen H., Larsen J.N., van Neerven R.J.J., Schou C., Loewenstein H., Spangfort M.D.
Nat. Struct. Biol. 3:1040-1045(1996) [PubMed: 8946858] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS), STRUCTURE BY NMR.
[7]"Dominant epitopes and allergic cross-reactivity: complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1."
Mirza O., Henriksen A., Ipsen H., Larsen J.N., Wissenbach M., Spangfort M.D., Gajhede M.
J. Immunol. 165:331-338(2000) [PubMed: 10861069] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) IN COMPLEX WITH THE FAB FRAGMENT FROM A MURINE MONOCLONAL IGG1 AB.
[8]"Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen, characterized by X-ray crystallography and site-directed mutagenesis."
Spangfort M.D., Mirza O., Ipsen H., Van Neerven R.J., Gajhede M., Larsen J.N.
J. Immunol. 171:3084-3090(2003) [PubMed: 12960334] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) IN COMPLEX WITH THE FAB FRAGMENT FROM THE HUMAN MONOCLONAL BV16 IMMUNOGLOBULIN, MUTAGENESIS OF ASN-29; LYS-33; GLU-46; ASN-48; GLU-61 AND PRO-109.
+Additional computationally mapped references.

Cross-references

Sequence databases

X15877 mRNA. Translation: CAA33887.1.
Z80098 mRNA. Translation: CAB02153.1.
Z80099 mRNA. Translation: CAB02154.1.
Z80104 mRNA. Translation: CAB02159.1.
PIRS05376.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1B6FNMR-A1-160[»]
1BTVNMR-A1-160[»]
1BV1X-ray2.00A1-160[»]
1FSKX-ray2.90A/D/G/J1-160[»]
1LLTX-ray3.10A1-160[»]
1QMRX-ray2.15A1-160[»]
ModBaseSearch...

Family and domain databases

InterProIPR000916. Bet_v_I.
[Graphical view]
PfamPF00407. Bet_v_I. 1 hit.
[Graphical view]
ProDomPD000531. Bet_v_I. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

LinkHubP15494.

Entry information

Entry nameBEV1A_BETVE
AccessionPrimary (citable) accession number: P15494
Secondary accession number(s): Q96369
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: November 25, 2008
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

Relevant documents

Allergens

Nomenclature of allergens and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents