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Protein

Major pollen allergen Bet v 1-A

Gene

BETVIA

Organism
Betula pendula (European white birch) (Betula verrucosa)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a general steroid carrier protein.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei70 – 701BrassinosteroidBy similarity
Binding sitei95 – 951BrassinosteroidBy similarity
Binding sitei121 – 1211BrassinosteroidBy similarity
Binding sitei127 – 1271BrassinosteroidBy similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Pathogenesis-related protein

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Major pollen allergen Bet v 1-A
Alternative name(s):
Allergen Bet v I-A
Allergen: Bet v 1-A
Gene namesi
Name:BETVIA
Synonyms:BETVI
OrganismiBetula pendula (European white birch) (Betula verrucosa)
Taxonomic identifieri3505 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeBetula

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Is a cause of type I allergic reactions in Europe, North America and USSR.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi29 – 291N → T: Slightly reduced interaction with BV16; when associated with N-33. 1 Publication
Mutagenesisi33 – 331K → N: Slightly reduced interaction with BV16; when associated with T-29. 1 Publication
Mutagenesisi46 – 461E → S: Strongly reduced interaction with BV16, hypoallergenic. 1 Publication
Mutagenesisi48 – 481N → S: Slightly reduced interaction with BV16. 1 Publication
Mutagenesisi61 – 611E → S: Slightly reduced interaction with BV16. 1 Publication
Mutagenesisi109 – 1091P → G: Slightly reduced interaction with BV16. 1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei123. Bet v 1.0112.
89. Bet v 1.
90. Bet v 1.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved2 Publications
Chaini2 – 160159Major pollen allergen Bet v 1-APRO_0000154174Add
BLAST

Structurei

Secondary structure

1
160
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 1412Combined sources
Helixi16 – 238Combined sources
Turni24 – 263Combined sources
Helixi27 – 348Combined sources
Turni36 – 383Combined sources
Beta strandi40 – 467Combined sources
Beta strandi48 – 503Combined sources
Beta strandi54 – 585Combined sources
Beta strandi61 – 644Combined sources
Beta strandi66 – 7611Combined sources
Turni77 – 804Combined sources
Beta strandi81 – 899Combined sources
Beta strandi93 – 953Combined sources
Beta strandi96 – 10712Combined sources
Turni109 – 1113Combined sources
Beta strandi113 – 12614Combined sources
Helixi131 – 15424Combined sources
Turni156 – 1594Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B6FNMR-A2-160[»]
1BTVNMR-A2-160[»]
1BV1X-ray2.00A2-160[»]
1FSKX-ray2.90A/D/G/J2-160[»]
1LLTX-ray3.10A2-160[»]
1QMRX-ray2.15A2-160[»]
4A80X-ray1.96A2-160[»]
4A81X-ray2.05A2-160[»]
4A83X-ray1.54A2-160[»]
4A84X-ray1.50A2-160[»]
4A85X-ray1.40A2-160[»]
4A86X-ray1.59A2-160[»]
4A87X-ray1.24A2-160[»]
4A88X-ray1.51A2-160[»]
4A8GX-ray2.10A2-160[»]
4B9RX-ray1.76A2-160[»]
4BK6X-ray1.63A/B2-160[»]
4BK7X-ray1.14A2-160[»]
4BKCX-ray1.73A/B2-160[»]
4BKDX-ray1.17A2-160[»]
4BTZX-ray1.47A2-160[»]
4MNSX-ray1.20A2-160[»]
4QIPX-ray2.00A2-160[»]
4Z3LX-ray2.50A/B/C/D/E/F2-160[»]
ProteinModelPortaliP15494.
SMRiP15494. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15494.

Family & Domainsi

Sequence similaritiesi

Belongs to the BetVI family.Curated

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15494-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVFNYETET TSVIPAARLF KAFILDGDNL FPKVAPQAIS SVENIEGNGG
60 70 80 90 100
PGTIKKISFP EGFPFKYVKD RVDEVDHTNF KYNYSVIEGG PIGDTLEKIS
110 120 130 140 150
NEIKIVATPD GGSILKISNK YHTKGDHEVK AEQVKASKEM GETLLRAVES
160
YLLAHSDAYN
Length:160
Mass (Da):17,571
Last modified:January 23, 2007 - v2
Checksum:i69B44110BBDA1AC6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631F → L.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15877 mRNA. Translation: CAA33887.1.
Z80098 mRNA. Translation: CAB02153.1.
Z80099 mRNA. Translation: CAB02154.1.
Z80104 mRNA. Translation: CAB02159.1.
PIRiS05376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15877 mRNA. Translation: CAA33887.1.
Z80098 mRNA. Translation: CAB02153.1.
Z80099 mRNA. Translation: CAB02154.1.
Z80104 mRNA. Translation: CAB02159.1.
PIRiS05376.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B6FNMR-A2-160[»]
1BTVNMR-A2-160[»]
1BV1X-ray2.00A2-160[»]
1FSKX-ray2.90A/D/G/J2-160[»]
1LLTX-ray3.10A2-160[»]
1QMRX-ray2.15A2-160[»]
4A80X-ray1.96A2-160[»]
4A81X-ray2.05A2-160[»]
4A83X-ray1.54A2-160[»]
4A84X-ray1.50A2-160[»]
4A85X-ray1.40A2-160[»]
4A86X-ray1.59A2-160[»]
4A87X-ray1.24A2-160[»]
4A88X-ray1.51A2-160[»]
4A8GX-ray2.10A2-160[»]
4B9RX-ray1.76A2-160[»]
4BK6X-ray1.63A/B2-160[»]
4BK7X-ray1.14A2-160[»]
4BKCX-ray1.73A/B2-160[»]
4BKDX-ray1.17A2-160[»]
4BTZX-ray1.47A2-160[»]
4MNSX-ray1.20A2-160[»]
4QIPX-ray2.00A2-160[»]
4Z3LX-ray2.50A/B/C/D/E/F2-160[»]
ProteinModelPortaliP15494.
SMRiP15494. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei123. Bet v 1.0112.
89. Bet v 1.
90. Bet v 1.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP15494.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBEV1A_BETPN
AccessioniPrimary (citable) accession number: P15494
Secondary accession number(s): Q96369
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.