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Protein

Major pollen allergen Bet v 1-A

Gene

BETVIA

Organism
Betula pendula (European white birch) (Betula verrucosa)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a general steroid carrier protein.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei70BrassinosteroidBy similarity1
Binding sitei95BrassinosteroidBy similarity1
Binding sitei121BrassinosteroidBy similarity1
Binding sitei127BrassinosteroidBy similarity1

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Pathogenesis-related protein

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Major pollen allergen Bet v 1-A
Alternative name(s):
Allergen Bet v I-A
Allergen: Bet v 1-A
Gene namesi
Name:BETVIA
Synonyms:BETVI
OrganismiBetula pendula (European white birch) (Betula verrucosa)
Taxonomic identifieri3505 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeBetula

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Is a cause of type I allergic reactions in Europe, North America and USSR.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi29N → T: Slightly reduced interaction with BV16; when associated with N-33. 1 Publication1
Mutagenesisi33K → N: Slightly reduced interaction with BV16; when associated with T-29. 1 Publication1
Mutagenesisi46E → S: Strongly reduced interaction with BV16, hypoallergenic. 1 Publication1
Mutagenesisi48N → S: Slightly reduced interaction with BV16. 1 Publication1
Mutagenesisi61E → S: Slightly reduced interaction with BV16. 1 Publication1
Mutagenesisi109P → G: Slightly reduced interaction with BV16. 1 Publication1

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei123. Bet v 1.0112.
89. Bet v 1.
90. Bet v 1.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001541742 – 160Major pollen allergen Bet v 1-AAdd BLAST159

Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 14Combined sources12
Helixi16 – 23Combined sources8
Turni24 – 26Combined sources3
Helixi27 – 34Combined sources8
Turni36 – 38Combined sources3
Beta strandi40 – 46Combined sources7
Beta strandi48 – 50Combined sources3
Beta strandi54 – 58Combined sources5
Beta strandi61 – 64Combined sources4
Beta strandi66 – 76Combined sources11
Turni77 – 80Combined sources4
Beta strandi81 – 89Combined sources9
Beta strandi93 – 95Combined sources3
Beta strandi96 – 107Combined sources12
Turni109 – 111Combined sources3
Beta strandi113 – 126Combined sources14
Helixi131 – 154Combined sources24
Turni156 – 159Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B6FNMR-A2-160[»]
1BTVNMR-A2-160[»]
1BV1X-ray2.00A2-160[»]
1FSKX-ray2.90A/D/G/J2-160[»]
1LLTX-ray3.10A2-160[»]
1QMRX-ray2.15A2-160[»]
4A80X-ray1.96A2-160[»]
4A81X-ray2.05A2-160[»]
4A83X-ray1.54A2-160[»]
4A84X-ray1.50A2-160[»]
4A85X-ray1.40A2-160[»]
4A86X-ray1.59A2-160[»]
4A87X-ray1.24A2-160[»]
4A88X-ray1.51A2-160[»]
4A8GX-ray2.10A2-160[»]
4B9RX-ray1.76A2-160[»]
4BK6X-ray1.63A/B2-160[»]
4BK7X-ray1.14A2-160[»]
4BKCX-ray1.73A/B2-160[»]
4BKDX-ray1.17A2-160[»]
4BTZX-ray1.47A2-160[»]
4MNSX-ray1.20A2-160[»]
4QIPX-ray2.00A2-160[»]
4Z3LX-ray2.50A/B/C/D/E/F2-160[»]
ProteinModelPortaliP15494.
SMRiP15494.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15494.

Family & Domainsi

Sequence similaritiesi

Belongs to the BetVI family.Curated

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15494-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVFNYETET TSVIPAARLF KAFILDGDNL FPKVAPQAIS SVENIEGNGG
60 70 80 90 100
PGTIKKISFP EGFPFKYVKD RVDEVDHTNF KYNYSVIEGG PIGDTLEKIS
110 120 130 140 150
NEIKIVATPD GGSILKISNK YHTKGDHEVK AEQVKASKEM GETLLRAVES
160
YLLAHSDAYN
Length:160
Mass (Da):17,571
Last modified:January 23, 2007 - v2
Checksum:i69B44110BBDA1AC6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti63F → L.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15877 mRNA. Translation: CAA33887.1.
Z80098 mRNA. Translation: CAB02153.1.
Z80099 mRNA. Translation: CAB02154.1.
Z80104 mRNA. Translation: CAB02159.1.
PIRiS05376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15877 mRNA. Translation: CAA33887.1.
Z80098 mRNA. Translation: CAB02153.1.
Z80099 mRNA. Translation: CAB02154.1.
Z80104 mRNA. Translation: CAB02159.1.
PIRiS05376.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B6FNMR-A2-160[»]
1BTVNMR-A2-160[»]
1BV1X-ray2.00A2-160[»]
1FSKX-ray2.90A/D/G/J2-160[»]
1LLTX-ray3.10A2-160[»]
1QMRX-ray2.15A2-160[»]
4A80X-ray1.96A2-160[»]
4A81X-ray2.05A2-160[»]
4A83X-ray1.54A2-160[»]
4A84X-ray1.50A2-160[»]
4A85X-ray1.40A2-160[»]
4A86X-ray1.59A2-160[»]
4A87X-ray1.24A2-160[»]
4A88X-ray1.51A2-160[»]
4A8GX-ray2.10A2-160[»]
4B9RX-ray1.76A2-160[»]
4BK6X-ray1.63A/B2-160[»]
4BK7X-ray1.14A2-160[»]
4BKCX-ray1.73A/B2-160[»]
4BKDX-ray1.17A2-160[»]
4BTZX-ray1.47A2-160[»]
4MNSX-ray1.20A2-160[»]
4QIPX-ray2.00A2-160[»]
4Z3LX-ray2.50A/B/C/D/E/F2-160[»]
ProteinModelPortaliP15494.
SMRiP15494.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei123. Bet v 1.0112.
89. Bet v 1.
90. Bet v 1.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP15494.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBEV1A_BETPN
AccessioniPrimary (citable) accession number: P15494
Secondary accession number(s): Q96369
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.