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P15479 (ACEA_RICCO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate lyase

Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
OrganismRicinus communis (Castor bean)
Taxonomic identifier3988 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesEuphorbiaceaeAcalyphoideaeAcalypheaeRicinus

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in storage lipid mobilization during the growth of higher plant seedling.

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer.

Subcellular location

Glyoxysome.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentGlyoxysome
Peroxisome
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentglyoxysome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 576576Isocitrate lyase
PRO_0000068810

Regions

Motif574 – 5763Microbody targeting signal Potential

Sites

Active site2131 Probable

Sequences

Sequence LengthMass (Da)Tools
P15479 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 8177A7679050579B

FASTA57664,752
        10         20         30         40         50         60 
MAASFSGPSM IMEEEGRFEA EVAEVQAWWN SERFKLTRRP YTARDVVALR GNLKQSYASN 

        70         80         90        100        110        120 
ELAKKLWRTL KTHQANGTAS RTFGALDPVQ VTMMAKHLDS IYVSGWQCSS THTTTNEPGP 

       130        140        150        160        170        180 
DLADYPYDTV PNKVEHLFFA QQYHDRKQRE ARMSMSREER ARTPYVDYLK PIIADGDTGF 

       190        200        210        220        230        240 
GGTTATVKLC KLFVERGAAG VHIEDQSSVT KKCGHMAGKV LVAISEHINR LVAARLQFDV 

       250        260        270        280        290        300 
MGVETLLVAR TDAEAANLIQ SNVDTRDHQF ILGVTNPNLR GKSLATLLAT GMANGKTGAE 

       310        320        330        340        350        360 
LQATEDNWLA MAQLKTFPEC VMDAIKNMNA GEDEKRRRMN EWMNHTSYDK CLSYEQGREI 

       370        380        390        400        410        420 
ADRMGLKNLF WDWDLPRTRE GFYRFKGSVM AAVVRGRAFA PHADIIWMET AKPDFAECTA 

       430        440        450        460        470        480 
FAEGVKSMHP EIMLAYNLSP SFNWDASGMT DEQMRDFIPR IARLGFCWQF ITLGGFHADA 

       490        500        510        520        530        540 
LVIDTFAKDY ARRGMLAYVE RIQREERKNG VDTLAHQKWS GANYYDRYLK TVQGGISSTA 

       550        560        570 
AMGKGVTEEQ FKETWTRPGA MEMGSAGSEV VAKARM 

« Hide

References

[1]"Nucleic acid (cDNA) and amino acid sequences of isocitrate lyase from castor bean."
Beeching J.R., Northcote D.H.
Plant Mol. Biol. 8:471-475(1987) [AGRICOLA] [Europe PMC]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M17145 mRNA. Translation: AAA53378.1.
PIRWZCSI. S06274.

3D structure databases

ProteinModelPortalP15479.
SMRP15479. Positions 9-535.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR000918. Isocitrate_lyase/Pmutase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. SSF51621. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA_RICCO
AccessionPrimary (citable) accession number: P15479
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways