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P15473

- IBP3_RAT

UniProt

P15473 - IBP3_RAT

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Protein
Insulin-like growth factor-binding protein 3
Gene
Igfbp3, Igfbp-3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

GO - Molecular functioni

  1. insulin-like growth factor I binding Source: RGD
  2. insulin-like growth factor II binding Source: RGD
  3. insulin-like growth factor binding Source: RGD
  4. protein binding Source: RGD
  5. protein tyrosine phosphatase activator activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. positive regulation of apoptotic process Source: UniProtKB
  2. positive regulation of catalytic activity Source: GOC
  3. positive regulation of myoblast differentiation Source: UniProtKB
  4. regulation of cell growth Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Protein family/group databases

MEROPSiI31.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 3
Short name:
IBP-3
Short name:
IGF-binding protein 3
Short name:
IGFBP-3
Gene namesi
Name:Igfbp3
Synonyms:Igfbp-3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2874. Igfbp3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RGD
  2. insulin-like growth factor binary complex Source: RGD
  3. insulin-like growth factor ternary complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27273 Publications
Add
BLAST
Chaini28 – 292265Insulin-like growth factor-binding protein 3
PRO_0000014380Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi124 – 1241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi137 – 1371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi214 ↔ 241 By similarity
Disulfide bondi252 ↔ 263 By similarity
Disulfide bondi265 ↔ 286 By similarity

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP15473.
PRIDEiP15473.

PTM databases

PhosphoSiteiP15473.

Expressioni

Gene expression databases

GenevestigatoriP15473.

Interactioni

Subunit structurei

Interacts with XLKD1. Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011678.

Structurei

3D structure databases

ProteinModelPortaliP15473.
SMRiP15473. Positions 38-118.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 11984IGFBP N-terminal
Add
BLAST
Domaini211 – 28676Thyroglobulin type-1
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38980.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP15473.
KOiK10138.
PhylomeDBiP15473.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR012211. IGFBP-3.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF3. PTHR11551:SF3. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01979. IGFBPFAMILY3.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15473-1 [UniParc]FASTAAdd to Basket

« Hide

MHPARPALWA AALTALTLLR GPPVARAGAG AVGAGPVVRC EPCDARALAQ    50
CAPPPTAPAC TELVREPGCG CCLTCALREG DACGVYTERC GTGLRCQPRP 100
AEQYPLKALL NGRGFCANAS AASNLSAYLP SQPSPGNTTE SEEDHNAGSV 150
ESQVVPSTHR VTDSKFHPLH SKMEVIIKGQ ARDSQRYKVD YESQSTDTQN 200
FSSESKRETE YGPCRREMED TLNHLKFLNV LSPRGVHIPN CDKKGFYKKK 250
QCRPSKGRKR GFCWCVDKYG QPLPGYDTKG KDDVHCLSVQ SQ 292
Length:292
Mass (Da):31,680
Last modified:August 1, 1990 - v2
Checksum:i1887D5E2A528F3B2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81Missing in AAB00989. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31837 mRNA. Translation: AAA41383.1.
M33300 mRNA. Translation: AAB00989.1.
PIRiA36748.
RefSeqiNP_036720.2. NM_012588.2.
UniGeneiRn.26369.

Genome annotation databases

GeneIDi24484.
KEGGirno:24484.
UCSCiRGD:2874. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31837 mRNA. Translation: AAA41383.1 .
M33300 mRNA. Translation: AAB00989.1 .
PIRi A36748.
RefSeqi NP_036720.2. NM_012588.2.
UniGenei Rn.26369.

3D structure databases

ProteinModelPortali P15473.
SMRi P15473. Positions 38-118.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000011678.

Protein family/group databases

MEROPSi I31.952.

PTM databases

PhosphoSitei P15473.

Proteomic databases

PaxDbi P15473.
PRIDEi P15473.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 24484.
KEGGi rno:24484.
UCSCi RGD:2874. rat.

Organism-specific databases

CTDi 3486.
RGDi 2874. Igfbp3.

Phylogenomic databases

eggNOGi NOG38980.
HOGENOMi HOG000253012.
HOVERGENi HBG002631.
InParanoidi P15473.
KOi K10138.
PhylomeDBi P15473.

Miscellaneous databases

NextBioi 603465.
PROi P15473.

Gene expression databases

Genevestigatori P15473.

Family and domain databases

Gene3Di 4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR012211. IGFBP-3.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view ]
PANTHERi PTHR11551. PTHR11551. 1 hit.
PTHR11551:SF3. PTHR11551:SF3. 1 hit.
Pfami PF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view ]
PRINTSi PR01976. IGFBPFAMILY.
PR01979. IGFBPFAMILY3.
SMARTi SM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEi PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complementary DNA structure of the high molecular weight rat insulin-like growth factor binding protein (IGF-BP3) and tissue distribution of its mRNA."
    Shimasaki S., Koba A., Mercado M., Shimonaka M., Ling N.
    Biochem. Biophys. Res. Commun. 165:907-912(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of the growth hormone-dependent insulin-like growth factor binding protein (IGFBP-3) in the rat."
    Albiston A.L., Herington A.C.
    Biochem. Biophys. Res. Commun. 166:892-897(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Isolation and NH2-terminal amino acid sequences of rat serum carrier proteins for insulin-like growth factors."
    Zapf J., Born W., Chang J.Y., James P., Froesch E.R., Fischer J.A.
    Biochem. Biophys. Res. Commun. 156:1187-1194(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 28-68.
  4. "Binding proteins for insulin-like growth factors in adult rat serum. Comparison with other human and rat binding proteins."
    Baxter R.C., Martin J.L.
    Biochem. Biophys. Res. Commun. 147:408-415(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 28-42.
  5. "Identification of a novel binding protein for insulin-like growth factors in adult rat serum."
    Shimonaka M., Schroeder R., Shimasaki S., Ling N.
    Biochem. Biophys. Res. Commun. 165:189-195(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 28-49.
    Tissue: Serum.

Entry informationi

Entry nameiIBP3_RAT
AccessioniPrimary (citable) accession number: P15473
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: August 1, 1990
Last modified: June 11, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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