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Protein

Insulin-like growth factor-binding protein 3

Gene

Igfbp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • cellular response to estradiol stimulus Source: RGD
  • cellular response to Thyroglobulin triiodothyronine Source: RGD
  • female pregnancy Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of testosterone secretion Source: RGD
  • positive regulation of apoptotic DNA fragmentation Source: RGD
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of cardiac muscle cell apoptotic process Source: RGD
  • positive regulation of myoblast differentiation Source: UniProtKB
  • regulation of cell growth Source: InterPro
  • regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
  • response to caloric restriction Source: RGD
  • response to drug Source: RGD
  • response to growth hormone Source: RGD
  • response to hypoxia Source: RGD
  • response to insulin Source: RGD
  • response to insulin-like growth factor stimulus Source: RGD
  • response to lipopolysaccharide Source: RGD

Keywordsi

Molecular functionGrowth factor binding

Protein family/group databases

MEROPSiI31.952

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 3
Short name:
IBP-3
Short name:
IGF-binding protein 3
Short name:
IGFBP-3
Gene namesi
Name:Igfbp3
Synonyms:Igfbp-3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2874 Igfbp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 273 PublicationsAdd BLAST27
ChainiPRO_000001438028 – 292Insulin-like growth factor-binding protein 3Add BLAST265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei149PhosphoserineBy similarity1
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei202PhosphoserineBy similarity1
Disulfide bondi214 ↔ 241PROSITE-ProRule annotation
Disulfide bondi252 ↔ 263PROSITE-ProRule annotation
Disulfide bondi265 ↔ 286PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP15473
PRIDEiP15473

PTM databases

PhosphoSitePlusiP15473

Interactioni

Subunit structurei

Interacts with XLKD1. Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011678

Structurei

3D structure databases

ProteinModelPortaliP15473
SMRiP15473
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 119IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST84
Domaini211 – 286Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST76

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHZU Eukaryota
ENOG4111MF3 LUCA
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP15473
KOiK10138
PhylomeDBiP15473

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012211 IGFBP-3
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF3 PTHR11551:SF3, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01979 IGFBPFAMILY3
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPARPALWA AALTALTLLR GPPVARAGAG AVGAGPVVRC EPCDARALAQ
60 70 80 90 100
CAPPPTAPAC TELVREPGCG CCLTCALREG DACGVYTERC GTGLRCQPRP
110 120 130 140 150
AEQYPLKALL NGRGFCANAS AASNLSAYLP SQPSPGNTTE SEEDHNAGSV
160 170 180 190 200
ESQVVPSTHR VTDSKFHPLH SKMEVIIKGQ ARDSQRYKVD YESQSTDTQN
210 220 230 240 250
FSSESKRETE YGPCRREMED TLNHLKFLNV LSPRGVHIPN CDKKGFYKKK
260 270 280 290
QCRPSKGRKR GFCWCVDKYG QPLPGYDTKG KDDVHCLSVQ SQ
Length:292
Mass (Da):31,680
Last modified:August 1, 1990 - v2
Checksum:i1887D5E2A528F3B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8Missing in AAB00989 (PubMed:1689154).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31837 mRNA Translation: AAA41383.1
M33300 mRNA Translation: AAB00989.1
PIRiA36748
RefSeqiNP_036720.2, NM_012588.2
UniGeneiRn.26369

Genome annotation databases

GeneIDi24484
KEGGirno:24484
UCSCiRGD:2874 rat

Similar proteinsi

Entry informationi

Entry nameiIBP3_RAT
AccessioniPrimary (citable) accession number: P15473
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: August 1, 1990
Last modified: May 23, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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