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Protein

Mu-conotoxin GS

Gene
N/A
Organism
Conus geographus (Geography cone) (Nubecula geographus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mu-conotoxins block voltage-gated sodium channels (Nav). No effect was observed upon injections into mice and goldfish (25 µg).1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Mu-conotoxin GS
Short name:
CGS
OrganismiConus geographus (Geography cone) (Nubecula geographus)
Taxonomic identifieri6491 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1268. conotoxin-GS.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000448781 – 34Mu-conotoxin GSAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 141 Publication
Disulfide bondi9 ↔ 191 Publication
Modified residuei104-hydroxyproline1 Publication1
Modified residuei114-hydroxyproline1 Publication1
Disulfide bondi13 ↔ 271 Publication
Modified residuei324-carboxyglutamate1 Publication1

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

Secondary structure

134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 11Combined sources3
Beta strandi17 – 20Combined sources4
Beta strandi22 – 24Combined sources3
Beta strandi26 – 29Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AG7NMR-A1-34[»]
ProteinModelPortaliP15472.
SMRiP15472.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15472.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
The cysteine framework is VI/VII (C-C-CC-C-C).

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR012629. Conotoxin_TVIIAGS.
[Graphical view]
PfamiPF08094. Toxin_24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15472-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
ACSGRGSRCP PQCCMGLRCG RGNPQKCIGA HEDV
Length:34
Mass (Da):3,548
Last modified:April 1, 1990 - v1
Checksum:i16614FD96DB1A78C
GO

Sequence databases

PIRiA31043.

Cross-referencesi

Sequence databases

PIRiA31043.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AG7NMR-A1-34[»]
ProteinModelPortaliP15472.
SMRiP15472.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1268. conotoxin-GS.

Miscellaneous databases

EvolutionaryTraceiP15472.

Family and domain databases

InterProiIPR012629. Conotoxin_TVIIAGS.
[Graphical view]
PfamiPF08094. Toxin_24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCGS_CONGE
AccessioniPrimary (citable) accession number: P15472
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.