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P15471 (CAS1_CONST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-conotoxin S1
Alternative name(s):
SI
OrganismConus striatus (Striated cone)
Taxonomic identifier6493 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Protein attributes

Sequence length64 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks muscular nAChRs alpha-1/gamma and alpha-1/delta subunits.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom duct.

Domain

The cysteine framework is I (CC-C-C).

Sequence similarities

Belongs to the conotoxin A superfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Propeptide22 – 4928
PRO_0000034887
Peptide50 – 6213Alpha-conotoxin S1 Ref.3
PRO_0000034888

Amino acid modifications

Modified residue621Cysteine amide Ref.4
Disulfide bond51 ↔ 56 Ref.4
Disulfide bond52 ↔ 62 Ref.4

Secondary structure

... 64
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P15471 [UniParc].

Last modified July 11, 2002. Version 2.
Checksum: B104B80CCD7C3B41

FASTA647,164
        10         20         30         40         50         60 
MGMRMMFTVF LLVVLATTVV SFPSDRASDG RDDEAKDERS DMHESDRKEI CCNPACGPKY 


SCGR 

« Hide

References

[1]"Conopeptides from Conus striatus and Conus textile by cDNA cloning."
Lu B.-S., Yu F., Zhao D., Huang P.-T., Huang C.-F.
Peptides 20:1139-1144(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom duct.
[2]"The A-superfamily of conotoxins: structural and functional divergence."
Santos A.D., McIntosh J.M., Hillyard D.R., Cruz L.J., Olivera B.M.
J. Biol. Chem. 279:17596-17606(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom duct.
[3]"Phylogenetic specificity of cholinergic ligands: alpha-conotoxin SI."
Zafaralla G.C., Ramilo C., Gray W.R., Karlstroem R., Olivera B.M., Cruz L.J.
Biochemistry 27:7102-7105(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 50-62.
Tissue: Venom.
[4]"Solution structure of alpha-conotoxin SI."
Benie A.J., Whitford D., Hargittai B., Barany G., Janes R.W.
FEBS Lett. 476:287-295(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 50-62, DISULFIDE BONDS, AMIDATION AT CYS-62.

Cross-references

Sequence databases

PIRA28953.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1HJEX-ray0.75A50-62[»]
1QMWNMR-A50-62[»]
ProteinModelPortalP15471.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ConoServer76. SI precursor.

Family and domain databases

InterProIPR009958. Conotoxin_a-typ.
IPR018072. Conotoxin_a-typ_CS.
[Graphical view]
PfamPF07365. Toxin_8. 1 hit.
[Graphical view]
PROSITEPS60014. ALPHA_CONOTOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP15471.

Entry information

Entry nameCAS1_CONST
AccessionPrimary (citable) accession number: P15471
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 11, 2002
Last modified: April 16, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references