Reviewed, UniProtKB/Swiss-Prot P15466 (RNL1_PIG)

Names and origin

Protein names	Recommended name:     Ribonuclease PL1     EC=3.1.27.5
Organism	Sus scrofa (Pig)
Taxonomic identifier	9823 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	34 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates.
Subcellular location	Lysosome Probable.
Sequence similarities	Belongs to the pancreatic ribonuclease family.

Ontologies

Keywords
Cellular component	Lysosome
Molecular function	Endonuclease Hydrolase Nuclease
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro pancreatic ribonuclease activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›34	›34	Ribonuclease PL1		PRO_0000057161
Sites
	Active site	15	1	Proton acceptor By similarity
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...); partial
Experimental info
	Non-terminal residue	34	1

Sequences

	Sequence		Length	Mass (Da)
	P15466-1 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: F2176DE8A6F517B3	FASTA	34	3,933
	10 20 30 IPKNLTRAQW FTIQHIQPSP LQXNKAMNGV NXYT

References

[1]	"Primary structure of a ribonuclease from porcine liver, a new member of the ribonuclease superfamily." Hofsteenge J., Matthies R., Stone S.R. Biochemistry 28:9806-9813(1989) [PubMed: 2611266] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Liver.

Cross-references

Sequence databases
PIR	A33627.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P15466.
Enzyme and pathway databases
BRENDA	3.1.27.5. 249.
Family and domain databases
InterPro	IPR001427. RNaseA. [Graphical view]
PANTHER	PTHR11437. RNaseA. 1 hit.
ProDom	PD000535. RNaseA. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00127. RNASE_PANCREATIC. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNL1_PIG

Accession

Primary (citable) accession number: P15466

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	June 16, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)