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Protein

Cytochrome c-552

Gene

HTH_0988

Organism
Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Reacts with hydrogenase.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281Heme (covalent)
Binding sitei31 – 311Heme (covalent)
Metal bindingi32 – 321Iron (heme axial ligand)
Metal bindingi77 – 771Iron (heme axial ligand)

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-552
Alternative name(s):
Cytochrome c552
Gene namesi
Ordered Locus Names:HTH_0988, Hydth_0984
OrganismiHydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)
Taxonomic identifieri608538 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobacter
Proteomesi
  • UP000002574 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 9880Cytochrome c-5521 PublicationPRO_0000006531Add
BLAST

Post-translational modificationi

Binds 1 heme group per subunit.

Interactioni

Protein-protein interaction databases

STRINGi608538.HTH_0988.

Structurei

Secondary structure

1
98
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi20 – 256Combined sources
Helixi28 – 303Combined sources
Beta strandi34 – 363Combined sources
Beta strandi38 – 403Combined sources
Helixi43 – 508Combined sources
Helixi56 – 6611Combined sources
Beta strandi70 – 756Combined sources
Helixi84 – 9512Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AYGNMR-A19-98[»]
1YNRX-ray2.00A/B/C/D19-98[»]
2AI5NMR-A19-98[»]
3VYMX-ray2.00A19-98[»]
4ZIDX-ray1.80A19-98[»]
5AURX-ray1.26A/C/E/G19-98[»]
5AUSX-ray1.30A/C19-98[»]
ProteinModelPortaliP15452.
SMRiP15452. Positions 19-98.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15452.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105W2Z. Bacteria.
COG4654. LUCA.
HOGENOMiHOG000254790.
KOiK08738.
OMAiATAKNCM.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002324. Cyt_c_ID.
[Graphical view]
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00606. CYTCHROMECID.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15452-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKFLLVAVV GLAGITFANE QLAKQKGCMA CHDLKAKKVG PAYADVAKKY
60 70 80 90
AGRKDAVDYL AGKIKKGGSG VWGSVPMPPQ NVTDAEAKQL AQWILSIK
Length:98
Mass (Da):10,431
Last modified:August 1, 1992 - v2
Checksum:iF49713D829DDE927
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57735 Genomic DNA. Translation: CAA40902.1.
AP011112 Genomic DNA. Translation: BAI69446.1.
CP002221 Genomic DNA. Translation: ADO45379.1.
PIRiS32485.
RefSeqiWP_012963626.1. NC_017161.1.

Genome annotation databases

EnsemblBacteriaiADO45379; ADO45379; Hydth_0984.
BAI69446; BAI69446; HTH_0988.
KEGGihte:Hydth_0984.
hth:HTH_0988.
PATRICi32210897. VBIHydThe36152_0997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57735 Genomic DNA. Translation: CAA40902.1.
AP011112 Genomic DNA. Translation: BAI69446.1.
CP002221 Genomic DNA. Translation: ADO45379.1.
PIRiS32485.
RefSeqiWP_012963626.1. NC_017161.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AYGNMR-A19-98[»]
1YNRX-ray2.00A/B/C/D19-98[»]
2AI5NMR-A19-98[»]
3VYMX-ray2.00A19-98[»]
4ZIDX-ray1.80A19-98[»]
5AURX-ray1.26A/C/E/G19-98[»]
5AUSX-ray1.30A/C19-98[»]
ProteinModelPortaliP15452.
SMRiP15452. Positions 19-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi608538.HTH_0988.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADO45379; ADO45379; Hydth_0984.
BAI69446; BAI69446; HTH_0988.
KEGGihte:Hydth_0984.
hth:HTH_0988.
PATRICi32210897. VBIHydThe36152_0997.

Phylogenomic databases

eggNOGiENOG4105W2Z. Bacteria.
COG4654. LUCA.
HOGENOMiHOG000254790.
KOiK08738.
OMAiATAKNCM.

Miscellaneous databases

EvolutionaryTraceiP15452.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002324. Cyt_c_ID.
[Graphical view]
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00606. CYTCHROMECID.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, nucleotide sequence and expression of the cytochrome c-552 gene from Hydrogenobacter thermophilus."
    Sanbongi Y., Yang J.H., Igarashi Y., Kodama T.
    Eur. J. Biochem. 198:7-12(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete genome sequence of the thermophilic, obligately chemolithoautotrophic hydrogen-oxidizing bacterium Hydrogenobacter thermophilus TK-6."
    Arai H., Kanbe H., Ishii M., Igarashi Y.
    J. Bacteriol. 192:2651-2652(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6534 / IAM 12695 / TK-6.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6534 / IAM 12695 / TK-6.
  4. "Amino acid sequence of cytochrome c-552 from a thermophilic hydrogen-oxidizing bacterium, Hydrogenobacter thermophilus."
    Sanbongi Y., Ishii M., Igarashi Y., Kodama T.
    J. Bacteriol. 171:65-69(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-98.
  5. "Thermostability of cytochrome c-552 from the thermophilic hydrogen-oxidizing bacterium Hydrogenobacter thermophilus."
    Sanbongi Y., Igarashi Y., Kodama T.
    Biochemistry 28:9574-9578(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: THERMOSTABILITY.
  6. "Solution structure of thermostable cytochrome c-552 from Hydrogenobacter thermophilus determined by 1H-NMR spectroscopy."
    Hasegawa J., Yoshida T., Yamazaki T., Sambongi Y., Yu Y., Igarashi Y., Kodama T., Yamazaki K., Kyogoku Y., Kobayashi Y.
    Biochemistry 37:9641-9649(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiCY552_HYDTT
AccessioniPrimary (citable) accession number: P15452
Secondary accession number(s): D3DHZ4, E3EUH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: August 1, 1992
Last modified: April 13, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.