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Protein

Globin, monomeric component M-IV

Gene
N/A
Organism
Glycera dibranchiata (Bloodworm)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi91 – 911Iron (heme axial ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Globin, monomeric component M-IV
Alternative name(s):
GMH4
OrganismiGlycera dibranchiata (Bloodworm)
Taxonomic identifieri6350 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaPolychaetaPalpataAciculataPhyllodocidaGlyceridaeGlycera

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 148147Globin, monomeric component M-IVPRO_0000052502Add
BLAST

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

Secondary structure

1
148
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1915Combined sources
Turni20 – 245Combined sources
Helixi25 – 3814Combined sources
Helixi40 – 423Combined sources
Helixi43 – 464Combined sources
Beta strandi49 – 524Combined sources
Helixi55 – 7218Combined sources
Turni73 – 753Combined sources
Helixi77 – 9014Combined sources
Helixi91 – 933Combined sources
Beta strandi94 – 974Combined sources
Helixi101 – 1033Combined sources
Helixi104 – 11916Combined sources
Helixi120 – 1223Combined sources
Helixi125 – 14622Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JF4X-ray1.40A2-148[»]
1JL6X-ray1.40A2-148[»]
1VRENMR-A2-148[»]
1VRFNMR-A2-148[»]
ProteinModelPortaliP15447.
SMRiP15447. Positions 2-148.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15447.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR013316. Globin_annelid-type.
IPR012292. Globin_dom.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR01907. WORMGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSAAQRQV VASTWKDIAG SDNGAGVGKE CFTKFLSAHH DIAAVFGFSG
60 70 80 90 100
ASDPGVADLG AKVLAQIGVA VSHLGDEGKM VAEMKAVGVR HKGYGYKHIK
110 120 130 140
AEYFEPLGAS LLSAMEHRIG GKMTAAAKDA WAAAYADISG ALISGLQS
Length:148
Mass (Da):15,178
Last modified:January 23, 2007 - v2
Checksum:i9206F7FBE1CAB7F1
GO

Mass spectrometryi

Molecular mass is 15031.6±3.8 Da from positions 2 - 148. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02873 mRNA. Translation: AAA29162.1.
PIRiA33420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02873 mRNA. Translation: AAA29162.1.
PIRiA33420.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JF4X-ray1.40A2-148[»]
1JL6X-ray1.40A2-148[»]
1VRENMR-A2-148[»]
1VRFNMR-A2-148[»]
ProteinModelPortaliP15447.
SMRiP15447. Positions 2-148.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP15447.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR013316. Globin_annelid-type.
IPR012292. Globin_dom.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR01907. WORMGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning and predicted amino acid sequence of Glycera dibranchiata monomer hemoglobin IV."
    Simons P.C., Satterlee J.D.
    Biochemistry 28:8525-8530(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-25.
  2. "Complete amino acid sequence of the Glycera dibranchiata monomer hemoglobin component IV: structural implications."
    Alam S.L., Satterlee J.D., Edmonds C.G.
    J. Protein Chem. 13:151-164(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-148, MASS SPECTROMETRY, 3D-STRUCTURE MODELING.
    Tissue: Erythrocyte.
  3. "Solution structure and backbone dynamics of component IV Glycera dibranchiata monomeric hemoglobin-CO."
    Volkman B.F., Alam S.L., Satterlee J.D., Markley J.L.
    Biochemistry 37:10906-10919(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  4. "Crystal structures of unligated and CN-ligated Glycera dibranchiata monomer ferric hemoglobin components III and IV."
    Park H.J., Yang C., Treff N., Satterlee J.D., Kang C.
    Proteins 49:49-60(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS)IN COMPLEX WITH HEME, SUBUNIT.

Entry informationi

Entry nameiGLB4_GLYDI
AccessioniPrimary (citable) accession number: P15447
Secondary accession number(s): P81779
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.