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Protein

Acidic phospholipase A2 2

Gene
N/A
Organism
Naja naja (Indian cobra)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+1 PublicationNote: Binds 1 Ca2+ ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi29Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi31Calcium; via carbonyl oxygenCombined sources1 Publication1
Active sitei471 Publication1
Metal bindingi48CalciumCombined sources1 Publication1
Active sitei931 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.4. 3557.

Chemistry databases

SwissLipidsiSLP:000000937.

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic phospholipase A2 2 (EC:3.1.1.4)
Short name:
PLA22
Short name:
svPLA2
Alternative name(s):
Phosphatidylcholine 2-acylhydrolase
OrganismiNaja naja (Indian cobra)
Taxonomic identifieri35670 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeNaja

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5584.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001616691 – 119Acidic phospholipase A2 2Add BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi11 ↔ 71Combined sources3 Publications
Disulfide bondi26 ↔ 118Combined sources3 Publications
Disulfide bondi28 ↔ 44Combined sources3 Publications
Disulfide bondi43 ↔ 99Combined sources3 Publications
Disulfide bondi50 ↔ 92Combined sources3 Publications
Disulfide bondi60 ↔ 85Combined sources3 Publications
Disulfide bondi78 ↔ 90Combined sources3 Publications

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Interactioni

Subunit structurei

Homotrimer.3 Publications

Chemistry databases

BindingDBiP15445.

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 12Combined sources11
Helixi18 – 21Combined sources4
Beta strandi22 – 24Combined sources3
Turni25 – 27Combined sources3
Beta strandi28 – 30Combined sources3
Beta strandi32 – 34Combined sources3
Helixi39 – 54Combined sources16
Helixi62 – 64Combined sources3
Beta strandi69 – 72Combined sources4
Beta strandi75 – 78Combined sources4
Helixi84 – 102Combined sources19
Helixi107 – 109Combined sources3
Helixi114 – 117Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A3DX-ray1.80A1-119[»]
1A3FX-ray2.65A/B/C1-119[»]
1OWSX-ray2.30A1-118[»]
B1-119[»]
1PSHX-ray2.30A/B/C1-119[»]
2WQ5X-ray1.65A1-119[»]
ProteinModelPortaliP15445.
SMRiP15445.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15445.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG008137.

Family and domain databases

CDDicd00125. PLA2c. 1 hit.
Gene3Di1.20.90.10. 1 hit.
InterProiIPR001211. PLipase_A2.
IPR033112. PLipase_A2_Asp_AS.
IPR016090. PLipase_A2_dom.
IPR033113. PLipase_A2_His_AS.
[Graphical view]
PANTHERiPTHR11716. PTHR11716. 1 hit.
PfamiPF00068. Phospholip_A2_1. 1 hit.
[Graphical view]
PRINTSiPR00389. PHPHLIPASEA2.
SMARTiSM00085. PA2c. 1 hit.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00119. PA2_ASP. 1 hit.
PS00118. PA2_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15445-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NLYQFKNMIK CTVPSRSWWD FADYGCYCGR GGSGTPVDDL DRCCQVHDNC
60 70 80 90 100
YNEAEKISGC WPYFKTYSYE CSQGTLTCKG DNNACAASVC DCDRLAAICF
110
AGAPYNDNNY NIDLKARCQ
Length:119
Mass (Da):13,346
Last modified:April 1, 1990 - v1
Checksum:iB725291AAB522966
GO

Sequence cautioni

The sequence CAA45372 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63947 Genomic DNA. Translation: CAA45372.1. Different initiation.
PIRiS07528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63947 Genomic DNA. Translation: CAA45372.1. Different initiation.
PIRiS07528.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A3DX-ray1.80A1-119[»]
1A3FX-ray2.65A/B/C1-119[»]
1OWSX-ray2.30A1-118[»]
B1-119[»]
1PSHX-ray2.30A/B/C1-119[»]
2WQ5X-ray1.65A1-119[»]
ProteinModelPortaliP15445.
SMRiP15445.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP15445.
ChEMBLiCHEMBL5584.
SwissLipidsiSLP:000000937.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG008137.

Enzyme and pathway databases

BRENDAi3.1.1.4. 3557.

Miscellaneous databases

EvolutionaryTraceiP15445.

Family and domain databases

CDDicd00125. PLA2c. 1 hit.
Gene3Di1.20.90.10. 1 hit.
InterProiIPR001211. PLipase_A2.
IPR033112. PLipase_A2_Asp_AS.
IPR016090. PLipase_A2_dom.
IPR033113. PLipase_A2_His_AS.
[Graphical view]
PANTHERiPTHR11716. PTHR11716. 1 hit.
PfamiPF00068. Phospholip_A2_1. 1 hit.
[Graphical view]
PRINTSiPR00389. PHPHLIPASEA2.
SMARTiSM00085. PA2c. 1 hit.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00119. PA2_ASP. 1 hit.
PS00118. PA2_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPA2A2_NAJNA
AccessioniPrimary (citable) accession number: P15445
Secondary accession number(s): Q65ZF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Is not neurotoxic.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.