Reviewed, UniProtKB/Swiss-Prot P15437 (AL1A1_HORSE)

Names and origin

Protein names

Recommended name:
    Retinal dehydrogenase 1
      Short name=RALDH 1
      Short name=RalDH1
    EC=1.2.1.36
Alternative name(s):
    Aldehyde dehydrogenase family 1 member A1
    Aldehyde dehydrogenase, cytosolic
    ALHDII
    ALDH-E1

Gene names

Name:	ALDH1A1
Synonyms:	ALDH1

Organism

Equus caballus (Horse)

Taxonomic identifier

9796 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid By similarity.
Catalytic activity	Retinal + NAD+ + H2O = retinoate + NADH.
Pathway	Cofactor metabolism; retinol metabolism.
Subunit structure	Homotetramer.
Subcellular location	Cytoplasm.
Post-translational modification	The N-terminus is blocked.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	retinal dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Retinal dehydrogenase 1		PRO_0000056414
Regions
	Nucleotide binding	245 – 250	6	NAD By similarity
Sites
	Active site	268	1	Proton acceptor By similarity
	Active site	302	1	Nucleophile By similarity
	Site	169	1	Transition state stabilizer By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylserine Probable Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P15437-1 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: A438E4204BEF7340	FASTA	500	54,744
	10 20 30 40 50 60 SSSGTPDLPV LLTDLKFQYT KIFINNEWHD SVSGKKFPVF NPATEEKLCE VEEGDKEDVN 70 80 90 100 110 120 KAVAAARQAF QIGSPWRTMD ASERGRLLYK LADLVERDRL ILATMESMNG GKLFSNAYLM 130 140 150 160 170 180 DLGGCLKTLR YCAGWADKIQ GRTIPSDGNF FTYTRHEPVG VCGQILPWNF PLLMFLWKIA 190 200 210 220 230 240 PALSCGNTVV VKPAEQTPLS ALHVATLIKE AGFPPGVVNI VPGYGPTAGA AISSHMDIDK 250 260 270 280 290 300 VAFTGSTEVG KLIKEAAGKS NLKRVTLELG GKSPFIVFAD ADLETALEVT HQALFYHQGQ 310 320 330 340 350 360 CCVAASRLFV EESIYDEFVR RSVERAKKYV LGNPLTPGVS QGPQIDKEQY DKILDLIESG 370 380 390 400 410 420 KKEGAKLECG GGPWGNKGYF IQPTVFSNVS DEMRIAKEEI FGPVQQIMKF KSLDDVIKRA 430 440 450 460 470 480 NNTTYGLFAG SFTKDLDKAI TVSAALQAGT VWVNCYGVVS AQCPFGGFKM SGNGREMGEY 490 500 GFHEYTEVKT VTVKISQKNS

References

[1]	"The cytoplasmic isoenzyme of horse liver aldehyde dehydrogenase. Relationship to the corresponding human isoenzyme." von Bahr-Lindstroem H., Hempel J., Joernvall H. Eur. J. Biochem. 141:37-42(1984) [PubMed: 6723662] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	S02302.
3D structure databases
HSSP	HSSP built from PDB template 1BXS based on UniProtKB P51977.
ModBase	Search...
Genome annotation databases
Ensembl	ENSECAG00000019343. Equus caballus. [Contig view]
Phylogenomic databases
HOVERGEN	P15437.
Enzyme and pathway databases
BRENDA	1.2.1.36. 1464.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL1A1_HORSE

Accession

Primary (citable) accession number: P15437

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)