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P15431

- GBRB1_RAT

UniProt

P15431 - GBRB1_RAT

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Protein

Gamma-aminobutyric acid receptor subunit beta-1

Gene
Gabrb1, Gabrb-1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.1 Publication

GO - Molecular functioni

  1. anion channel activity Source: RGD
  2. chloride channel activity Source: UniProtKB-KW
  3. extracellular ligand-gated ion channel activity Source: InterPro
  4. GABA-A receptor activity Source: RGD
  5. GABA receptor binding Source: RGD
  6. ligand-gated ion channel activity Source: RGD

GO - Biological processi

  1. central nervous system neuron development Source: RGD
  2. chloride transport Source: RGD
  3. gamma-aminobutyric acid signaling pathway Source: RGD
  4. ion transmembrane transport Source: GOC
  5. ovulation cycle Source: RGD
  6. response to progesterone Source: RGD
  7. response to toxic substance Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_199021. GABA A receptor activation.
REACT_199029. Ligand-gated ion channel transport.

Protein family/group databases

TCDBi1.A.9.5.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit beta-1
Alternative name(s):
GABA(A) receptor subunit beta-1
Gene namesi
Name:Gabrb1
Synonyms:Gabrb-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2649. Gabrb1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 245220Extracellular InferredAdd
BLAST
Transmembranei246 – 26722Helical; InferredAdd
BLAST
Transmembranei271 – 29323Helical; InferredAdd
BLAST
Transmembranei305 – 32723Helical; InferredAdd
BLAST
Topological domaini328 – 451124Cytoplasmic InferredAdd
BLAST
Transmembranei452 – 47322Helical; InferredAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. cytoplasm Source: RGD
  4. dendrite Source: RGD
  5. membrane Source: RGD
  6. nuclear envelope Source: RGD
  7. nucleus Source: RGD
  8. postsynaptic membrane Source: UniProtKB-SubCell
  9. receptor complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 474449Gamma-aminobutyric acid receptor subunit beta-1PRO_0000000458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi105 – 1051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi161 ↔ 175 By similarity
Glycosylationi174 – 1741N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP15431.
PRIDEiP15431.

PTM databases

PhosphoSiteiP15431.

Expressioni

Gene expression databases

GenevestigatoriP15431.

Interactioni

Subunit structurei

Binds UBQLN1 By similarity. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents By similarity.

Protein-protein interaction databases

IntActiP15431. 2 interactions.
MINTiMINT-219840.
STRINGi10116.ENSRNOP00000003170.

Structurei

3D structure databases

ProteinModelPortaliP15431.
SMRiP15431. Positions 274-330.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77438.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP15431.
KOiK05181.
OrthoDBiEOG712TVZ.
PhylomeDBiP15431.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR002289. GABAAb_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01160. GABAARBETA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15431-1 [UniParc]FASTAAdd to Basket

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MWTVQNRESL GLLSFPVMVA MVCCAHSSNE PSNMSYVKET VDRLLKGYDI    50
RLRPDFGGPP VDVGMRIDVA SIDMVSEVNM DYTLTMYFQQ SWKDKRLSYS 100
GIPLNLTLDN RVADQLWVPD TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL 150
YGLRITTTAA CMMDLRRYPL DEQNCTLEIE SYGYTTDDIE FYWNGGEGAV 200
TGVNKIELPQ FSIVDYKMVS KKVEFTTGAY PRLSLSFRLK RNIGYFILQT 250
YMPSTLITIL SWVSFWINYD ASAARVALGI TTVLTMTTIS THLRETLPKI 300
PYVKAIDIYL MGCFVFVFLA LLEYAFVNYI FFGKGPQKKG ASKQDQSANE 350
KNKLEMNKVQ VDAHGNILLS TLEIRNETSG SEVLTGVSDP KATMYSYDSA 400
SIQYRKPLSS REGFGRGLDR HGVPGKGRIR RRASQLKVKI PDLTDVNSID 450
KWSRMFFPIT FSLFNVVYWL YYVH 474
Length:474
Mass (Da):54,072
Last modified:April 1, 1990 - v1
Checksum:i986277FDBD66377A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti420 – 4201R → Q no nucleotide entry 1 Publication
Sequence conflicti428 – 4281R → P no nucleotide entry 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15466 mRNA. Translation: CAA33493.1.
PIRiS04464. B60039.
RefSeqiNP_037088.1. NM_012956.1.
UniGeneiRn.207157.

Genome annotation databases

GeneIDi25450.
KEGGirno:25450.
UCSCiRGD:2649. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15466 mRNA. Translation: CAA33493.1 .
PIRi S04464. B60039.
RefSeqi NP_037088.1. NM_012956.1.
UniGenei Rn.207157.

3D structure databases

ProteinModelPortali P15431.
SMRi P15431. Positions 274-330.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P15431. 2 interactions.
MINTi MINT-219840.
STRINGi 10116.ENSRNOP00000003170.

Chemistry

BindingDBi P15431.
ChEMBLi CHEMBL2096683.
GuidetoPHARMACOLOGYi 410.

Protein family/group databases

TCDBi 1.A.9.5.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

PTM databases

PhosphoSitei P15431.

Proteomic databases

PaxDbi P15431.
PRIDEi P15431.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25450.
KEGGi rno:25450.
UCSCi RGD:2649. rat.

Organism-specific databases

CTDi 2560.
RGDi 2649. Gabrb1.

Phylogenomic databases

eggNOGi NOG77438.
HOGENOMi HOG000231335.
HOVERGENi HBG051707.
InParanoidi P15431.
KOi K05181.
OrthoDBi EOG712TVZ.
PhylomeDBi P15431.
TreeFami TF315453.

Enzyme and pathway databases

Reactomei REACT_199021. GABA A receptor activation.
REACT_199029. Ligand-gated ion channel transport.

Miscellaneous databases

NextBioi 606697.
PROi P15431.

Gene expression databases

Genevestigatori P15431.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR002289. GABAAb_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR01160. GABAARBETA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs."
    Ymer S., Schofield P.R., Draguhn A., Werner P., Koehler M., Seeburg P.H.
    EMBO J. 8:1665-1670(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "GABAA-receptor expressed from rat brain alpha- and beta-subunit cDNAs displays potentiation by benzodiazepine receptor ligands."
    Malherbe P., Draguhn A., Multhaup G., Beyreuther K., Mohler H.
    Brain Res. Mol. Brain Res. 8:199-208(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.

Entry informationi

Entry nameiGBRB1_RAT
AccessioniPrimary (citable) accession number: P15431
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 3, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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