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Protein

Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme

Gene

ninaA

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts on the folding of rhodopsin RH1 and RH2 (but not RH3) and is required for visual transduction.1 Publication

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • cyclosporin A binding Source: FlyBase
  • peptidyl-prolyl cis-trans isomerase activity Source: FlyBase

GO - Biological processi

  • 'de novo' protein folding Source: FlyBase
  • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: FlyBase
  • N-glycan processing Source: FlyBase
  • photoreceptor cell maintenance Source: FlyBase
  • phototransduction Source: FlyBase
  • phototransduction, visible light Source: FlyBase
  • protein deglycosylation Source: FlyBase
  • rhodopsin biosynthetic process Source: FlyBase
  • rhodopsin metabolic process Source: FlyBase
  • transport Source: FlyBase
  • visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Biological processi

Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Rotamase
Gene namesi
Name:ninaA
ORF Names:CG3966
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0002936. ninaA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: FlyBase
  • endoplasmic reticulum lumen Source: FlyBase
  • integral component of membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002549321 – 237Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozymeAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP15425.
PRIDEiP15425.

Expressioni

Tissue specificityi

Expressed specifically in photoreceptor cells.

Gene expression databases

BgeeiFBgn0002936.
GenevisibleiP15425. DM.

Interactioni

Protein-protein interaction databases

BioGridi59525. 6 interactors.
DIPiDIP-18923N.
IntActiP15425. 2 interactors.
MINTiMINT-306426.
STRINGi7227.FBpp0077688.

Structurei

3D structure databases

ProteinModelPortaliP15425.
SMRiP15425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 190PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST161

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0880. Eukaryota.
ENOG410Z0G4. LUCA.
InParanoidiP15425.
KOiK01802.
OMAiYVGARFH.
OrthoDBiEOG091G0BGL.
PhylomeDBiP15425.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLLNRIIL CSAFLAVASG LSFTVTSRIY MDVKHNKKPV GRITFGLFGK
60 70 80 90 100
LAPKTVANFR HICLRGINGT SYVGSRFHRV VDRFLVQGGD IVNGDGTGSI
110 120 130 140 150
SIYGDYFPDE DKALAVEHNR PGYLGMANRG PDTNGCQFYV TTVGAKWLDG
160 170 180 190 200
KHTVFGKVLE GMDTIYAIED VKTDTDDFPV EPVVISNCGE IPTEQFEFYP
210 220 230
DDFNILGWIK AAGLPVTSSF CVLLIFHYFF RQLNMYC
Length:237
Mass (Da):26,351
Last modified:April 1, 1990 - v1
Checksum:i1BF3CD01C31119B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14769 Genomic DNA. Translation: CAA32877.1.
M22851 Genomic DNA. Translation: AAA28717.1.
AE014134 Genomic DNA. Translation: AAF51437.1.
PIRiA33906. CYFFBE.
RefSeqiNP_476656.1. NM_057308.4.
UniGeneiDm.19760.

Genome annotation databases

EnsemblMetazoaiFBtr0078023; FBpp0077688; FBgn0002936.
GeneIDi33271.
KEGGidme:Dmel_CG3966.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14769 Genomic DNA. Translation: CAA32877.1.
M22851 Genomic DNA. Translation: AAA28717.1.
AE014134 Genomic DNA. Translation: AAF51437.1.
PIRiA33906. CYFFBE.
RefSeqiNP_476656.1. NM_057308.4.
UniGeneiDm.19760.

3D structure databases

ProteinModelPortaliP15425.
SMRiP15425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59525. 6 interactors.
DIPiDIP-18923N.
IntActiP15425. 2 interactors.
MINTiMINT-306426.
STRINGi7227.FBpp0077688.

Proteomic databases

PaxDbiP15425.
PRIDEiP15425.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078023; FBpp0077688; FBgn0002936.
GeneIDi33271.
KEGGidme:Dmel_CG3966.

Organism-specific databases

CTDi33271.
FlyBaseiFBgn0002936. ninaA.

Phylogenomic databases

eggNOGiKOG0880. Eukaryota.
ENOG410Z0G4. LUCA.
InParanoidiP15425.
KOiK01802.
OMAiYVGARFH.
OrthoDBiEOG091G0BGL.
PhylomeDBiP15425.

Miscellaneous databases

GenomeRNAii33271.
PROiP15425.

Gene expression databases

BgeeiFBgn0002936.
GenevisibleiP15425. DM.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYPR_DROME
AccessioniPrimary (citable) accession number: P15425
Secondary accession number(s): Q9VPV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 2, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.