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Protein

Glycophorin-E

Gene

GYPE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is a minor sialoglycoprotein in human erythrocyte membranes.

Keywords - Ligandi

Sialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Glycophorin-E
Gene namesi
Name:GYPE
Synonyms:GPE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:4705. GYPE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 5233ExtracellularSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Topological domaini74 – 785CytoplasmicSequence Analysis

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29083.

Polymorphism and mutation databases

BioMutaiGYPE.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 7859Glycophorin-EPRO_0000012138Add
BLAST

Post-translational modificationi

The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues.By similarity

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Erythrocytes.

Gene expression databases

BgeeiP15421.
CleanExiHS_GYPE.
ExpressionAtlasiP15421. baseline and differential.
GenevisibleiP15421. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351430.

Structurei

3D structure databases

ProteinModelPortaliP15421.
SMRiP15421. Positions 46-78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycophorin-A family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00610000087442.
HOGENOMiHOG000089933.
HOVERGENiHBG005850.
InParanoidiP15421.
OMAiSYCIRLI.
PhylomeDBiP15421.
TreeFamiTF341456.

Family and domain databases

InterProiIPR001195. Glycophorin.
[Graphical view]
PANTHERiPTHR13813. PTHR13813. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGKIIFVLL LSGIVSISAS STTGVAMHTS TSSSVTKSYI SSQTNGITLI
60 70
NWWAMARVIF EVMLVVVGMI ILISYCIR
Length:78
Mass (Da):8,463
Last modified:May 27, 2002 - v2
Checksum:iF1F5B6EE5CFB3EB3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131G → E.2 Publications
Corresponds to variant rs28721877 [ dbSNP | Ensembl ].
VAR_062006
Natural varianti78 – 781R → P.
Corresponds to variant rs17018900 [ dbSNP | Ensembl ].
VAR_053111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57233 Genomic DNA. Translation: AAA63179.1.
M29605, M29609, M29608 Genomic DNA. Translation: AAA52766.1.
M29610 mRNA. Translation: AAA52575.1.
X53010 Genomic DNA. Translation: CAA37191.1.
X53004, X53005, X53008 Genomic DNA. Translation: CAA37189.1.
CH471056 Genomic DNA. Translation: EAX05065.1.
CH471056 Genomic DNA. Translation: EAX05066.1.
CH471056 Genomic DNA. Translation: EAX05067.1.
BC017864 mRNA. Translation: AAH17864.1.
M57234 Genomic DNA. No translation available.
M57232 Genomic DNA. Translation: AAA35923.1.
L31863 Genomic DNA. Translation: AAC41697.1.
CCDSiCCDS47138.1.
PIRiA34931.
RefSeqiNP_002093.2. NM_002102.3.
NP_941391.2. NM_198682.2.
UniGeneiHs.654368.
Hs.728753.

Genome annotation databases

EnsembliENST00000358615; ENSP00000351430; ENSG00000197465.
ENST00000437468; ENSP00000400698; ENSG00000197465.
GeneIDi2996.
KEGGihsa:2996.
UCSCiuc003ijj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57233 Genomic DNA. Translation: AAA63179.1.
M29605, M29609, M29608 Genomic DNA. Translation: AAA52766.1.
M29610 mRNA. Translation: AAA52575.1.
X53010 Genomic DNA. Translation: CAA37191.1.
X53004, X53005, X53008 Genomic DNA. Translation: CAA37189.1.
CH471056 Genomic DNA. Translation: EAX05065.1.
CH471056 Genomic DNA. Translation: EAX05066.1.
CH471056 Genomic DNA. Translation: EAX05067.1.
BC017864 mRNA. Translation: AAH17864.1.
M57234 Genomic DNA. No translation available.
M57232 Genomic DNA. Translation: AAA35923.1.
L31863 Genomic DNA. Translation: AAC41697.1.
CCDSiCCDS47138.1.
PIRiA34931.
RefSeqiNP_002093.2. NM_002102.3.
NP_941391.2. NM_198682.2.
UniGeneiHs.654368.
Hs.728753.

3D structure databases

ProteinModelPortaliP15421.
SMRiP15421. Positions 46-78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000351430.

Polymorphism and mutation databases

BioMutaiGYPE.

Protocols and materials databases

DNASUi2996.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358615; ENSP00000351430; ENSG00000197465.
ENST00000437468; ENSP00000400698; ENSG00000197465.
GeneIDi2996.
KEGGihsa:2996.
UCSCiuc003ijj.3. human.

Organism-specific databases

CTDi2996.
GeneCardsiGC04M144792.
HGNCiHGNC:4705. GYPE.
MIMi138590. gene.
neXtProtiNX_P15421.
PharmGKBiPA29083.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00610000087442.
HOGENOMiHOG000089933.
HOVERGENiHBG005850.
InParanoidiP15421.
OMAiSYCIRLI.
PhylomeDBiP15421.
TreeFamiTF341456.

Miscellaneous databases

GeneWikiiGYPE.
GenomeRNAii2996.
NextBioi11878.
PROiP15421.
SOURCEiSearch...

Gene expression databases

BgeeiP15421.
CleanExiHS_GYPE.
ExpressionAtlasiP15421. baseline and differential.
GenevisibleiP15421. HS.

Family and domain databases

InterProiIPR001195. Glycophorin.
[Graphical view]
PANTHERiPTHR13813. PTHR13813. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel human glycophorin, glycophorin E, by isolation of genomic clones and complementary DNA clones utilizing polymerase chain reaction."
    Kudo S., Fukuda M.
    J. Biol. Chem. 265:1102-1110(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-13.
  2. "A novel gene member of the human glycophorin A and B gene family. Molecular cloning and expression."
    Vignal A., Rahuel C., London J., Cherif-Zahar B., Schaff S., Hattab C., Okubo Y., Cartron J.-P.
    Eur. J. Biochem. 191:619-625(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-13.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "Promoter sequence and chromosomal organization of the genes encoding glycophorins A, B and E."
    Vignal A., London J., Rahuel C., Cartron J.-P.
    Gene 95:289-293(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-12.
  6. "Characterization of glycophorin A transcripts: control by the common erythroid-specific promoter and alternative usage of different polyadenylation signals."
    Kudo S., Onda M., Fukuda M.
    J. Biochem. 116:183-192(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-12.
    Tissue: Blood.

Entry informationi

Entry nameiGLPE_HUMAN
AccessioniPrimary (citable) accession number: P15421
Secondary accession number(s): D3DNZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: May 27, 2002
Last modified: June 24, 2015
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.