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P15421 (GLPE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycophorin-E
Gene names
Name:GYPE
Synonyms:GPE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length78 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein is a minor sialoglycoprotein in human erythrocyte membranes.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Erythrocytes.

Post-translational modification

The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues By similarity.

Sequence similarities

Belongs to the glycophorin-A family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   LigandSialic acid
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of plasma membrane

Traceable author statement PubMed 7622054. Source: ProtInc

plasma membrane

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919
Chain20 – 7859Glycophorin-E
PRO_0000012138

Regions

Topological domain20 – 5233Extracellular Potential
Transmembrane53 – 7321Helical; Potential
Topological domain74 – 785Cytoplasmic Potential

Natural variations

Natural variant131G → E. Ref.1 Ref.3
Corresponds to variant rs28721877 [ dbSNP | Ensembl ].
VAR_062006
Natural variant781R → P.
Corresponds to variant rs17018900 [ dbSNP | Ensembl ].
VAR_053111

Sequences

Sequence LengthMass (Da)Tools
P15421 [UniParc].

Last modified May 27, 2002. Version 2.
Checksum: F1F5B6EE5CFB3EB3

FASTA788,463
        10         20         30         40         50         60 
MYGKIIFVLL LSGIVSISAS STTGVAMHTS TSSSVTKSYI SSQTNGITLI NWWAMARVIF 

        70 
EVMLVVVGMI ILISYCIR 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel human glycophorin, glycophorin E, by isolation of genomic clones and complementary DNA clones utilizing polymerase chain reaction."
Kudo S., Fukuda M.
J. Biol. Chem. 265:1102-1110(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-13.
[2]"A novel gene member of the human glycophorin A and B gene family. Molecular cloning and expression."
Vignal A., Rahuel C., London J., Cherif-Zahar B., Schaff S., Hattab C., Okubo Y., Cartron J.-P.
Eur. J. Biochem. 191:619-625(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Blood.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-13.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"Promoter sequence and chromosomal organization of the genes encoding glycophorins A, B and E."
Vignal A., London J., Rahuel C., Cartron J.-P.
Gene 95:289-293(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-12.
[6]"Characterization of glycophorin A transcripts: control by the common erythroid-specific promoter and alternative usage of different polyadenylation signals."
Kudo S., Onda M., Fukuda M.
J. Biochem. 116:183-192(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-12.
Tissue: Blood.

Web resources

dbRBC/BGMUT

Blood group antigen gene mutation database

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M57233 Genomic DNA. Translation: AAA63179.1.
M29605, M29609, M29608 Genomic DNA. Translation: AAA52766.1.
M29610 mRNA. Translation: AAA52575.1.
X53010 Genomic DNA. Translation: CAA37191.1.
X53004, X53005, X53008 Genomic DNA. Translation: CAA37189.1.
CH471056 Genomic DNA. Translation: EAX05065.1.
CH471056 Genomic DNA. Translation: EAX05066.1.
CH471056 Genomic DNA. Translation: EAX05067.1.
BC017864 mRNA. Translation: AAH17864.1.
M57234 Genomic DNA. No translation available.
M57232 Genomic DNA. Translation: AAA35923.1.
L31863 Genomic DNA. Translation: AAC41697.1.
PIRA34931.
RefSeqNP_002093.2. NM_002102.3.
NP_941391.2. NM_198682.2.
UniGeneHs.654368.
Hs.728753.

3D structure databases

ProteinModelPortalP15421.
SMRP15421. Positions 46-78.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000351430.

Protocols and materials databases

DNASU2996.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000358615; ENSP00000351430; ENSG00000197465.
ENST00000437468; ENSP00000400698; ENSG00000197465.
GeneID2996.
KEGGhsa:2996.
UCSCuc003ijj.3. human.

Organism-specific databases

CTD2996.
GeneCardsGC04M144792.
HGNCHGNC:4705. GYPE.
MIM138590. gene.
neXtProtNX_P15421.
PharmGKBPA29083.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000089933.
HOVERGENHBG005850.
OMASYCIRLI.
TreeFamTF341456.

Gene expression databases

ArrayExpressP15421.
BgeeP15421.
CleanExHS_GYPE.
GenevestigatorP15421.

Family and domain databases

InterProIPR001195. Glycophorin.
[Graphical view]
PANTHERPTHR13813. PTHR13813. 1 hit.
ProtoNetSearch...

Other

GeneWikiGYPE.
GenomeRNAi2996.
NextBio11878.
PROP15421.
SOURCESearch...

Entry information

Entry nameGLPE_HUMAN
AccessionPrimary (citable) accession number: P15421
Secondary accession number(s): D3DNZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: May 27, 2002
Last modified: April 16, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM