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P15421

- GLPE_HUMAN

UniProt

P15421 - GLPE_HUMAN

Protein

Glycophorin-E

Gene

GYPE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    This protein is a minor sialoglycoprotein in human erythrocyte membranes.

    Keywords - Ligandi

    Sialic acid

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycophorin-E
    Gene namesi
    Name:GYPE
    Synonyms:GPE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:4705. GYPE.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29083.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Add
    BLAST
    Chaini20 – 7859Glycophorin-EPRO_0000012138Add
    BLAST

    Post-translational modificationi

    The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues.By similarity

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Erythrocytes.

    Gene expression databases

    ArrayExpressiP15421.
    BgeeiP15421.
    CleanExiHS_GYPE.
    GenevestigatoriP15421.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000351430.

    Structurei

    3D structure databases

    ProteinModelPortaliP15421.
    SMRiP15421. Positions 46-78.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 5233ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini74 – 785CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycophorin-A family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000089933.
    HOVERGENiHBG005850.
    PhylomeDBiP15421.
    TreeFamiTF341456.

    Family and domain databases

    InterProiIPR001195. Glycophorin.
    [Graphical view]
    PANTHERiPTHR13813. PTHR13813. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15421-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYGKIIFVLL LSGIVSISAS STTGVAMHTS TSSSVTKSYI SSQTNGITLI   50
    NWWAMARVIF EVMLVVVGMI ILISYCIR 78
    Length:78
    Mass (Da):8,463
    Last modified:May 27, 2002 - v2
    Checksum:iF1F5B6EE5CFB3EB3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti13 – 131G → E.2 Publications
    Corresponds to variant rs28721877 [ dbSNP | Ensembl ].
    VAR_062006
    Natural varianti78 – 781R → P.
    Corresponds to variant rs17018900 [ dbSNP | Ensembl ].
    VAR_053111

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57233 Genomic DNA. Translation: AAA63179.1.
    M29605, M29609, M29608 Genomic DNA. Translation: AAA52766.1.
    M29610 mRNA. Translation: AAA52575.1.
    X53010 Genomic DNA. Translation: CAA37191.1.
    X53004, X53005, X53008 Genomic DNA. Translation: CAA37189.1.
    CH471056 Genomic DNA. Translation: EAX05065.1.
    CH471056 Genomic DNA. Translation: EAX05066.1.
    CH471056 Genomic DNA. Translation: EAX05067.1.
    BC017864 mRNA. Translation: AAH17864.1.
    M57234 Genomic DNA. No translation available.
    M57232 Genomic DNA. Translation: AAA35923.1.
    L31863 Genomic DNA. Translation: AAC41697.1.
    CCDSiCCDS47138.1.
    PIRiA34931.
    RefSeqiNP_002093.2. NM_002102.3.
    NP_941391.2. NM_198682.2.
    UniGeneiHs.654368.
    Hs.728753.

    Genome annotation databases

    EnsembliENST00000358615; ENSP00000351430; ENSG00000197465.
    ENST00000437468; ENSP00000400698; ENSG00000197465.
    GeneIDi2996.
    KEGGihsa:2996.
    UCSCiuc003ijj.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    dbRBC/BGMUT

    Blood group antigen gene mutation database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57233 Genomic DNA. Translation: AAA63179.1 .
    M29605 , M29609 , M29608 Genomic DNA. Translation: AAA52766.1 .
    M29610 mRNA. Translation: AAA52575.1 .
    X53010 Genomic DNA. Translation: CAA37191.1 .
    X53004 , X53005 , X53008 Genomic DNA. Translation: CAA37189.1 .
    CH471056 Genomic DNA. Translation: EAX05065.1 .
    CH471056 Genomic DNA. Translation: EAX05066.1 .
    CH471056 Genomic DNA. Translation: EAX05067.1 .
    BC017864 mRNA. Translation: AAH17864.1 .
    M57234 Genomic DNA. No translation available.
    M57232 Genomic DNA. Translation: AAA35923.1 .
    L31863 Genomic DNA. Translation: AAC41697.1 .
    CCDSi CCDS47138.1.
    PIRi A34931.
    RefSeqi NP_002093.2. NM_002102.3.
    NP_941391.2. NM_198682.2.
    UniGenei Hs.654368.
    Hs.728753.

    3D structure databases

    ProteinModelPortali P15421.
    SMRi P15421. Positions 46-78.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000351430.

    Protocols and materials databases

    DNASUi 2996.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358615 ; ENSP00000351430 ; ENSG00000197465 .
    ENST00000437468 ; ENSP00000400698 ; ENSG00000197465 .
    GeneIDi 2996.
    KEGGi hsa:2996.
    UCSCi uc003ijj.3. human.

    Organism-specific databases

    CTDi 2996.
    GeneCardsi GC04M144792.
    HGNCi HGNC:4705. GYPE.
    MIMi 138590. gene.
    neXtProti NX_P15421.
    PharmGKBi PA29083.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000089933.
    HOVERGENi HBG005850.
    PhylomeDBi P15421.
    TreeFami TF341456.

    Miscellaneous databases

    GeneWikii GYPE.
    GenomeRNAii 2996.
    NextBioi 11878.
    PROi P15421.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P15421.
    Bgeei P15421.
    CleanExi HS_GYPE.
    Genevestigatori P15421.

    Family and domain databases

    InterProi IPR001195. Glycophorin.
    [Graphical view ]
    PANTHERi PTHR13813. PTHR13813. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel human glycophorin, glycophorin E, by isolation of genomic clones and complementary DNA clones utilizing polymerase chain reaction."
      Kudo S., Fukuda M.
      J. Biol. Chem. 265:1102-1110(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-13.
    2. "A novel gene member of the human glycophorin A and B gene family. Molecular cloning and expression."
      Vignal A., Rahuel C., London J., Cherif-Zahar B., Schaff S., Hattab C., Okubo Y., Cartron J.-P.
      Eur. J. Biochem. 191:619-625(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-13.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. "Promoter sequence and chromosomal organization of the genes encoding glycophorins A, B and E."
      Vignal A., London J., Rahuel C., Cartron J.-P.
      Gene 95:289-293(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-12.
    6. "Characterization of glycophorin A transcripts: control by the common erythroid-specific promoter and alternative usage of different polyadenylation signals."
      Kudo S., Onda M., Fukuda M.
      J. Biochem. 116:183-192(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-12.
      Tissue: Blood.

    Entry informationi

    Entry nameiGLPE_HUMAN
    AccessioniPrimary (citable) accession number: P15421
    Secondary accession number(s): D3DNZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: May 27, 2002
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3