P15421 (GLPE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycophorin-E

Gene names

Name:	GYPE
Synonyms:	GPE

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	78 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This protein is a minor sialoglycoprotein in human erythrocyte membranes.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Erythrocytes.
Post-translational modification	The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues By similarity.
Sequence similarities	Belongs to the glycophorin-A family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Ligand	Sialic acid
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to plasma membrane Traceable author statement PubMed 7622054. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19
	Chain	20 – 78	59	Glycophorin-E		PRO_0000012138
Regions
	Topological domain	20 – 52	33	Extracellular Potential
	Transmembrane	53 – 73	21	Helical; Potential
	Topological domain	74 – 78	5	Cytoplasmic Potential
Natural variations
	Natural variant	13	1	G → E. Ref.1 Ref.3 Corresponds to variant rs28721877 [ dbSNP | Ensembl ].		VAR_062006
	Natural variant	78	1	R → P. Corresponds to variant rs17018900 [ dbSNP | Ensembl ].		VAR_053111

Sequences

	Sequence		Length	Mass (Da)
	P15421 [UniParc]. Last modified May 27, 2002. Version 2. Checksum: F1F5B6EE5CFB3EB3	FASTA	78	8,463
	10 20 30 40 50 60 MYGKIIFVLL LSGIVSISAS STTGVAMHTS TSSSVTKSYI SSQTNGITLI NWWAMARVIF 70 EVMLVVVGMI ILISYCIR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel human glycophorin, glycophorin E, by isolation of genomic clones and complementary DNA clones utilizing polymerase chain reaction." Kudo S., Fukuda M. J. Biol. Chem. 265:1102-1110(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-13.
[2]	"A novel gene member of the human glycophorin A and B gene family. Molecular cloning and expression." Vignal A., Rahuel C., London J., Cherif-Zahar B., Schaff S., Hattab C., Okubo Y., Cartron J.-P. Eur. J. Biochem. 191:619-625(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-13.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	"Promoter sequence and chromosomal organization of the genes encoding glycophorins A, B and E." Vignal A., London J., Rahuel C., Cartron J.-P. Gene 95:289-293(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-12.
[6]	"Characterization of glycophorin A transcripts: control by the common erythroid-specific promoter and alternative usage of different polyadenylation signals." Kudo S., Onda M., Fukuda M. J. Biochem. 116:183-192(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-12. Tissue: Blood.

Web resources

dbRBC/BGMUT

Blood group antigen gene mutation database

Cross-references

Sequence databases
EMBL GenBank DDBJ	M57233 Genomic DNA. Translation: AAA63179.1. M29605, M29609, M29608 Genomic DNA. Translation: AAA52766.1. M29610 mRNA. Translation: AAA52575.1. X53010 Genomic DNA. Translation: CAA37191.1. X53004, X53005, X53008 Genomic DNA. Translation: CAA37189.1. CH471056 Genomic DNA. Translation: EAX05065.1. CH471056 Genomic DNA. Translation: EAX05066.1. CH471056 Genomic DNA. Translation: EAX05067.1. BC017864 mRNA. Translation: AAH17864.1. M57234 Genomic DNA. No translation available. M57232 Genomic DNA. Translation: AAA35923.1. L31863 Genomic DNA. Translation: AAC41697.1.
IPI	IPI00011617.
PIR	A34931.
RefSeq	NP_002093.2. NM_002102.3. NP_941391.2. NM_198682.2.
UniGene	Hs.654368. Hs.728753.
3D structure databases
ProteinModelPortal	P15421.
SMR	P15421. Positions 47-78.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000351430.
Polymorphism databases
DMDM	21264422.
Protocols and materials databases
DNASU	2996.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358615; ENSP00000351430; ENSG00000197465. ENST00000437468; ENSP00000400698; ENSG00000197465.
GeneID	2996.
KEGG	hsa:2996.
UCSC	uc003ijj.3. human.
Organism-specific databases
CTD	2996.
GeneCards	GC04M144792.
HGNC	HGNC:4705. GYPE.
MIM	138590. gene.
neXtProt	NX_P15421.
PharmGKB	PA29083.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000089933.
HOVERGEN	HBG005850.
OMA	CIRLIKA.
OrthoDB	EOG4G7C1P.
Gene expression databases
ArrayExpress	P15421.
Bgee	P15421.
CleanEx	HS_GYPE.
Genevestigator	P15421.
GermOnline	ENSG00000197465. Homo sapiens.
Family and domain databases
InterPro	IPR001195. Glycophorin. [Graphical view]
PANTHER	PTHR13813. PTHR13813. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	2996.
NextBio	11878.
SOURCE	Search...

Entry information

Entry name

GLPE_HUMAN

Accession

Primary (citable) accession number: P15421
Secondary accession number(s): D3DNZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	May 27, 2002
Last modified:	April 3, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.