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Protein

Glycophorin-E

Gene

GYPE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is a minor sialoglycoprotein in human erythrocyte membranes.

Keywordsi

LigandSialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Glycophorin-E
Gene namesi
Name:GYPE
Synonyms:GPE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000197465.13.
HGNCiHGNC:4705. GYPE.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 52ExtracellularSequence analysisAdd BLAST33
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 78CytoplasmicSequence analysis5

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2996.
OpenTargetsiENSG00000197465.
PharmGKBiPA29083.

Polymorphism and mutation databases

BioMutaiGYPE.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000001213820 – 78Glycophorin-EAdd BLAST59

Post-translational modificationi

The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP15421.
PeptideAtlasiP15421.
PRIDEiP15421.

Expressioni

Tissue specificityi

Erythrocytes.

Gene expression databases

BgeeiENSG00000197465.
CleanExiHS_GYPE.
ExpressionAtlasiP15421. baseline and differential.
GenevisibleiP15421. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351430.

Structurei

3D structure databases

ProteinModelPortaliP15421.
SMRiP15421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycophorin-A family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00900000142578.
HOGENOMiHOG000089933.
HOVERGENiHBG005850.
InParanoidiP15421.
OMAiSYCIRLI.
OrthoDBiEOG093719HS.
PhylomeDBiP15421.
TreeFamiTF341456.

Family and domain databases

InterProiView protein in InterPro
IPR001195. Glycophorin.
PANTHERiPTHR13813. PTHR13813. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGKIIFVLL LSGIVSISAS STTGVAMHTS TSSSVTKSYI SSQTNGITLI
60 70
NWWAMARVIF EVMLVVVGMI ILISYCIR
Length:78
Mass (Da):8,463
Last modified:May 27, 2002 - v2
Checksum:iF1F5B6EE5CFB3EB3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06200613G → E2 PublicationsCorresponds to variant dbSNP:rs28721877Ensembl.1
Natural variantiVAR_05311178R → P. Corresponds to variant dbSNP:rs17018900Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57233 Genomic DNA. Translation: AAA63179.1.
M29605, M29609, M29608 Genomic DNA. Translation: AAA52766.1.
M29610 mRNA. Translation: AAA52575.1.
X53010 Genomic DNA. Translation: CAA37191.1.
X53004, X53005, X53008 Genomic DNA. Translation: CAA37189.1.
CH471056 Genomic DNA. Translation: EAX05065.1.
CH471056 Genomic DNA. Translation: EAX05066.1.
CH471056 Genomic DNA. Translation: EAX05067.1.
BC017864 mRNA. Translation: AAH17864.1.
M57234 Genomic DNA. No translation available.
M57232 Genomic DNA. Translation: AAA35923.1.
L31863 Genomic DNA. Translation: AAC41697.1.
CCDSiCCDS47138.1.
PIRiA34931.
RefSeqiNP_002093.2. NM_002102.3.
NP_941391.2. NM_198682.2.
XP_016863628.1. XM_017008139.1.
XP_016863629.1. XM_017008140.1.
UniGeneiHs.654368.
Hs.728753.

Genome annotation databases

EnsembliENST00000358615; ENSP00000351430; ENSG00000197465.
ENST00000437468; ENSP00000400698; ENSG00000197465.
GeneIDi2996.
KEGGihsa:2996.
UCSCiuc003ijj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGLPE_HUMAN
AccessioniPrimary (citable) accession number: P15421
Secondary accession number(s): D3DNZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: May 27, 2002
Last modified: October 25, 2017
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families