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P15421

- GLPE_HUMAN

UniProt

P15421 - GLPE_HUMAN

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Protein
Glycophorin-E
Gene
GYPE, GPE
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This protein is a minor sialoglycoprotein in human erythrocyte membranes.

Keywords - Ligandi

Sialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Glycophorin-E
Gene namesi
Name:GYPE
Synonyms:GPE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:4705. GYPE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 5233Extracellular Reviewed prediction
Add
BLAST
Transmembranei53 – 7321Helical; Reviewed prediction
Add
BLAST
Topological domaini74 – 785Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919
Add
BLAST
Chaini20 – 7859Glycophorin-E
PRO_0000012138Add
BLAST

Post-translational modificationi

The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues By similarity.

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Erythrocytes.

Gene expression databases

ArrayExpressiP15421.
BgeeiP15421.
CleanExiHS_GYPE.
GenevestigatoriP15421.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351430.

Structurei

3D structure databases

ProteinModelPortaliP15421.
SMRiP15421. Positions 46-78.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycophorin-A family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000089933.
HOVERGENiHBG005850.
PhylomeDBiP15421.
TreeFamiTF341456.

Family and domain databases

InterProiIPR001195. Glycophorin.
[Graphical view]
PANTHERiPTHR13813. PTHR13813. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15421-1 [UniParc]FASTAAdd to Basket

« Hide

MYGKIIFVLL LSGIVSISAS STTGVAMHTS TSSSVTKSYI SSQTNGITLI   50
NWWAMARVIF EVMLVVVGMI ILISYCIR 78
Length:78
Mass (Da):8,463
Last modified:May 27, 2002 - v2
Checksum:iF1F5B6EE5CFB3EB3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131G → E.2 Publications
Corresponds to variant rs28721877 [ dbSNP | Ensembl ].
VAR_062006
Natural varianti78 – 781R → P.
Corresponds to variant rs17018900 [ dbSNP | Ensembl ].
VAR_053111

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57233 Genomic DNA. Translation: AAA63179.1.
M29605, M29609, M29608 Genomic DNA. Translation: AAA52766.1.
M29610 mRNA. Translation: AAA52575.1.
X53010 Genomic DNA. Translation: CAA37191.1.
X53004, X53005, X53008 Genomic DNA. Translation: CAA37189.1.
CH471056 Genomic DNA. Translation: EAX05065.1.
CH471056 Genomic DNA. Translation: EAX05066.1.
CH471056 Genomic DNA. Translation: EAX05067.1.
BC017864 mRNA. Translation: AAH17864.1.
M57234 Genomic DNA. No translation available.
M57232 Genomic DNA. Translation: AAA35923.1.
L31863 Genomic DNA. Translation: AAC41697.1.
CCDSiCCDS47138.1.
PIRiA34931.
RefSeqiNP_002093.2. NM_002102.3.
NP_941391.2. NM_198682.2.
UniGeneiHs.654368.
Hs.728753.

Genome annotation databases

EnsembliENST00000358615; ENSP00000351430; ENSG00000197465.
ENST00000437468; ENSP00000400698; ENSG00000197465.
GeneIDi2996.
KEGGihsa:2996.
UCSCiuc003ijj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57233 Genomic DNA. Translation: AAA63179.1 .
M29605 , M29609 , M29608 Genomic DNA. Translation: AAA52766.1 .
M29610 mRNA. Translation: AAA52575.1 .
X53010 Genomic DNA. Translation: CAA37191.1 .
X53004 , X53005 , X53008 Genomic DNA. Translation: CAA37189.1 .
CH471056 Genomic DNA. Translation: EAX05065.1 .
CH471056 Genomic DNA. Translation: EAX05066.1 .
CH471056 Genomic DNA. Translation: EAX05067.1 .
BC017864 mRNA. Translation: AAH17864.1 .
M57234 Genomic DNA. No translation available.
M57232 Genomic DNA. Translation: AAA35923.1 .
L31863 Genomic DNA. Translation: AAC41697.1 .
CCDSi CCDS47138.1.
PIRi A34931.
RefSeqi NP_002093.2. NM_002102.3.
NP_941391.2. NM_198682.2.
UniGenei Hs.654368.
Hs.728753.

3D structure databases

ProteinModelPortali P15421.
SMRi P15421. Positions 46-78.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000351430.

Protocols and materials databases

DNASUi 2996.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358615 ; ENSP00000351430 ; ENSG00000197465 .
ENST00000437468 ; ENSP00000400698 ; ENSG00000197465 .
GeneIDi 2996.
KEGGi hsa:2996.
UCSCi uc003ijj.3. human.

Organism-specific databases

CTDi 2996.
GeneCardsi GC04M144792.
HGNCi HGNC:4705. GYPE.
MIMi 138590. gene.
neXtProti NX_P15421.
PharmGKBi PA29083.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000089933.
HOVERGENi HBG005850.
PhylomeDBi P15421.
TreeFami TF341456.

Miscellaneous databases

GeneWikii GYPE.
GenomeRNAii 2996.
NextBioi 11878.
PROi P15421.
SOURCEi Search...

Gene expression databases

ArrayExpressi P15421.
Bgeei P15421.
CleanExi HS_GYPE.
Genevestigatori P15421.

Family and domain databases

InterProi IPR001195. Glycophorin.
[Graphical view ]
PANTHERi PTHR13813. PTHR13813. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel human glycophorin, glycophorin E, by isolation of genomic clones and complementary DNA clones utilizing polymerase chain reaction."
    Kudo S., Fukuda M.
    J. Biol. Chem. 265:1102-1110(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-13.
  2. "A novel gene member of the human glycophorin A and B gene family. Molecular cloning and expression."
    Vignal A., Rahuel C., London J., Cherif-Zahar B., Schaff S., Hattab C., Okubo Y., Cartron J.-P.
    Eur. J. Biochem. 191:619-625(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-13.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "Promoter sequence and chromosomal organization of the genes encoding glycophorins A, B and E."
    Vignal A., London J., Rahuel C., Cartron J.-P.
    Gene 95:289-293(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-12.
  6. "Characterization of glycophorin A transcripts: control by the common erythroid-specific promoter and alternative usage of different polyadenylation signals."
    Kudo S., Onda M., Fukuda M.
    J. Biochem. 116:183-192(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-12.
    Tissue: Blood.

Entry informationi

Entry nameiGLPE_HUMAN
AccessioniPrimary (citable) accession number: P15421
Secondary accession number(s): D3DNZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: May 27, 2002
Last modified: July 9, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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