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Protein

Fos-related antigen 2

Gene

FOSL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075426-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fos-related antigen 2
Short name:
FRA-2
Gene namesi
Name:FOSL2
Synonyms:FRA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:3798. FOSL2.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: HPA
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2355.
OpenTargetsiENSG00000075426.
PharmGKBiPA28215.

Polymorphism and mutation databases

BioMutaiFOSL2.
DMDMi120487.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764831 – 326Fos-related antigen 2Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei104N6-acetyllysineBy similarity1
Modified residuei120PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Cross-linki222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei230PhosphoserineCombined sources1
Modified residuei308PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP15408.
PaxDbiP15408.
PeptideAtlasiP15408.
PRIDEiP15408.

PTM databases

iPTMnetiP15408.
PhosphoSitePlusiP15408.

Expressioni

Gene expression databases

BgeeiENSG00000075426.
CleanExiHS_FOSL2.
ExpressionAtlasiP15408. baseline and differential.
GenevisibleiP15408. HS.

Organism-specific databases

HPAiCAB013460.
HPA004817.
HPA061417.

Interactioni

Subunit structurei

Heterodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ATF2P153364EBI-3893419,EBI-1170906
ATF7P175442EBI-3893419,EBI-765623
CREB5Q02930-311EBI-3893419,EBI-10192698
DDIT3P356385EBI-3893419,EBI-742651
DDIT3P35638-23EBI-3893419,EBI-10173632
DNAJA3Q96EY1-23EBI-3893419,EBI-3952284
FHL3Q136433EBI-3893419,EBI-741101
FLJ13057Q53SE73EBI-3893419,EBI-10172181
GOPCQ9HD263EBI-3893419,EBI-349832
JUNP054129EBI-3893419,EBI-852823
JUNBP172755EBI-3893419,EBI-748062
JUNDP175353EBI-3893419,EBI-2682803
LUZP4Q9P1273EBI-3893419,EBI-10198848
TRAF1Q130775EBI-3893419,EBI-359224

Protein-protein interaction databases

BioGridi108638. 59 interactors.
DIPiDIP-48788N.
IntActiP15408. 33 interactors.
STRINGi9606.ENSP00000264716.

Structurei

3D structure databases

ProteinModelPortaliP15408.
SMRiP15408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 187bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 128Basic motifPROSITE-ProRule annotation3
Regioni129 – 136Leucine-zipperPROSITE-ProRule annotation8

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP15408.
KOiK09030.
OMAiLVFTYPN.
OrthoDBiEOG091G0GGW.
PhylomeDBiP15408.
TreeFamiTF326301.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029814. Fra2.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF25. PTHR23351:SF25. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P15408-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYQDYPGNFD TSSRGSSGSP AHAESYSSGG GGQQKFRVDM PGSGSAFIPT
60 70 80 90 100
INAITTSQDL QWMVQPTVIT SMSNPYPRSH PYSPLPGLAS VPGHMALPRP
110 120 130 140 150
GVIKTIGTTV GRRRRDEQLS PEEEEKRRIR RERNKLAAAK CRNRRRELTE
160 170 180 190 200
KLQAETEELE EEKSGLQKEI AELQKEKEKL EFMLVAHGPV CKISPEERRS
210 220 230 240 250
PPAPGLQPMR SGGGSVGAVV VKQEPLEEDS PSSSSAGLDK AQRSVIKPIS
260 270 280 290 300
IAGGFYGEEP LHTPIVVTST PAVTPGTSNL VFTYPSVLEQ ESPASPSESC
310 320
SKAHRRSSSS GDQSSDSLNS PTLLAL
Length:326
Mass (Da):35,193
Last modified:April 1, 1990 - v1
Checksum:iF61738BE23C5026F
GO
Isoform 2 (identifier: P15408-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.
     26-34: YSSGGGGQQ → MVQGWRIKS
     154-154: A → AIGPWQVAVPHIPLFPWQ

Note: No experimental confirmation available.
Show »
Length:318
Mass (Da):34,795
Checksum:iC17D7E59D9DABCB4
GO
Isoform 3 (identifier: P15408-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Note: No experimental confirmation available.
Show »
Length:287
Mass (Da):31,095
Checksum:iF198987B0A81B778
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89A → V in BX647822 (PubMed:17974005).Curated1
Sequence conflicti111G → D in BAG51539 (PubMed:14702039).Curated1
Sequence conflicti298E → G in BAG37805 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0420831 – 39Missing in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_0391271 – 25Missing in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_03912826 – 34YSSGGGGQQ → MVQGWRIKS in isoform 2. 1 Publication9
Alternative sequenceiVSP_039129154A → AIGPWQVAVPHIPLFPWQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16706 mRNA. Translation: CAA34678.1.
AK055579 mRNA. Translation: BAG51539.1.
AK302622 mRNA. Translation: BAG63866.1.
AK315415 mRNA. Translation: BAG37805.1.
BX647822 mRNA. No translation available.
CR542262 mRNA. Translation: CAG47058.1.
AC104695 Genomic DNA. Translation: AAY14908.1.
CH471053 Genomic DNA. Translation: EAX00538.1.
CH471053 Genomic DNA. Translation: EAX00539.1.
BC022791 mRNA. Translation: AAH22791.1.
CCDSiCCDS1766.1. [P15408-1]
PIRiS15749.
RefSeqiNP_005244.1. NM_005253.3. [P15408-1]
XP_016859226.1. XM_017003737.1. [P15408-3]
UniGeneiHs.220971.
Hs.596972.

Genome annotation databases

EnsembliENST00000264716; ENSP00000264716; ENSG00000075426. [P15408-1]
ENST00000379619; ENSP00000368939; ENSG00000075426. [P15408-2]
GeneIDi2355.
KEGGihsa:2355.
UCSCiuc002rma.4. human. [P15408-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16706 mRNA. Translation: CAA34678.1.
AK055579 mRNA. Translation: BAG51539.1.
AK302622 mRNA. Translation: BAG63866.1.
AK315415 mRNA. Translation: BAG37805.1.
BX647822 mRNA. No translation available.
CR542262 mRNA. Translation: CAG47058.1.
AC104695 Genomic DNA. Translation: AAY14908.1.
CH471053 Genomic DNA. Translation: EAX00538.1.
CH471053 Genomic DNA. Translation: EAX00539.1.
BC022791 mRNA. Translation: AAH22791.1.
CCDSiCCDS1766.1. [P15408-1]
PIRiS15749.
RefSeqiNP_005244.1. NM_005253.3. [P15408-1]
XP_016859226.1. XM_017003737.1. [P15408-3]
UniGeneiHs.220971.
Hs.596972.

3D structure databases

ProteinModelPortaliP15408.
SMRiP15408.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108638. 59 interactors.
DIPiDIP-48788N.
IntActiP15408. 33 interactors.
STRINGi9606.ENSP00000264716.

PTM databases

iPTMnetiP15408.
PhosphoSitePlusiP15408.

Polymorphism and mutation databases

BioMutaiFOSL2.
DMDMi120487.

Proteomic databases

EPDiP15408.
PaxDbiP15408.
PeptideAtlasiP15408.
PRIDEiP15408.

Protocols and materials databases

DNASUi2355.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264716; ENSP00000264716; ENSG00000075426. [P15408-1]
ENST00000379619; ENSP00000368939; ENSG00000075426. [P15408-2]
GeneIDi2355.
KEGGihsa:2355.
UCSCiuc002rma.4. human. [P15408-1]

Organism-specific databases

CTDi2355.
DisGeNETi2355.
GeneCardsiFOSL2.
HGNCiHGNC:3798. FOSL2.
HPAiCAB013460.
HPA004817.
HPA061417.
MIMi601575. gene.
neXtProtiNX_P15408.
OpenTargetsiENSG00000075426.
PharmGKBiPA28215.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP15408.
KOiK09030.
OMAiLVFTYPN.
OrthoDBiEOG091G0GGW.
PhylomeDBiP15408.
TreeFamiTF326301.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075426-MONOMER.

Miscellaneous databases

ChiTaRSiFOSL2. human.
GeneWikiiFOSL2.
GenomeRNAii2355.
PROiP15408.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075426.
CleanExiHS_FOSL2.
ExpressionAtlasiP15408. baseline and differential.
GenevisibleiP15408. HS.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029814. Fra2.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF25. PTHR23351:SF25. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOSL2_HUMAN
AccessioniPrimary (citable) accession number: P15408
Secondary accession number(s): B2RD58
, B3KP27, B4DYV4, Q6FG46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.