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P15408

- FOSL2_HUMAN

UniProt

P15408 - FOSL2_HUMAN

Protein

Fos-related antigen 2

Gene

FOSL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.By similarity

    GO - Molecular functioni

    1. double-stranded DNA binding Source: Ensembl
    2. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. cell death Source: ProtInc
    2. cellular response to hormone stimulus Source: Ensembl
    3. female pregnancy Source: Ensembl
    4. positive regulation of fibroblast proliferation Source: Ensembl
    5. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    6. response to cAMP Source: Ensembl
    7. response to corticosterone Source: Ensembl
    8. response to drug Source: Ensembl
    9. response to mechanical stimulus Source: Ensembl
    10. response to morphine Source: Ensembl
    11. response to progesterone Source: Ensembl
    12. transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fos-related antigen 2
    Short name:
    FRA-2
    Gene namesi
    Name:FOSL2
    Synonyms:FRA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:3798. FOSL2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28215.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Fos-related antigen 2PRO_0000076483Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei104 – 1041N6-acetyllysineBy similarity
    Modified residuei120 – 1201Phosphoserine1 Publication
    Modified residuei200 – 2001Phosphoserine3 Publications
    Modified residuei211 – 2111Phosphoserine2 Publications
    Modified residuei230 – 2301Phosphoserine2 Publications
    Modified residuei320 – 3201Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP15408.
    PaxDbiP15408.
    PRIDEiP15408.

    PTM databases

    PhosphoSiteiP15408.

    Expressioni

    Gene expression databases

    ArrayExpressiP15408.
    BgeeiP15408.
    CleanExiHS_FOSL2.
    GenevestigatoriP15408.

    Organism-specific databases

    HPAiCAB013460.
    HPA004817.

    Interactioni

    Subunit structurei

    Heterodimer.By similarity

    Protein-protein interaction databases

    BioGridi108638. 7 interactions.
    DIPiDIP-48788N.
    IntActiP15408. 1 interaction.
    STRINGi9606.ENSP00000264716.

    Structurei

    3D structure databases

    ProteinModelPortaliP15408.
    SMRiP15408. Positions 125-187.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini124 – 18764bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni126 – 1283Basic motifPROSITE-ProRule annotation
    Regioni129 – 1368Leucine-zipperPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the bZIP family. Fos subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG301361.
    HOGENOMiHOG000234334.
    HOVERGENiHBG005743.
    InParanoidiP15408.
    KOiK09030.
    OMAiIKPICLG.
    OrthoDBiEOG761BVN.
    PhylomeDBiP15408.
    TreeFamiTF326301.

    Family and domain databases

    InterProiIPR004827. bZIP.
    IPR000837. Leuzip_Fos.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    [Graphical view]
    PRINTSiPR00042. LEUZIPPRFOS.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P15408-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYQDYPGNFD TSSRGSSGSP AHAESYSSGG GGQQKFRVDM PGSGSAFIPT    50
    INAITTSQDL QWMVQPTVIT SMSNPYPRSH PYSPLPGLAS VPGHMALPRP 100
    GVIKTIGTTV GRRRRDEQLS PEEEEKRRIR RERNKLAAAK CRNRRRELTE 150
    KLQAETEELE EEKSGLQKEI AELQKEKEKL EFMLVAHGPV CKISPEERRS 200
    PPAPGLQPMR SGGGSVGAVV VKQEPLEEDS PSSSSAGLDK AQRSVIKPIS 250
    IAGGFYGEEP LHTPIVVTST PAVTPGTSNL VFTYPSVLEQ ESPASPSESC 300
    SKAHRRSSSS GDQSSDSLNS PTLLAL 326
    Length:326
    Mass (Da):35,193
    Last modified:April 1, 1990 - v1
    Checksum:iF61738BE23C5026F
    GO
    Isoform 2 (identifier: P15408-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-25: Missing.
         26-34: YSSGGGGQQ → MVQGWRIKS
         154-154: A → AIGPWQVAVPHIPLFPWQ

    Note: No experimental confirmation available.

    Show »
    Length:318
    Mass (Da):34,795
    Checksum:iC17D7E59D9DABCB4
    GO
    Isoform 3 (identifier: P15408-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-39: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:287
    Mass (Da):31,095
    Checksum:iF198987B0A81B778
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti89 – 891A → V in BX647822. (PubMed:17974005)Curated
    Sequence conflicti111 – 1111G → D in BAG51539. (PubMed:14702039)Curated
    Sequence conflicti298 – 2981E → G in BAG37805. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3939Missing in isoform 3. 1 PublicationVSP_042083Add
    BLAST
    Alternative sequencei1 – 2525Missing in isoform 2. 1 PublicationVSP_039127Add
    BLAST
    Alternative sequencei26 – 349YSSGGGGQQ → MVQGWRIKS in isoform 2. 1 PublicationVSP_039128
    Alternative sequencei154 – 1541A → AIGPWQVAVPHIPLFPWQ in isoform 2. 1 PublicationVSP_039129

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16706 mRNA. Translation: CAA34678.1.
    AK055579 mRNA. Translation: BAG51539.1.
    AK302622 mRNA. Translation: BAG63866.1.
    AK315415 mRNA. Translation: BAG37805.1.
    BX647822 mRNA. No translation available.
    CR542262 mRNA. Translation: CAG47058.1.
    AC104695 Genomic DNA. Translation: AAY14908.1.
    CH471053 Genomic DNA. Translation: EAX00538.1.
    CH471053 Genomic DNA. Translation: EAX00539.1.
    BC022791 mRNA. Translation: AAH22791.1.
    CCDSiCCDS1766.1. [P15408-1]
    PIRiS15749.
    RefSeqiNP_005244.1. NM_005253.3. [P15408-1]
    UniGeneiHs.220971.
    Hs.596972.

    Genome annotation databases

    EnsembliENST00000264716; ENSP00000264716; ENSG00000075426. [P15408-1]
    ENST00000379619; ENSP00000368939; ENSG00000075426. [P15408-2]
    GeneIDi2355.
    KEGGihsa:2355.
    UCSCiuc002rma.3. human. [P15408-1]
    uc021vfg.1. human. [P15408-2]

    Polymorphism databases

    DMDMi120487.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16706 mRNA. Translation: CAA34678.1 .
    AK055579 mRNA. Translation: BAG51539.1 .
    AK302622 mRNA. Translation: BAG63866.1 .
    AK315415 mRNA. Translation: BAG37805.1 .
    BX647822 mRNA. No translation available.
    CR542262 mRNA. Translation: CAG47058.1 .
    AC104695 Genomic DNA. Translation: AAY14908.1 .
    CH471053 Genomic DNA. Translation: EAX00538.1 .
    CH471053 Genomic DNA. Translation: EAX00539.1 .
    BC022791 mRNA. Translation: AAH22791.1 .
    CCDSi CCDS1766.1. [P15408-1 ]
    PIRi S15749.
    RefSeqi NP_005244.1. NM_005253.3. [P15408-1 ]
    UniGenei Hs.220971.
    Hs.596972.

    3D structure databases

    ProteinModelPortali P15408.
    SMRi P15408. Positions 125-187.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108638. 7 interactions.
    DIPi DIP-48788N.
    IntActi P15408. 1 interaction.
    STRINGi 9606.ENSP00000264716.

    PTM databases

    PhosphoSitei P15408.

    Polymorphism databases

    DMDMi 120487.

    Proteomic databases

    MaxQBi P15408.
    PaxDbi P15408.
    PRIDEi P15408.

    Protocols and materials databases

    DNASUi 2355.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264716 ; ENSP00000264716 ; ENSG00000075426 . [P15408-1 ]
    ENST00000379619 ; ENSP00000368939 ; ENSG00000075426 . [P15408-2 ]
    GeneIDi 2355.
    KEGGi hsa:2355.
    UCSCi uc002rma.3. human. [P15408-1 ]
    uc021vfg.1. human. [P15408-2 ]

    Organism-specific databases

    CTDi 2355.
    GeneCardsi GC02P028615.
    HGNCi HGNC:3798. FOSL2.
    HPAi CAB013460.
    HPA004817.
    MIMi 601575. gene.
    neXtProti NX_P15408.
    PharmGKBi PA28215.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG301361.
    HOGENOMi HOG000234334.
    HOVERGENi HBG005743.
    InParanoidi P15408.
    KOi K09030.
    OMAi IKPICLG.
    OrthoDBi EOG761BVN.
    PhylomeDBi P15408.
    TreeFami TF326301.

    Miscellaneous databases

    ChiTaRSi FOSL2. human.
    GeneWikii FOSL2.
    GenomeRNAii 2355.
    NextBioi 9551.
    PROi P15408.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P15408.
    Bgeei P15408.
    CleanExi HS_FOSL2.
    Genevestigatori P15408.

    Family and domain databases

    InterProi IPR004827. bZIP.
    IPR000837. Leuzip_Fos.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00042. LEUZIPPRFOS.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation."
      Matsui M., Tokuhara M., Konuma Y., Nomura N., Ishizaki R.
      Oncogene 5:249-255(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Endothelial cell.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Lung and Tongue.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Retina.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211 AND SER-230, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120; SER-200; SER-211; SER-230 AND SER-320, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFOSL2_HUMAN
    AccessioniPrimary (citable) accession number: P15408
    Secondary accession number(s): B2RD58
    , B3KP27, B4DYV4, Q6FG46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3