P15408 (FOSL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fos-related antigen 2
Short name=FRA-2

Gene names

Name:	FOSL2
Synonyms:	FRA2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Controls osteoclast survival and size By similarity. As a dimer with JUN, activates LIF transcription By similarity. Activates CEBPB transcription in PGE2-activated osteoblasts By similarity.
Subunit structure	Heterodimer By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell death Traceable author statement PubMed 8954781. Source: ProtInc positive regulation of fibroblast proliferation Inferred from electronic annotation. Source: Compara regulation of transcription from RNA polymerase II promoter Traceable author statement PubMed 8954781. Source: ProtInc transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay. Source: HPA
Molecular_function	RNA polymerase II regulatory region sequence-specific DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Traceable author statement PubMed 8954781. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P15408-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P15408-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.
     26-34: YSSGGGGQQ → MVQGWRIKS
     154-154: A → AIGPWQVAVPHIPLFPWQ

Note: No experimental confirmation available.

Isoform 3 (identifier: P15408-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Fos-related antigen 2		PRO_0000076483
Regions
	Domain	124 – 187	64	bZIP
	Region	126 – 128	3	Basic motif By similarity
	Region	129 – 136	8	Leucine-zipper By similarity
Amino acid modifications
	Modified residue	120	1	Phosphoserine Ref.10
	Modified residue	200	1	Phosphoserine Ref.8 Ref.10 Ref.11
	Modified residue	211	1	Phosphoserine Ref.9 Ref.10
	Modified residue	230	1	Phosphoserine Ref.9 Ref.10
	Modified residue	320	1	Phosphoserine Ref.10
Natural variations
	Alternative sequence	1 – 39	39	Missing in isoform 3.		VSP_042083
	Alternative sequence	1 – 25	25	Missing in isoform 2.		VSP_039127
	Alternative sequence	26 – 34	9	YSSGGGGQQ → MVQGWRIKS in isoform 2.		VSP_039128
	Alternative sequence	154	1	A → AIGPWQVAVPHIPLFPWQ in isoform 2.		VSP_039129
Experimental info
	Sequence conflict	89	1	A → V in BX647822. Ref.3
	Sequence conflict	111	1	G → D in BAG51539. Ref.2
	Sequence conflict	298	1	E → G in BAG37805. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: F61738BE23C5026F	FASTA	326	35,193
	10 20 30 40 50 60 MYQDYPGNFD TSSRGSSGSP AHAESYSSGG GGQQKFRVDM PGSGSAFIPT INAITTSQDL 70 80 90 100 110 120 QWMVQPTVIT SMSNPYPRSH PYSPLPGLAS VPGHMALPRP GVIKTIGTTV GRRRRDEQLS 130 140 150 160 170 180 PEEEEKRRIR RERNKLAAAK CRNRRRELTE KLQAETEELE EEKSGLQKEI AELQKEKEKL 190 200 210 220 230 240 EFMLVAHGPV CKISPEERRS PPAPGLQPMR SGGGSVGAVV VKQEPLEEDS PSSSSAGLDK 250 260 270 280 290 300 AQRSVIKPIS IAGGFYGEEP LHTPIVVTST PAVTPGTSNL VFTYPSVLEQ ESPASPSESC 310 320 SKAHRRSSSS GDQSSDSLNS PTLLAL
	Isoform 2 [UniParc]. Checksum: C17D7E59D9DABCB4	FASTA	318	34,795
	10 20 30 40 50 60 MVQGWRIKSK FRVDMPGSGS AFIPTINAIT TSQDLQWMVQ PTVITSMSNP YPRSHPYSPL 70 80 90 100 110 120 PGLASVPGHM ALPRPGVIKT IGTTVGRRRR DEQLSPEEEE KRRIRRERNK LAAAKCRNRR 130 140 150 160 170 180 RELTEKLQAI GPWQVAVPHI PLFPWQETEE LEEEKSGLQK EIAELQKEKE KLEFMLVAHG 190 200 210 220 230 240 PVCKISPEER RSPPAPGLQP MRSGGGSVGA VVVKQEPLEE DSPSSSSAGL DKAQRSVIKP 250 260 270 280 290 300 ISIAGGFYGE EPLHTPIVVT STPAVTPGTS NLVFTYPSVL EQESPASPSE SCSKAHRRSS 310 SSGDQSSDSL NSPTLLAL
	Isoform 3 [UniParc]. Checksum: F198987B0A81B778	FASTA	287	31,095
	10 20 30 40 50 60 MPGSGSAFIP TINAITTSQD LQWMVQPTVI TSMSNPYPRS HPYSPLPGLA SVPGHMALPR 70 80 90 100 110 120 PGVIKTIGTT VGRRRRDEQL SPEEEEKRRI RRERNKLAAA KCRNRRRELT EKLQAETEEL 130 140 150 160 170 180 EEEKSGLQKE IAELQKEKEK LEFMLVAHGP VCKISPEERR SPPAPGLQPM RSGGGSVGAV 190 200 210 220 230 240 VVKQEPLEED SPSSSSAGLD KAQRSVIKPI SIAGGFYGEE PLHTPIVVTS TPAVTPGTSN 250 260 270 280 LVFTYPSVLE QESPASPSES CSKAHRRSSS SGDQSSDSLN SPTLLAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation." Matsui M., Tokuhara M., Konuma Y., Nomura N., Ishizaki R. Oncogene 5:249-255(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Endothelial cell.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Lung and Tongue.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Retina.
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211 AND SER-230, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120; SER-200; SER-211; SER-230 AND SER-320, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X16706 mRNA. Translation: CAA34678.1. AK055579 mRNA. Translation: BAG51539.1. AK302622 mRNA. Translation: BAG63866.1. AK315415 mRNA. Translation: BAG37805.1. BX647822 mRNA. No translation available. CR542262 mRNA. Translation: CAG47058.1. AC104695 Genomic DNA. Translation: AAY14908.1. CH471053 Genomic DNA. Translation: EAX00538.1. CH471053 Genomic DNA. Translation: EAX00539.1. BC022791 mRNA. Translation: AAH22791.1.
IPI	IPI00011593. IPI00657842.
PIR	S15749.
RefSeq	NP_005244.1. NM_005253.3.
UniGene	Hs.220971. Hs.596972.
3D structure databases
ProteinModelPortal	P15408.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-48788N.
IntAct	P15408. 1 interaction.
STRING	9606.ENSP00000264716.
PTM databases
PhosphoSite	P15408.
Polymorphism databases
DMDM	120487.
Proteomic databases
PaxDb	P15408.
PRIDE	P15408.
Protocols and materials databases
DNASU	2355.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264716; ENSP00000264716; ENSG00000075426. ENST00000379619; ENSP00000368939; ENSG00000075426. ENST00000545753; ENSP00000439303; ENSG00000075426.
GeneID	2355.
KEGG	hsa:2355.
UCSC	uc002rma.3. human. uc021vfg.1. human.
Organism-specific databases
CTD	2355.
GeneCards	GC02P028615.
HGNC	HGNC:3798. FOSL2.
HPA	CAB013460. HPA004817.
MIM	601575. gene.
neXtProt	NX_P15408.
PharmGKB	PA28215.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG301361.
HOGENOM	HOG000234334.
HOVERGEN	HBG005743.
InParanoid	P15408.
KO	K09030.
OMA	FMLVAHN.
PhylomeDB	P15408.
Gene expression databases
ArrayExpress	P15408.
Bgee	P15408.
CleanEx	HS_FOSL2.
Genevestigator	P15408.
GermOnline	ENSG00000075426. Homo sapiens.
Family and domain databases
InterPro	IPR004827. bZIP. IPR000837. Leuzip_Fos. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FOSL2. human.
GenomeRNAi	2355.
NextBio	9551.
SOURCE	Search...

Entry information

Entry name

FOSL2_HUMAN

Accession

Primary (citable) accession number: P15408
Secondary accession number(s): B2RD58 , B3KP27, B4DYV4, Q6FG46

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	May 1, 2013
This is version 124 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.