Reviewed, UniProtKB/Swiss-Prot P15408 (FOSL2_HUMAN)

Names and origin

Protein names

Recommended name:
    Fos-related antigen 2

Gene names

Name:	FOSL2
Synonyms:	FRA2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Heterodimer By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	DNA-binding
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	cell death Traceable author statement. Source: ProtInc regulation of transcription from RNA polymerase II promoter Traceable author statement. Source: ProtInc
Cellular component	nucleus Traceable author statement. Source: ProtInc
Molecular function	protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Fos-related antigen 2		PRO_0000076483
Regions
	Domain	152 – 180	29	Leucine-zipper
	DNA binding	130 – 148	19	Basic motif
Amino acid modifications
	Modified residue	83	1	Phosphoserine Ref.4
	Modified residue	120	1	Phosphoserine Ref.4
	Modified residue	200	1	Phosphoserine Ref.4 Ref.3 Ref.5 Ref.6
	Modified residue	211	1	Phosphoserine Ref.6
	Modified residue	215	1	Phosphoserine Ref.6
	Modified residue	230	1	Phosphoserine Ref.4 Ref.3 Ref.6
	Modified residue	308	1	Phosphoserine Ref.4
	Modified residue	320	1	Phosphoserine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P15408-1 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: F61738BE23C5026F	FASTA	326	35,193
	10 20 30 40 50 60 MYQDYPGNFD TSSRGSSGSP AHAESYSSGG GGQQKFRVDM PGSGSAFIPT INAITTSQDL 70 80 90 100 110 120 QWMVQPTVIT SMSNPYPRSH PYSPLPGLAS VPGHMALPRP GVIKTIGTTV GRRRRDEQLS 130 140 150 160 170 180 PEEEEKRRIR RERNKLAAAK CRNRRRELTE KLQAETEELE EEKSGLQKEI AELQKEKEKL 190 200 210 220 230 240 EFMLVAHGPV CKISPEERRS PPAPGLQPMR SGGGSVGAVV VKQEPLEEDS PSSSSAGLDK 250 260 270 280 290 300 AQRSVIKPIS IAGGFYGEEP LHTPIVVTST PAVTPGTSNL VFTYPSVLEQ ESPASPSESC 310 320 SKAHRRSSSS GDQSSDSLNS PTLLAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation." Matsui M., Tokuhara M., Konuma Y., Nomura N., Ishizaki R. Oncogene 5:249-255(1990) [PubMed: 2107490] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Endothelial cell.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200 AND SER-230, MASS SPECTROMETRY. Tissue: Epithelium.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-120; SER-200; SER-230; SER-308 AND SER-320, MASS SPECTROMETRY. Tissue: Epithelium.
[5]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, MASS SPECTROMETRY.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200; SER-211; SER-215 AND SER-230, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X16706 mRNA. Translation: CAA34678.1. BC022791 mRNA. Translation: AAH22791.1.
IPI	IPI00011593.
PIR	S15749.
RefSeq	NP_005244.1.
UniGene	Hs.220971 Hs.596972
3D structure databases
HSSP	HSSP built from PDB template 1FOS based on UniProtKB P01100.
SMR	P15408. Positions 126-184.
ModBase	Search...
PTM databases
PhosphoSite	P15408.
Proteomic databases
PRIDE	P15408.
Genome annotation databases
Ensembl	ENSG00000075426. Homo sapiens. [Contig view]
GeneID	2355.
KEGG	hsa:2355.
Organism-specific databases
GeneCards	GC02P028527.
H-InvDB	HIX0001936.
HGNC	HGNC:3798. FOSL2.
HPA	CAB013460. HPA004817.
MIM	601575. gene.
PharmGKB	PA28215.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P15408.
HOVERGEN	P15408.
OMA	P15408. ITPGTSN.
Gene expression databases
ArrayExpress	P15408.
Bgee	P15408.
CleanEx	HS_FOSL2.
GermOnline	ENSG00000075426. Homo sapiens.
Family and domain databases
InterPro	IPR011616. bZIP_1. IPR000837. Leuzip_Fos. IPR004827. TF_bZIP. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	9551.
SOURCE	Search...

Entry information

Entry name

FOSL2_HUMAN

Accession

Primary (citable) accession number: P15408

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	June 16, 2009
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)