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Reviewed, UniProtKB/Swiss-Prot P15408 (FOSL2_HUMAN)

Last modified June 16, 2009. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Fos-related antigen 2
Gene names
Name: FOSL2
Synonyms: FRA2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Subunit structure

Heterodimer By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the bZIP family. Fos subfamily.

Contains 1 bZIP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Fos-related antigen 2
PRO_0000076483

Regions

Domain152 – 18029Leucine-zipper
DNA binding130 – 14819Basic motif

Amino acid modifications

Modified residue831Phosphoserine Ref.4
Modified residue1201Phosphoserine Ref.4
Modified residue2001Phosphoserine Ref.4 Ref.3 Ref.5 Ref.6
Modified residue2111Phosphoserine Ref.6
Modified residue2151Phosphoserine Ref.6
Modified residue2301Phosphoserine Ref.4 Ref.3 Ref.6
Modified residue3081Phosphoserine Ref.4
Modified residue3201Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
P15408-1 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: F61738BE23C5026F

FASTA32635,193
        10         20         30         40         50         60 
MYQDYPGNFD TSSRGSSGSP AHAESYSSGG GGQQKFRVDM PGSGSAFIPT INAITTSQDL 

        70         80         90        100        110        120 
QWMVQPTVIT SMSNPYPRSH PYSPLPGLAS VPGHMALPRP GVIKTIGTTV GRRRRDEQLS 

       130        140        150        160        170        180 
PEEEEKRRIR RERNKLAAAK CRNRRRELTE KLQAETEELE EEKSGLQKEI AELQKEKEKL 

       190        200        210        220        230        240 
EFMLVAHGPV CKISPEERRS PPAPGLQPMR SGGGSVGAVV VKQEPLEEDS PSSSSAGLDK 

       250        260        270        280        290        300 
AQRSVIKPIS IAGGFYGEEP LHTPIVVTST PAVTPGTSNL VFTYPSVLEQ ESPASPSESC 

       310        320 
SKAHRRSSSS GDQSSDSLNS PTLLAL 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation."
Matsui M., Tokuhara M., Konuma Y., Nomura N., Ishizaki R.
Oncogene 5:249-255(1990) [PubMed: 2107490] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Endothelial cell.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[3]"Large-scale characterization of HeLa cell nuclear phosphoproteins."
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200 AND SER-230, MASS SPECTROMETRY.
Tissue: Epithelium.
[4]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-120; SER-200; SER-230; SER-308 AND SER-320, MASS SPECTROMETRY.
Tissue: Epithelium.
[5]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, MASS SPECTROMETRY.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200; SER-211; SER-215 AND SER-230, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

X16706 mRNA. Translation: CAA34678.1.
BC022791 mRNA. Translation: AAH22791.1.
IPIIPI00011593.
PIRS15749.
RefSeqNP_005244.1.
UniGeneHs.220971
Hs.596972

3D structure databases

HSSPHSSP built from PDB template 1FOS based on UniProtKB P01100.
SMRP15408. Positions 126-184.
ModBaseSearch...

PTM databases

PhosphoSiteP15408.

Proteomic databases

PRIDEP15408.

Genome annotation databases

EnsemblENSG00000075426. Homo sapiens. [Contig view]
GeneID2355.
KEGGhsa:2355.

Organism-specific databases

GeneCardsGC02P028527.
H-InvDBHIX0001936.
HGNCHGNC:3798. FOSL2.
HPACAB013460.
HPA004817.
MIM601575. gene.
PharmGKBPA28215.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP15408.
HOVERGENP15408.
OMAP15408. ITPGTSN.

Gene expression databases

ArrayExpressP15408.
BgeeP15408.
CleanExHS_FOSL2.
GermOnlineENSG00000075426. Homo sapiens.

Family and domain databases

InterProIPR011616. bZIP_1.
IPR000837. Leuzip_Fos.
IPR004827. TF_bZIP.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSPR00042. LEUZIPPRFOS.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio9551.
SOURCESearch...

Entry information

Entry nameFOSL2_HUMAN
AccessionPrimary (citable) accession number: P15408
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 16, 2009
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents