ID FOSL1_HUMAN Reviewed; 271 AA. AC P15407; B4DR11; Q6FG51; DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1990, sequence version 1. DT 24-JAN-2024, entry version 201. DE RecName: Full=Fos-related antigen 1; DE Short=FRA-1; GN Name=FOSL1; Synonyms=FRA1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Endothelial cell; RX PubMed=2107490; RA Matsui M., Tokuhara M., Konuma Y., Nomura N., Ishizaki R.; RT "Isolation of human fos-related genes and their expression during monocyte- RT macrophage differentiation."; RL Oncogene 5:249-255(1990). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Blood; RA Albagha O.M.E., Ralston S.H.; RT "Intron/exon structure of the human fos related antigen, identification of RT a novel pseudogene."; RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5. RX PubMed=8230424; DOI=10.1128/jvi.67.12.7001-7007.1993; RA Tsuchiya H., Fujii M., Niki T., Tokuhara M., Matsui M., Seiki M.; RT "Human T-cell leukemia virus type 1 Tax activates transcription of the RT human fra-1 gene through multiple cis elements responsive to transmembrane RT signals."; RL J. Virol. 67:7001-7007(1993). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-265, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). CC -!- SUBUNIT: Heterodimer (By similarity). Interacts with the BAF CC multiprotein chromatin-remodeling complex subunits SMARCB1 and SMARCD1 CC (By similarity). Interacts with ARID1A and JUN (By similarity). CC {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P48755}. CC -!- INTERACTION: CC P15407; P18848: ATF4; NbExp=2; IntAct=EBI-744510, EBI-492498; CC P15407; Q9NR55: BATF3; NbExp=3; IntAct=EBI-744510, EBI-10312707; CC P15407; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-744510, EBI-744556; CC P15407; P28329-3: CHAT; NbExp=3; IntAct=EBI-744510, EBI-25837549; CC P15407; Q02930-3: CREB5; NbExp=6; IntAct=EBI-744510, EBI-10192698; CC P15407; P22607: FGFR3; NbExp=3; IntAct=EBI-744510, EBI-348399; CC P15407; Q0VDC6: FKBP1A; NbExp=3; IntAct=EBI-744510, EBI-10226858; CC P15407; Q96CN9: GCC1; NbExp=3; IntAct=EBI-744510, EBI-746252; CC P15407; Q14957: GRIN2C; NbExp=3; IntAct=EBI-744510, EBI-8285963; CC P15407; P06396: GSN; NbExp=3; IntAct=EBI-744510, EBI-351506; CC P15407; P01112: HRAS; NbExp=3; IntAct=EBI-744510, EBI-350145; CC P15407; P54652: HSPA2; NbExp=3; IntAct=EBI-744510, EBI-356991; CC P15407; P05412: JUN; NbExp=10; IntAct=EBI-744510, EBI-852823; CC P15407; P17275: JUNB; NbExp=9; IntAct=EBI-744510, EBI-748062; CC P15407; O60333-2: KIF1B; NbExp=3; IntAct=EBI-744510, EBI-10975473; CC P15407; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-744510, EBI-14069005; CC P15407; O95751: LDOC1; NbExp=3; IntAct=EBI-744510, EBI-740738; CC P15407; Q9Y5B8: NME7; NbExp=9; IntAct=EBI-744510, EBI-744782; CC P15407; Q13526: PIN1; NbExp=3; IntAct=EBI-744510, EBI-714158; CC P15407; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-744510, EBI-396669; CC P15407; Q9NYJ8: TAB2; NbExp=4; IntAct=EBI-744510, EBI-358708; CC P15407; P22415: USF1; NbExp=6; IntAct=EBI-744510, EBI-1054489; CC P15407; O76024: WFS1; NbExp=3; IntAct=EBI-744510, EBI-720609; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P51145}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=P15407-1; Sequence=Displayed; CC Name=2; CC IsoId=P15407-2; Sequence=VSP_055566; CC -!- SIMILARITY: Belongs to the bZIP family. Fos subfamily. {ECO:0000305}. CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and CC Haematology; CC URL="https://atlasgeneticsoncology.org/gene/40622/FOSL1"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X16707; CAA34679.1; -; mRNA. DR EMBL; AJ297411; CAC50237.1; -; Genomic_DNA. DR EMBL; AJ297412; CAC50237.1; JOINED; Genomic_DNA. DR EMBL; AJ297413; CAC50237.1; JOINED; Genomic_DNA. DR EMBL; AK299050; BAG61123.1; -; mRNA. DR EMBL; CR542257; CAG47053.1; -; mRNA. DR EMBL; CR542278; CAG47074.1; -; mRNA. DR EMBL; AP006287; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471076; EAW74469.1; -; Genomic_DNA. DR EMBL; BC016648; AAH16648.1; -; mRNA. DR CCDS; CCDS76436.1; -. [P15407-2] DR CCDS; CCDS8121.1; -. [P15407-1] DR PIR; S15750; S15750. DR RefSeq; NP_001287773.1; NM_001300844.1. DR RefSeq; NP_001287784.1; NM_001300855.1. DR RefSeq; NP_001287785.1; NM_001300856.1. DR RefSeq; NP_001287786.1; NM_001300857.1. [P15407-2] DR RefSeq; NP_005429.1; NM_005438.4. [P15407-1] DR AlphaFoldDB; P15407; -. DR SMR; P15407; -. DR BioGRID; 113742; 68. DR ComplexPortal; CPX-6417; bZIP transcription factor complex, ATF2-FOSL1. DR ComplexPortal; CPX-6478; bZIP transcription factor complex, ATF3-FOSL1. DR ComplexPortal; CPX-6565; bZIP transcription factor complex, ATF4-FOSL1. DR DIP; DIP-660N; -. DR IntAct; P15407; 40. DR MINT; P15407; -. DR STRING; 9606.ENSP00000310170; -. DR GlyGen; P15407; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; P15407; -. DR PhosphoSitePlus; P15407; -. DR BioMuta; FOSL1; -. DR EPD; P15407; -. DR jPOST; P15407; -. DR MassIVE; P15407; -. DR MaxQB; P15407; -. DR PaxDb; 9606-ENSP00000310170; -. DR PeptideAtlas; P15407; -. DR ProteomicsDB; 4915; -. DR ProteomicsDB; 53136; -. [P15407-1] DR Pumba; P15407; -. DR Antibodypedia; 3828; 472 antibodies from 40 providers. DR DNASU; 8061; -. DR Ensembl; ENST00000312562.7; ENSP00000310170.2; ENSG00000175592.9. [P15407-1] DR Ensembl; ENST00000448083.6; ENSP00000393302.2; ENSG00000175592.9. [P15407-2] DR GeneID; 8061; -. DR KEGG; hsa:8061; -. DR MANE-Select; ENST00000312562.7; ENSP00000310170.2; NM_005438.5; NP_005429.1. DR UCSC; uc001ogg.2; human. [P15407-1] DR AGR; HGNC:13718; -. DR CTD; 8061; -. DR DisGeNET; 8061; -. DR GeneCards; FOSL1; -. DR HGNC; HGNC:13718; FOSL1. DR HPA; ENSG00000175592; Tissue enhanced (adipose tissue, urinary bladder). DR MIM; 136515; gene. DR neXtProt; NX_P15407; -. DR OpenTargets; ENSG00000175592; -. DR PharmGKB; PA28214; -. DR VEuPathDB; HostDB:ENSG00000175592; -. DR eggNOG; KOG1414; Eukaryota. DR GeneTree; ENSGT00940000160034; -. DR HOGENOM; CLU_131869_0_0_1; -. DR InParanoid; P15407; -. DR OMA; LEPADSC; -. DR OrthoDB; 4135378at2759; -. DR PhylomeDB; P15407; -. DR TreeFam; TF326301; -. DR PathwayCommons; P15407; -. DR Reactome; R-HSA-9031628; NGF-stimulated transcription. DR SignaLink; P15407; -. DR SIGNOR; P15407; -. DR BioGRID-ORCS; 8061; 189 hits in 1203 CRISPR screens. DR ChiTaRS; FOSL1; human. DR GeneWiki; FOSL1; -. DR GenomeRNAi; 8061; -. DR Pharos; P15407; Tbio. DR PRO; PR:P15407; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; P15407; Protein. DR Bgee; ENSG00000175592; Expressed in cartilage tissue and 122 other cell types or tissues. DR ExpressionAtlas; P15407; baseline and differential. DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0042734; C:presynaptic membrane; IEA:Ensembl. DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IPI:ComplexPortal. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl. DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:ProtInc. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB. DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:BHF-UCL. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL. DR GO; GO:0006968; P:cellular defense response; TAS:ProtInc. DR GO; GO:0031668; P:cellular response to extracellular stimulus; IEA:Ensembl. DR GO; GO:0006935; P:chemotaxis; TAS:ProtInc. DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0007565; P:female pregnancy; IEA:Ensembl. DR GO; GO:0010467; P:gene expression; IEA:Ensembl. DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl. DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl. DR GO; GO:0140467; P:integrated stress response signaling; NAS:ComplexPortal. DR GO; GO:0007612; P:learning; IEA:Ensembl. DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl. DR GO; GO:0060674; P:placenta blood vessel development; IEA:Ensembl. DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl. DR GO; GO:0045787; P:positive regulation of cell cycle; IEA:Ensembl. DR GO; GO:0008284; P:positive regulation of cell population proliferation; TAS:ProtInc. DR GO; GO:2000144; P:positive regulation of DNA-templated transcription initiation; IDA:CACAO. DR GO; GO:1902895; P:positive regulation of miRNA transcription; IDA:BHF-UCL. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0051591; P:response to cAMP; IEA:Ensembl. DR GO; GO:0051412; P:response to corticosterone; IEA:Ensembl. DR GO; GO:0009629; P:response to gravity; IEA:Ensembl. DR GO; GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl. DR GO; GO:0009612; P:response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0032570; P:response to progesterone; IEA:Ensembl. DR GO; GO:0009615; P:response to virus; TAS:ProtInc. DR GO; GO:0009611; P:response to wounding; IEA:Ensembl. DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl. DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:Ensembl. DR GO; GO:0007296; P:vitellogenesis; IEA:Ensembl. DR CDD; cd14721; bZIP_Fos; 1. DR Gene3D; 1.20.5.170; -; 1. DR InterPro; IPR000837; AP-1. DR InterPro; IPR004827; bZIP. DR InterPro; IPR046347; bZIP_sf. DR PANTHER; PTHR23351; FOS TRANSCRIPTION FACTOR-RELATED; 1. DR PANTHER; PTHR23351:SF6; FOS-RELATED ANTIGEN 1; 1. DR Pfam; PF00170; bZIP_1; 1. DR PRINTS; PR00042; LEUZIPPRFOS. DR SMART; SM00338; BRLZ; 1. DR SUPFAM; SSF57959; Leucine zipper domain; 1. DR PROSITE; PS50217; BZIP; 1. DR PROSITE; PS00036; BZIP_BASIC; 1. DR Genevisible; P15407; HS. PE 1: Evidence at protein level; KW Alternative splicing; DNA-binding; Nucleus; Phosphoprotein; KW Reference proteome. FT CHAIN 1..271 FT /note="Fos-related antigen 1" FT /id="PRO_0000076479" FT DOMAIN 105..168 FT /note="bZIP" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978" FT REGION 1..34 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 68..112 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 107..127 FT /note="Basic motif" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978" FT REGION 133..161 FT /note="Leucine-zipper" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978" FT REGION 173..202 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 237..271 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 68..85 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 97..112 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 237..262 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 265 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:20068231" FT VAR_SEQ 34..135 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_055566" SQ SEQUENCE 271 AA; 29413 MW; 1B6492D709E66570 CRC64; MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL QWMVQPHFLG PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI SPEEEERRRV RRERNKLAAA KCRNRRKELT DFLQAETDKL EDEKSGLQRE IEELQKQKER LELVLEAHRP ICKIPEGAKE GDTGSTSGTS SPPAPCRPVP CISLSPGPVL EPEALHTPTL MTTPSLTPFT PSLVFTYPST PEPCASAHRK SSSSSGDPSS DPLGSPTLLA L //