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Protein

Fos-related antigen 1

Gene

FOSL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. cellular defense response Source: ProtInc
  2. cellular response to extracellular stimulus Source: Ensembl
  3. chemotaxis Source: ProtInc
  4. female pregnancy Source: Ensembl
  5. in utero embryonic development Source: Ensembl
  6. learning Source: Ensembl
  7. negative regulation of cell proliferation Source: Ensembl
  8. placenta blood vessel development Source: Ensembl
  9. positive regulation of apoptotic process Source: Ensembl
  10. positive regulation of cell cycle Source: Ensembl
  11. positive regulation of cell proliferation Source: ProtInc
  12. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  13. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  14. response to cAMP Source: Ensembl
  15. response to corticosterone Source: Ensembl
  16. response to cytokine Source: Ensembl
  17. response to drug Source: Ensembl
  18. response to gravity Source: Ensembl
  19. response to hydrogen peroxide Source: Ensembl
  20. response to mechanical stimulus Source: Ensembl
  21. response to progesterone Source: Ensembl
  22. response to virus Source: ProtInc
  23. transcription from RNA polymerase II promoter Source: ProtInc
  24. vitellogenesis Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fos-related antigen 1
Short name:
FRA-1
Gene namesi
Name:FOSL1
Synonyms:FRA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:13718. FOSL1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. neuron projection Source: Ensembl
  3. nucleoplasm Source: HPA
  4. nucleus Source: HPA
  5. presynaptic membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28214.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Fos-related antigen 1PRO_0000076479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP15407.
PaxDbiP15407.
PRIDEiP15407.

PTM databases

PhosphoSiteiP15407.

Expressioni

Gene expression databases

BgeeiP15407.
CleanExiHS_FOSL1.
ExpressionAtlasiP15407. baseline and differential.
GenevestigatoriP15407.

Organism-specific databases

HPAiCAB004396.
HPA030728.

Interactioni

Subunit structurei

Heterodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
LDOC1O957513EBI-744510,EBI-740738

Protein-protein interaction databases

BioGridi113742. 28 interactions.
DIPiDIP-660N.
IntActiP15407. 12 interactions.
MINTiMINT-1445608.
STRINGi9606.ENSP00000310170.

Structurei

3D structure databases

ProteinModelPortaliP15407.
SMRiP15407. Positions 108-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 16864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni107 – 12721Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni133 – 16129Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi103 – 1064Poly-Glu
Compositional biasi251 – 2555Poly-Ser

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG252534.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP15407.
KOiK04502.
OMAiPCEQISP.
PhylomeDBiP15407.
TreeFamiTF326301.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029815. Fra1.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF6. PTHR23351:SF6. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P15407-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL
60 70 80 90 100
QWMVQPHFLG PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI
110 120 130 140 150
SPEEEERRRV RRERNKLAAA KCRNRRKELT DFLQAETDKL EDEKSGLQRE
160 170 180 190 200
IEELQKQKER LELVLEAHRP ICKIPEGAKE GDTGSTSGTS SPPAPCRPVP
210 220 230 240 250
CISLSPGPVL EPEALHTPTL MTTPSLTPFT PSLVFTYPST PEPCASAHRK
260 270
SSSSSGDPSS DPLGSPTLLA L
Length:271
Mass (Da):29,413
Last modified:April 1, 1990 - v1
Checksum:i1B6492D709E66570
GO
Isoform 2 (identifier: P15407-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-135: Missing.

Note: No experimental confirmation available.

Show »
Length:169
Mass (Da):17,560
Checksum:i71375CD7300A1169
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei34 – 135102Missing in isoform 2. 1 PublicationVSP_055566Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16707 mRNA. Translation: CAA34679.1.
AJ297411, AJ297412, AJ297413 Genomic DNA. Translation: CAC50237.1.
AK299050 mRNA. Translation: BAG61123.1.
CR542257 mRNA. Translation: CAG47053.1.
CR542278 mRNA. Translation: CAG47074.1.
AP006287 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74469.1.
BC016648 mRNA. Translation: AAH16648.1.
CCDSiCCDS8121.1. [P15407-1]
PIRiS15750.
RefSeqiNP_001287773.1. NM_001300844.1.
NP_001287784.1. NM_001300855.1.
NP_001287785.1. NM_001300856.1.
NP_001287786.1. NM_001300857.1. [P15407-2]
NP_005429.1. NM_005438.4. [P15407-1]
UniGeneiHs.283565.

Genome annotation databases

EnsembliENST00000312562; ENSP00000310170; ENSG00000175592. [P15407-1]
ENST00000448083; ENSP00000393302; ENSG00000175592. [P15407-2]
GeneIDi8061.
KEGGihsa:8061.
UCSCiuc001ogg.1. human. [P15407-1]
uc010ros.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16707 mRNA. Translation: CAA34679.1.
AJ297411, AJ297412, AJ297413 Genomic DNA. Translation: CAC50237.1.
AK299050 mRNA. Translation: BAG61123.1.
CR542257 mRNA. Translation: CAG47053.1.
CR542278 mRNA. Translation: CAG47074.1.
AP006287 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74469.1.
BC016648 mRNA. Translation: AAH16648.1.
CCDSiCCDS8121.1. [P15407-1]
PIRiS15750.
RefSeqiNP_001287773.1. NM_001300844.1.
NP_001287784.1. NM_001300855.1.
NP_001287785.1. NM_001300856.1.
NP_001287786.1. NM_001300857.1. [P15407-2]
NP_005429.1. NM_005438.4. [P15407-1]
UniGeneiHs.283565.

3D structure databases

ProteinModelPortaliP15407.
SMRiP15407. Positions 108-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113742. 28 interactions.
DIPiDIP-660N.
IntActiP15407. 12 interactions.
MINTiMINT-1445608.
STRINGi9606.ENSP00000310170.

PTM databases

PhosphoSiteiP15407.

Proteomic databases

MaxQBiP15407.
PaxDbiP15407.
PRIDEiP15407.

Protocols and materials databases

DNASUi8061.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312562; ENSP00000310170; ENSG00000175592. [P15407-1]
ENST00000448083; ENSP00000393302; ENSG00000175592. [P15407-2]
GeneIDi8061.
KEGGihsa:8061.
UCSCiuc001ogg.1. human. [P15407-1]
uc010ros.1. human.

Organism-specific databases

CTDi8061.
GeneCardsiGC11M065659.
HGNCiHGNC:13718. FOSL1.
HPAiCAB004396.
HPA030728.
MIMi136515. gene.
neXtProtiNX_P15407.
PharmGKBiPA28214.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG252534.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP15407.
KOiK04502.
OMAiPCEQISP.
PhylomeDBiP15407.
TreeFamiTF326301.

Miscellaneous databases

ChiTaRSiFOSL1. human.
GeneWikiiFOSL1.
GenomeRNAii8061.
NextBioi30651.
PROiP15407.
SOURCEiSearch...

Gene expression databases

BgeeiP15407.
CleanExiHS_FOSL1.
ExpressionAtlasiP15407. baseline and differential.
GenevestigatoriP15407.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029815. Fra1.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF6. PTHR23351:SF6. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation."
    Matsui M., Tokuhara M., Konuma Y., Nomura N., Ishizaki R.
    Oncogene 5:249-255(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Endothelial cell.
  2. "Intron/exon structure of the human fos related antigen, identification of a novel pseudogene."
    Albagha O.M.E., Ralston S.H.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  8. "Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals."
    Tsuchiya H., Fujii M., Niki T., Tokuhara M., Matsui M., Seiki M.
    J. Virol. 67:7001-7007(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-265, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiFOSL1_HUMAN
AccessioniPrimary (citable) accession number: P15407
Secondary accession number(s): B4DR11, Q6FG51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: March 4, 2015
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.