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P15407 (FOSL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fos-related antigen 1

Short name=FRA-1
Gene names
Name:FOSL1
Synonyms:FRA1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Heterodimer By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the bZIP family. Fos subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandDNA-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular defense response

Traceable author statement PubMed 10918580. Source: ProtInc

cellular response to extracellular stimulus

Inferred from electronic annotation. Source: Ensembl

chemotaxis

Traceable author statement PubMed 10918580. Source: ProtInc

female pregnancy

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

learning

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

placenta blood vessel development

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell cycle

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Traceable author statement Ref.6. Source: ProtInc

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

regulation of transcription from RNA polymerase II promoter

Traceable author statement PubMed 10918580. Source: ProtInc

response to cAMP

Inferred from electronic annotation. Source: Ensembl

response to corticosterone

Inferred from electronic annotation. Source: Ensembl

response to cytokine

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to gravity

Inferred from electronic annotation. Source: Ensembl

response to hydrogen peroxide

Inferred from electronic annotation. Source: Ensembl

response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

response to progesterone

Inferred from electronic annotation. Source: Ensembl

response to virus

Traceable author statement Ref.6. Source: ProtInc

transcription from RNA polymerase II promoter

Traceable author statement Ref.1. Source: ProtInc

vitellogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytosol

Inferred from electronic annotation. Source: Ensembl

neuron projection

Inferred from electronic annotation. Source: Ensembl

nucleus

Traceable author statement PubMed 10918580. Source: ProtInc

presynaptic membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionRNA polymerase II regulatory region sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Traceable author statement PubMed 10918580. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

LDOC1O957513EBI-744510,EBI-740738

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Fos-related antigen 1
PRO_0000076479

Regions

Domain105 – 16864bZIP
Region107 – 12721Basic motif By similarity
Region133 – 16129Leucine-zipper By similarity
Compositional bias103 – 1064Poly-Glu
Compositional bias251 – 2555Poly-Ser

Amino acid modifications

Modified residue2651Phosphoserine Ref.7

Sequences

Sequence LengthMass (Da)Tools
P15407 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 1B6492D709E66570

FASTA27129,413
        10         20         30         40         50         60 
MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL QWMVQPHFLG 

        70         80         90        100        110        120 
PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI SPEEEERRRV RRERNKLAAA 

       130        140        150        160        170        180 
KCRNRRKELT DFLQAETDKL EDEKSGLQRE IEELQKQKER LELVLEAHRP ICKIPEGAKE 

       190        200        210        220        230        240 
GDTGSTSGTS SPPAPCRPVP CISLSPGPVL EPEALHTPTL MTTPSLTPFT PSLVFTYPST 

       250        260        270 
PEPCASAHRK SSSSSGDPSS DPLGSPTLLA L 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation."
Matsui M., Tokuhara M., Konuma Y., Nomura N., Ishizaki R.
Oncogene 5:249-255(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Endothelial cell.
[2]"Intron/exon structure of the human fos related antigen, identification of a novel pseudogene."
Albagha O.M.E., Ralston S.H.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Blood.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[6]"Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals."
Tsuchiya H., Fujii M., Niki T., Tokuhara M., Matsui M., Seiki M.
J. Virol. 67:7001-7007(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5.
[7]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-265, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X16707 mRNA. Translation: CAA34679.1.
AJ297411, AJ297412, AJ297413 Genomic DNA. Translation: CAC50237.1.
CR542257 mRNA. Translation: CAG47053.1.
CR542278 mRNA. Translation: CAG47074.1.
CH471076 Genomic DNA. Translation: EAW74469.1.
BC016648 mRNA. Translation: AAH16648.1.
PIRS15750.
RefSeqNP_005429.1. NM_005438.3.
UniGeneHs.283565.

3D structure databases

ProteinModelPortalP15407.
SMRP15407. Positions 108-160.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113742. 26 interactions.
DIPDIP-660N.
IntActP15407. 12 interactions.
MINTMINT-1445608.
STRING9606.ENSP00000310170.

PTM databases

PhosphoSiteP15407.

Proteomic databases

PaxDbP15407.
PRIDEP15407.

Protocols and materials databases

DNASU8061.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312562; ENSP00000310170; ENSG00000175592.
GeneID8061.
KEGGhsa:8061.
UCSCuc001ogg.1. human.

Organism-specific databases

CTD8061.
GeneCardsGC11M065659.
HGNCHGNC:13718. FOSL1.
HPACAB004396.
MIM136515. gene.
neXtProtNX_P15407.
PharmGKBPA28214.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG252534.
HOGENOMHOG000234334.
HOVERGENHBG005743.
InParanoidP15407.
KOK04502.
OMACASAHRK.
PhylomeDBP15407.
TreeFamTF326301.

Gene expression databases

ArrayExpressP15407.
BgeeP15407.
CleanExHS_FOSL1.
GenevestigatorP15407.

Family and domain databases

InterProIPR004827. bZIP.
IPR000837. Leuzip_Fos.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSPR00042. LEUZIPPRFOS.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFOSL1. human.
GeneWikiFOSL1.
GenomeRNAi8061.
NextBio30651.
PROP15407.
SOURCESearch...

Entry information

Entry nameFOSL1_HUMAN
AccessionPrimary (citable) accession number: P15407
Secondary accession number(s): Q6FG51
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 16, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM