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Reviewed, UniProtKB/Swiss-Prot P15407 (FOSL1_HUMAN)

Last modified January 19, 2010. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Fos-related antigen 1
      Short name=FRA-1
Gene names
Name: FOSL1
Synonyms: FRA1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Subunit structure

Heterodimer By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the bZIP family. Fos subfamily.

Contains 1 bZIP domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

LDOC1O957512EBI-744510,EBI-740738

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Fos-related antigen 1
PRO_0000076479

Regions

Domain133 – 16129Leucine-zipper
DNA binding111 – 12919Basic motif
Compositional bias103 – 1064Poly-Glu
Compositional bias251 – 2555Poly-Ser

Sequences

Sequence LengthMass (Da)Tools
P15407-1 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 1B6492D709E66570

FASTA27129,413
        10         20         30         40         50         60 
MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL QWMVQPHFLG 

        70         80         90        100        110        120 
PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI SPEEEERRRV RRERNKLAAA 

       130        140        150        160        170        180 
KCRNRRKELT DFLQAETDKL EDEKSGLQRE IEELQKQKER LELVLEAHRP ICKIPEGAKE 

       190        200        210        220        230        240 
GDTGSTSGTS SPPAPCRPVP CISLSPGPVL EPEALHTPTL MTTPSLTPFT PSLVFTYPST 

       250        260        270 
PEPCASAHRK SSSSSGDPSS DPLGSPTLLA L 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation."
Matsui M., Tokuhara M., Konuma Y., Nomura N., Ishizaki R.
Oncogene 5:249-255(1990) [PubMed: 2107490] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Endothelial cell.
[2]"Intron/exon structure of the human fos related antigen, identification of a novel pseudogene."
Albagha O.M.E., Ralston S.H.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Blood.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[6]"Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals."
Tsuchiya H., Fujii M., Niki T., Tokuhara M., Matsui M., Seiki M.
J. Virol. 67:7001-7007(1993) [PubMed: 8230424] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X16707 mRNA. Translation: CAA34679.1.
AJ297411, AJ297412, AJ297413 Genomic DNA. Translation: CAC50237.1.
CR542257 mRNA. Translation: CAG47053.1.
CR542278 mRNA. Translation: CAG47074.1.
CH471076 Genomic DNA. Translation: EAW74469.1.
BC016648 mRNA. Translation: AAH16648.1.
IPIIPI00011590.
PIRS15750.
RefSeqNP_005429.1.
UniGeneHs.283565

3D structure databases

SMRP15407. Positions 107-165.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-660N.
IntActP15407. 3 interactions.
STRINGP15407.

PTM databases

PhosphoSiteP15407.

Proteomic databases

PRIDEP15407.

Genome annotation databases

EnsemblENST00000312562; ENSP00000310170; ENSG00000175592; Homo sapiens. [Genome view]
GeneID8061.
KEGGhsa:8061.
UCSCuc001ogg.1. human.

Organism-specific databases

CTD8061.
GeneCardsGC11M065416.
H-InvDBHIX0009813.
HGNCHGNC:13718. FOSL1.
HPACAB004396.
MIM136515. gene.
PharmGKBPA28214.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG14109.
HOGENOMHBG714812.
HOVERGENP15407.
InParanoidP15407.
OMACASAHRK.
OrthoDBEOG91RSDG.
PhylomeDBP15407.

Enzyme and pathway databases

Pathway_Interaction_DBnfat_tfpathway. Calcineurin-regulated NFAT-dependent transcription in lymphocytes.
tcrcalciumpathway. Calcium signaling in the CD4+ TCR pathway.
cd8tcrdownstreampathway. Downstream signaling in naive CD8+ T cells.

Gene expression databases

ArrayExpressP15407.
BgeeP15407.
CleanExHS_FOSL1.
GenevestigatorP15407.
GermOnlineENSG00000175592. Homo sapiens.

Family and domain databases

InterProIPR011616. bZIP_1.
IPR000837. Leuzip_Fos.
IPR004827. TF_bZIP.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSPR00042. LEUZIPPRFOS.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio30651.
SOURCESearch...

Entry information

Entry nameFOSL1_HUMAN
AccessionPrimary (citable) accession number: P15407
Secondary accession number(s): Q6FG51
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: January 19, 2010
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents