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Protein

Fos-related antigen 1

Gene

FOSL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175592-MONOMER.
SIGNORiP15407.

Names & Taxonomyi

Protein namesi
Recommended name:
Fos-related antigen 1
Short name:
FRA-1
Gene namesi
Name:FOSL1
Synonyms:FRA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:13718. FOSL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8061.
OpenTargetsiENSG00000175592.
PharmGKBiPA28214.

Polymorphism and mutation databases

BioMutaiFOSL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764791 – 271Fos-related antigen 1Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei265PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP15407.
MaxQBiP15407.
PaxDbiP15407.
PeptideAtlasiP15407.
PRIDEiP15407.

PTM databases

iPTMnetiP15407.
PhosphoSitePlusiP15407.

Expressioni

Gene expression databases

BgeeiENSG00000175592.
CleanExiHS_FOSL1.
ExpressionAtlasiP15407. baseline and differential.
GenevisibleiP15407. HS.

Organism-specific databases

HPAiCAB004396.
HPA030728.

Interactioni

Subunit structurei

Heterodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB5Q02930-35EBI-744510,EBI-10192698
JUNP054127EBI-744510,EBI-852823
JUNBP172754EBI-744510,EBI-748062
LDOC1O957513EBI-744510,EBI-740738
NME7Q9Y5B86EBI-744510,EBI-744782
USF1P224153EBI-744510,EBI-1054489

Protein-protein interaction databases

BioGridi113742. 28 interactors.
DIPiDIP-660N.
IntActiP15407. 15 interactors.
MINTiMINT-1445608.
STRINGi9606.ENSP00000310170.

Structurei

3D structure databases

ProteinModelPortaliP15407.
SMRiP15407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 168bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 127Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni133 – 161Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi103 – 106Poly-Glu4
Compositional biasi251 – 255Poly-Ser5

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP15407.
KOiK04502.
OMAiPCEQISP.
OrthoDBiEOG091G0GGW.
PhylomeDBiP15407.
TreeFamiTF326301.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P15407-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL
60 70 80 90 100
QWMVQPHFLG PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI
110 120 130 140 150
SPEEEERRRV RRERNKLAAA KCRNRRKELT DFLQAETDKL EDEKSGLQRE
160 170 180 190 200
IEELQKQKER LELVLEAHRP ICKIPEGAKE GDTGSTSGTS SPPAPCRPVP
210 220 230 240 250
CISLSPGPVL EPEALHTPTL MTTPSLTPFT PSLVFTYPST PEPCASAHRK
260 270
SSSSSGDPSS DPLGSPTLLA L
Length:271
Mass (Da):29,413
Last modified:April 1, 1990 - v1
Checksum:i1B6492D709E66570
GO
Isoform 2 (identifier: P15407-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-135: Missing.

Note: No experimental confirmation available.
Show »
Length:169
Mass (Da):17,560
Checksum:i71375CD7300A1169
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05556634 – 135Missing in isoform 2. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16707 mRNA. Translation: CAA34679.1.
AJ297411, AJ297412, AJ297413 Genomic DNA. Translation: CAC50237.1.
AK299050 mRNA. Translation: BAG61123.1.
CR542257 mRNA. Translation: CAG47053.1.
CR542278 mRNA. Translation: CAG47074.1.
AP006287 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74469.1.
BC016648 mRNA. Translation: AAH16648.1.
CCDSiCCDS76436.1. [P15407-2]
CCDS8121.1. [P15407-1]
PIRiS15750.
RefSeqiNP_001287773.1. NM_001300844.1.
NP_001287784.1. NM_001300855.1.
NP_001287785.1. NM_001300856.1.
NP_001287786.1. NM_001300857.1. [P15407-2]
NP_005429.1. NM_005438.4. [P15407-1]
UniGeneiHs.283565.

Genome annotation databases

EnsembliENST00000312562; ENSP00000310170; ENSG00000175592. [P15407-1]
ENST00000448083; ENSP00000393302; ENSG00000175592. [P15407-2]
GeneIDi8061.
KEGGihsa:8061.
UCSCiuc001ogg.2. human. [P15407-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16707 mRNA. Translation: CAA34679.1.
AJ297411, AJ297412, AJ297413 Genomic DNA. Translation: CAC50237.1.
AK299050 mRNA. Translation: BAG61123.1.
CR542257 mRNA. Translation: CAG47053.1.
CR542278 mRNA. Translation: CAG47074.1.
AP006287 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74469.1.
BC016648 mRNA. Translation: AAH16648.1.
CCDSiCCDS76436.1. [P15407-2]
CCDS8121.1. [P15407-1]
PIRiS15750.
RefSeqiNP_001287773.1. NM_001300844.1.
NP_001287784.1. NM_001300855.1.
NP_001287785.1. NM_001300856.1.
NP_001287786.1. NM_001300857.1. [P15407-2]
NP_005429.1. NM_005438.4. [P15407-1]
UniGeneiHs.283565.

3D structure databases

ProteinModelPortaliP15407.
SMRiP15407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113742. 28 interactors.
DIPiDIP-660N.
IntActiP15407. 15 interactors.
MINTiMINT-1445608.
STRINGi9606.ENSP00000310170.

PTM databases

iPTMnetiP15407.
PhosphoSitePlusiP15407.

Polymorphism and mutation databases

BioMutaiFOSL1.

Proteomic databases

EPDiP15407.
MaxQBiP15407.
PaxDbiP15407.
PeptideAtlasiP15407.
PRIDEiP15407.

Protocols and materials databases

DNASUi8061.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312562; ENSP00000310170; ENSG00000175592. [P15407-1]
ENST00000448083; ENSP00000393302; ENSG00000175592. [P15407-2]
GeneIDi8061.
KEGGihsa:8061.
UCSCiuc001ogg.2. human. [P15407-1]

Organism-specific databases

CTDi8061.
DisGeNETi8061.
GeneCardsiFOSL1.
HGNCiHGNC:13718. FOSL1.
HPAiCAB004396.
HPA030728.
MIMi136515. gene.
neXtProtiNX_P15407.
OpenTargetsiENSG00000175592.
PharmGKBiPA28214.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP15407.
KOiK04502.
OMAiPCEQISP.
OrthoDBiEOG091G0GGW.
PhylomeDBiP15407.
TreeFamiTF326301.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175592-MONOMER.
SIGNORiP15407.

Miscellaneous databases

ChiTaRSiFOSL1. human.
GeneWikiiFOSL1.
GenomeRNAii8061.
PROiP15407.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175592.
CleanExiHS_FOSL1.
ExpressionAtlasiP15407. baseline and differential.
GenevisibleiP15407. HS.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOSL1_HUMAN
AccessioniPrimary (citable) accession number: P15407
Secondary accession number(s): B4DR11, Q6FG51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.