P15407 (FOSL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fos-related antigen 1
Short name=FRA-1

Gene names

Name:	FOSL1
Synonyms:	FRA1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Heterodimer By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular defense response Traceable author statement PubMed 10918580. Source: ProtInc cellular response to extracellular stimulus Inferred from electronic annotation. Source: Compara chemotaxis Traceable author statement PubMed 10918580. Source: ProtInc female pregnancy Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara learning Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara placenta blood vessel development Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of cell cycle Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Traceable author statement Ref.6. Source: ProtInc positive regulation of sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara regulation of transcription from RNA polymerase II promoter Traceable author statement PubMed 10918580. Source: ProtInc response to cAMP Inferred from electronic annotation. Source: Compara response to corticosterone stimulus Inferred from electronic annotation. Source: Compara response to cytokine stimulus Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to gravity Inferred from electronic annotation. Source: Compara response to hydrogen peroxide Inferred from electronic annotation. Source: Compara response to mechanical stimulus Inferred from electronic annotation. Source: Compara response to progesterone stimulus Inferred from electronic annotation. Source: Compara response to virus Traceable author statement Ref.6. Source: ProtInc transcription from RNA polymerase II promoter Traceable author statement Ref.1. Source: ProtInc vitellogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara neuron projection Inferred from electronic annotation. Source: Compara nucleus Traceable author statement PubMed 10918580. Source: ProtInc presynaptic membrane Inferred from electronic annotation. Source: Compara
Molecular_function	RNA polymerase II regulatory region sequence-specific DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Traceable author statement PubMed 10918580. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LDOC1	O95751	3	EBI-744510,EBI-740738

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Fos-related antigen 1		PRO_0000076479
Regions
	Domain	105 – 168	64	bZIP
	Region	107 – 127	21	Basic motif By similarity
	Region	133 – 161	29	Leucine-zipper By similarity
	Compositional bias	103 – 106	4	Poly-Glu
	Compositional bias	251 – 255	5	Poly-Ser
Amino acid modifications
	Modified residue	265	1	Phosphoserine Ref.7

Sequences

	Sequence		Length	Mass (Da)
	P15407 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: 1B6492D709E66570	FASTA	271	29,413
	10 20 30 40 50 60 MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL QWMVQPHFLG 70 80 90 100 110 120 PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI SPEEEERRRV RRERNKLAAA 130 140 150 160 170 180 KCRNRRKELT DFLQAETDKL EDEKSGLQRE IEELQKQKER LELVLEAHRP ICKIPEGAKE 190 200 210 220 230 240 GDTGSTSGTS SPPAPCRPVP CISLSPGPVL EPEALHTPTL MTTPSLTPFT PSLVFTYPST 250 260 270 PEPCASAHRK SSSSSGDPSS DPLGSPTLLA L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation." Matsui M., Tokuhara M., Konuma Y., Nomura N., Ishizaki R. Oncogene 5:249-255(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Endothelial cell.
[2]	"Intron/exon structure of the human fos related antigen, identification of a novel pseudogene." Albagha O.M.E., Ralston S.H. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[6]	"Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals." Tsuchiya H., Fujii M., Niki T., Tokuhara M., Matsui M., Seiki M. J. Virol. 67:7001-7007(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5.
[7]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-265, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X16707 mRNA. Translation: CAA34679.1. AJ297411, AJ297412, AJ297413 Genomic DNA. Translation: CAC50237.1. CR542257 mRNA. Translation: CAG47053.1. CR542278 mRNA. Translation: CAG47074.1. CH471076 Genomic DNA. Translation: EAW74469.1. BC016648 mRNA. Translation: AAH16648.1.
IPI	IPI00011590.
PIR	S15750.
RefSeq	NP_005429.1. NM_005438.3.
UniGene	Hs.283565.
3D structure databases
ProteinModelPortal	P15407.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-660N.
IntAct	P15407. 9 interactions.
MINT	MINT-1445608.
STRING	9606.ENSP00000310170.
PTM databases
PhosphoSite	P15407.
Polymorphism databases
DMDM	120484.
Proteomic databases
PaxDb	P15407.
PRIDE	P15407.
Protocols and materials databases
DNASU	8061.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000312562; ENSP00000310170; ENSG00000175592.
GeneID	8061.
KEGG	hsa:8061.
UCSC	uc001ogg.1. human.
Organism-specific databases
CTD	8061.
GeneCards	GC11M065659.
HGNC	HGNC:13718. FOSL1.
HPA	CAB004396.
MIM	136515. gene.
neXtProt	NX_P15407.
PharmGKB	PA28214.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG252534.
HOGENOM	HOG000234334.
HOVERGEN	HBG005743.
InParanoid	P15407.
KO	K04502.
OMA	CASAHRK.
PhylomeDB	P15407.
Enzyme and pathway databases
Pathway_Interaction_DB	nfat_tfpathway. Calcineurin-regulated NFAT-dependent transcription in lymphocytes. tcrcalciumpathway. Calcium signaling in the CD4+ TCR pathway. cd8tcrdownstreampathway. Downstream signaling in naive CD8+ T cells.
Gene expression databases
ArrayExpress	P15407.
Bgee	P15407.
CleanEx	HS_FOSL1.
Genevestigator	P15407.
GermOnline	ENSG00000175592. Homo sapiens.
Family and domain databases
InterPro	IPR004827. bZIP. IPR000837. Leuzip_Fos. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FOSL1. human.
GenomeRNAi	8061.
NextBio	30651.
SOURCE	Search...

Entry information

Entry name

FOSL1_HUMAN

Accession

Primary (citable) accession number: P15407
Secondary accession number(s): Q6FG51

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	May 1, 2013
This is version 124 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.