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P15407

- FOSL1_HUMAN

UniProt

P15407 - FOSL1_HUMAN

Protein

Fos-related antigen 1

Gene

FOSL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. protein binding Source: IntAct
    3. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
    4. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. cellular defense response Source: ProtInc
    2. cellular response to extracellular stimulus Source: Ensembl
    3. chemotaxis Source: ProtInc
    4. female pregnancy Source: Ensembl
    5. in utero embryonic development Source: Ensembl
    6. learning Source: Ensembl
    7. negative regulation of cell proliferation Source: Ensembl
    8. placenta blood vessel development Source: Ensembl
    9. positive regulation of apoptotic process Source: Ensembl
    10. positive regulation of cell cycle Source: Ensembl
    11. positive regulation of cell proliferation Source: ProtInc
    12. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    13. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    14. response to cAMP Source: Ensembl
    15. response to corticosterone Source: Ensembl
    16. response to cytokine Source: Ensembl
    17. response to drug Source: Ensembl
    18. response to gravity Source: Ensembl
    19. response to hydrogen peroxide Source: Ensembl
    20. response to mechanical stimulus Source: Ensembl
    21. response to progesterone Source: Ensembl
    22. response to virus Source: ProtInc
    23. transcription from RNA polymerase II promoter Source: ProtInc
    24. vitellogenesis Source: Ensembl

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fos-related antigen 1
    Short name:
    FRA-1
    Gene namesi
    Name:FOSL1
    Synonyms:FRA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:13718. FOSL1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. neuron projection Source: Ensembl
    3. nucleus Source: ProtInc
    4. presynaptic membrane Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28214.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Fos-related antigen 1PRO_0000076479Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei265 – 2651Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP15407.
    PaxDbiP15407.
    PRIDEiP15407.

    PTM databases

    PhosphoSiteiP15407.

    Expressioni

    Gene expression databases

    ArrayExpressiP15407.
    BgeeiP15407.
    CleanExiHS_FOSL1.
    GenevestigatoriP15407.

    Organism-specific databases

    HPAiCAB004396.

    Interactioni

    Subunit structurei

    Heterodimer.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LDOC1O957513EBI-744510,EBI-740738

    Protein-protein interaction databases

    BioGridi113742. 26 interactions.
    DIPiDIP-660N.
    IntActiP15407. 12 interactions.
    MINTiMINT-1445608.
    STRINGi9606.ENSP00000310170.

    Structurei

    3D structure databases

    ProteinModelPortaliP15407.
    SMRiP15407. Positions 108-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini105 – 16864bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni107 – 12721Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni133 – 16129Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi103 – 1064Poly-Glu
    Compositional biasi251 – 2555Poly-Ser

    Sequence similaritiesi

    Belongs to the bZIP family. Fos subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG252534.
    HOGENOMiHOG000234334.
    HOVERGENiHBG005743.
    InParanoidiP15407.
    KOiK04502.
    OMAiPCEQISP.
    PhylomeDBiP15407.
    TreeFamiTF326301.

    Family and domain databases

    InterProiIPR004827. bZIP.
    IPR000837. Leuzip_Fos.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    [Graphical view]
    PRINTSiPR00042. LEUZIPPRFOS.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P15407-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL    50
    QWMVQPHFLG PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI 100
    SPEEEERRRV RRERNKLAAA KCRNRRKELT DFLQAETDKL EDEKSGLQRE 150
    IEELQKQKER LELVLEAHRP ICKIPEGAKE GDTGSTSGTS SPPAPCRPVP 200
    CISLSPGPVL EPEALHTPTL MTTPSLTPFT PSLVFTYPST PEPCASAHRK 250
    SSSSSGDPSS DPLGSPTLLA L 271
    Length:271
    Mass (Da):29,413
    Last modified:April 1, 1990 - v1
    Checksum:i1B6492D709E66570
    GO
    Isoform 2 (identifier: P15407-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         34-135: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:169
    Mass (Da):17,560
    Checksum:i71375CD7300A1169
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei34 – 135102Missing in isoform 2. 1 PublicationVSP_055566Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16707 mRNA. Translation: CAA34679.1.
    AJ297411, AJ297412, AJ297413 Genomic DNA. Translation: CAC50237.1.
    AK299050 mRNA. Translation: BAG61123.1.
    CR542257 mRNA. Translation: CAG47053.1.
    CR542278 mRNA. Translation: CAG47074.1.
    AP006287 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74469.1.
    BC016648 mRNA. Translation: AAH16648.1.
    CCDSiCCDS8121.1.
    PIRiS15750.
    RefSeqiNP_005429.1. NM_005438.3.
    UniGeneiHs.283565.

    Genome annotation databases

    EnsembliENST00000312562; ENSP00000310170; ENSG00000175592. [P15407-1]
    ENST00000448083; ENSP00000393302; ENSG00000175592. [P15407-2]
    GeneIDi8061.
    KEGGihsa:8061.
    UCSCiuc001ogg.1. human.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16707 mRNA. Translation: CAA34679.1 .
    AJ297411 , AJ297412 , AJ297413 Genomic DNA. Translation: CAC50237.1 .
    AK299050 mRNA. Translation: BAG61123.1 .
    CR542257 mRNA. Translation: CAG47053.1 .
    CR542278 mRNA. Translation: CAG47074.1 .
    AP006287 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74469.1 .
    BC016648 mRNA. Translation: AAH16648.1 .
    CCDSi CCDS8121.1.
    PIRi S15750.
    RefSeqi NP_005429.1. NM_005438.3.
    UniGenei Hs.283565.

    3D structure databases

    ProteinModelPortali P15407.
    SMRi P15407. Positions 108-160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113742. 26 interactions.
    DIPi DIP-660N.
    IntActi P15407. 12 interactions.
    MINTi MINT-1445608.
    STRINGi 9606.ENSP00000310170.

    PTM databases

    PhosphoSitei P15407.

    Proteomic databases

    MaxQBi P15407.
    PaxDbi P15407.
    PRIDEi P15407.

    Protocols and materials databases

    DNASUi 8061.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312562 ; ENSP00000310170 ; ENSG00000175592 . [P15407-1 ]
    ENST00000448083 ; ENSP00000393302 ; ENSG00000175592 . [P15407-2 ]
    GeneIDi 8061.
    KEGGi hsa:8061.
    UCSCi uc001ogg.1. human.

    Organism-specific databases

    CTDi 8061.
    GeneCardsi GC11M065659.
    HGNCi HGNC:13718. FOSL1.
    HPAi CAB004396.
    MIMi 136515. gene.
    neXtProti NX_P15407.
    PharmGKBi PA28214.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG252534.
    HOGENOMi HOG000234334.
    HOVERGENi HBG005743.
    InParanoidi P15407.
    KOi K04502.
    OMAi PCEQISP.
    PhylomeDBi P15407.
    TreeFami TF326301.

    Miscellaneous databases

    ChiTaRSi FOSL1. human.
    GeneWikii FOSL1.
    GenomeRNAii 8061.
    NextBioi 30651.
    PROi P15407.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P15407.
    Bgeei P15407.
    CleanExi HS_FOSL1.
    Genevestigatori P15407.

    Family and domain databases

    InterProi IPR004827. bZIP.
    IPR000837. Leuzip_Fos.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00042. LEUZIPPRFOS.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation."
      Matsui M., Tokuhara M., Konuma Y., Nomura N., Ishizaki R.
      Oncogene 5:249-255(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Endothelial cell.
    2. "Intron/exon structure of the human fos related antigen, identification of a novel pseudogene."
      Albagha O.M.E., Ralston S.H.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    8. "Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals."
      Tsuchiya H., Fujii M., Niki T., Tokuhara M., Matsui M., Seiki M.
      J. Virol. 67:7001-7007(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-265, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiFOSL1_HUMAN
    AccessioniPrimary (citable) accession number: P15407
    Secondary accession number(s): B4DR11, Q6FG51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3