P15407 (FOSL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 124.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Fos-related antigen 1 Short name=FRA-1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 271 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Subunit structure | Heterodimer By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP (basic-leucine zipper) domain. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| LDOC1 | O95751 | 3 | EBI-744510,EBI-740738 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 271 | 271 | Fos-related antigen 1 | PRO_0000076479 | |||||
Regions | |||||||||
| Domain | 105 – 168 | 64 | bZIP | ||||||
| Region | 107 – 127 | 21 | Basic motif By similarity | ||||||
| Region | 133 – 161 | 29 | Leucine-zipper By similarity | ||||||
| Compositional bias | 103 – 106 | 4 | Poly-Glu | ||||||
| Compositional bias | 251 – 255 | 5 | Poly-Ser | ||||||
Amino acid modifications | |||||||||
| Modified residue | 265 | 1 | Phosphoserine Ref.7 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation." Matsui M., Tokuhara M., Konuma Y., Nomura N., Ishizaki R. Oncogene 5:249-255(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Endothelial cell. |
| [2] | "Intron/exon structure of the human fos related antigen, identification of a novel pseudogene." Albagha O.M.E., Ralston S.H. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood. |
| [3] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin. |
| [6] | "Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals." Tsuchiya H., Fujii M., Niki T., Tokuhara M., Matsui M., Seiki M. J. Virol. 67:7001-7007(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5. |
| [7] | "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-265, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X16707 mRNA. Translation: CAA34679.1. AJ297411, AJ297412, AJ297413 Genomic DNA. Translation: CAC50237.1. CR542257 mRNA. Translation: CAG47053.1. CR542278 mRNA. Translation: CAG47074.1. CH471076 Genomic DNA. Translation: EAW74469.1. BC016648 mRNA. Translation: AAH16648.1. |
| IPI | IPI00011590. |
| PIR | S15750. |
| RefSeq | NP_005429.1. NM_005438.3. |
| UniGene | Hs.283565. |
3D structure databases | |
| ProteinModelPortal | P15407. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-660N. |
| IntAct | P15407. 9 interactions. |
| MINT | MINT-1445608. |
| STRING | 9606.ENSP00000310170. |
PTM databases | |
| PhosphoSite | P15407. |
Polymorphism databases | |
| DMDM | 120484. |
Proteomic databases | |
| PaxDb | P15407. |
| PRIDE | P15407. |
Protocols and materials databases | |
| DNASU | 8061. |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000312562; ENSP00000310170; ENSG00000175592. |
| GeneID | 8061. |
| KEGG | hsa:8061. |
| UCSC | uc001ogg.1. human. |
Organism-specific databases | |
| CTD | 8061. |
| GeneCards | GC11M065659. |
| HGNC | HGNC:13718. FOSL1. |
| HPA | CAB004396. |
| MIM | 136515. gene. |
| neXtProt | NX_P15407. |
| PharmGKB | PA28214. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG252534. |
| HOGENOM | HOG000234334. |
| HOVERGEN | HBG005743. |
| InParanoid | P15407. |
| KO | K04502. |
| OMA | CASAHRK. |
| PhylomeDB | P15407. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | nfat_tfpathway. Calcineurin-regulated NFAT-dependent transcription in lymphocytes. tcrcalciumpathway. Calcium signaling in the CD4+ TCR pathway. cd8tcrdownstreampathway. Downstream signaling in naive CD8+ T cells. |
Gene expression databases | |
| ArrayExpress | P15407. |
| Bgee | P15407. |
| CleanEx | HS_FOSL1. |
| Genevestigator | P15407. |
| GermOnline | ENSG00000175592. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR004827. bZIP. IPR000837. Leuzip_Fos. [Graphical view] |
| Pfam | PF00170. bZIP_1. 1 hit. [Graphical view] |
| PRINTS | PR00042. LEUZIPPRFOS. |
| SMART | SM00338. BRLZ. 1 hit. [Graphical view] |
| PROSITE | PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| ChiTaRS | FOSL1. human. |
| GenomeRNAi | 8061. |
| NextBio | 30651. |
| SOURCE | Search... |
Entry information
| Entry name | FOSL1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P15407 Secondary accession number(s): Q6FG51 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
