Reviewed, UniProtKB/Swiss-Prot P15407 (FOSL1_HUMAN)

Names and origin

Protein names

Recommended name:
    Fos-related antigen 1
      Short name=FRA-1

Gene names

Name:	FOSL1
Synonyms:	FRA1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Heterodimer By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular defense response Traceable author statement. Source: ProtInc chemotaxis Traceable author statement. Source: ProtInc positive regulation of cell proliferation Ref.6 Traceable author statement. Source: ProtInc response to virus Ref.6 Traceable author statement. Source: ProtInc transcription from RNA polymerase II promoter Ref.1 Traceable author statement. Source: ProtInc
Cellular component	nucleus Traceable author statement. Source: ProtInc
Molecular function	protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LDOC1	O95751	2	EBI-744510,EBI-740738

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Fos-related antigen 1		PRO_0000076479
Regions
	Domain	133 – 161	29	Leucine-zipper
	DNA binding	111 – 129	19	Basic motif
	Compositional bias	103 – 106	4	Poly-Glu
	Compositional bias	251 – 255	5	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	P15407-1 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: 1B6492D709E66570	FASTA	271	29,413
	10 20 30 40 50 60 MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL QWMVQPHFLG 70 80 90 100 110 120 PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI SPEEEERRRV RRERNKLAAA 130 140 150 160 170 180 KCRNRRKELT DFLQAETDKL EDEKSGLQRE IEELQKQKER LELVLEAHRP ICKIPEGAKE 190 200 210 220 230 240 GDTGSTSGTS SPPAPCRPVP CISLSPGPVL EPEALHTPTL MTTPSLTPFT PSLVFTYPST 250 260 270 PEPCASAHRK SSSSSGDPSS DPLGSPTLLA L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation." Matsui M., Tokuhara M., Konuma Y., Nomura N., Ishizaki R. Oncogene 5:249-255(1990) [PubMed: 2107490] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Endothelial cell.
[2]	"Intron/exon structure of the human fos related antigen, identification of a novel pseudogene." Albagha O.M.E., Ralston S.H. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[6]	"Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals." Tsuchiya H., Fujii M., Niki T., Tokuhara M., Matsui M., Seiki M. J. Virol. 67:7001-7007(1993) [PubMed: 8230424] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X16707 mRNA. Translation: CAA34679.1. AJ297411, AJ297412, AJ297413 Genomic DNA. Translation: CAC50237.1. CR542257 mRNA. Translation: CAG47053.1. CR542278 mRNA. Translation: CAG47074.1. CH471076 Genomic DNA. Translation: EAW74469.1. BC016648 mRNA. Translation: AAH16648.1.
IPI	IPI00011590.
PIR	S15750.
RefSeq	NP_005429.1.
UniGene	Hs.283565
3D structure databases
SMR	P15407. Positions 107-165.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-660N.
IntAct	P15407. 3 interactions.
STRING	P15407.
PTM databases
PhosphoSite	P15407.
Proteomic databases
PRIDE	P15407.
Genome annotation databases
Ensembl	ENST00000312562; ENSP00000310170; ENSG00000175592; Homo sapiens. [Genome view]
GeneID	8061.
KEGG	hsa:8061.
UCSC	uc001ogg.1. human.
Organism-specific databases
CTD	8061.
GeneCards	GC11M065416.
H-InvDB	HIX0009813.
HGNC	HGNC:13718. FOSL1.
HPA	CAB004396.
MIM	136515. gene.
PharmGKB	PA28214.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14109.
HOGENOM	HBG714812.
HOVERGEN	P15407.
InParanoid	P15407.
OMA	CASAHRK.
OrthoDB	EOG91RSDG.
PhylomeDB	P15407.
Enzyme and pathway databases
Pathway_Interaction_DB	nfat_tfpathway. Calcineurin-regulated NFAT-dependent transcription in lymphocytes. tcrcalciumpathway. Calcium signaling in the CD4+ TCR pathway. cd8tcrdownstreampathway. Downstream signaling in naive CD8+ T cells.
Gene expression databases
ArrayExpress	P15407.
Bgee	P15407.
CleanEx	HS_FOSL1.
Genevestigator	P15407.
GermOnline	ENSG00000175592. Homo sapiens.
Family and domain databases
InterPro	IPR011616. bZIP_1. IPR000837. Leuzip_Fos. IPR004827. TF_bZIP. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	30651.
SOURCE	Search...

Entry information

Entry name

FOSL1_HUMAN

Accession

Primary (citable) accession number: P15407
Secondary accession number(s): Q6FG51

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	January 19, 2010
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.