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Protein

Anthranilate synthase

Gene

trpE(G)

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase (trpE(G))
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei607 – 6071Nucleophile; for GATase activityPROSITE-ProRule annotation
Binding sitei611 – 6111GlutamineBy similarity
Active sitei697 – 6971For GATase activityPROSITE-ProRule annotation
Active sitei699 – 6991For GATase activityPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3117-MONOMER.
SMEL266834:GJF6-2442-MONOMER.
UniPathwayiUPA00035; UER00040.

Protein family/group databases

MEROPSiC26.955.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate synthase (EC:4.1.3.27)
Including the following 1 domains:
Glutamine amidotransferase
Gene namesi
Name:trpE(G)
Ordered Locus Names:R02387
ORF Names:SMc02725
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Anthranilate synthasePRO_0000056868Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc02725.

Structurei

3D structure databases

ProteinModelPortaliP15395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini530 – 726197Glutamine amidotransferase type-1PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni580 – 5823Glutamine bindingBy similarity
Regioni658 – 6592Glutamine bindingBy similarity

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiENOG4105CRQ. Bacteria.
COG0147. LUCA.
COG0512. LUCA.
HOGENOMiHOG000271519.
KOiK13503.
OMAiLFHTVDH.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
3.60.120.10. 1 hit.
InterProiIPR005801. ADC_synthase.
IPR006805. Anth_synth_I_N.
IPR015890. Chorismate_C.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR010112. TrpE-G.
IPR006221. TrpG/PapA_dom.
[Graphical view]
PfamiPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
PIRSFiPIRSF036934. TrpE-G. 1 hit.
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF56322. SSF56322. 1 hit.
TIGRFAMsiTIGR01815. TrpE-clade3. 1 hit.
TIGR00566. trpG_papA. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15395-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVILEDGA ESYTTKGGIV VTRRRREASY SDAIAGYVDR LDERRGAVFS
60 70 80 90 100
SNYEYPGRYT RWDTAVVDPP LAISSFGRSL WIEAYNERGE VLLALIAEDL
110 120 130 140 150
KSVADITLGS LAARRLDLTI NEPDRVFTEE ERSKMPTVFT VLRAVTNLFH
160 170 180 190 200
SEEDSNLGLY GAFGYDLAFQ FDAIELKLSR PDDQRDMVLF LPDEILVVDH
210 220 230 240 250
YAAKAWIDRY DFARENLSTE GKAADIAPEP FRSVDSIPPH GDHRPGEYAE
260 270 280 290 300
LVVKAKESFR RGDLFEVVPG QKFYERCESR PSEISNRLKA INPSPYSFFI
310 320 330 340 350
NLGNQEYLVG ASPEMFVRVS GRRIETCPIS GTIKRGDDPI ADSEQILKLL
360 370 380 390 400
NSKKDESELT MCSDVDRNDK SRVCVPGSVK VIGRRQIEMY SRLIHTVDHI
410 420 430 440 450
EGRLRDDMDA FDGFLSHAWA VTVTGAPKLW AMRFIESHEK SPRAWYGGAI
460 470 480 490 500
GMVGFNGDMN TGLTLRTIRI KDGIAEVRAG ATLLYDSNPE EEEAETELKA
510 520 530 540 550
SAMIAAIRDA KSANSAKSAR DVAAVGAGVS ILLVDHEDSF VHTLANYFRQ
560 570 580 590 600
TGASVTTVRT PVAEEIFDRV KPDLVVLSPG PGTPKDFDCK ATIKKARARD
610 620 630 640 650
LPIFGVCLGL QALAEAYGGD LRQLAIPMHG KPSRIRVLEP GIVFSGLGKE
660 670 680 690 700
VTVGRYHSIF ADPSNLPREF VITAESEDGT IMGIEHSKEP VAAVQFHPES
710 720
IMTLGGDAGM RMIENVVAHL AKRAKTKAA
Length:729
Mass (Da):80,505
Last modified:April 1, 1990 - v1
Checksum:iF16F10A90E3846E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22983 Genomic DNA. Translation: AAA26370.1.
AL591688 Genomic DNA. Translation: CAC46966.1.
PIRiB44515. A30904.
RefSeqiNP_386493.1. NC_003047.1.
WP_010969900.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC46966; CAC46966; SMc02725.
GeneIDi1234054.
KEGGisme:SMc02725.
PATRICi23634267. VBISinMel96828_3871.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22983 Genomic DNA. Translation: AAA26370.1.
AL591688 Genomic DNA. Translation: CAC46966.1.
PIRiB44515. A30904.
RefSeqiNP_386493.1. NC_003047.1.
WP_010969900.1. NC_003047.1.

3D structure databases

ProteinModelPortaliP15395.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266834.SMc02725.

Protein family/group databases

MEROPSiC26.955.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC46966; CAC46966; SMc02725.
GeneIDi1234054.
KEGGisme:SMc02725.
PATRICi23634267. VBISinMel96828_3871.

Phylogenomic databases

eggNOGiENOG4105CRQ. Bacteria.
COG0147. LUCA.
COG0512. LUCA.
HOGENOMiHOG000271519.
KOiK13503.
OMAiLFHTVDH.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00040.
BioCyciRETL1328306-WGS:GSTH-3117-MONOMER.
SMEL266834:GJF6-2442-MONOMER.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
3.60.120.10. 1 hit.
InterProiIPR005801. ADC_synthase.
IPR006805. Anth_synth_I_N.
IPR015890. Chorismate_C.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR010112. TrpE-G.
IPR006221. TrpG/PapA_dom.
[Graphical view]
PfamiPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
PIRSFiPIRSF036934. TrpE-G. 1 hit.
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF56322. SSF56322. 1 hit.
TIGRFAMsiTIGR01815. TrpE-clade3. 1 hit.
TIGR00566. trpG_papA. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPE_RHIME
AccessioniPrimary (citable) accession number: P15395
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.