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Protein

Cytochrome P450 11B1, mitochondrial

Gene

Cyp11b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Forms corticosterone from 11-deoxycorticosterone.

Catalytic activityi

A steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11-beta- hydroxysteroid + 2 oxidized adrenodoxin + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi446Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • adenosine metabolic process Source: RGD
  • aldosterone biosynthetic process Source: UniProtKB
  • cellular response to interferon-gamma Source: RGD
  • cellular response to peptide hormone stimulus Source: GO_Central
  • cholesterol metabolic process Source: GO_Central
  • cortisol biosynthetic process Source: UniProtKB
  • dibenzo-p-dioxin metabolic process Source: RGD
  • glucocorticoid biosynthetic process Source: RGD
  • glucocorticoid metabolic process Source: RGD
  • response to dexamethasone Source: RGD
  • response to drug Source: RGD
  • secondary metabolite biosynthetic process Source: GO_Central
  • steroid biosynthetic process Source: RGD
  • steroid metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP15393.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 11B1, mitochondrial
Alternative name(s):
CYPXIB1
Cytochrome P450(11 beta)-DS
Cytochrome P450C11
Steroid 11-beta-hydroxylase (EC:1.14.15.4)
Gene namesi
Name:Cyp11b1
Synonyms:Cyp11b-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2453. Cyp11b1.

Subcellular locationi

GO - Cellular componenti

  • integral component of endoplasmic reticulum membrane Source: RGD
  • mitochondrial inner membrane Source: GO_Central
  • mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4970.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24Mitochondrion1 PublicationAdd BLAST24
ChainiPRO_000000360325 – 499Cytochrome P450 11B1, mitochondrialAdd BLAST475

Proteomic databases

PRIDEiP15393.

Expressioni

Tissue specificityi

Adrenal zona fasciculata/reticularis.

Interactioni

Chemistry databases

BindingDBiP15393.

Structurei

3D structure databases

ProteinModelPortaliP15393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000013161.
HOVERGENiHBG051098.
InParanoidiP15393.
PhylomeDBiP15393.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00408. MITP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRVTADVW LARPWQCLHR TRALGTTAKV APKTLKPFEA IPQYSRNKWL
60 70 80 90 100
KMIQILREQG QENLHLEMHQ AFQELGPIFR HSAGGAQIVS VMLPEDAEKL
110 120 130 140 150
HQVESILPHR MPLEPWVAHR ELRGLRRGVF LLNGADWRFN RLQLNPNMLS
160 170 180 190 200
PKAIQSFVPF VDVVARDFVE NLKKRMLENV HGSMSINIQS NMFNYTMEAS
210 220 230 240 250
HFVISGERLG LTGHDLKPES VTFTHALHSM FKSTTQLMFL PKSLTRWTST
260 270 280 290 300
RVWKEHFDSW DIISEYVTKC IKNVYRELAE GRQQSWSVIS EMVAQSTLSM
310 320 330 340 350
DAIHANSMEL IAGSVDTTAI SLVMTLFELA RNPDVQQALR QESLAAEASI
360 370 380 390 400
VANPQKAMSD LPLLRAALKE TLRLYPVGSF VERIVHSDLV LQNYHVPAGT
410 420 430 440 450
FVIIYLYSMG RNPAVFPRPE RYMPQRWLER KRSFQHLAFG FGVRQCLGRR
460 470 480 490
LAEVEMLLLL HHMLKTFQVE TLRQEDMQMV FRFLLMPSSS PFLTFRPVS
Length:499
Mass (Da):57,459
Last modified:April 1, 1990 - v1
Checksum:i19C041F96A673C7E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti127R → C in strain: Dahl salt-resistant. 1
Natural varianti351V → A in strain: Dahl salt-resistant. 1
Natural varianti381V → L in strain: Dahl salt-resistant. 1
Natural varianti384I → L in strain: Dahl salt-resistant. 1
Natural varianti443V → M in strain: Dahl salt-resistant. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11354 mRNA. Translation: BAA01957.1.
D14091 Genomic DNA. Translation: BAA03171.1.
X15431 mRNA. Translation: CAA33472.1.
D10107 mRNA. Translation: BAA00988.1.
PIRiA46039.
UniGeneiRn.198235.

Genome annotation databases

UCSCiRGD:2453. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11354 mRNA. Translation: BAA01957.1.
D14091 Genomic DNA. Translation: BAA03171.1.
X15431 mRNA. Translation: CAA33472.1.
D10107 mRNA. Translation: BAA00988.1.
PIRiA46039.
UniGeneiRn.198235.

3D structure databases

ProteinModelPortaliP15393.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP15393.
ChEMBLiCHEMBL4970.

Proteomic databases

PRIDEiP15393.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2453. rat.

Organism-specific databases

RGDi2453. Cyp11b1.

Phylogenomic databases

HOGENOMiHOG000013161.
HOVERGENiHBG051098.
InParanoidiP15393.
PhylomeDBiP15393.

Enzyme and pathway databases

SABIO-RKP15393.

Miscellaneous databases

PROiP15393.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00408. MITP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC11B1_RAT
AccessioniPrimary (citable) accession number: P15393
Secondary accession number(s): Q64655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 6, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.