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Protein

Cytochrome P450 11B1, mitochondrial

Gene

Cyp11b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms corticosterone from 11-deoxycorticosterone.

Catalytic activityi

A steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11-beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi446Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • corticosterone 18-monooxygenase activity Source: GO_Central
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • steroid 11-beta-monooxygenase activity Source: RGD
  • steroid binding Source: RGD

GO - Biological processi

  • adenosine metabolic process Source: RGD
  • aldosterone biosynthetic process Source: UniProtKB
  • cellular response to interferon-gamma Source: RGD
  • cortisol biosynthetic process Source: UniProtKB
  • dibenzo-p-dioxin metabolic process Source: RGD
  • glucocorticoid biosynthetic process Source: RGD
  • glucocorticoid metabolic process Source: RGD
  • response to dexamethasone Source: RGD
  • response to drug Source: RGD
  • steroid biosynthetic process Source: RGD
  • steroid metabolic process Source: RGD

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processSteroidogenesis
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP15393

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 11B1, mitochondrial
Alternative name(s):
CYPXIB1
Cytochrome P450(11 beta)-DS
Cytochrome P450C11
Steroid 11-beta-hydroxylase (EC:1.14.15.4)
Gene namesi
Name:Cyp11b1
Synonyms:Cyp11b-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2453 Cyp11b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4970

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24Mitochondrion1 PublicationAdd BLAST24
ChainiPRO_000000360325 – 499Cytochrome P450 11B1, mitochondrialAdd BLAST475

Proteomic databases

PRIDEiP15393

Expressioni

Tissue specificityi

Adrenal zona fasciculata/reticularis.

Interactioni

Chemistry databases

BindingDBiP15393

Structurei

3D structure databases

ProteinModelPortaliP15393
SMRiP15393
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000013161
HOVERGENiHBG051098
InParanoidiP15393
PhylomeDBiP15393

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002399 Cyt_P450_mitochondrial
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00408 MITP450
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRVTADVW LARPWQCLHR TRALGTTAKV APKTLKPFEA IPQYSRNKWL
60 70 80 90 100
KMIQILREQG QENLHLEMHQ AFQELGPIFR HSAGGAQIVS VMLPEDAEKL
110 120 130 140 150
HQVESILPHR MPLEPWVAHR ELRGLRRGVF LLNGADWRFN RLQLNPNMLS
160 170 180 190 200
PKAIQSFVPF VDVVARDFVE NLKKRMLENV HGSMSINIQS NMFNYTMEAS
210 220 230 240 250
HFVISGERLG LTGHDLKPES VTFTHALHSM FKSTTQLMFL PKSLTRWTST
260 270 280 290 300
RVWKEHFDSW DIISEYVTKC IKNVYRELAE GRQQSWSVIS EMVAQSTLSM
310 320 330 340 350
DAIHANSMEL IAGSVDTTAI SLVMTLFELA RNPDVQQALR QESLAAEASI
360 370 380 390 400
VANPQKAMSD LPLLRAALKE TLRLYPVGSF VERIVHSDLV LQNYHVPAGT
410 420 430 440 450
FVIIYLYSMG RNPAVFPRPE RYMPQRWLER KRSFQHLAFG FGVRQCLGRR
460 470 480 490
LAEVEMLLLL HHMLKTFQVE TLRQEDMQMV FRFLLMPSSS PFLTFRPVS
Length:499
Mass (Da):57,459
Last modified:April 1, 1990 - v1
Checksum:i19C041F96A673C7E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti127R → C in strain: Dahl salt-resistant. 1
Natural varianti351V → A in strain: Dahl salt-resistant. 1
Natural varianti381V → L in strain: Dahl salt-resistant. 1
Natural varianti384I → L in strain: Dahl salt-resistant. 1
Natural varianti443V → M in strain: Dahl salt-resistant. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11354 mRNA Translation: BAA01957.1
D14091 Genomic DNA Translation: BAA03171.1
X15431 mRNA Translation: CAA33472.1
D10107 mRNA Translation: BAA00988.1
PIRiA46039
UniGeneiRn.198235

Genome annotation databases

UCSCiRGD:2453 rat

Similar proteinsi

Entry informationi

Entry nameiC11B1_RAT
AccessioniPrimary (citable) accession number: P15393
Secondary accession number(s): Q64655
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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