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Protein

B-lymphocyte antigen CD19

Gene

CD19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177455-MONOMER.
ReactomeiR-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
SignaLinkiP15391.
SIGNORiP15391.

Names & Taxonomyi

Protein namesi
Recommended name:
B-lymphocyte antigen CD19
Alternative name(s):
B-lymphocyte surface antigen B4
Differentiation antigen CD19
T-cell surface antigen Leu-12
CD_antigen: CD19
Gene namesi
Name:CD19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:1633. CD19.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 291ExtracellularSequence analysisAdd BLAST272
Transmembranei292 – 313HelicalSequence analysisAdd BLAST22
Topological domaini314 – 556CytoplasmicSequence analysisAdd BLAST243

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency, common variable, 3 (CVID3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
See also OMIM:613493

Organism-specific databases

DisGeNETi930.
MalaCardsiCD19.
MIMi613493. phenotype.
OpenTargetsiENSG00000177455.
Orphaneti1572. Common variable immunodeficiency.
PharmGKBiPA26192.

Chemistry databases

ChEMBLiCHEMBL3390821.
DrugBankiDB09052. Blinatumomab.
GuidetoPHARMACOLOGYi2764.

Polymorphism and mutation databases

BioMutaiCD19.
DMDMi160332376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001464820 – 556B-lymphocyte antigen CD19Add BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 97PROSITE-ProRule annotation
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Glycosylationi125N-linked (GlcNAc...)Sequence analysis1
Glycosylationi138N-linked (GlcNAc...)Sequence analysis1
Glycosylationi181N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi200 ↔ 261PROSITE-ProRule annotation
Modified residuei227PhosphoserineBy similarity1
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1
Modified residuei348Phosphotyrosine1 Publication1
Modified residuei378Phosphotyrosine1 Publication1
Modified residuei409Phosphotyrosine1 Publication1
Modified residuei439Phosphotyrosine1 Publication1
Modified residuei500PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP15391.
PeptideAtlasiP15391.
PRIDEiP15391.

PTM databases

iPTMnetiP15391.
PhosphoSitePlusiP15391.

Expressioni

Gene expression databases

BgeeiENSG00000177455.
CleanExiHS_CD19.
GenevisibleiP15391. HS.

Organism-specific databases

HPAiCAB016110.

Interactioni

Subunit structurei

Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Interacts with LYN.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IGHMP018712EBI-79902,EBI-953797

Protein-protein interaction databases

BioGridi107368. 16 interactors.
IntActiP15391. 8 interactors.
MINTiMINT-1508267.
STRINGi9606.ENSP00000437940.

Structurei

3D structure databases

ProteinModelPortaliP15391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 113Ig-like C2-type 1Add BLAST94
Domaini176 – 277Ig-like C2-type 2Add BLAST102

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ3V. Eukaryota.
ENOG41115SQ. LUCA.
GeneTreeiENSGT00390000014991.
HOGENOMiHOG000111478.
HOVERGENiHBG003388.
InParanoidiP15391.
KOiK06465.
OMAiLYVWAKD.
OrthoDBiEOG091G08D8.
PhylomeDBiP15391.
TreeFamiTF338293.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P15391-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPPRLLFFL LFLTPMEVRP EEPLVVKVEE GDNAVLQCLK GTSDGPTQQL
60 70 80 90 100
TWSRESPLKP FLKLSLGLPG LGIHMRPLAI WLFIFNVSQQ MGGFYLCQPG
110 120 130 140 150
PPSEKAWQPG WTVNVEGSGE LFRWNVSDLG GLGCGLKNRS SEGPSSPSGK
160 170 180 190 200
LMSPKLYVWA KDRPEIWEGE PPCLPPRDSL NQSLSQDLTM APGSTLWLSC
210 220 230 240 250
GVPPDSVSRG PLSWTHVHPK GPKSLLSLEL KDDRPARDMW VMETGLLLPR
260 270 280 290 300
ATAQDAGKYY CHRGNLTMSF HLEITARPVL WHWLLRTGGW KVSAVTLAYL
310 320 330 340 350
IFCLCSLVGI LHLQRALVLR RKRKRMTDPT RRFFKVTPPP GSGPQNQYGN
360 370 380 390 400
VLSLPTPTSG LGRAQRWAAG LGGTAPSYGN PSSDVQADGA LGSRSPPGVG
410 420 430 440 450
PEEEEGEGYE EPDSEEDSEF YENDSNLGQD QLSQDGSGYE NPEDEPLGPE
460 470 480 490 500
DEDSFSNAES YENEDEELTQ PVARTMDFLS PHGSAWDPSR EATSLGSQSY
510 520 530 540 550
EDMRGILYAA PQLRSIRGQP GPNHEEDADS YENMDNPDGP DPAWGGGGRM

GTWSTR
Length:556
Mass (Da):61,128
Last modified:November 13, 2007 - v6
Checksum:iA0E08DD628B69E51
GO
Isoform 2 (identifier: P15391-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-495: L → LA

Note: No experimental confirmation available.
Show »
Length:557
Mass (Da):61,200
Checksum:i49A39D679F6C6C9A
GO

Sequence cautioni

The sequence AAA35533 differs from that shown. Reason: Frameshift at position 396.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29E → EG in AAB60697 (PubMed:1370948).Curated1
Sequence conflicti80I → S in AAA68490 (PubMed:2472450).Curated1
Sequence conflicti80I → S in AAA69966 (PubMed:1375324).Curated1
Sequence conflicti80I → S in AAB60697 (PubMed:1370948).Curated1
Sequence conflicti80I → S in BAB60954 (PubMed:12215898).Curated1
Sequence conflicti186Q → QAFLVLSLPVP in AAA69966 (PubMed:1375324).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026963174L → V.8 PublicationsCorresponds to variant rs2904880dbSNPEnsembl.1
Natural variantiVAR_036987514R → H.2 PublicationsCorresponds to variant rs34763945dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047194495L → LA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21097 mRNA. Translation: AAA35533.1. Frameshift.
M28170 mRNA. Translation: AAA68490.1.
M84371 Genomic DNA. Translation: AAA69966.1.
M62550
, M62544, M62545, M62546, M62547, M62548, M62549 Genomic DNA. Translation: AAB60697.1.
AB052799 Genomic DNA. Translation: BAB60954.1.
AK313577 mRNA. No translation available.
EF064757 Genomic DNA. Translation: ABK41940.1.
AC109460 Genomic DNA. No translation available.
CH471267 Genomic DNA. Translation: EAW52012.1.
BC006338 mRNA. Translation: AAH06338.1.
CCDSiCCDS10644.1. [P15391-1]
CCDS53998.1. [P15391-2]
PIRiA44441.
RefSeqiNP_001171569.1. NM_001178098.1. [P15391-2]
NP_001761.3. NM_001770.5. [P15391-1]
UniGeneiHs.652262.

Genome annotation databases

EnsembliENST00000324662; ENSP00000313419; ENSG00000177455. [P15391-1]
ENST00000538922; ENSP00000437940; ENSG00000177455. [P15391-2]
ENST00000567541; ENSP00000456201; ENSG00000177455. [P15391-2]
GeneIDi930.
KEGGihsa:930.
UCSCiuc002drs.4. human. [P15391-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

CD19base

CD19 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21097 mRNA. Translation: AAA35533.1. Frameshift.
M28170 mRNA. Translation: AAA68490.1.
M84371 Genomic DNA. Translation: AAA69966.1.
M62550
, M62544, M62545, M62546, M62547, M62548, M62549 Genomic DNA. Translation: AAB60697.1.
AB052799 Genomic DNA. Translation: BAB60954.1.
AK313577 mRNA. No translation available.
EF064757 Genomic DNA. Translation: ABK41940.1.
AC109460 Genomic DNA. No translation available.
CH471267 Genomic DNA. Translation: EAW52012.1.
BC006338 mRNA. Translation: AAH06338.1.
CCDSiCCDS10644.1. [P15391-1]
CCDS53998.1. [P15391-2]
PIRiA44441.
RefSeqiNP_001171569.1. NM_001178098.1. [P15391-2]
NP_001761.3. NM_001770.5. [P15391-1]
UniGeneiHs.652262.

3D structure databases

ProteinModelPortaliP15391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107368. 16 interactors.
IntActiP15391. 8 interactors.
MINTiMINT-1508267.
STRINGi9606.ENSP00000437940.

Chemistry databases

ChEMBLiCHEMBL3390821.
DrugBankiDB09052. Blinatumomab.
GuidetoPHARMACOLOGYi2764.

PTM databases

iPTMnetiP15391.
PhosphoSitePlusiP15391.

Polymorphism and mutation databases

BioMutaiCD19.
DMDMi160332376.

Proteomic databases

PaxDbiP15391.
PeptideAtlasiP15391.
PRIDEiP15391.

Protocols and materials databases

DNASUi930.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324662; ENSP00000313419; ENSG00000177455. [P15391-1]
ENST00000538922; ENSP00000437940; ENSG00000177455. [P15391-2]
ENST00000567541; ENSP00000456201; ENSG00000177455. [P15391-2]
GeneIDi930.
KEGGihsa:930.
UCSCiuc002drs.4. human. [P15391-1]

Organism-specific databases

CTDi930.
DisGeNETi930.
GeneCardsiCD19.
GeneReviewsiCD19.
HGNCiHGNC:1633. CD19.
HPAiCAB016110.
MalaCardsiCD19.
MIMi107265. gene.
613493. phenotype.
neXtProtiNX_P15391.
OpenTargetsiENSG00000177455.
Orphaneti1572. Common variable immunodeficiency.
PharmGKBiPA26192.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ3V. Eukaryota.
ENOG41115SQ. LUCA.
GeneTreeiENSGT00390000014991.
HOGENOMiHOG000111478.
HOVERGENiHBG003388.
InParanoidiP15391.
KOiK06465.
OMAiLYVWAKD.
OrthoDBiEOG091G08D8.
PhylomeDBiP15391.
TreeFamiTF338293.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177455-MONOMER.
ReactomeiR-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
SignaLinkiP15391.
SIGNORiP15391.

Miscellaneous databases

GeneWikiiCD19.
GenomeRNAii930.
PROiP15391.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177455.
CleanExiHS_CD19.
GenevisibleiP15391. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD19_HUMAN
AccessioniPrimary (citable) accession number: P15391
Secondary accession number(s): A0N0P9
, F5H635, Q96S68, Q9BRD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 13, 2007
Last modified: November 30, 2016
This is version 181 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.