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P15391

- CD19_HUMAN

UniProt

P15391 - CD19_HUMAN

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Protein
B-lymphocyte antigen CD19
Gene
CD19
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

GO - Molecular functioni

  1. receptor signaling protein activity Source: ProtInc

GO - Biological processi

  1. B cell receptor signaling pathway Source: Ensembl
  2. Fc-epsilon receptor signaling pathway Source: Reactome
  3. cell surface receptor signaling pathway Source: ProtInc
  4. cellular defense response Source: ProtInc
  5. epidermal growth factor receptor signaling pathway Source: Reactome
  6. fibroblast growth factor receptor signaling pathway Source: Reactome
  7. innate immune response Source: Reactome
  8. neurotrophin TRK receptor signaling pathway Source: Reactome
  9. phosphatidylinositol-mediated signaling Source: Reactome
  10. regulation of immune response Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_75829. PIP3 activates AKT signaling.
SignaLinkiP15391.

Names & Taxonomyi

Protein namesi
Recommended name:
B-lymphocyte antigen CD19
Alternative name(s):
B-lymphocyte surface antigen B4
Differentiation antigen CD19
T-cell surface antigen Leu-12
CD_antigen: CD19
Gene namesi
Name:CD19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:1633. CD19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 291272Extracellular Reviewed prediction
Add
BLAST
Transmembranei292 – 31322Helical; Reviewed prediction
Add
BLAST
Topological domaini314 – 556243Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of plasma membrane Source: ProtInc
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency, common variable, 3 (CVID3) [MIM:613493]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Organism-specific databases

MIMi613493. phenotype.
Orphaneti1572. Common variable immunodeficiency.
PharmGKBiPA26192.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 556537B-lymphocyte antigen CD19
PRO_0000014648Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 ↔ 97 Reviewed prediction
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi138 – 1381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi181 – 1811N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi200 ↔ 261 Reviewed prediction
Modified residuei227 – 2271Phosphoserine By similarity
Glycosylationi265 – 2651N-linked (GlcNAc...) Reviewed prediction
Modified residuei348 – 3481Phosphotyrosine1 Publication
Modified residuei378 – 3781Phosphotyrosine1 Publication
Modified residuei409 – 4091Phosphotyrosine1 Publication
Modified residuei439 – 4391Phosphotyrosine1 Publication
Modified residuei497 – 4971Phosphoserine

Post-translational modificationi

Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP15391.
PRIDEiP15391.

PTM databases

PhosphoSiteiP15391.

Expressioni

Gene expression databases

ArrayExpressiP15391.
BgeeiP15391.
CleanExiHS_CD19.
GenevestigatoriP15391.

Organism-specific databases

HPAiCAB016110.

Interactioni

Subunit structurei

Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Interacts with LYN.2 Publications

Protein-protein interaction databases

BioGridi107368. 12 interactions.
IntActiP15391. 6 interactions.
MINTiMINT-1508267.
STRINGi9606.ENSP00000313419.

Structurei

3D structure databases

ProteinModelPortaliP15391.
SMRiP15391. Positions 23-56, 186-262.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 11394Ig-like C2-type 1
Add
BLAST
Domaini176 – 277102Ig-like C2-type 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46561.
HOGENOMiHOG000111478.
HOVERGENiHBG003388.
InParanoidiP15391.
KOiK06465.
OMAiSPHGSAW.
OrthoDBiEOG74N5GS.
PhylomeDBiP15391.
TreeFamiTF338293.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P15391-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPPPRLLFFL LFLTPMEVRP EEPLVVKVEE GDNAVLQCLK GTSDGPTQQL    50
TWSRESPLKP FLKLSLGLPG LGIHMRPLAI WLFIFNVSQQ MGGFYLCQPG 100
PPSEKAWQPG WTVNVEGSGE LFRWNVSDLG GLGCGLKNRS SEGPSSPSGK 150
LMSPKLYVWA KDRPEIWEGE PPCLPPRDSL NQSLSQDLTM APGSTLWLSC 200
GVPPDSVSRG PLSWTHVHPK GPKSLLSLEL KDDRPARDMW VMETGLLLPR 250
ATAQDAGKYY CHRGNLTMSF HLEITARPVL WHWLLRTGGW KVSAVTLAYL 300
IFCLCSLVGI LHLQRALVLR RKRKRMTDPT RRFFKVTPPP GSGPQNQYGN 350
VLSLPTPTSG LGRAQRWAAG LGGTAPSYGN PSSDVQADGA LGSRSPPGVG 400
PEEEEGEGYE EPDSEEDSEF YENDSNLGQD QLSQDGSGYE NPEDEPLGPE 450
DEDSFSNAES YENEDEELTQ PVARTMDFLS PHGSAWDPSR EATSLGSQSY 500
EDMRGILYAA PQLRSIRGQP GPNHEEDADS YENMDNPDGP DPAWGGGGRM 550
GTWSTR 556
Length:556
Mass (Da):61,128
Last modified:November 13, 2007 - v6
Checksum:iA0E08DD628B69E51
GO
Isoform 2 (identifier: P15391-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-495: L → LA

Note: No experimental confirmation available.

Show »
Length:557
Mass (Da):61,200
Checksum:i49A39D679F6C6C9A
GO

Sequence cautioni

The sequence AAA35533.1 differs from that shown. Reason: Frameshift at position 396.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti174 – 1741L → V.8 Publications
Corresponds to variant rs2904880 [ dbSNP | Ensembl ].
VAR_026963
Natural varianti514 – 5141R → H.2 Publications
Corresponds to variant rs34763945 [ dbSNP | Ensembl ].
VAR_036987

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei495 – 4951L → LA in isoform 2.
VSP_047194

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291E → EG in AAB60697. 1 Publication
Sequence conflicti80 – 801I → S in AAA68490. 1 Publication
Sequence conflicti80 – 801I → S in AAA69966. 1 Publication
Sequence conflicti80 – 801I → S in AAB60697. 1 Publication
Sequence conflicti80 – 801I → S in BAB60954. 1 Publication
Sequence conflicti186 – 1861Q → QAFLVLSLPVP in AAA69966. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21097 mRNA. Translation: AAA35533.1. Frameshift.
M28170 mRNA. Translation: AAA68490.1.
M84371 Genomic DNA. Translation: AAA69966.1.
M62550
, M62544, M62545, M62546, M62547, M62548, M62549 Genomic DNA. Translation: AAB60697.1.
AB052799 Genomic DNA. Translation: BAB60954.1.
AK313577 mRNA. No translation available.
EF064757 Genomic DNA. Translation: ABK41940.1.
AC109460 Genomic DNA. No translation available.
CH471267 Genomic DNA. Translation: EAW52012.1.
BC006338 mRNA. Translation: AAH06338.1.
CCDSiCCDS10644.1. [P15391-1]
CCDS53998.1. [P15391-2]
PIRiA44441.
RefSeqiNP_001171569.1. NM_001178098.1. [P15391-2]
NP_001761.3. NM_001770.5. [P15391-1]
UniGeneiHs.652262.

Genome annotation databases

EnsembliENST00000324662; ENSP00000313419; ENSG00000177455. [P15391-1]
ENST00000538922; ENSP00000437940; ENSG00000177455. [P15391-2]
ENST00000567541; ENSP00000456201; ENSG00000177455. [P15391-2]
GeneIDi930.
KEGGihsa:930.
UCSCiuc002drs.3. human. [P15391-1]

Polymorphism databases

DMDMi160332376.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

CD19base

CD19 mutation db

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21097 mRNA. Translation: AAA35533.1 . Frameshift.
M28170 mRNA. Translation: AAA68490.1 .
M84371 Genomic DNA. Translation: AAA69966.1 .
M62550
, M62544 , M62545 , M62546 , M62547 , M62548 , M62549 Genomic DNA. Translation: AAB60697.1 .
AB052799 Genomic DNA. Translation: BAB60954.1 .
AK313577 mRNA. No translation available.
EF064757 Genomic DNA. Translation: ABK41940.1 .
AC109460 Genomic DNA. No translation available.
CH471267 Genomic DNA. Translation: EAW52012.1 .
BC006338 mRNA. Translation: AAH06338.1 .
CCDSi CCDS10644.1. [P15391-1 ]
CCDS53998.1. [P15391-2 ]
PIRi A44441.
RefSeqi NP_001171569.1. NM_001178098.1. [P15391-2 ]
NP_001761.3. NM_001770.5. [P15391-1 ]
UniGenei Hs.652262.

3D structure databases

ProteinModelPortali P15391.
SMRi P15391. Positions 23-56, 186-262.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107368. 12 interactions.
IntActi P15391. 6 interactions.
MINTi MINT-1508267.
STRINGi 9606.ENSP00000313419.

PTM databases

PhosphoSitei P15391.

Polymorphism databases

DMDMi 160332376.

Proteomic databases

PaxDbi P15391.
PRIDEi P15391.

Protocols and materials databases

DNASUi 930.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000324662 ; ENSP00000313419 ; ENSG00000177455 . [P15391-1 ]
ENST00000538922 ; ENSP00000437940 ; ENSG00000177455 . [P15391-2 ]
ENST00000567541 ; ENSP00000456201 ; ENSG00000177455 . [P15391-2 ]
GeneIDi 930.
KEGGi hsa:930.
UCSCi uc002drs.3. human. [P15391-1 ]

Organism-specific databases

CTDi 930.
GeneCardsi GC16P028943.
GeneReviewsi CD19.
HGNCi HGNC:1633. CD19.
HPAi CAB016110.
MIMi 107265. gene.
613493. phenotype.
neXtProti NX_P15391.
Orphaneti 1572. Common variable immunodeficiency.
PharmGKBi PA26192.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46561.
HOGENOMi HOG000111478.
HOVERGENi HBG003388.
InParanoidi P15391.
KOi K06465.
OMAi SPHGSAW.
OrthoDBi EOG74N5GS.
PhylomeDBi P15391.
TreeFami TF338293.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_75829. PIP3 activates AKT signaling.
SignaLinki P15391.

Miscellaneous databases

GeneWikii CD19.
GenomeRNAii 930.
NextBioi 3856.
PROi P15391.
SOURCEi Search...

Gene expression databases

ArrayExpressi P15391.
Bgeei P15391.
CleanExi HS_CD19.
Genevestigatori P15391.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail."
    Stamenkovic I., Seed B.
    J. Exp. Med. 168:1205-1210(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-174 AND HIS-514.
  2. "Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily."
    Tedder T.F., Isaacs C.M.
    J. Immunol. 143:712-717(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-174 AND HIS-514.
    Tissue: Tonsil.
  3. "The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP."
    Kozmik Z., Wang S., Doerfler P., Adams B., Busslinger M.
    Mol. Cell. Biol. 12:2662-2672(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-174.
  4. "Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes."
    Zhou L.J., Ord D.C., Omori S.A., Tedder T.F.
    Immunogenetics 35:102-111(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-174.
    Tissue: Blood.
  5. "Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese."
    Kuroki K., Tsuchiya N., Tsao B.P., Grossman J.M., Fukazawa T., Hagiwara K., Kano H., Takazoe M., Iwata T., Hashimoto H., Tokunaga K.
    Genes Immun. 3:S21-S30(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-174.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-174.
    Tissue: Spleen.
  7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-174.
  8. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-174.
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: B-cell.
  11. "CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells."
    Roifman C.M., Ke S.
    Biochem. Biophys. Res. Commun. 194:222-225(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, INTERACTION WITH LYN.
  12. "Tyrosine phosphorylation of CD19 in pre-B and mature B cells."
    Chalupny N.J., Kanner S.B., Schieven G.L., Wee S., Gilliland L.K., Aruffo A., Ledbetter J.A.
    EMBO J. 12:2691-2696(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
  13. "Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines."
    Brooks S.R., Li X., Volanakis E.J., Carter R.H.
    J. Immunol. 164:3123-3131(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GRB2; SOS; VAV AND PLCG2, PHOSPHORYLATION AT TYR-348; TYR-378; TYR-409 AND TYR-439.
  14. Cited for: INVOLVEMENT IN CVID3.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.

Entry informationi

Entry nameiCD19_HUMAN
AccessioniPrimary (citable) accession number: P15391
Secondary accession number(s): A0N0P9
, F5H635, Q96S68, Q9BRD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 158 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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