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P15391

- CD19_HUMAN

UniProt

P15391 - CD19_HUMAN

Protein

B-lymphocyte antigen CD19

Gene

CD19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 159 (01 Oct 2014)
      Sequence version 6 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

    GO - Molecular functioni

    1. receptor signaling protein activity Source: ProtInc

    GO - Biological processi

    1. B cell receptor signaling pathway Source: Ensembl
    2. cell surface receptor signaling pathway Source: ProtInc
    3. cellular defense response Source: ProtInc
    4. epidermal growth factor receptor signaling pathway Source: Reactome
    5. Fc-epsilon receptor signaling pathway Source: Reactome
    6. fibroblast growth factor receptor signaling pathway Source: Reactome
    7. innate immune response Source: Reactome
    8. neurotrophin TRK receptor signaling pathway Source: Reactome
    9. phosphatidylinositol-mediated signaling Source: Reactome
    10. regulation of immune response Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_75829. PIP3 activates AKT signaling.
    SignaLinkiP15391.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B-lymphocyte antigen CD19
    Alternative name(s):
    B-lymphocyte surface antigen B4
    Differentiation antigen CD19
    T-cell surface antigen Leu-12
    CD_antigen: CD19
    Gene namesi
    Name:CD19
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:1633. CD19.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of plasma membrane Source: ProtInc
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Immunodeficiency, common variable, 3 (CVID3) [MIM:613493]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi613493. phenotype.
    Orphaneti1572. Common variable immunodeficiency.
    PharmGKBiPA26192.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 556537B-lymphocyte antigen CD19PRO_0000014648Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi38 ↔ 97PROSITE-ProRule annotation
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi200 ↔ 261PROSITE-ProRule annotation
    Modified residuei227 – 2271PhosphoserineBy similarity
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
    Modified residuei348 – 3481Phosphotyrosine1 Publication
    Modified residuei378 – 3781Phosphotyrosine1 Publication
    Modified residuei409 – 4091Phosphotyrosine1 Publication
    Modified residuei439 – 4391Phosphotyrosine1 Publication
    Modified residuei497 – 4971Phosphoserine

    Post-translational modificationi

    Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN.3 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP15391.
    PRIDEiP15391.

    PTM databases

    PhosphoSiteiP15391.

    Expressioni

    Gene expression databases

    ArrayExpressiP15391.
    BgeeiP15391.
    CleanExiHS_CD19.
    GenevestigatoriP15391.

    Organism-specific databases

    HPAiCAB016110.

    Interactioni

    Subunit structurei

    Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Interacts with LYN.2 Publications

    Protein-protein interaction databases

    BioGridi107368. 12 interactions.
    IntActiP15391. 7 interactions.
    MINTiMINT-1508267.
    STRINGi9606.ENSP00000313419.

    Structurei

    3D structure databases

    ProteinModelPortaliP15391.
    SMRiP15391. Positions 23-56, 186-262.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 291272ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini314 – 556243CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei292 – 31322HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 11394Ig-like C2-type 1Add
    BLAST
    Domaini176 – 277102Ig-like C2-type 2Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46561.
    HOGENOMiHOG000111478.
    HOVERGENiHBG003388.
    InParanoidiP15391.
    KOiK06465.
    OMAiSPHGSAW.
    OrthoDBiEOG74N5GS.
    PhylomeDBiP15391.
    TreeFamiTF338293.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P15391-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPPPRLLFFL LFLTPMEVRP EEPLVVKVEE GDNAVLQCLK GTSDGPTQQL    50
    TWSRESPLKP FLKLSLGLPG LGIHMRPLAI WLFIFNVSQQ MGGFYLCQPG 100
    PPSEKAWQPG WTVNVEGSGE LFRWNVSDLG GLGCGLKNRS SEGPSSPSGK 150
    LMSPKLYVWA KDRPEIWEGE PPCLPPRDSL NQSLSQDLTM APGSTLWLSC 200
    GVPPDSVSRG PLSWTHVHPK GPKSLLSLEL KDDRPARDMW VMETGLLLPR 250
    ATAQDAGKYY CHRGNLTMSF HLEITARPVL WHWLLRTGGW KVSAVTLAYL 300
    IFCLCSLVGI LHLQRALVLR RKRKRMTDPT RRFFKVTPPP GSGPQNQYGN 350
    VLSLPTPTSG LGRAQRWAAG LGGTAPSYGN PSSDVQADGA LGSRSPPGVG 400
    PEEEEGEGYE EPDSEEDSEF YENDSNLGQD QLSQDGSGYE NPEDEPLGPE 450
    DEDSFSNAES YENEDEELTQ PVARTMDFLS PHGSAWDPSR EATSLGSQSY 500
    EDMRGILYAA PQLRSIRGQP GPNHEEDADS YENMDNPDGP DPAWGGGGRM 550
    GTWSTR 556
    Length:556
    Mass (Da):61,128
    Last modified:November 13, 2007 - v6
    Checksum:iA0E08DD628B69E51
    GO
    Isoform 2 (identifier: P15391-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         495-495: L → LA

    Note: No experimental confirmation available.

    Show »
    Length:557
    Mass (Da):61,200
    Checksum:i49A39D679F6C6C9A
    GO

    Sequence cautioni

    The sequence AAA35533.1 differs from that shown. Reason: Frameshift at position 396.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291E → EG in AAB60697. (PubMed:1370948)Curated
    Sequence conflicti80 – 801I → S in AAA68490. (PubMed:2472450)Curated
    Sequence conflicti80 – 801I → S in AAA69966. (PubMed:1375324)Curated
    Sequence conflicti80 – 801I → S in AAB60697. (PubMed:1370948)Curated
    Sequence conflicti80 – 801I → S in BAB60954. (PubMed:12215898)Curated
    Sequence conflicti186 – 1861Q → QAFLVLSLPVP in AAA69966. (PubMed:1375324)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti174 – 1741L → V.8 Publications
    Corresponds to variant rs2904880 [ dbSNP | Ensembl ].
    VAR_026963
    Natural varianti514 – 5141R → H.2 Publications
    Corresponds to variant rs34763945 [ dbSNP | Ensembl ].
    VAR_036987

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei495 – 4951L → LA in isoform 2. 1 PublicationVSP_047194

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21097 mRNA. Translation: AAA35533.1. Frameshift.
    M28170 mRNA. Translation: AAA68490.1.
    M84371 Genomic DNA. Translation: AAA69966.1.
    M62550
    , M62544, M62545, M62546, M62547, M62548, M62549 Genomic DNA. Translation: AAB60697.1.
    AB052799 Genomic DNA. Translation: BAB60954.1.
    AK313577 mRNA. No translation available.
    EF064757 Genomic DNA. Translation: ABK41940.1.
    AC109460 Genomic DNA. No translation available.
    CH471267 Genomic DNA. Translation: EAW52012.1.
    BC006338 mRNA. Translation: AAH06338.1.
    CCDSiCCDS10644.1. [P15391-1]
    CCDS53998.1. [P15391-2]
    PIRiA44441.
    RefSeqiNP_001171569.1. NM_001178098.1. [P15391-2]
    NP_001761.3. NM_001770.5. [P15391-1]
    UniGeneiHs.652262.

    Genome annotation databases

    EnsembliENST00000324662; ENSP00000313419; ENSG00000177455. [P15391-1]
    ENST00000538922; ENSP00000437940; ENSG00000177455. [P15391-2]
    ENST00000567541; ENSP00000456201; ENSG00000177455. [P15391-2]
    GeneIDi930.
    KEGGihsa:930.
    UCSCiuc002drs.3. human. [P15391-1]

    Polymorphism databases

    DMDMi160332376.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    CD19base

    CD19 mutation db

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21097 mRNA. Translation: AAA35533.1 . Frameshift.
    M28170 mRNA. Translation: AAA68490.1 .
    M84371 Genomic DNA. Translation: AAA69966.1 .
    M62550
    , M62544 , M62545 , M62546 , M62547 , M62548 , M62549 Genomic DNA. Translation: AAB60697.1 .
    AB052799 Genomic DNA. Translation: BAB60954.1 .
    AK313577 mRNA. No translation available.
    EF064757 Genomic DNA. Translation: ABK41940.1 .
    AC109460 Genomic DNA. No translation available.
    CH471267 Genomic DNA. Translation: EAW52012.1 .
    BC006338 mRNA. Translation: AAH06338.1 .
    CCDSi CCDS10644.1. [P15391-1 ]
    CCDS53998.1. [P15391-2 ]
    PIRi A44441.
    RefSeqi NP_001171569.1. NM_001178098.1. [P15391-2 ]
    NP_001761.3. NM_001770.5. [P15391-1 ]
    UniGenei Hs.652262.

    3D structure databases

    ProteinModelPortali P15391.
    SMRi P15391. Positions 23-56, 186-262.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107368. 12 interactions.
    IntActi P15391. 7 interactions.
    MINTi MINT-1508267.
    STRINGi 9606.ENSP00000313419.

    PTM databases

    PhosphoSitei P15391.

    Polymorphism databases

    DMDMi 160332376.

    Proteomic databases

    PaxDbi P15391.
    PRIDEi P15391.

    Protocols and materials databases

    DNASUi 930.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324662 ; ENSP00000313419 ; ENSG00000177455 . [P15391-1 ]
    ENST00000538922 ; ENSP00000437940 ; ENSG00000177455 . [P15391-2 ]
    ENST00000567541 ; ENSP00000456201 ; ENSG00000177455 . [P15391-2 ]
    GeneIDi 930.
    KEGGi hsa:930.
    UCSCi uc002drs.3. human. [P15391-1 ]

    Organism-specific databases

    CTDi 930.
    GeneCardsi GC16P028943.
    GeneReviewsi CD19.
    HGNCi HGNC:1633. CD19.
    HPAi CAB016110.
    MIMi 107265. gene.
    613493. phenotype.
    neXtProti NX_P15391.
    Orphaneti 1572. Common variable immunodeficiency.
    PharmGKBi PA26192.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46561.
    HOGENOMi HOG000111478.
    HOVERGENi HBG003388.
    InParanoidi P15391.
    KOi K06465.
    OMAi SPHGSAW.
    OrthoDBi EOG74N5GS.
    PhylomeDBi P15391.
    TreeFami TF338293.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_75829. PIP3 activates AKT signaling.
    SignaLinki P15391.

    Miscellaneous databases

    GeneWikii CD19.
    GenomeRNAii 930.
    NextBioi 3856.
    PROi P15391.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P15391.
    Bgeei P15391.
    CleanExi HS_CD19.
    Genevestigatori P15391.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail."
      Stamenkovic I., Seed B.
      J. Exp. Med. 168:1205-1210(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-174 AND HIS-514.
    2. "Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily."
      Tedder T.F., Isaacs C.M.
      J. Immunol. 143:712-717(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-174 AND HIS-514.
      Tissue: Tonsil.
    3. "The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP."
      Kozmik Z., Wang S., Doerfler P., Adams B., Busslinger M.
      Mol. Cell. Biol. 12:2662-2672(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-174.
    4. "Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes."
      Zhou L.J., Ord D.C., Omori S.A., Tedder T.F.
      Immunogenetics 35:102-111(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-174.
      Tissue: Blood.
    5. "Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese."
      Kuroki K., Tsuchiya N., Tsao B.P., Grossman J.M., Fukazawa T., Hagiwara K., Kano H., Takazoe M., Iwata T., Hashimoto H., Tokunaga K.
      Genes Immun. 3:S21-S30(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-174.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-174.
      Tissue: Spleen.
    7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-174.
    8. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-174.
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: B-cell.
    11. "CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells."
      Roifman C.M., Ke S.
      Biochem. Biophys. Res. Commun. 194:222-225(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, INTERACTION WITH LYN.
    12. "Tyrosine phosphorylation of CD19 in pre-B and mature B cells."
      Chalupny N.J., Kanner S.B., Schieven G.L., Wee S., Gilliland L.K., Aruffo A., Ledbetter J.A.
      EMBO J. 12:2691-2696(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.
    13. "Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines."
      Brooks S.R., Li X., Volanakis E.J., Carter R.H.
      J. Immunol. 164:3123-3131(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GRB2; SOS; VAV AND PLCG2, PHOSPHORYLATION AT TYR-348; TYR-378; TYR-409 AND TYR-439.
    14. Cited for: INVOLVEMENT IN CVID3.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.

    Entry informationi

    Entry nameiCD19_HUMAN
    AccessioniPrimary (citable) accession number: P15391
    Secondary accession number(s): A0N0P9
    , F5H635, Q96S68, Q9BRD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 159 of the entry and version 6 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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