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P15389

- SCN5A_RAT

UniProt

P15389 - SCN5A_RAT

Protein

Sodium channel protein type 5 subunit alpha

Gene

Scn5a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. Channel inactivation is regulated by intracellular calcium levels By similarity.By similarity

    GO - Molecular functioni

    1. ankyrin binding Source: BHF-UCL
    2. fibroblast growth factor binding Source: RGD
    3. protein binding Source: BHF-UCL
    4. voltage-gated sodium channel activity Source: UniProtKB

    GO - Biological processi

    1. brainstem development Source: RGD
    2. cellular response to calcium ion Source: UniProtKB
    3. cerebellum development Source: RGD
    4. membrane depolarization during action potential Source: RefGenome
    5. neuronal action potential Source: RefGenome
    6. odontogenesis of dentin-containing tooth Source: RGD
    7. positive regulation of action potential Source: RGD
    8. positive regulation of epithelial cell proliferation Source: RGD
    9. positive regulation of heart rate Source: RGD
    10. response to denervation involved in regulation of muscle adaptation Source: RGD
    11. sodium ion transmembrane transport Source: RGD
    12. sodium ion transport Source: UniProtKB
    13. telencephalon development Source: RGD

    Keywords - Molecular functioni

    Ion channel, Sodium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Calmodulin-binding, Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium channel protein type 5 subunit alpha
    Alternative name(s):
    Sodium channel protein cardiac muscle subunit alpha
    Sodium channel protein type V subunit alpha
    Voltage-gated sodium channel subunit alpha Nav1.5
    Gene namesi
    Name:Scn5a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3637. Scn5a.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. intercalated disc Source: BHF-UCL
    3. T-tubule Source: BHF-UCL
    4. voltage-gated sodium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20192019Sodium channel protein type 5 subunit alphaPRO_0000048498Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371PhosphoserineBy similarity
    Modified residuei39 – 391PhosphothreonineBy similarity
    Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi319 – 3191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
    Modified residuei458 – 4581PhosphoserineBy similarity
    Modified residuei461 – 4611PhosphoserineBy similarity
    Modified residuei484 – 4841PhosphoserineBy similarity
    Modified residuei485 – 4851PhosphoserineBy similarity
    Modified residuei498 – 4981PhosphoserineBy similarity
    Modified residuei511 – 5111PhosphoserineBy similarity
    Modified residuei527 – 5271Dimethylated arginine; alternateBy similarity
    Modified residuei527 – 5271Omega-N-methylarginine; alternateBy similarity
    Modified residuei572 – 5721PhosphoserineBy similarity
    Modified residuei665 – 6651PhosphoserineBy similarity
    Modified residuei668 – 6681PhosphoserineBy similarity
    Glycosylationi741 – 7411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi804 – 8041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi865 – 8651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1367 – 13671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1376 – 13761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1382 – 13821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1390 – 13901N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1505 – 15051Phosphoserine; by PKCBy similarity

    Post-translational modificationi

    Regulated through phosphorylation by CaMK2D.By similarity
    Ubiquitinated by NEDD4L; which promotes its endocytosis.By similarity
    Phosphorylation at Ser-1505 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.By similarity

    Keywords - PTMi

    Glycoprotein, Methylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP15389.
    PRIDEiP15389.

    PTM databases

    PhosphoSiteiP15389.

    Expressioni

    Tissue specificityi

    Strongly expressed in the heart. Also expressed in adult and fetal brain, spinal cord, testis, and at moderate levels in kidney, adrenal gland, lung, skeletal muscle, spleen, stomach and bladder. Isoform 2 is expressed in brain.2 Publications

    Gene expression databases

    GenevestigatoriP15389.

    Interactioni

    Subunit structurei

    Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2. Interacts with NEDD4, NEDD4L, WWP2 and GPD1L. Interacts with CALM. Interacts with FGF13; the interaction is direct and may regulate SNC5A density at membranes and function By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-60063N.

    Structurei

    3D structure databases

    ProteinModelPortaliP15389.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 127127CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini152 – 1598ExtracellularSequence Analysis
    Topological domaini180 – 19213CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini212 – 2176ExtracellularSequence Analysis
    Topological domaini238 – 25316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini278 – 390113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini417 – 712296CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini738 – 74811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini773 – 7808CytoplasmicSequence Analysis
    Topological domaini801 – 8066ExtracellularSequence Analysis
    Topological domaini827 – 84216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini864 – 91653ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini943 – 1202260CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1227 – 123913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1266 – 12716CytoplasmicSequence Analysis
    Topological domaini1294 – 12974ExtracellularSequence Analysis
    Topological domaini1320 – 133819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1362 – 144584ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1473 – 152553CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1550 – 156011ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1585 – 15906CytoplasmicSequence Analysis
    Topological domaini1615 – 162410ExtracellularSequence Analysis
    Topological domaini1647 – 166115CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1685 – 174965ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1775 – 2019245CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei128 – 15124Helical; Name=S1 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei160 – 17920Helical; Name=S2 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei193 – 21119Helical; Name=S3 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei218 – 23720Helical; Voltage-sensor; Name=S4 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei254 – 27724Helical; Name=S5 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei391 – 41626Helical; Name=S6 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei713 – 73725Helical; Name=S1 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei749 – 77224Helical; Name=S2 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei781 – 80020Helical; Name=S3 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei807 – 82620Helical; Voltage-sensor; Name=S4 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei843 – 86321Helical; Name=S5 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei917 – 94226Helical; Name=S6 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei1203 – 122624Helical; Name=S1 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1240 – 126526Helical; Name=S2 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1272 – 129322Helical; Name=S3 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1298 – 131922Helical; Voltage-sensor; Name=S4 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1339 – 136123Helical; Name=S5 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1446 – 147227Helical; Name=S6 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1526 – 154924Helical; Name=S1 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1561 – 158424Helical; Name=S2 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1591 – 161424Helical; Name=S3 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1625 – 164622Helical; Voltage-sensor; Name=S4 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1662 – 168423Helical; Name=S5 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1750 – 177425Helical; Name=S6 of repeat IVSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1903 – 193230IQAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1841 – 190363Interaction with FGF13By similarityAdd
    BLAST
    Regioni1977 – 19804Interaction with NEDD4, NEDD4L and WWP2By similarity

    Domaini

    The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
    The IQ domain mediates association with calmodulin.By similarity

    Sequence similaritiesi

    Contains 1 IQ domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231755.
    HOVERGENiHBG053100.
    KOiK04838.
    PhylomeDBiP15389.

    Family and domain databases

    Gene3Di1.20.120.350. 4 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR008053. Na_channel_a5su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view]
    PfamiPF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view]
    PRINTSiPR00170. NACHANNEL.
    PR01666. NACHANNEL5.
    SMARTiSM00015. IQ. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P15389-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MANLLLPRGT SSFRRFTRES LAAIEKRMAE KQARGGSATS QESREGLQEE     50
    EAPRPQLDLQ ASKKLPDLYG NPPRELIGEP LEDLDPFYST QKTFIVLNKG 100
    KTIFRFSATN ALYVLSPFHP VRRAAVKILV HSLFSMLIMC TILTNCVFMA 150
    QHDPPPWTKY VEYTFTAIYT FESLVKILAR GFCLHAFTFL RDPWNWLDFS 200
    VIVMAYTTEF VDLGNVSALR TFRVLRALKT ISVISGLKTI VGALIQSVKK 250
    LADVMVLTVF CLSVFALIGL QLFMGNLRHK CVRNFTELNG TNGSVEADGL 300
    VWNSLDVYLN DPANYLLKNG TTDVLLCGNS SDAGTCPEGY RCLKAGENPD 350
    HGYTSFDSFA WAFLALFRLM TQDCWERLYQ QTLRSAGKIY MIFFMLVIFL 400
    GSFYLVNLIL AVVAMAYEEQ NQATIAETEE KEKRFQEAME MLKKEHEALT 450
    IRGVDTVSRS SLEMSPLAPV TNHERKSKRR KRLSSGTEDG GDDRLPKSDS 500
    EDGPRALNQL SLTHGLSRTS MRPRSSRGSI FTFRRRDQGS EADFADDENS 550
    TAGESESHRT SLLVPWPLRH PSAQGQPGPG ASAPGYVLNG KRNSTVDCNG 600
    VVSLLGAGDA EATSPGSYLL RPMVLDRPPD TTTPSEEPGG PQMLTPQAPC 650
    ADGFEEPGAR QRALSAVSVL TSALEELEES HRKCPPCWNR FAQHYLIWEC 700
    CPLWMSIKQK VKFVVMDPFA DLTITMCIVL NTLFMALEHY NMTAEFEEML 750
    QVGNLVFTGI FTAEMTFKII ALDPYYYFQQ GWNIFDSIIV ILSLMELGLS 800
    RMGNLSVLRS FRLLRVFKLA KSWPTLNTLI KIIGNSVGAL GNLTLVLAII 850
    VFIFAVVGMQ LFGKNYSELR HRISDSGLLP RWHMMDFFHA FLIIFRILCG 900
    EWIETMWDCM EVSGQSLCLL VFLLVMVIGN LVVLNLFLAL LLSSFSADNL 950
    TAPDEDGEMN NLQLALARIQ RGLRFVKRTT WDFCCGILRR RPKKPAALAT 1000
    HSQLPSCITA PRSPPPPEVE KVPPARKETR FEEDKRPGQG TPGDSEPVCV 1050
    PIAVAESDTE DQEEDEENSL GTEEESSKQE SQVVSGGHEP YQEPRAWSQV 1100
    SETTSSEAGA STSQADWQQE QKTEPQAPGC GETPEDSYSE GSTADMTNTA 1150
    DLLEQIPDLG EDVKDPEDCF TEGCVRRCPC CMVDTTQSPG KVWWRLRKTC 1200
    YRIVEHSWFE TFIIFMILLS SGALAFEDIY LEERKTIKVL LEYADKMFTY 1250
    VFVLEMLLKW VAYGFKKYFT NAWCWLDFLI VDVSLVSLVA NTLGFAEMGP 1300
    IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF 1350
    SIMGVNLFAG KFGRCINQTE GDLPLNYTIV NNKSECESFN VTGELYWTKV 1400
    KVNFDNVGAG YLALLQVATF KGWMDIMYAA VDSRGYEEQP QWEDNLYMYI 1450
    YFVVFIIFGS FFTLNLFIGV IIDNFNQQKK KLGGQDIFMT EEQKKYYNAM 1500
    KKLGSKKPQK PIPRPLNKYQ GFIFDIVTKQ AFDVTIMFLI CLNMVTMMVE 1550
    TDDQSPEKVN ILAKINLLFV AIFTGECIVK MAALRHYYFT NSWNIFDFVV 1600
    VILSIVGTVL SDIIQKYFFS PTLFRVIRLA RIGRILRLIR GAKGIRTLLF 1650
    ALMMSLPALF NIGLLLFLVM FIYSIFGMAN FAYVKWEAGI DDMFNFQTFA 1700
    NSMLCLFQIT TSAGWDGLLS PILNTGPPYC DPNLPNSNGS RGNCGSPAVG 1750
    ILFFTTYIII SFLIVVNMYI AIILENFSVA TEESTEPLSE DDFDMFYEIW 1800
    EKFDPEATQF IEYLALSDFA DALSEPLRIA KPNQISLINM DLPMVSGDRI 1850
    HCMDILFAFT KRVLGESGEM DALKIQMEEK FMAANPSKIS YEPITTTLRR 1900
    KHEEVSATVI QRAFRRHLLQ RSVKHASFLF RQQAGGSGLS DEDAPEREGL 1950
    IAYMMNGNFS RRSAPLSSSS ISSTSFPPSY DSVTRATSDN LPVRASDYSR 2000
    SEDLADFPPS PDRDRESIV 2019
    Length:2,019
    Mass (Da):227,367
    Last modified:April 1, 1990 - v1
    Checksum:iCFC3B03CEAE708AD
    GO
    Isoform 2 (identifier: P15389-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1080-1132: Missing.

    Show »
    Length:1,966
    Mass (Da):221,706
    Checksum:iE4AC1FB7CF825647
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1080 – 113253Missing in isoform 2. 1 PublicationVSP_037482Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27902 mRNA. Translation: AAA42114.1.
    AF353637 mRNA. Translation: AAK38884.1.
    PIRiA33996.
    RefSeqiNP_001153634.1. NM_001160162.1. [P15389-2]
    NP_037257.1. NM_013125.2. [P15389-1]
    UniGeneiRn.32074.

    Genome annotation databases

    GeneIDi25665.
    KEGGirno:25665.
    UCSCiRGD:3637. rat. [P15389-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27902 mRNA. Translation: AAA42114.1 .
    AF353637 mRNA. Translation: AAK38884.1 .
    PIRi A33996.
    RefSeqi NP_001153634.1. NM_001160162.1. [P15389-2 ]
    NP_037257.1. NM_013125.2. [P15389-1 ]
    UniGenei Rn.32074.

    3D structure databases

    ProteinModelPortali P15389.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60063N.

    Chemistry

    BindingDBi P15389.
    ChEMBLi CHEMBL3866.
    GuidetoPHARMACOLOGYi 582.

    PTM databases

    PhosphoSitei P15389.

    Proteomic databases

    PaxDbi P15389.
    PRIDEi P15389.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25665.
    KEGGi rno:25665.
    UCSCi RGD:3637. rat. [P15389-1 ]

    Organism-specific databases

    CTDi 6331.
    RGDi 3637. Scn5a.

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231755.
    HOVERGENi HBG053100.
    KOi K04838.
    PhylomeDBi P15389.

    Miscellaneous databases

    NextBioi 607581.
    PROi P15389.

    Gene expression databases

    Genevestigatori P15389.

    Family and domain databases

    Gene3Di 1.20.120.350. 4 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR008053. Na_channel_a5su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view ]
    Pfami PF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view ]
    PRINTSi PR00170. NACHANNEL.
    PR01666. NACHANNEL5.
    SMARTi SM00015. IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a putative tetrodotoxin-resistant rat heart Na+ channel isoform."
      Rogart R.B., Cribbs L.L., Muglia L.K., Kephart D.D., Kaiser M.W.
      Proc. Natl. Acad. Sci. U.S.A. 86:8170-8174(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Heart.
    2. "Characterisation of the novel voltage-gated Na+ channel rNav1.5a isolated from the rat hippocampal progenitor stem cell line HiB5."
      Korsgaard M.P.G., Christophersen P., Ahring P.K., Olesen S.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: Sprague-Dawley.
    3. "New variants of Nav1.5/SCN5A encode Na+ channels in the brain."
      Wang J., Ou S.-W., Wang Y.-J., Zong Z.-H., Lin L., Kameyama M., Kameyama A.
      J. Neurogenet. 22:57-75(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    4. "Analysis of four novel variants of Nav1.5/SCN5A cloned from the brain."
      Wang J., Ou S.-W., Wang Y.-J., Kameyama M., Kameyama A., Zong Z.-H.
      Neurosci. Res. 64:339-347(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSCN5A_RAT
    AccessioniPrimary (citable) accession number: P15389
    Secondary accession number(s): Q925G6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Na+ channels in mammalian cardiac membrane have functional properties quite distinct from Na+ channels in nerve and skeletal muscle.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3