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P15388

- KCNC1_MOUSE

UniProt

P15388 - KCNC1_MOUSE

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Protein

Potassium voltage-gated channel subfamily C member 1

Gene

Kcnc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome
  2. kinesin binding Source: MGI

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily C member 1
Alternative name(s):
NGK2
Voltage-gated potassium channel subunit Kv3.1
Voltage-gated potassium channel subunit Kv4
Gene namesi
Name:Kcnc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:96667. Kcnc1.

Subcellular locationi

GO - Cellular componenti

  1. axolemma Source: MGI
  2. dendrite membrane Source: MGI
  3. neuronal cell body membrane Source: MGI
  4. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Potassium voltage-gated channel subfamily C member 1PRO_0000054052Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP15388.
PRIDEiP15388.

PTM databases

PhosphoSiteiP15388.

Expressioni

Gene expression databases

BgeeiP15388.
ExpressionAtlasiP15388. baseline and differential.
GenevestigatoriP15388.

Interactioni

Subunit structurei

Heteromultimer with KCNG3, KCNG4 and KCNV2.By similarity

Protein-protein interaction databases

BioGridi200887. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP15388.
SMRiP15388. Positions 7-443.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 190190CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini268 – 2769CytoplasmicSequence Analysis
Topological domaini332 – 34413CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini437 – 51175CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei191 – 20919Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei248 – 26720Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei277 – 29519Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei309 – 33123Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei345 – 36622Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei415 – 43622Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi400 – 4056Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280627.
HOGENOMiHOG000231012.
HOVERGENiHBG105862.
InParanoidiP15388.
KOiK04887.
PhylomeDBiP15388.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005403. K_chnl_volt-dep_Kv3.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01581. KV31CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform KV3.1 (identifier: P15388-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQGDESERI VINVGGTRHQ TYRSTLRTLP GTRLAWLAEP DAHSHFDYDP
60 70 80 90 100
RADEFFFDRH PGVFAHILNY YRTGKLHCPA DVCGPLYEEE LAFWGIDETD
110 120 130 140 150
VEPCCWMTYR QHRDAEEALD SFGGAPLDNS ADDADADGPG DSGDGEDELE
160 170 180 190 200
MTKRLALSDS PDGRPGGFWR RWQPRIWALF EDPYSSRYAR YVAFASLFFI
210 220 230 240 250
LVSITTFCLE THERFNPIVN KTEIENVRNG TQVRYYREAE TEAFLTYIEG
260 270 280 290 300
VCVVWFTFEF LMRVVFCPNK VEFIKNSLNI IDFVAILPFY LEVGLSGLSS
310 320 330 340 350
KAAKDVLGFL RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII
360 370 380 390 400
FLALGVLIFA TMIYYAERIG AQPNDPSASE HTHFKNIPIG FWWAVVTMTT
410 420 430 440 450
LGYGDMYPQT WSGMLVGALC ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ
460 470 480 490 500
KLPKKKKKHI PRPPQLGSPN YCKSVVNSPH HSTQSDTCPL AQEEILEINR
510
AGRKPLRGMS I
Length:511
Mass (Da):57,928
Last modified:April 1, 1990 - v1
Checksum:i50A939E8F7120F37
GO
Isoform KV4 (identifier: P15388-2)

Sequence is not available
Length:
Mass (Da):

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07521 mRNA. Translation: CAA68814.1.
CCDSiCCDS21278.1. [P15388-1]
PIRiS07095.
RefSeqiNP_032447.1. NM_008421.3. [P15388-1]
UniGeneiMm.249386.

Genome annotation databases

EnsembliENSMUST00000025202; ENSMUSP00000025202; ENSMUSG00000058975. [P15388-1]
GeneIDi16502.
KEGGimmu:16502.
UCSCiuc009gyo.2. mouse. [P15388-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07521 mRNA. Translation: CAA68814.1 .
CCDSi CCDS21278.1. [P15388-1 ]
PIRi S07095.
RefSeqi NP_032447.1. NM_008421.3. [P15388-1 ]
UniGenei Mm.249386.

3D structure databases

ProteinModelPortali P15388.
SMRi P15388. Positions 7-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200887. 2 interactions.

Chemistry

GuidetoPHARMACOLOGYi 548.

PTM databases

PhosphoSitei P15388.

Proteomic databases

PaxDbi P15388.
PRIDEi P15388.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025202 ; ENSMUSP00000025202 ; ENSMUSG00000058975 . [P15388-1 ]
GeneIDi 16502.
KEGGi mmu:16502.
UCSCi uc009gyo.2. mouse. [P15388-1 ]

Organism-specific databases

CTDi 3746.
MGIi MGI:96667. Kcnc1.

Phylogenomic databases

eggNOGi NOG280627.
HOGENOMi HOG000231012.
HOVERGENi HBG105862.
InParanoidi P15388.
KOi K04887.
PhylomeDBi P15388.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 289827.
PROi P15388.
SOURCEi Search...

Gene expression databases

Bgeei P15388.
ExpressionAtlasi P15388. baseline and differential.
Genevestigatori P15388.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005403. K_chnl_volt-dep_Kv3.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01581. KV31CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs."
    Yokoyama S., Imoto K., Kawamura T., Higashida H., Iwabe N., Miyata T., Numa S.
    FEBS Lett. 259:37-42(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiKCNC1_MOUSE
AccessioniPrimary (citable) accession number: P15388
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 29, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3