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P15388

- KCNC1_MOUSE

UniProt

P15388 - KCNC1_MOUSE

Protein

Potassium voltage-gated channel subfamily C member 1

Gene

Kcnc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome
    2. kinesin binding Source: MGI

    GO - Biological processi

    1. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199077. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily C member 1
    Alternative name(s):
    NGK2
    Voltage-gated potassium channel subunit Kv3.1
    Voltage-gated potassium channel subunit Kv4
    Gene namesi
    Name:Kcnc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:96667. Kcnc1.

    Subcellular locationi

    GO - Cellular componenti

    1. axolemma Source: MGI
    2. dendrite membrane Source: MGI
    3. neuronal cell body membrane Source: MGI
    4. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 511511Potassium voltage-gated channel subfamily C member 1PRO_0000054052Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP15388.
    PRIDEiP15388.

    PTM databases

    PhosphoSiteiP15388.

    Expressioni

    Gene expression databases

    ArrayExpressiP15388.
    BgeeiP15388.
    GenevestigatoriP15388.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNG3, KCNG4 and KCNV2.By similarity

    Protein-protein interaction databases

    BioGridi200887. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP15388.
    SMRiP15388. Positions 7-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 190190CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini268 – 2769CytoplasmicSequence Analysis
    Topological domaini332 – 34413CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini437 – 51175CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei191 – 20919Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26720Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29519Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei309 – 33123Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei345 – 36622Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei415 – 43622Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi400 – 4056Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG280627.
    HOGENOMiHOG000231012.
    HOVERGENiHBG105862.
    InParanoidiP15388.
    KOiK04887.
    PhylomeDBiP15388.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003974. K_chnl_volt-dep_Kv3.
    IPR005403. K_chnl_volt-dep_Kv3.1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01581. KV31CHANNEL.
    PR01491. KVCHANNEL.
    PR01498. SHAWCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform KV3.1 (identifier: P15388-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGQGDESERI VINVGGTRHQ TYRSTLRTLP GTRLAWLAEP DAHSHFDYDP    50
    RADEFFFDRH PGVFAHILNY YRTGKLHCPA DVCGPLYEEE LAFWGIDETD 100
    VEPCCWMTYR QHRDAEEALD SFGGAPLDNS ADDADADGPG DSGDGEDELE 150
    MTKRLALSDS PDGRPGGFWR RWQPRIWALF EDPYSSRYAR YVAFASLFFI 200
    LVSITTFCLE THERFNPIVN KTEIENVRNG TQVRYYREAE TEAFLTYIEG 250
    VCVVWFTFEF LMRVVFCPNK VEFIKNSLNI IDFVAILPFY LEVGLSGLSS 300
    KAAKDVLGFL RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII 350
    FLALGVLIFA TMIYYAERIG AQPNDPSASE HTHFKNIPIG FWWAVVTMTT 400
    LGYGDMYPQT WSGMLVGALC ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ 450
    KLPKKKKKHI PRPPQLGSPN YCKSVVNSPH HSTQSDTCPL AQEEILEINR 500
    AGRKPLRGMS I 511
    Length:511
    Mass (Da):57,928
    Last modified:April 1, 1990 - v1
    Checksum:i50A939E8F7120F37
    GO
    Isoform KV4 (identifier: P15388-2)

    Sequence is not available
    Length:
    Mass (Da):

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07521 mRNA. Translation: CAA68814.1.
    CCDSiCCDS21278.1. [P15388-1]
    PIRiS07095.
    RefSeqiNP_032447.1. NM_008421.3. [P15388-1]
    UniGeneiMm.249386.

    Genome annotation databases

    EnsembliENSMUST00000025202; ENSMUSP00000025202; ENSMUSG00000058975. [P15388-1]
    GeneIDi16502.
    KEGGimmu:16502.
    UCSCiuc009gyo.2. mouse. [P15388-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07521 mRNA. Translation: CAA68814.1 .
    CCDSi CCDS21278.1. [P15388-1 ]
    PIRi S07095.
    RefSeqi NP_032447.1. NM_008421.3. [P15388-1 ]
    UniGenei Mm.249386.

    3D structure databases

    ProteinModelPortali P15388.
    SMRi P15388. Positions 7-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200887. 2 interactions.

    Chemistry

    GuidetoPHARMACOLOGYi 548.

    PTM databases

    PhosphoSitei P15388.

    Proteomic databases

    PaxDbi P15388.
    PRIDEi P15388.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025202 ; ENSMUSP00000025202 ; ENSMUSG00000058975 . [P15388-1 ]
    GeneIDi 16502.
    KEGGi mmu:16502.
    UCSCi uc009gyo.2. mouse. [P15388-1 ]

    Organism-specific databases

    CTDi 3746.
    MGIi MGI:96667. Kcnc1.

    Phylogenomic databases

    eggNOGi NOG280627.
    HOGENOMi HOG000231012.
    HOVERGENi HBG105862.
    InParanoidi P15388.
    KOi K04887.
    PhylomeDBi P15388.

    Enzyme and pathway databases

    Reactomei REACT_199077. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 289827.
    PROi P15388.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P15388.
    Bgeei P15388.
    Genevestigatori P15388.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003974. K_chnl_volt-dep_Kv3.
    IPR005403. K_chnl_volt-dep_Kv3.1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01581. KV31CHANNEL.
    PR01491. KVCHANNEL.
    PR01498. SHAWCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs."
      Yokoyama S., Imoto K., Kawamura T., Higashida H., Iwabe N., Miyata T., Numa S.
      FEBS Lett. 259:37-42(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiKCNC1_MOUSE
    AccessioniPrimary (citable) accession number: P15388
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3