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P15388 (KCNC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily C member 1
Alternative name(s):
NGK2
Voltage-gated potassium channel subunit Kv3.1
Voltage-gated potassium channel subunit Kv4
Gene names
Name:Kcnc1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit structure

Heteromultimer with KCNG3, KCNG4 and KCNV2 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similarities

Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily. [View classification]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Select]
Isoform KV3.1 (identifier: P15388-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform KV4 (identifier: P15388-2)

The sequence of this isoform is not available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 511511Potassium voltage-gated channel subfamily C member 1
PRO_0000054052

Regions

Topological domain1 – 190190Cytoplasmic Potential
Transmembrane191 – 20919Helical; Name=Segment S1; Potential
Transmembrane248 – 26720Helical; Name=Segment S2; Potential
Topological domain268 – 2769Cytoplasmic Potential
Transmembrane277 – 29519Helical; Name=Segment S3; Potential
Transmembrane309 – 33123Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain332 – 34413Cytoplasmic Potential
Transmembrane345 – 36622Helical; Name=Segment S5; Potential
Transmembrane415 – 43622Helical; Name=Segment S6; Potential
Topological domain437 – 51175Cytoplasmic Potential
Motif400 – 4056Selectivity filter By similarity

Amino acid modifications

Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Isoform KV3.1 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 50A939E8F7120F37

FASTA51157,928
        10         20         30         40         50         60 
MGQGDESERI VINVGGTRHQ TYRSTLRTLP GTRLAWLAEP DAHSHFDYDP RADEFFFDRH 

        70         80         90        100        110        120 
PGVFAHILNY YRTGKLHCPA DVCGPLYEEE LAFWGIDETD VEPCCWMTYR QHRDAEEALD 

       130        140        150        160        170        180 
SFGGAPLDNS ADDADADGPG DSGDGEDELE MTKRLALSDS PDGRPGGFWR RWQPRIWALF 

       190        200        210        220        230        240 
EDPYSSRYAR YVAFASLFFI LVSITTFCLE THERFNPIVN KTEIENVRNG TQVRYYREAE 

       250        260        270        280        290        300 
TEAFLTYIEG VCVVWFTFEF LMRVVFCPNK VEFIKNSLNI IDFVAILPFY LEVGLSGLSS 

       310        320        330        340        350        360 
KAAKDVLGFL RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII FLALGVLIFA 

       370        380        390        400        410        420 
TMIYYAERIG AQPNDPSASE HTHFKNIPIG FWWAVVTMTT LGYGDMYPQT WSGMLVGALC 

       430        440        450        460        470        480 
ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ KLPKKKKKHI PRPPQLGSPN YCKSVVNSPH 

       490        500        510 
HSTQSDTCPL AQEEILEINR AGRKPLRGMS I 

« Hide

Isoform KV4 (Sequence not available).

References

[1]"Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs."
Yokoyama S., Imoto K., Kawamura T., Higashida H., Iwabe N., Miyata T., Numa S.
FEBS Lett. 259:37-42(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y07521 mRNA. Translation: CAA68814.1.
PIRS07095.
RefSeqNP_032447.1. NM_008421.3.
UniGeneMm.249386.

3D structure databases

ProteinModelPortalP15388.
SMRP15388. Positions 7-443.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200887. 2 interactions.

Chemistry

GuidetoPHARMACOLOGY548.

PTM databases

PhosphoSiteP15388.

Proteomic databases

PaxDbP15388.
PRIDEP15388.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025202; ENSMUSP00000025202; ENSMUSG00000058975. [P15388-1]
GeneID16502.
KEGGmmu:16502.
UCSCuc009gyo.2. mouse. [P15388-1]

Organism-specific databases

CTD3746.
MGIMGI:96667. Kcnc1.

Phylogenomic databases

eggNOGNOG280627.
HOGENOMHOG000231012.
HOVERGENHBG105862.
InParanoidP15388.
KOK04887.
PhylomeDBP15388.

Gene expression databases

ArrayExpressP15388.
BgeeP15388.
GenevestigatorP15388.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005403. K_chnl_volt-dep_Kv3.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01581. KV31CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

NextBio289827.
PROP15388.
SOURCESearch...

Entry information

Entry nameKCNC1_MOUSE
AccessionPrimary (citable) accession number: P15388
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 16, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot