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P15379

- CD44_MOUSE

UniProt

P15379 - CD44_MOUSE

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Protein
CD44 antigen
Gene
Cd44, Ly-24
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431Hyaluronan
Binding sitei80 – 801Hyaluronan
Binding sitei81 – 811Hyaluronan
Binding sitei107 – 1071Hyaluronan

GO - Molecular functioni

  1. hyaluronic acid binding Source: MGI
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. Wnt signaling pathway Source: MGI
  2. branching involved in prostate gland morphogenesis Source: MGI
  3. branching involved in ureteric bud morphogenesis Source: MGI
  4. cell adhesion Source: MGI
  5. negative regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
  6. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: BHF-UCL
  7. negative regulation of mature B cell apoptotic process Source: BHF-UCL
  8. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  9. positive regulation of adaptive immune response Source: BHF-UCL
  10. positive regulation of gene expression Source: MGI
  11. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  12. positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  13. wound healing involved in inflammatory response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
CD44 antigen
Alternative name(s):
Extracellular matrix receptor III
Short name:
ECMR-III
GP90 lymphocyte homing/adhesion receptor
HUTCH-I
Hermes antigen
Hyaluronate receptor
Lymphocyte antigen 24
Short name:
Ly-24
Phagocytic glycoprotein 1
Short name:
PGP-1
Phagocytic glycoprotein I
Short name:
PGP-I
CD_antigen: CD44
Gene namesi
Name:Cd44
Synonyms:Ly-24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:88338. Cd44.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein
Note: Colocalizes with actin in membrane protrusions at wounding edges.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 685663Extracellular Reviewed prediction
Add
BLAST
Transmembranei686 – 70621Helical; Reviewed prediction
Add
BLAST
Topological domaini707 – 77872Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: MGI
  2. cell surface Source: MGI
  3. external side of plasma membrane Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
  5. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 By similarity
Add
BLAST
Chaini23 – 778756CD44 antigen
PRO_0000026689Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi30 ↔ 1321 Publication
Disulfide bondi55 ↔ 1211 Publication
Glycosylationi59 – 591N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi79 ↔ 991 Publication
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi113 – 1131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi123 – 1231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi368 – 3681N-linked (GlcNAc...) Reviewed prediction
Modified residuei410 – 4101Sulfotyrosine By similarity
Glycosylationi425 – 4251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi529 – 5291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi545 – 5451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi603 – 6031N-linked (GlcNAc...) Reviewed prediction
Modified residuei708 – 7081Phosphoserine; by PKC By similarity
Modified residuei726 – 7261Phosphothreonine1 Publication
Modified residuei733 – 7331Phosphoserine1 Publication
Modified residuei742 – 7421Phosphoserine1 Publication

Post-translational modificationi

N-glycosylated By similarity.
O-glycosylated; contains chondroitin sulfate glycans which can be more or less sulfated By similarity.
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-742 (constitutive phosphorylation site), and the phosphorylation of Ser-708 By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, Sulfation

Proteomic databases

PaxDbiP15379.
PRIDEiP15379.

PTM databases

PhosphoSiteiP15379.

Expressioni

Gene expression databases

CleanExiMM_CD44.
GenevestigatoriP15379.

Interactioni

Subunit structurei

Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment By similarity. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Interacts with PKN2. Interacts with TIAM1 and TIAM2.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Tiam1Q606108EBI-7565891,EBI-1030321
Tiam2Q6ZPF38EBI-7565891,EBI-7565978

Protein-protein interaction databases

DIPiDIP-29095N.
IntActiP15379. 5 interactions.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi23 – 286
Beta strandi35 – 406
Helixi48 – 5710
Helixi65 – 739
Beta strandi85 – 9410
Helixi100 – 1023
Beta strandi105 – 1084
Beta strandi117 – 1226
Beta strandi128 – 1314
Beta strandi142 – 15211
Beta strandi157 – 1637
Helixi168 – 1703
Beta strandi715 – 7195

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JCPX-ray1.30A23-174[»]
2JCQX-ray1.25A23-174[»]
2JCRX-ray2.00A23-174[»]
2ZPYX-ray2.10B708-727[»]
4MRDX-ray2.55A23-171[»]
4MREX-ray1.58A23-171[»]
4MRFX-ray1.55A23-171[»]
4MRGX-ray1.69A23-171[»]
4MRHX-ray1.12A23-171[»]
4NP2X-ray1.75A23-171[»]
4NP3X-ray1.61A23-171[»]
ProteinModelPortaliP15379.
SMRiP15379. Positions 23-171.

Miscellaneous databases

EvolutionaryTraceiP15379.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 12390Link
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni227 – 685459Stem
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi153 – 1619Arg/Lys-rich (basic)

Domaini

The lectin-like LINK domain is responsible for hyaluronan binding.

Sequence similaritiesi

Contains 1 Link domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41023.
HOVERGENiHBG003850.
InParanoidiP15379.
KOiK06256.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR001231. CD44_antigen.
IPR000538. Link.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR00658. CD44.
PR01265. LINKMODULE.
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]

Sequences (13)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 13 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P15379-14) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDKFWWHTAW GLCLLQLSLA HQQIDLNVTC RYAGVFHVEK NGRYSISRTE    50
AADLCQAFNS TLPTMDQMKL ALSKGFETCR YGFIEGNVVI PRIHPNAICA 100
ANHTGVYILV TSNTSHYDTY CFNASAPPEE DCTSVTDLPN SFDGPVTITI 150
VNRDGTRYSK KGEYRTHQED IDASNIIDDD VSSGSTIEKS TPEGYILHTY 200
LPTEQPTGDQ DDSFFIRSTL ATIASTVHSK SHAAAQKQNN WIWSWFGNSQ 250
STTQTQEPTT SATTALMTTP ETPPKRQEAQ NWFSWLFQPS ESKSHLHTTT 300
KMPGTESNTN PTGWEPNEEN EDETDTYPSF SGSGIDDDED FISSTIATTP 350
RVSARTEDNQ DWTQWKPNHS NPEVLLQTTT RMADIDRIST SAHGENWTPE 400
PQPPFNNHEY QDEEETPHAT STTPNSTAEA AATQQETWFQ NGWQGKNPPT 450
PSEDSHVTEG TTASAHNNHP SQRITTQSQE DVSWTDFFDP ISHPMGQGHQ 500
TESKDTDSSH STTLQPTAAP NTHLVEDLNR TGPLSVTTPQ SHSQNFSTLH 550
GEPEEDENYP TTSILPSSTK SSAKDARRGG SLPTDTTTSV EGYTFQYPDT 600
MENGTLFPVT PAKTEVFGET EVTLATDSNV NVDGSLPGDR DSSKDSRGSS 650
RTVTHGSELA GHSSANQDSG VTTTSGPMRR PQIPEWLIIL ASLLALALIL 700
AVCIAVNSRR RCGQKKKLVI NGGNGTVEDR KPSELNGEAS KSQEMVHLVN 750
KEPSETPDQC MTADETRNLQ SVDMKIGV 778
Length:778
Mass (Da):85,617
Last modified:April 30, 2003 - v3
Checksum:iBD2C073250F6C956
GO
Isoform 2 (identifier: P15379-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-264: Missing.

Show »
Length:736
Mass (Da):81,015
Checksum:iA4697E905F8DCDA5
GO
Isoform 3 (identifier: P15379-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-303: Missing.

Show »
Length:697
Mass (Da):76,463
Checksum:i796CC452E28B8BC5
GO
Isoform 4 (identifier: P15379-4) [UniParc]FASTAAdd to Basket

Also known as: M2

The sequence of this isoform differs from the canonical sequence as follows:
     223-346: Missing.

Show »
Length:654
Mass (Da):71,780
Checksum:i6211C96F93F72A16
GO
Isoform 5 (identifier: P15379-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-383: Missing.

Show »
Length:617
Mass (Da):67,517
Checksum:i2CA109453C5D8A90
GO
Isoform 6 (identifier: P15379-5) [UniParc]FASTAAdd to Basket

Also known as: M3

The sequence of this isoform differs from the canonical sequence as follows:
     223-424: Missing.

Show »
Length:576
Mass (Da):62,858
Checksum:iE7052A0A1690F9DB
GO
Isoform 7 (identifier: P15379-6) [UniParc]FASTAAdd to Basket

Also known as: M4

The sequence of this isoform differs from the canonical sequence as follows:
     223-504: Missing.

Show »
Length:496
Mass (Da):54,055
Checksum:i8CF72BC7AD2C2490
GO
Isoform 8 (identifier: P15379-10) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-303: Missing.
     424-504: Missing.

Show »
Length:616
Mass (Da):67,563
Checksum:iF945E31D9E1AB63D
GO
Isoform 9 (identifier: P15379-11) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-383: Missing.
     463-504: Missing.

Show »
Length:575
Mass (Da):62,800
Checksum:i771039FF04C95470
GO
Isoform 10 (identifier: P15379-12) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-580: TKSSAKDARRGG → VCLVVVADFSAL
     581-778: Missing.

Show »
Length:580
Mass (Da):64,443
Checksum:iF6CB36489A1C9885
GO
Isoform 11 (identifier: P15379-13) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-592: TKSSAKDARRGGSLPTDTTTSVEG → VRIIKSNWLLSRNQDVMGVSGGGC
     593-778: Missing.

Show »
Length:592
Mass (Da):65,797
Checksum:i60BAF55CBB1308C0
GO
Isoform 12 (identifier: P15379-3) [UniParc]FASTAAdd to Basket

Also known as: M1

The sequence of this isoform differs from the canonical sequence as follows:
     223-539: Missing.

Show »
Length:461
Mass (Da):50,398
Checksum:i031244225F1D8AFE
GO
Isoform 13 (identifier: P15379-2) [UniParc]FASTAAdd to Basket

Also known as: M0

The sequence of this isoform differs from the canonical sequence as follows:
     223-637: Missing.
     638-638: G → R

Show »
Length:363
Mass (Da):39,999
Checksum:i80031C90F26F8880
GO

Polymorphismi

Two allelic forms of this glycoprotein, PGP-1.1 and PGP-1.2, have been reported. The expressed product is PGP-1.1 (Ly-24.1).

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211H → HPH in Ly-24.2.
Natural varianti194 – 1941G → S in Ly-24.2.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei223 – 637415Missing in isoform 13.
VSP_005329Add
BLAST
Alternative sequencei223 – 539317Missing in isoform 12.
VSP_005328Add
BLAST
Alternative sequencei223 – 504282Missing in isoform 7.
VSP_005327Add
BLAST
Alternative sequencei223 – 424202Missing in isoform 6.
VSP_005326Add
BLAST
Alternative sequencei223 – 383161Missing in isoform 5 and isoform 9.
VSP_007332Add
BLAST
Alternative sequencei223 – 346124Missing in isoform 4.
VSP_007331Add
BLAST
Alternative sequencei223 – 30381Missing in isoform 3 and isoform 8.
VSP_007330Add
BLAST
Alternative sequencei223 – 26442Missing in isoform 2.
VSP_007329Add
BLAST
Alternative sequencei424 – 50481Missing in isoform 8.
VSP_007334Add
BLAST
Alternative sequencei463 – 50442Missing in isoform 9.
VSP_007335Add
BLAST
Alternative sequencei569 – 59224TKSSA…TSVEG → VRIIKSNWLLSRNQDVMGVS GGGC in isoform 11.
VSP_007338Add
BLAST
Alternative sequencei569 – 58012TKSSA…ARRGG → VCLVVVADFSAL in isoform 10.
VSP_007336Add
BLAST
Alternative sequencei581 – 778198Missing in isoform 10.
VSP_007337Add
BLAST
Alternative sequencei593 – 778186Missing in isoform 11.
VSP_007339Add
BLAST
Alternative sequencei638 – 6381G → R in isoform 13.
VSP_007333

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti326 – 3261T → K1 Publication
Sequence conflicti326 – 3261T → K1 Publication
Sequence conflicti348 – 3481T → S1 Publication
Sequence conflicti559 – 5591Y → H1 Publication
Sequence conflicti559 – 5591Y → H1 Publication
Sequence conflicti559 – 5591Y → H1 Publication
Sequence conflicti572 – 5721S → G1 Publication
Sequence conflicti572 – 5721S → G1 Publication
Sequence conflicti572 – 5721S → G1 Publication
Sequence conflicti639 – 6391D → RD1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66084 mRNA. Translation: CAA46883.1.
X66083 mRNA. Translation: CAA46882.1.
X66082 mRNA. Translation: CAA46881.1.
X66081 mRNA. Translation: CAA46880.1.
M30655 mRNA. Translation: AAA39922.1.
M27129 mRNA. Translation: AAA37406.1.
M27130 mRNA. Translation: AAA37407.1.
AJ251594 mRNA. Translation: CAB61888.1.
BC005676 mRNA. Translation: AAH05676.1.
AK045226 mRNA. Translation: BAC32269.1.
J05163 mRNA. Translation: AAA39923.1.
X69724 mRNA. Translation: CAA49380.1.
L13611 mRNA. Translation: AAA37145.1.
U57610 mRNA. Translation: AAC52804.1.
U57611 mRNA. Translation: AAB08756.1.
U57612 Genomic DNA. Translation: AAC52805.1.
U57612 Genomic DNA. Translation: AAC52806.1.
PIRiA34424.
A37009.
B44355.
D44355.
S30397.
RefSeqiNP_001034240.1. NM_001039151.1.
NP_001171256.1. NM_001177785.1.
NP_001171257.1. NM_001177786.1.
NP_001171258.1. NM_001177787.1.
NP_033981.2. NM_009851.2.
UniGeneiMm.423621.

Genome annotation databases

GeneIDi12505.
KEGGimmu:12505.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66084 mRNA. Translation: CAA46883.1 .
X66083 mRNA. Translation: CAA46882.1 .
X66082 mRNA. Translation: CAA46881.1 .
X66081 mRNA. Translation: CAA46880.1 .
M30655 mRNA. Translation: AAA39922.1 .
M27129 mRNA. Translation: AAA37406.1 .
M27130 mRNA. Translation: AAA37407.1 .
AJ251594 mRNA. Translation: CAB61888.1 .
BC005676 mRNA. Translation: AAH05676.1 .
AK045226 mRNA. Translation: BAC32269.1 .
J05163 mRNA. Translation: AAA39923.1 .
X69724 mRNA. Translation: CAA49380.1 .
L13611 mRNA. Translation: AAA37145.1 .
U57610 mRNA. Translation: AAC52804.1 .
U57611 mRNA. Translation: AAB08756.1 .
U57612 Genomic DNA. Translation: AAC52805.1 .
U57612 Genomic DNA. Translation: AAC52806.1 .
PIRi A34424.
A37009.
B44355.
D44355.
S30397.
RefSeqi NP_001034240.1. NM_001039151.1.
NP_001171256.1. NM_001177785.1.
NP_001171257.1. NM_001177786.1.
NP_001171258.1. NM_001177787.1.
NP_033981.2. NM_009851.2.
UniGenei Mm.423621.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2JCP X-ray 1.30 A 23-174 [» ]
2JCQ X-ray 1.25 A 23-174 [» ]
2JCR X-ray 2.00 A 23-174 [» ]
2ZPY X-ray 2.10 B 708-727 [» ]
4MRD X-ray 2.55 A 23-171 [» ]
4MRE X-ray 1.58 A 23-171 [» ]
4MRF X-ray 1.55 A 23-171 [» ]
4MRG X-ray 1.69 A 23-171 [» ]
4MRH X-ray 1.12 A 23-171 [» ]
4NP2 X-ray 1.75 A 23-171 [» ]
4NP3 X-ray 1.61 A 23-171 [» ]
ProteinModelPortali P15379.
SMRi P15379. Positions 23-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-29095N.
IntActi P15379. 5 interactions.

PTM databases

PhosphoSitei P15379.

Proteomic databases

PaxDbi P15379.
PRIDEi P15379.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 12505.
KEGGi mmu:12505.

Organism-specific databases

CTDi 960.
MGIi MGI:88338. Cd44.

Phylogenomic databases

eggNOGi NOG41023.
HOVERGENi HBG003850.
InParanoidi P15379.
KOi K06256.

Miscellaneous databases

EvolutionaryTracei P15379.
NextBioi 281466.
PROi P15379.
SOURCEi Search...

Gene expression databases

CleanExi MM_CD44.
Genevestigatori P15379.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR001231. CD44_antigen.
IPR000538. Link.
[Graphical view ]
Pfami PF00193. Xlink. 1 hit.
[Graphical view ]
PRINTSi PR00658. CD44.
PR01265. LINKMODULE.
SMARTi SM00445. LINK. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular isoforms of murine CD44 and evidence that the membrane proximal domain is not critical for hyaluronate recognition."
    He Q., Lesley J., Hyman R., Ishihara K., Kincade P.W.
    J. Cell Biol. 119:1711-1719(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 6; 7 AND 12).
    Strain: DBA/2.
    Tissue: Lung.
  2. "Molecular cloning and expression of Pgp-1. The mouse homolog of the human H-CAM (Hermes) lymphocyte homing receptor."
    Zhou D.F.H., Ding J.F., Picker L.J., Bargatze R.F., Butcher E.C., Goeddel D.V.
    J. Immunol. 143:3390-3395(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 13).
  3. "Isolation of mouse CD44 cDNA: structural features are distinct from the primate cDNA."
    Nottenburg C., Rees G., St John T.
    Proc. Natl. Acad. Sci. U.S.A. 86:8521-8525(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 13).
  4. "Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7)."
    Wittig B.M., Johansson B., Zoeller M., Schwaerzler C., Guenthert U.
    J. Exp. Med. 191:2053-2064(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 13).
  6. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 13).
    Strain: C57BL/6J.
    Tissue: Embryo.
  7. "The cDNA sequence of mouse Pgp-1 and homology to human CD44 cell surface antigen and proteoglycan core/link proteins."
    Wolffe E.J., Gause W.C., Pelfrey C.M., Holland S.M., Steinberg A.D., August J.T.
    J. Biol. Chem. 265:341-347(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-778 (ISOFORM 13).
  8. "Splicing choice from ten variant exons establishes CD44 variability."
    Toelg C., Hofmann M., Herrlich P., Ponta H.
    Nucleic Acids Res. 21:1225-1229(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 224-637 (ISOFORMS 1; 2; 3; 4; 5; 6; 7 AND 8).
    Strain: GR.
  9. "The identification of a new alternative exon with highly restricted tissue expression in transcripts encoding the mouse Pgp-1 (CD44) homing receptor. Comparison of all 10 variable exons between mouse, human, and rat."
    Screaton G.R., Bell M.V., Bell J.I., Jackson D.G.
    J. Biol. Chem. 268:12235-12238(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 224-637 (ISOFORM 9).
    Strain: BALB/c.
  10. "A new alternatively spliced exon between v9 and v10 provides a molecular basis for synthesis of soluble CD44."
    Yu Q., Toole B.P.
    J. Biol. Chem. 271:20603-20607(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 10 AND 11).
    Strain: Swiss Webster.
  11. "Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes."
    Bourguignon L.Y., Gilad E., Peyrollier K., Brightman A., Swanson R.A.
    J. Neurochem. 101:1002-1017(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PKN2, SUBCELLULAR LOCATION.
  12. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-726; SER-733 AND SER-742, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module."
    Terawaki S., Kitano K., Mori T., Zhai Y., Higuchi Y., Itoh N., Watanabe T., Kaibuchi K., Hakoshima T.
    EMBO J. 29:236-250(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TIAM1 AND TIAM2.
  14. "Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction."
    Banerji S., Wright A.J., Noble M., Mahoney D.J., Campbell I.D., Day A.J., Jackson D.G.
    Nat. Struct. Mol. Biol. 14:234-239(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 23-174 ALONE AND IN COMPLEX WITH HYALURONAN, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiCD44_MOUSE
AccessioniPrimary (citable) accession number: P15379
Secondary accession number(s): Q05732
, Q61395, Q62060, Q62061, Q62062, Q62063, Q62408, Q62409, Q64296, Q99J14, Q9QYX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 30, 2003
Last modified: September 3, 2014
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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