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Protein

CD44 antigen

Gene

Cd44

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis (By similarity). Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (PubMed:25065622).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43Hyaluronan1 Publication1
Binding sitei80Hyaluronan1 Publication1
Binding sitei81Hyaluronan1 Publication1
Binding sitei107Hyaluronan1 Publication1

GO - Molecular functioni

  • hyaluronic acid binding Source: MGI
  • type II transforming growth factor beta receptor binding Source: UniProtKB

GO - Biological processi

  • branching involved in prostate gland morphogenesis Source: MGI
  • branching involved in ureteric bud morphogenesis Source: MGI
  • cell adhesion Source: MGI
  • cellular response to fibroblast growth factor stimulus Source: MGI
  • cytokine-mediated signaling pathway Source: GOC
  • hyaluronan catabolic process Source: MGI
  • monocyte aggregation Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of CD4-positive, alpha-beta T cell proliferation Source: UniProtKB
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • negative regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
  • negative regulation of inflammatory response Source: UniProtKB
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: BHF-UCL
  • negative regulation of mature B cell apoptotic process Source: BHF-UCL
  • negative regulation of regulatory T cell differentiation Source: UniProtKB
  • positive regulation of adaptive immune response Source: BHF-UCL
  • positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of heterotypic cell-cell adhesion Source: MGI
  • positive regulation of kinase activity Source: MGI
  • positive regulation of monocyte aggregation Source: MGI
  • positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  • positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  • Wnt signaling pathway Source: MGI
  • wound healing involved in inflammatory response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
CD44 antigen
Alternative name(s):
Extracellular matrix receptor III
Short name:
ECMR-III
GP90 lymphocyte homing/adhesion receptor
HUTCH-I
Hermes antigen
Hyaluronate receptor
Lymphocyte antigen 24
Short name:
Ly-24
Phagocytic glycoprotein 1
Short name:
PGP-1
Phagocytic glycoprotein I
Short name:
PGP-I
CD_antigen: CD44
Gene namesi
Name:Cd44
Synonyms:Ly-24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:88338. Cd44.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 685ExtracellularSequence analysisAdd BLAST663
Transmembranei686 – 706HelicalSequence analysisAdd BLAST21
Topological domaini707 – 778CytoplasmicSequence analysisAdd BLAST72

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3232693.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000002668923 – 778CD44 antigenAdd BLAST756

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi30 ↔ 132PROSITE-ProRule annotation1 Publication
Disulfide bondi55 ↔ 121PROSITE-ProRule annotation1 Publication
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi79 ↔ 99PROSITE-ProRule annotation1 Publication
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Glycosylationi123N-linked (GlcNAc...)Sequence analysis1
Glycosylationi368N-linked (GlcNAc...)Sequence analysis1
Modified residuei410SulfotyrosineBy similarity1
Glycosylationi425N-linked (GlcNAc...)Sequence analysis1
Glycosylationi529N-linked (GlcNAc...)Sequence analysis1
Glycosylationi545N-linked (GlcNAc...)Sequence analysis1
Glycosylationi603N-linked (GlcNAc...)Sequence analysis1
Modified residuei708Phosphoserine; by PKCBy similarity1
Modified residuei726PhosphothreonineCombined sources1
Modified residuei733PhosphoserineCombined sources1
Modified residuei742PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.By similarity
O-glycosylated; contains chondroitin sulfate glycans which can be more or less sulfated.By similarity
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-742 (constitutive phosphorylation site), and the phosphorylation of Ser-708.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, Sulfation

Proteomic databases

PaxDbiP15379.
PeptideAtlasiP15379.
PRIDEiP15379.

PTM databases

iPTMnetiP15379.
PhosphoSitePlusiP15379.
SwissPalmiP15379.

Expressioni

Gene expression databases

CleanExiMM_CD44.

Interactioni

Subunit structurei

Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment (By similarity). Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Interacts with PKN2 (PubMed:17403031). Interacts with TIAM1 and TIAM2 (PubMed:19893486). Interacts with UNC119 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Lgals9O085732EBI-7565891,EBI-8377586
Tgfbr1Q647294EBI-7565891,EBI-2899393
Tiam1Q606108EBI-7565891,EBI-1030321
Tiam2Q6ZPF38EBI-7565891,EBI-7565978

GO - Molecular functioni

  • type II transforming growth factor beta receptor binding Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-29095N.
IntActiP15379. 11 interactors.
STRINGi10090.ENSMUSP00000005218.

Chemistry databases

BindingDBiP15379.

Structurei

Secondary structure

1778
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 28Combined sources6
Beta strandi35 – 40Combined sources6
Helixi48 – 57Combined sources10
Helixi65 – 73Combined sources9
Beta strandi85 – 94Combined sources10
Helixi100 – 102Combined sources3
Beta strandi105 – 108Combined sources4
Beta strandi117 – 122Combined sources6
Beta strandi128 – 131Combined sources4
Beta strandi142 – 152Combined sources11
Beta strandi157 – 163Combined sources7
Helixi168 – 170Combined sources3
Beta strandi715 – 719Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JCPX-ray1.30A23-174[»]
2JCQX-ray1.25A23-174[»]
2JCRX-ray2.00A23-174[»]
2ZPYX-ray2.10B708-727[»]
4MRDX-ray2.55A23-171[»]
4MREX-ray1.58A23-171[»]
4MRFX-ray1.55A23-171[»]
4MRGX-ray1.69A23-171[»]
4MRHX-ray1.12A23-171[»]
4NP2X-ray1.75A23-171[»]
4NP3X-ray1.61A23-171[»]
5BZCX-ray1.95A22-171[»]
5BZEX-ray1.31A23-171[»]
5BZFX-ray2.77A21-171[»]
5BZGX-ray2.19A21-171[»]
5BZHX-ray1.95A21-171[»]
5BZIX-ray1.32A21-171[»]
5BZJX-ray1.40A21-171[»]
5BZKX-ray1.40A21-171[»]
5BZLX-ray1.23A21-171[»]
5BZMX-ray1.25A21-171[»]
5BZNX-ray1.23A21-171[»]
5BZOX-ray1.22A21-171[»]
5BZPX-ray1.23A21-171[»]
5BZQX-ray1.20A21-171[»]
5BZRX-ray1.15A21-171[»]
5BZSX-ray1.50A21-171[»]
5BZTX-ray1.25A21-171[»]
ProteinModelPortaliP15379.
SMRiP15379.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15379.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 123LinkPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni227 – 685StemAdd BLAST459

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi153 – 161Arg/Lys-rich (basic)9

Domaini

The lectin-like LINK domain is responsible for hyaluronan binding.

Sequence similaritiesi

Contains 1 Link domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZCP. Eukaryota.
ENOG4111S6T. LUCA.
HOVERGENiHBG003850.
InParanoidiP15379.
KOiK06256.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like/link.
IPR001231. CD44_antigen.
IPR016187. CTDL_fold.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR00658. CD44.
PR01265. LINKMODULE.
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]

Sequences (13)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 13 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P15379-14) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKFWWHTAW GLCLLQLSLA HQQIDLNVTC RYAGVFHVEK NGRYSISRTE
60 70 80 90 100
AADLCQAFNS TLPTMDQMKL ALSKGFETCR YGFIEGNVVI PRIHPNAICA
110 120 130 140 150
ANHTGVYILV TSNTSHYDTY CFNASAPPEE DCTSVTDLPN SFDGPVTITI
160 170 180 190 200
VNRDGTRYSK KGEYRTHQED IDASNIIDDD VSSGSTIEKS TPEGYILHTY
210 220 230 240 250
LPTEQPTGDQ DDSFFIRSTL ATIASTVHSK SHAAAQKQNN WIWSWFGNSQ
260 270 280 290 300
STTQTQEPTT SATTALMTTP ETPPKRQEAQ NWFSWLFQPS ESKSHLHTTT
310 320 330 340 350
KMPGTESNTN PTGWEPNEEN EDETDTYPSF SGSGIDDDED FISSTIATTP
360 370 380 390 400
RVSARTEDNQ DWTQWKPNHS NPEVLLQTTT RMADIDRIST SAHGENWTPE
410 420 430 440 450
PQPPFNNHEY QDEEETPHAT STTPNSTAEA AATQQETWFQ NGWQGKNPPT
460 470 480 490 500
PSEDSHVTEG TTASAHNNHP SQRITTQSQE DVSWTDFFDP ISHPMGQGHQ
510 520 530 540 550
TESKDTDSSH STTLQPTAAP NTHLVEDLNR TGPLSVTTPQ SHSQNFSTLH
560 570 580 590 600
GEPEEDENYP TTSILPSSTK SSAKDARRGG SLPTDTTTSV EGYTFQYPDT
610 620 630 640 650
MENGTLFPVT PAKTEVFGET EVTLATDSNV NVDGSLPGDR DSSKDSRGSS
660 670 680 690 700
RTVTHGSELA GHSSANQDSG VTTTSGPMRR PQIPEWLIIL ASLLALALIL
710 720 730 740 750
AVCIAVNSRR RCGQKKKLVI NGGNGTVEDR KPSELNGEAS KSQEMVHLVN
760 770
KEPSETPDQC MTADETRNLQ SVDMKIGV
Length:778
Mass (Da):85,617
Last modified:April 30, 2003 - v3
Checksum:iBD2C073250F6C956
GO
Isoform 2 (identifier: P15379-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-264: Missing.

Show »
Length:736
Mass (Da):81,015
Checksum:iA4697E905F8DCDA5
GO
Isoform 3 (identifier: P15379-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-303: Missing.

Show »
Length:697
Mass (Da):76,463
Checksum:i796CC452E28B8BC5
GO
Isoform 4 (identifier: P15379-4) [UniParc]FASTAAdd to basket
Also known as: M2

The sequence of this isoform differs from the canonical sequence as follows:
     223-346: Missing.

Show »
Length:654
Mass (Da):71,780
Checksum:i6211C96F93F72A16
GO
Isoform 5 (identifier: P15379-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-383: Missing.

Show »
Length:617
Mass (Da):67,517
Checksum:i2CA109453C5D8A90
GO
Isoform 6 (identifier: P15379-5) [UniParc]FASTAAdd to basket
Also known as: M3

The sequence of this isoform differs from the canonical sequence as follows:
     223-424: Missing.

Show »
Length:576
Mass (Da):62,858
Checksum:iE7052A0A1690F9DB
GO
Isoform 7 (identifier: P15379-6) [UniParc]FASTAAdd to basket
Also known as: M4

The sequence of this isoform differs from the canonical sequence as follows:
     223-504: Missing.

Show »
Length:496
Mass (Da):54,055
Checksum:i8CF72BC7AD2C2490
GO
Isoform 8 (identifier: P15379-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-303: Missing.
     424-504: Missing.

Show »
Length:616
Mass (Da):67,563
Checksum:iF945E31D9E1AB63D
GO
Isoform 9 (identifier: P15379-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-383: Missing.
     463-504: Missing.

Show »
Length:575
Mass (Da):62,800
Checksum:i771039FF04C95470
GO
Isoform 10 (identifier: P15379-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-580: TKSSAKDARRGG → VCLVVVADFSAL
     581-778: Missing.

Show »
Length:580
Mass (Da):64,443
Checksum:iF6CB36489A1C9885
GO
Isoform 11 (identifier: P15379-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-592: TKSSAKDARRGGSLPTDTTTSVEG → VRIIKSNWLLSRNQDVMGVSGGGC
     593-778: Missing.

Show »
Length:592
Mass (Da):65,797
Checksum:i60BAF55CBB1308C0
GO
Isoform 12 (identifier: P15379-3) [UniParc]FASTAAdd to basket
Also known as: M1

The sequence of this isoform differs from the canonical sequence as follows:
     223-539: Missing.

Show »
Length:461
Mass (Da):50,398
Checksum:i031244225F1D8AFE
GO
Isoform 13 (identifier: P15379-2) [UniParc]FASTAAdd to basket
Also known as: M0

The sequence of this isoform differs from the canonical sequence as follows:
     223-637: Missing.
     638-638: G → R

Show »
Length:363
Mass (Da):39,999
Checksum:i80031C90F26F8880
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti326T → K (PubMed:10859330).Curated1
Sequence conflicti326T → K (PubMed:8509359).Curated1
Sequence conflicti348T → S (PubMed:8509359).Curated1
Sequence conflicti559Y → H (PubMed:10859330).Curated1
Sequence conflicti559Y → H (PubMed:8464707).Curated1
Sequence conflicti559Y → H (PubMed:8509359).Curated1
Sequence conflicti572S → G (PubMed:10859330).Curated1
Sequence conflicti572S → G (PubMed:8464707).Curated1
Sequence conflicti572S → G (PubMed:8509359).Curated1
Sequence conflicti639D → RD (PubMed:2403559).Curated1

Polymorphismi

Two allelic forms of this glycoprotein, PGP-1.1 and PGP-1.2, have been reported. The expressed product is PGP-1.1 (Ly-24.1).

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti21H → HPH in Ly-24.2. 1 Publication1
Natural varianti194G → S in Ly-24.2. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005329223 – 637Missing in isoform 13. 5 PublicationsAdd BLAST415
Alternative sequenceiVSP_005328223 – 539Missing in isoform 12. 1 PublicationAdd BLAST317
Alternative sequenceiVSP_005327223 – 504Missing in isoform 7. 2 PublicationsAdd BLAST282
Alternative sequenceiVSP_005326223 – 424Missing in isoform 6. 2 PublicationsAdd BLAST202
Alternative sequenceiVSP_007332223 – 383Missing in isoform 5 and isoform 9. 2 PublicationsAdd BLAST161
Alternative sequenceiVSP_007331223 – 346Missing in isoform 4. 2 PublicationsAdd BLAST124
Alternative sequenceiVSP_007330223 – 303Missing in isoform 3 and isoform 8. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_007329223 – 264Missing in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_007334424 – 504Missing in isoform 8. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_007335463 – 504Missing in isoform 9. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_007338569 – 592TKSSA…TSVEG → VRIIKSNWLLSRNQDVMGVS GGGC in isoform 11. CuratedAdd BLAST24
Alternative sequenceiVSP_007336569 – 580TKSSA…ARRGG → VCLVVVADFSAL in isoform 10. CuratedAdd BLAST12
Alternative sequenceiVSP_007337581 – 778Missing in isoform 10. CuratedAdd BLAST198
Alternative sequenceiVSP_007339593 – 778Missing in isoform 11. CuratedAdd BLAST186
Alternative sequenceiVSP_007333638G → R in isoform 13. 5 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66084 mRNA. Translation: CAA46883.1.
X66083 mRNA. Translation: CAA46882.1.
X66082 mRNA. Translation: CAA46881.1.
X66081 mRNA. Translation: CAA46880.1.
M30655 mRNA. Translation: AAA39922.1.
M27129 mRNA. Translation: AAA37406.1.
M27130 mRNA. Translation: AAA37407.1.
AJ251594 mRNA. Translation: CAB61888.1.
BC005676 mRNA. Translation: AAH05676.1.
AK045226 mRNA. Translation: BAC32269.1.
J05163 mRNA. Translation: AAA39923.1.
X69724 mRNA. Translation: CAA49380.1.
L13611 mRNA. Translation: AAA37145.1.
U57610 mRNA. Translation: AAC52804.1.
U57611 mRNA. Translation: AAB08756.1.
U57612 Genomic DNA. Translation: AAC52805.1.
U57612 Genomic DNA. Translation: AAC52806.1.
PIRiA34424.
A37009.
B44355.
D44355.
S30397.
RefSeqiNP_001034240.1. NM_001039151.1.
NP_001171256.1. NM_001177785.1.
NP_001171257.1. NM_001177786.1.
NP_001171258.1. NM_001177787.1.
NP_033981.2. NM_009851.2.
UniGeneiMm.423621.

Genome annotation databases

GeneIDi12505.
KEGGimmu:12505.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66084 mRNA. Translation: CAA46883.1.
X66083 mRNA. Translation: CAA46882.1.
X66082 mRNA. Translation: CAA46881.1.
X66081 mRNA. Translation: CAA46880.1.
M30655 mRNA. Translation: AAA39922.1.
M27129 mRNA. Translation: AAA37406.1.
M27130 mRNA. Translation: AAA37407.1.
AJ251594 mRNA. Translation: CAB61888.1.
BC005676 mRNA. Translation: AAH05676.1.
AK045226 mRNA. Translation: BAC32269.1.
J05163 mRNA. Translation: AAA39923.1.
X69724 mRNA. Translation: CAA49380.1.
L13611 mRNA. Translation: AAA37145.1.
U57610 mRNA. Translation: AAC52804.1.
U57611 mRNA. Translation: AAB08756.1.
U57612 Genomic DNA. Translation: AAC52805.1.
U57612 Genomic DNA. Translation: AAC52806.1.
PIRiA34424.
A37009.
B44355.
D44355.
S30397.
RefSeqiNP_001034240.1. NM_001039151.1.
NP_001171256.1. NM_001177785.1.
NP_001171257.1. NM_001177786.1.
NP_001171258.1. NM_001177787.1.
NP_033981.2. NM_009851.2.
UniGeneiMm.423621.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JCPX-ray1.30A23-174[»]
2JCQX-ray1.25A23-174[»]
2JCRX-ray2.00A23-174[»]
2ZPYX-ray2.10B708-727[»]
4MRDX-ray2.55A23-171[»]
4MREX-ray1.58A23-171[»]
4MRFX-ray1.55A23-171[»]
4MRGX-ray1.69A23-171[»]
4MRHX-ray1.12A23-171[»]
4NP2X-ray1.75A23-171[»]
4NP3X-ray1.61A23-171[»]
5BZCX-ray1.95A22-171[»]
5BZEX-ray1.31A23-171[»]
5BZFX-ray2.77A21-171[»]
5BZGX-ray2.19A21-171[»]
5BZHX-ray1.95A21-171[»]
5BZIX-ray1.32A21-171[»]
5BZJX-ray1.40A21-171[»]
5BZKX-ray1.40A21-171[»]
5BZLX-ray1.23A21-171[»]
5BZMX-ray1.25A21-171[»]
5BZNX-ray1.23A21-171[»]
5BZOX-ray1.22A21-171[»]
5BZPX-ray1.23A21-171[»]
5BZQX-ray1.20A21-171[»]
5BZRX-ray1.15A21-171[»]
5BZSX-ray1.50A21-171[»]
5BZTX-ray1.25A21-171[»]
ProteinModelPortaliP15379.
SMRiP15379.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29095N.
IntActiP15379. 11 interactors.
STRINGi10090.ENSMUSP00000005218.

Chemistry databases

BindingDBiP15379.
ChEMBLiCHEMBL3232693.

PTM databases

iPTMnetiP15379.
PhosphoSitePlusiP15379.
SwissPalmiP15379.

Proteomic databases

PaxDbiP15379.
PeptideAtlasiP15379.
PRIDEiP15379.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12505.
KEGGimmu:12505.

Organism-specific databases

CTDi960.
MGIiMGI:88338. Cd44.

Phylogenomic databases

eggNOGiENOG410IZCP. Eukaryota.
ENOG4111S6T. LUCA.
HOVERGENiHBG003850.
InParanoidiP15379.
KOiK06256.

Miscellaneous databases

ChiTaRSiCd44. mouse.
EvolutionaryTraceiP15379.
PROiP15379.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CD44.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like/link.
IPR001231. CD44_antigen.
IPR016187. CTDL_fold.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR00658. CD44.
PR01265. LINKMODULE.
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD44_MOUSE
AccessioniPrimary (citable) accession number: P15379
Secondary accession number(s): Q05732
, Q61395, Q62060, Q62061, Q62062, Q62063, Q62408, Q62409, Q64296, Q99J14, Q9QYX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 30, 2003
Last modified: November 30, 2016
This is version 177 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.