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P15375

- MYF6_MOUSE

UniProt

P15375 - MYF6_MOUSE

Protein

Myogenic factor 6

Gene

Myf6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. muscle tissue morphogenesis Source: MGI
    2. negative regulation of transcription, DNA-templated Source: MGI
    3. positive regulation of transcription, DNA-templated Source: MGI
    4. regulation of transcription from RNA polymerase II promoter Source: GOC
    5. skeletal muscle cell differentiation Source: MGI
    6. skeletal muscle tissue development Source: MGI
    7. skeletal muscle tissue regeneration Source: Ensembl
    8. somitogenesis Source: MGI
    9. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Myogenesis

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myogenic factor 6
    Short name:
    Myf-6
    Alternative name(s):
    Herculin
    Muscle-specific regulatory factor 4
    Gene namesi
    Name:Myf6
    Synonyms:Mrf4, Myf-6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:97253. Myf6.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 242242Myogenic factor 6PRO_0000127352Add
    BLAST

    Proteomic databases

    PRIDEiP15375.

    PTM databases

    PhosphoSiteiP15375.

    Expressioni

    Tissue specificityi

    Skeletal muscle.

    Gene expression databases

    BgeeiP15375.
    CleanExiMM_MYF6.
    GenevestigatoriP15375.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000047529.

    Structurei

    3D structure databases

    ProteinModelPortaliP15375.
    SMRiP15375. Positions 93-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini93 – 14452bHLHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG309598.
    HOGENOMiHOG000234799.
    HOVERGENiHBG006429.
    InParanoidiP15375.
    OMAiHRLDQQD.
    OrthoDBiEOG76QFK1.
    PhylomeDBiP15375.
    TreeFamiTF316344.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR002546. Basic.
    IPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF01586. Basic. 1 hit.
    PF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00520. BASIC. 1 hit.
    SM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15375-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMMDLFETGS YFFYLDGENV TLQPLEVAEG SPLYPGSDGT LSPCQDQMPQ    50
    EAGSDSSGEE HVLAPPGLQP PHCPGQCLIW ACKTCKRKSA PTDRRKAATL 100
    RERRRLKKIN EAFEALKRRT VANPNQRLPK VEILRSAISY IERLQDLLHR 150
    LDQQEKMQEL GVDPYSYKPK QEILEGADFL RTCSPQWPSV SDHSRGLVIT 200
    AKEGGANVDA SASSSLQRLS SIVDSISSEE RKLPSVEEVV EK 242
    Length:242
    Mass (Da):26,987
    Last modified:April 1, 1990 - v1
    Checksum:iDF5FF9A3FA5BBFD5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30499 Genomic DNA. Translation: AAA37802.1.
    X59060 mRNA. Translation: CAA41785.1.
    AK029370 mRNA. Translation: BAC26423.1.
    CCDSiCCDS24162.1.
    PIRiA34872.
    RefSeqiNP_032683.1. NM_008657.2.
    UniGeneiMm.11.

    Genome annotation databases

    EnsembliENSMUST00000044210; ENSMUSP00000047529; ENSMUSG00000035923.
    GeneIDi17878.
    KEGGimmu:17878.
    UCSCiuc007gza.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30499 Genomic DNA. Translation: AAA37802.1 .
    X59060 mRNA. Translation: CAA41785.1 .
    AK029370 mRNA. Translation: BAC26423.1 .
    CCDSi CCDS24162.1.
    PIRi A34872.
    RefSeqi NP_032683.1. NM_008657.2.
    UniGenei Mm.11.

    3D structure databases

    ProteinModelPortali P15375.
    SMRi P15375. Positions 93-148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000047529.

    PTM databases

    PhosphoSitei P15375.

    Proteomic databases

    PRIDEi P15375.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044210 ; ENSMUSP00000047529 ; ENSMUSG00000035923 .
    GeneIDi 17878.
    KEGGi mmu:17878.
    UCSCi uc007gza.1. mouse.

    Organism-specific databases

    CTDi 4618.
    MGIi MGI:97253. Myf6.

    Phylogenomic databases

    eggNOGi NOG309598.
    HOGENOMi HOG000234799.
    HOVERGENi HBG006429.
    InParanoidi P15375.
    OMAi HRLDQQD.
    OrthoDBi EOG76QFK1.
    PhylomeDBi P15375.
    TreeFami TF316344.

    Miscellaneous databases

    NextBioi 292669.
    PROi P15375.
    SOURCEi Search...

    Gene expression databases

    Bgeei P15375.
    CleanExi MM_MYF6.
    Genevestigatori P15375.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR002546. Basic.
    IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF01586. Basic. 1 hit.
    PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00520. BASIC. 1 hit.
    SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Herculin, a fourth member of the MyoD family of myogenic regulatory genes."
      Miner J.H., Wold B.
      Proc. Natl. Acad. Sci. U.S.A. 87:1089-1093(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c Charon 4A.
      Tissue: Spleen.
    2. "The muscle regulatory gene, Myf-6, has a biphasic pattern of expression during early mouse development."
      Bober E., Lyons G.L., Braun T., Cossu G., Buckingham M., Arnold H.-H.
      J. Cell Biol. 113:1255-1265(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Skeletal muscle.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.

    Entry informationi

    Entry nameiMYF6_MOUSE
    AccessioniPrimary (citable) accession number: P15375
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3