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Protein

Myogenic factor 6

Gene

Myf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

GO - Molecular functioni

GO - Biological processi

  • muscle tissue morphogenesis Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • positive regulation of myoblast differentiation Source: GO_Central
  • positive regulation of myoblast fusion Source: GO_Central
  • positive regulation of skeletal muscle fiber development Source: GO_Central
  • positive regulation of transcription, DNA-templated Source: MGI
  • skeletal muscle cell differentiation Source: MGI
  • skeletal muscle tissue development Source: MGI
  • skeletal muscle tissue regeneration Source: Ensembl
  • somitogenesis Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Myogenesis

Enzyme and pathway databases

ReactomeiR-MMU-375170. CDO in myogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Myogenic factor 6
Short name:
Myf-6
Alternative name(s):
Herculin
Muscle-specific regulatory factor 4
Gene namesi
Name:Myf6
Synonyms:Mrf4, Myf-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:97253. Myf6.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273521 – 242Myogenic factor 6Add BLAST242

Proteomic databases

PaxDbiP15375.
PRIDEiP15375.

PTM databases

iPTMnetiP15375.
PhosphoSitePlusiP15375.

Expressioni

Tissue specificityi

Skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000035923.
CleanExiMM_MYF6.
ExpressionAtlasiP15375. baseline and differential.
GenevisibleiP15375. MM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Interacts with CSRP3.By similarity

Protein-protein interaction databases

IntActiP15375. 1 interactor.
STRINGi10090.ENSMUSP00000047529.

Structurei

3D structure databases

ProteinModelPortaliP15375.
SMRiP15375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 144bHLHPROSITE-ProRule annotationAdd BLAST52

Phylogenomic databases

eggNOGiKOG3960. Eukaryota.
ENOG4111SED. LUCA.
GeneTreeiENSGT00530000063004.
HOGENOMiHOG000234799.
HOVERGENiHBG006429.
InParanoidiP15375.
KOiK18485.
OMAiQQDKMQE.
OrthoDBiEOG09040IW0.
PhylomeDBiP15375.
TreeFamiTF316344.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR002546. Basic.
IPR011598. bHLH_dom.
PfamiView protein in Pfam
PF01586. Basic. 1 hit.
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00520. BASIC. 1 hit.
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

P15375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMMDLFETGS YFFYLDGENV TLQPLEVAEG SPLYPGSDGT LSPCQDQMPQ
60 70 80 90 100
EAGSDSSGEE HVLAPPGLQP PHCPGQCLIW ACKTCKRKSA PTDRRKAATL
110 120 130 140 150
RERRRLKKIN EAFEALKRRT VANPNQRLPK VEILRSAISY IERLQDLLHR
160 170 180 190 200
LDQQEKMQEL GVDPYSYKPK QEILEGADFL RTCSPQWPSV SDHSRGLVIT
210 220 230 240
AKEGGANVDA SASSSLQRLS SIVDSISSEE RKLPSVEEVV EK
Length:242
Mass (Da):26,987
Last modified:April 1, 1990 - v1
Checksum:iDF5FF9A3FA5BBFD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30499 Genomic DNA. Translation: AAA37802.1.
X59060 mRNA. Translation: CAA41785.1.
AK029370 mRNA. Translation: BAC26423.1.
CCDSiCCDS24162.1.
PIRiA34872.
RefSeqiNP_032683.1. NM_008657.2.
UniGeneiMm.11.

Genome annotation databases

EnsembliENSMUST00000044210; ENSMUSP00000047529; ENSMUSG00000035923.
GeneIDi17878.
KEGGimmu:17878.
UCSCiuc007gza.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30499 Genomic DNA. Translation: AAA37802.1.
X59060 mRNA. Translation: CAA41785.1.
AK029370 mRNA. Translation: BAC26423.1.
CCDSiCCDS24162.1.
PIRiA34872.
RefSeqiNP_032683.1. NM_008657.2.
UniGeneiMm.11.

3D structure databases

ProteinModelPortaliP15375.
SMRiP15375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP15375. 1 interactor.
STRINGi10090.ENSMUSP00000047529.

PTM databases

iPTMnetiP15375.
PhosphoSitePlusiP15375.

Proteomic databases

PaxDbiP15375.
PRIDEiP15375.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044210; ENSMUSP00000047529; ENSMUSG00000035923.
GeneIDi17878.
KEGGimmu:17878.
UCSCiuc007gza.1. mouse.

Organism-specific databases

CTDi4618.
MGIiMGI:97253. Myf6.

Phylogenomic databases

eggNOGiKOG3960. Eukaryota.
ENOG4111SED. LUCA.
GeneTreeiENSGT00530000063004.
HOGENOMiHOG000234799.
HOVERGENiHBG006429.
InParanoidiP15375.
KOiK18485.
OMAiQQDKMQE.
OrthoDBiEOG09040IW0.
PhylomeDBiP15375.
TreeFamiTF316344.

Enzyme and pathway databases

ReactomeiR-MMU-375170. CDO in myogenesis.

Miscellaneous databases

PROiP15375.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035923.
CleanExiMM_MYF6.
ExpressionAtlasiP15375. baseline and differential.
GenevisibleiP15375. MM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR002546. Basic.
IPR011598. bHLH_dom.
PfamiView protein in Pfam
PF01586. Basic. 1 hit.
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00520. BASIC. 1 hit.
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMYF6_MOUSE
AccessioniPrimary (citable) accession number: P15375
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: February 15, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.