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Protein

Myogenic factor 6

Gene

Myf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  3. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI

GO - Biological processi

  1. muscle tissue morphogenesis Source: MGI
  2. negative regulation of transcription, DNA-templated Source: MGI
  3. positive regulation of transcription, DNA-templated Source: MGI
  4. positive regulation of transcription from RNA polymerase II promoter Source: GOC
  5. regulation of transcription from RNA polymerase II promoter Source: GOC
  6. skeletal muscle cell differentiation Source: MGI
  7. skeletal muscle tissue development Source: MGI
  8. skeletal muscle tissue regeneration Source: Ensembl
  9. somitogenesis Source: MGI
  10. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_258600. CDO in myogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Myogenic factor 6
Short name:
Myf-6
Alternative name(s):
Herculin
Muscle-specific regulatory factor 4
Gene namesi
Name:Myf6
Synonyms:Mrf4, Myf-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:97253. Myf6.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Myogenic factor 6PRO_0000127352Add
BLAST

Proteomic databases

PRIDEiP15375.

PTM databases

PhosphoSiteiP15375.

Expressioni

Tissue specificityi

Skeletal muscle.

Gene expression databases

BgeeiP15375.
CleanExiMM_MYF6.
ExpressionAtlasiP15375. baseline and differential.
GenevestigatoriP15375.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047529.

Structurei

3D structure databases

ProteinModelPortaliP15375.
SMRiP15375. Positions 93-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 14452bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG309598.
HOGENOMiHOG000234799.
HOVERGENiHBG006429.
InParanoidiP15375.
KOiK18485.
OMAiQQDKMQE.
OrthoDBiEOG76QFK1.
PhylomeDBiP15375.
TreeFamiTF316344.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR002546. Basic.
IPR011598. bHLH_dom.
[Graphical view]
PfamiPF01586. Basic. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00520. BASIC. 1 hit.
SM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15375-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMMDLFETGS YFFYLDGENV TLQPLEVAEG SPLYPGSDGT LSPCQDQMPQ
60 70 80 90 100
EAGSDSSGEE HVLAPPGLQP PHCPGQCLIW ACKTCKRKSA PTDRRKAATL
110 120 130 140 150
RERRRLKKIN EAFEALKRRT VANPNQRLPK VEILRSAISY IERLQDLLHR
160 170 180 190 200
LDQQEKMQEL GVDPYSYKPK QEILEGADFL RTCSPQWPSV SDHSRGLVIT
210 220 230 240
AKEGGANVDA SASSSLQRLS SIVDSISSEE RKLPSVEEVV EK
Length:242
Mass (Da):26,987
Last modified:April 1, 1990 - v1
Checksum:iDF5FF9A3FA5BBFD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30499 Genomic DNA. Translation: AAA37802.1.
X59060 mRNA. Translation: CAA41785.1.
AK029370 mRNA. Translation: BAC26423.1.
CCDSiCCDS24162.1.
PIRiA34872.
RefSeqiNP_032683.1. NM_008657.2.
UniGeneiMm.11.

Genome annotation databases

EnsembliENSMUST00000044210; ENSMUSP00000047529; ENSMUSG00000035923.
GeneIDi17878.
KEGGimmu:17878.
UCSCiuc007gza.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30499 Genomic DNA. Translation: AAA37802.1.
X59060 mRNA. Translation: CAA41785.1.
AK029370 mRNA. Translation: BAC26423.1.
CCDSiCCDS24162.1.
PIRiA34872.
RefSeqiNP_032683.1. NM_008657.2.
UniGeneiMm.11.

3D structure databases

ProteinModelPortaliP15375.
SMRiP15375. Positions 93-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047529.

PTM databases

PhosphoSiteiP15375.

Proteomic databases

PRIDEiP15375.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044210; ENSMUSP00000047529; ENSMUSG00000035923.
GeneIDi17878.
KEGGimmu:17878.
UCSCiuc007gza.1. mouse.

Organism-specific databases

CTDi4618.
MGIiMGI:97253. Myf6.

Phylogenomic databases

eggNOGiNOG309598.
HOGENOMiHOG000234799.
HOVERGENiHBG006429.
InParanoidiP15375.
KOiK18485.
OMAiQQDKMQE.
OrthoDBiEOG76QFK1.
PhylomeDBiP15375.
TreeFamiTF316344.

Enzyme and pathway databases

ReactomeiREACT_258600. CDO in myogenesis.

Miscellaneous databases

NextBioi292669.
PROiP15375.
SOURCEiSearch...

Gene expression databases

BgeeiP15375.
CleanExiMM_MYF6.
ExpressionAtlasiP15375. baseline and differential.
GenevestigatoriP15375.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR002546. Basic.
IPR011598. bHLH_dom.
[Graphical view]
PfamiPF01586. Basic. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00520. BASIC. 1 hit.
SM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Herculin, a fourth member of the MyoD family of myogenic regulatory genes."
    Miner J.H., Wold B.
    Proc. Natl. Acad. Sci. U.S.A. 87:1089-1093(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c Charon 4A.
    Tissue: Spleen.
  2. "The muscle regulatory gene, Myf-6, has a biphasic pattern of expression during early mouse development."
    Bober E., Lyons G.L., Braun T., Cossu G., Buckingham M., Arnold H.-H.
    J. Cell Biol. 113:1255-1265(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Skeletal muscle.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.

Entry informationi

Entry nameiMYF6_MOUSE
AccessioniPrimary (citable) accession number: P15375
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: January 7, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.