Peripherin - Mus musculus (Mouse)

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P15331 (PERI_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 106. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Peripherin

Gene names

Name:	Prph
Synonyms:	Prph1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Class-III neuronal intermediate filament protein.
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Nitration Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	intermediate filament cytoskeleton organization Inferred from direct assay PubMed 12642616. Source: MGI
Cellular_component	C-fiber Inferred from direct assay PubMed 16029194. Source: MGI neurofilament Inferred from direct assay PubMed 10221457. Source: MGI neuronal cell body Inferred from sequence orthology PubMed 8616889. Source: MGI photoreceptor outer segment membrane Inferred from direct assay PubMed 10414956. Source: MGI
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 5g (identifier: P15331-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 3u (identifier: P15331-2) The sequence of this isoform differs from the canonical sequence as follows: 294-294: K → KVREHWGNPGGPRVGRHWEWRCASQPGLSATAQ

Isoform 5b (identifier: P15331-3) The sequence of this isoform differs from the canonical sequence as follows: 454-475: KVVTESQKEQHSDLDKSSIHSY → LLRPQPEL

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 475

475

Peripherin

PRO_0000063780

Regions

Region

1 – 103

103

Head

Region

104 – 409

306

Rod

Region

104 – 136

Coil 1A

Region

137 – 147

Linker 1

Region

148 – 243

Coil 1B

Region

244 – 266

Linker 2

Region

267 – 409

143

Coil 2

Region

410 – 475

Tail

Amino acid modifications

Modified residue

Nitrated tyrosine By similarity

Modified residue

383

Nitrated tyrosine By similarity

Modified residue

475

Phosphotyrosine By similarity

Natural variations

Alternative sequence

294

K → KVREHWGNPGGPRVGRHWEW RCASQPGLSATAQ in isoform 3u.

VSP_002466

Alternative sequence

454 – 475

KVVTE…SIHSY → LLRPQPEL in isoform 5b.

VSP_002467

Sequences

Sequence		Length	Mass (Da)
Isoform 5g [UniParc]. Last modified July 15, 1998. Version 2. Checksum: 777300B08A312953 Show »	FASTA	475	54,268
10 20 30 40 50 60 MPSSASMSHH HSSGLRSSIS STSYRRTFGP PPSLSPGAFS YSSSSRFSSS RLLGSGSPSS 70 80 90 100 110 120 SARLGSFRAP RAGALRLPSE RLDFSMAEAL NQEFLATRSN EKQELQELND RFANFIEKVR 130 140 150 160 170 180 FLEQQNAALR GELSQARGQE PARADQLCQQ ELRELRRELE LLGRERDRVQ VERDGLAEDL 190 200 210 220 230 240 AALKQRLEEE TRKREDAEHN LVLFRKDVDD ATLSRLELER KIESLMDEIE FLKKLHEEEL 250 260 270 280 290 300 RDLQVSVESQ QVQQVEVEAT VKPELTAALR DIRAQYENIA AKNLQEAEEW YKSKYADLSD 310 320 330 340 350 360 AANRNHEALR QAKQEMNESR RQIQSLTCEV DGLRGTNEAL LRQLRELEEQ FALEAGGYQA 370 380 390 400 410 420 GAARLEEELR QLKEEMARHL REYQELLNVK MALDIEIATY RKLLEGEESR ISVPVHSFAS 430 440 450 460 470 LSLKTTVPEM EPLQDSHSKK MVLIRTIETR DGEKVVTESQ KEQHSDLDKS SIHSY « Hide
Isoform 3u [UniParc]. Checksum: 17267805F7EB06B1 Show »	FASTA	507	57,834
10 20 30 40 50 60 MPSSASMSHH HSSGLRSSIS STSYRRTFGP PPSLSPGAFS YSSSSRFSSS RLLGSGSPSS 70 80 90 100 110 120 SARLGSFRAP RAGALRLPSE RLDFSMAEAL NQEFLATRSN EKQELQELND RFANFIEKVR 130 140 150 160 170 180 FLEQQNAALR GELSQARGQE PARADQLCQQ ELRELRRELE LLGRERDRVQ VERDGLAEDL 190 200 210 220 230 240 AALKQRLEEE TRKREDAEHN LVLFRKDVDD ATLSRLELER KIESLMDEIE FLKKLHEEEL 250 260 270 280 290 300 RDLQVSVESQ QVQQVEVEAT VKPELTAALR DIRAQYENIA AKNLQEAEEW YKSKVREHWG 310 320 330 340 350 360 NPGGPRVGRH WEWRCASQPG LSATAQYADL SDAANRNHEA LRQAKQEMNE SRRQIQSLTC 370 380 390 400 410 420 EVDGLRGTNE ALLRQLRELE EQFALEAGGY QAGAARLEEE LRQLKEEMAR HLREYQELLN 430 440 450 460 470 480 VKMALDIEIA TYRKLLEGEE SRISVPVHSF ASLSLKTTVP EMEPLQDSHS KKMVLIRTIE 490 500 TRDGEKVVTE SQKEQHSDLD KSSIHSY « Hide
Isoform 5b [UniParc]. Checksum: 933A0F49FF99D55C Show »	FASTA	461	52,687
10 20 30 40 50 60 MPSSASMSHH HSSGLRSSIS STSYRRTFGP PPSLSPGAFS YSSSSRFSSS RLLGSGSPSS 70 80 90 100 110 120 SARLGSFRAP RAGALRLPSE RLDFSMAEAL NQEFLATRSN EKQELQELND RFANFIEKVR 130 140 150 160 170 180 FLEQQNAALR GELSQARGQE PARADQLCQQ ELRELRRELE LLGRERDRVQ VERDGLAEDL 190 200 210 220 230 240 AALKQRLEEE TRKREDAEHN LVLFRKDVDD ATLSRLELER KIESLMDEIE FLKKLHEEEL 250 260 270 280 290 300 RDLQVSVESQ QVQQVEVEAT VKPELTAALR DIRAQYENIA AKNLQEAEEW YKSKYADLSD 310 320 330 340 350 360 AANRNHEALR QAKQEMNESR RQIQSLTCEV DGLRGTNEAL LRQLRELEEQ FALEAGGYQA 370 380 390 400 410 420 GAARLEEELR QLKEEMARHL REYQELLNVK MALDIEIATY RKLLEGEESR ISVPVHSFAS 430 440 450 460 LSLKTTVPEM EPLQDSHSKK MVLIRTIETR DGELLRPQPE L « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure of the mouse gene encoding peripherin: a neuronal intermediate filament protein." Karpov V., Landon F., Djabali K., Gros F., Portier M.M. Biol. Cell 76:43-48(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5G). Strain: FVB/N. Tissue: Colon.
[3]	"Multiple mRNAs encode peripherin, a neuronal intermediate filament protein." Landon F., Lemonnier M., Benarous R., Huc C., Fiszman M., Gros F., Portier M.M. EMBO J. 8:1719-1726(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 70-475, ALTERNATIVE SPLICING.
[4]	Lubec G., Yang J.W., Zigmond M. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 411-424. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X15475 mRNA. Translation: CAA33502.1. BC046291 mRNA. Translation: AAH46291.1. X59840 Genomic DNA. Translation: CAA42499.1. X59840 Genomic DNA. Translation: CAA42500.1. X59840 Genomic DNA. Translation: CAA42501.1.
IPI	IPI00129527. IPI00230444. IPI00230445.
PIR	S14887.
UniGene	Mm.2477.
3D structure databases
ProteinModelPortal	P15331.
SMR	P15331. Positions 97-236, 263-406.
ModBase	Search...
Protein-protein interaction databases
IntAct	P15331. 1 interaction.
MINT	MINT-4107153.
PTM databases
PhosphoSite	P15331.
2D gel databases
UCD-2DPAGE	P15331.
Proteomic databases
PaxDb	P15331.
PRIDE	P15331.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:97774. Prph.
Phylogenomic databases
eggNOG	NOG282699.
HOGENOM	HOG000230977.
HOVERGEN	HBG013015.
OrthoDB	EOG4JWVDP.
Gene expression databases
CleanEx	MM_PRPH.
Genevestigator	P15331.
GermOnline	ENSMUSG00000023484. Mus musculus.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR006821. Intermed_filament_DNA-bd. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view]
PANTHER	PTHR23239. PTHR23239. 1 hit.
Pfam	PF00038. Filament. 1 hit. PF04732. Filament_head. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

PERI_MOUSE

Accession

Primary (citable) accession number: P15331
Secondary accession number(s): O35688, O35689

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	July 15, 1998
Last modified:	May 29, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents