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P15329

- GUNX_CLOTM

UniProt

P15329 - GUNX_CLOTM

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Protein
Putative endoglucanase X
Gene
celX
Organism
Clostridium thermocellum
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Putative endoglucanase X (EC:3.2.1.4)
Short name:
EGX
Alternative name(s):
Cellulase
Endo-1,4-beta-glucanase
Gene namesi
Name:celX
OrganismiClostridium thermocellum
Taxonomic identifieri1515 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 224›224Putative endoglucanase X
PRO_0000184076Add
BLAST

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VPTX-ray1.40A9-149[»]
ProteinModelPortaliP15329.
SMRiP15329. Positions 9-146.

Miscellaneous databases

EvolutionaryTraceiP15329.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati168 – 191241
Add
BLAST
Repeati202 – 224232
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 224572 X 24 AA approximate repeats
Add
BLAST

Domaini

A 24 residue domain is repeated twice in this enzyme as well as in other C.thermocellum cellulosome enzymes. This domain may function as the binding ligand for the SL component.

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.1330.10. 1 hit.
3.40.50.1110. 1 hit.
InterProiIPR016134. Cellulos_enz_dockerin_1.
IPR002105. Cellulos_enz_dockerin_1_Ca-bd.
IPR018242. Dockerin_1.
IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view]
PfamiPF00404. Dockerin_1. 2 hits.
[Graphical view]
SUPFAMiSSF63446. SSF63446. 1 hit.
PROSITEiPS00448. CLOS_CELLULOSOME_RPT. 2 hits.
PS00018. EF_HAND_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P15329-1 [UniParc]FASTAAdd to Basket

« Hide

IMKVTQDGSI PQIASNINNW LNTHNPDVVF LWIGGNDLLL SGNVNATGLS    50
NLIDQIFTVK PNVTLFVADY YPWPEAVKQY NAVIPGIVQQ KANAGKKVYF 100
VKLSEIQFDR NTDISWDGLH LSEIGYTKIA NIWYKYTIDI LKALAGQTQP 150
TPSPSPTPTD SPLVKKGDVN LDGQVNSTDF SLLKRYILKV VDINSINVTN 200
ADMNNDGNIN STDISILKRI LLRN 224
Length:224
Mass (Da):24,860
Last modified:April 1, 1990 - v1
Checksum:iF8822C5663FF2E80
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22759 Genomic DNA. Translation: AAA23223.1.
PIRiA30476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22759 Genomic DNA. Translation: AAA23223.1 .
PIRi A30476.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2VPT X-ray 1.40 A 9-149 [» ]
ProteinModelPortali P15329.
SMRi P15329. Positions 9-146.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P15329.

Family and domain databases

Gene3Di 1.10.1330.10. 1 hit.
3.40.50.1110. 1 hit.
InterProi IPR016134. Cellulos_enz_dockerin_1.
IPR002105. Cellulos_enz_dockerin_1_Ca-bd.
IPR018242. Dockerin_1.
IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view ]
Pfami PF00404. Dockerin_1. 2 hits.
[Graphical view ]
SUPFAMi SSF63446. SSF63446. 1 hit.
PROSITEi PS00448. CLOS_CELLULOSOME_RPT. 2 hits.
PS00018. EF_HAND_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Conserved reiterated domains in Clostridium thermocellum endoglucanases are not essential for catalytic activity."
    Hall J., Hazlewood G.P., Barker P.J., Gilbert H.J.
    Gene 69:29-38(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGUNX_CLOTM
AccessioniPrimary (citable) accession number: P15329
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

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