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P15329

- GUNX_CLOTM

UniProt

P15329 - GUNX_CLOTM

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Protein

Putative endoglucanase X

Gene

celX

Organism
Clostridium thermocellum (Ruminiclostridium thermocellum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Putative endoglucanase X (EC:3.2.1.4)
Short name:
EGX
Alternative name(s):
Cellulase
Endo-1,4-beta-glucanase
Gene namesi
Name:celX
OrganismiClostridium thermocellum (Ruminiclostridium thermocellum)
Taxonomic identifieri1515 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 224›224Putative endoglucanase XPRO_0000184076Add
BLAST

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VPTX-ray1.40A9-149[»]
ProteinModelPortaliP15329.
SMRiP15329. Positions 9-146.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15329.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati168 – 191241Add
BLAST
Repeati202 – 224232Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 224572 X 24 AA approximate repeatsAdd
BLAST

Domaini

A 24 residue domain is repeated twice in this enzyme as well as in other C.thermocellum cellulosome enzymes. This domain may function as the binding ligand for the SL component.

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.1330.10. 1 hit.
3.40.50.1110. 1 hit.
InterProiIPR016134. Cellulos_enz_dockerin_1.
IPR002105. Cellulos_enz_dockerin_1_Ca-bd.
IPR018242. Dockerin_1.
IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view]
PfamiPF00404. Dockerin_1. 2 hits.
[Graphical view]
SUPFAMiSSF63446. SSF63446. 1 hit.
PROSITEiPS00448. CLOS_CELLULOSOME_RPT. 2 hits.
PS00018. EF_HAND_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P15329-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
IMKVTQDGSI PQIASNINNW LNTHNPDVVF LWIGGNDLLL SGNVNATGLS
60 70 80 90 100
NLIDQIFTVK PNVTLFVADY YPWPEAVKQY NAVIPGIVQQ KANAGKKVYF
110 120 130 140 150
VKLSEIQFDR NTDISWDGLH LSEIGYTKIA NIWYKYTIDI LKALAGQTQP
160 170 180 190 200
TPSPSPTPTD SPLVKKGDVN LDGQVNSTDF SLLKRYILKV VDINSINVTN
210 220
ADMNNDGNIN STDISILKRI LLRN
Length:224
Mass (Da):24,860
Last modified:April 1, 1990 - v1
Checksum:iF8822C5663FF2E80
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22759 Genomic DNA. Translation: AAA23223.1.
PIRiA30476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22759 Genomic DNA. Translation: AAA23223.1 .
PIRi A30476.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2VPT X-ray 1.40 A 9-149 [» ]
ProteinModelPortali P15329.
SMRi P15329. Positions 9-146.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P15329.

Family and domain databases

Gene3Di 1.10.1330.10. 1 hit.
3.40.50.1110. 1 hit.
InterProi IPR016134. Cellulos_enz_dockerin_1.
IPR002105. Cellulos_enz_dockerin_1_Ca-bd.
IPR018242. Dockerin_1.
IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view ]
Pfami PF00404. Dockerin_1. 2 hits.
[Graphical view ]
SUPFAMi SSF63446. SSF63446. 1 hit.
PROSITEi PS00448. CLOS_CELLULOSOME_RPT. 2 hits.
PS00018. EF_HAND_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Conserved reiterated domains in Clostridium thermocellum endoglucanases are not essential for catalytic activity."
    Hall J., Hazlewood G.P., Barker P.J., Gilbert H.J.
    Gene 69:29-38(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGUNX_CLOTM
AccessioniPrimary (citable) accession number: P15329
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 1, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3