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Protein

Bisphosphoglycerate mutase

Gene

Bpgm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity.By similarity

Catalytic activityi

3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.By similarity
2-phospho-D-glycerate = 3-phospho-D-glycerate.By similarity

Enzyme regulationi

At alkaline pH BPGM favors the synthase reaction; however, at lower pH the phosphatase reaction is dominant. Inhibited by citrate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11Tele-phosphohistidine intermediateBy similarity1
Binding sitei62SubstrateBy similarity1
Active sitei89Proton donor/acceptorBy similarity1
Binding sitei100SubstrateBy similarity1
Sitei188Transition state stabilizerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Isomerase
Biological processGlycolysis

Enzyme and pathway databases

ReactomeiR-MMU-70171 Glycolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Bisphosphoglycerate mutase (EC:5.4.2.4By similarity)
Short name:
BPGM
Alternative name(s):
2,3-bisphosphoglycerate mutase, erythrocyte
2,3-bisphosphoglycerate synthase (EC:5.4.2.11By similarity)
BPG-dependent PGAM
Gene namesi
Name:Bpgm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1098242 Bpgm

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001798352 – 259Bisphosphoglycerate mutaseAdd BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei122PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP15327
PaxDbiP15327
PeptideAtlasiP15327
PRIDEiP15327

2D gel databases

REPRODUCTION-2DPAGEiP15327

PTM databases

iPTMnetiP15327
PhosphoSitePlusiP15327
SwissPalmiP15327

Expressioni

Tissue specificityi

Expressed in red blood cells. Expressed in placenta (labyrinthine trophoblasts).2 Publications

Gene expression databases

BgeeiENSMUSG00000038871
CleanExiMM_BPGM
ExpressionAtlasiP15327 baseline and differential
GenevisibleiP15327 MM

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiP15327, 1 interactor
MINTiP15327
STRINGi10090.ENSMUSP00000047393

Structurei

3D structure databases

ProteinModelPortaliP15327
SMRiP15327
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 17Substrate bindingBy similarity8
Regioni23 – 24Substrate bindingBy similarity2
Regioni89 – 92Substrate bindingBy similarity4
Regioni116 – 117Substrate bindingBy similarity2
Regioni189 – 190Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0235 Eukaryota
COG0588 LUCA
GeneTreeiENSGT00390000016700
HOGENOMiHOG000221682
HOVERGENiHBG027528
InParanoidiP15327
KOiK01837
OMAiNLHAVGP
OrthoDBiEOG091G0GIS
PhylomeDBiP15327
TreeFamiTF300007

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 2 hits
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15327-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKHKLIILR HGEGQWNKEN RFCSWVDQKL NNDGLEEARN CGRQLKALNF
60 70 80 90 100
EFDLVFTSIL NRSIHTAWLI LEELGQEWVP VESSWRLNER HYGALIGLNR
110 120 130 140 150
EKMALNHGEE QVRLWRRSYN VTPPPIEESH PYFHEIYSDR RYKVCDVPLD
160 170 180 190 200
QLPRSESLKD VLERLLPYWK ERIAPEILKG KSILISAHGN SSRALLKHLE
210 220 230 240 250
GISDEDIINI TLPTGVPILL ELDENLRAVG PHQFLGNQEA IQAAIKKVDD

QGKVKQGKQ
Length:259
Mass (Da):29,978
Last modified:January 23, 2007 - v2
Checksum:i6C2674005B41A0C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13586 mRNA Translation: CAA31927.1
AK043412 mRNA Translation: BAC31541.1
AK078119 mRNA Translation: BAC37133.1
BC004589 mRNA Translation: AAH04589.1
CCDSiCCDS19994.1
PIRiA31585 PMMSBM
RefSeqiNP_031589.1, NM_007563.4
UniGeneiMm.282863

Genome annotation databases

EnsembliENSMUST00000045372; ENSMUSP00000047393; ENSMUSG00000038871
GeneIDi12183
KEGGimmu:12183
UCSCiuc009bhf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPMGE_MOUSE
AccessioniPrimary (citable) accession number: P15327
Secondary accession number(s): Q543Z6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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