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Protein

Allergen Sin a 1

Gene
N/A
Organism
Sinapis alba (White mustard) (Brassica hirta)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a 2S seed storage protein.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Seed storage protein, Storage protein

Names & Taxonomyi

Protein namesi
Recommended name:
Allergen Sin a 1
Alternative name(s):
Allergen Sin a I
Allergen: Sin a 1
Cleaved into the following 2 chains:
OrganismiSinapis alba (White mustard) (Brassica hirta)
Taxonomic identifieri3728 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeBrassiceaeSinapis

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Causes cabbage allergy.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3477. Sin a 1.0101.
627. Sin a 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000321671 – 39Allergen Sin a 1 small chainAdd BLAST39
PropeptideiPRO_000003216840 – 541 PublicationAdd BLAST15
ChainiPRO_000003216955 – 145Allergen Sin a 1 large chainAdd BLAST91

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

The protein consists of two chains linked by disulfide bonds.

Structurei

3D structure databases

ProteinModelPortaliP15322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2S seed storage albumins family.Curated

Family and domain databases

InterProiIPR016140. Bifunc_inhib/LTP/seed_store.
IPR000617. Napin.
[Graphical view]
PfamiPF00234. Tryp_alpha_amyl. 1 hit.
[Graphical view]
PRINTSiPR00496. NAPIN.
SMARTiSM00499. AAI. 1 hit.
[Graphical view]
SUPFAMiSSF47699. SSF47699. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PAGPFRIPKC RKEFQQAQHL RACQQWLHKQ AMQSGSGPSW TLDDEFDFED
60 70 80 90 100
DMENPQGPQQ RPPLLQQCCN ELHQEEPLCV CPTLKGASKA VKQQVRQQLG
110 120 130 140
QQGQQGPHLQ HVISRIYQTA THLPKVCNIR QVSVCPFKKT MPGPS
Length:145
Mass (Da):16,449
Last modified:August 16, 2004 - v2
Checksum:iF8EE8E5CC2C2DDA7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108 – 110Missing AA sequence (PubMed:3181153).Curated3

Polymorphismi

There seems to be at least 8 variants: 1.0101 (PubMed:3181153), 1.0102/SA2S1 (PubMed:8093997), 1.0103/SA2S2 (PubMed:8093997), 1.0104/SIN1 (PubMed:8647131), 1.0105/SIN2 (PubMed:8647131), 1.0106/SIN3 (PubMed:8647131), 1.0107/SIN4 (PubMed:8647131), and 1.0108/SIN5 (PubMed:8647131).3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti6R → G in 1.0101, 1.0104/SIN1, 1.0106/SIN3 and 1.0108/SIN5. 2 Publications1
Natural varianti36S → G in 1.0103/SA2S2. 1 Publication1
Natural varianti40W → L in 1.0103/SA2S2. 1 Publication1
Natural varianti41T → A in 1.0103/SA2S2. 1 Publication1
Natural varianti43D → E in 1.0105/SIN2. 1
Natural varianti43D → Y in 1.0103/SA2S2. 1 Publication1
Natural varianti44D → G in 1.0103/SA2S2 and 1.0105/SIN2. 1 Publication1
Natural varianti61R → K in 1.0108/SIN5. 1 Publication1
Natural varianti100G → E in 1.0101, 1.0103/SA2S2, 1.0104/SIN1, 1.0105/SIN2 and 1.0107/SIN4. 3 Publications1
Natural varianti108H → Q in 1.0106/SIN3 and 1.0108/SIN5. 1
Natural varianti109L → V in 1.0106/SIN3 and 1.0108/SIN5. 1
Natural varianti111H → Q in 1.0103/SA2S2. 2 Publications1
Natural varianti125K → R in 1.0104/SIN1. 1 Publication1
Natural varianti130R → P in 1.0101, 1.0105/SIN2, 1.0106/SIN3, 1.0107/SIN4 and 1.0108/SIN5. 2 Publications1
Natural varianti138K → Q in 1.0104/SIN1. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S54101 Genomic DNA. Translation: AAB25214.2.
X91798 Genomic DNA. Translation: CAA62908.1.
X91799 Genomic DNA. Translation: CAA62909.1.
X91800 Genomic DNA. Translation: CAA62910.1.
X91801 Genomic DNA. Translation: CAA62911.1.
X91802 Genomic DNA. Translation: CAA62912.1.
PIRiPC1246.
PC1247.
S01791.
S65447.
S65478.
S65479.
S65480.
S65481.
S65482.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S54101 Genomic DNA. Translation: AAB25214.2.
X91798 Genomic DNA. Translation: CAA62908.1.
X91799 Genomic DNA. Translation: CAA62909.1.
X91800 Genomic DNA. Translation: CAA62910.1.
X91801 Genomic DNA. Translation: CAA62911.1.
X91802 Genomic DNA. Translation: CAA62912.1.
PIRiPC1246.
PC1247.
S01791.
S65447.
S65478.
S65479.
S65480.
S65481.
S65482.

3D structure databases

ProteinModelPortaliP15322.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3477. Sin a 1.0101.
627. Sin a 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR016140. Bifunc_inhib/LTP/seed_store.
IPR000617. Napin.
[Graphical view]
PfamiPF00234. Tryp_alpha_amyl. 1 hit.
[Graphical view]
PRINTSiPR00496. NAPIN.
SMARTiSM00499. AAI. 1 hit.
[Graphical view]
SUPFAMiSSF47699. SSF47699. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALL1_SINAL
AccessioniPrimary (citable) accession number: P15322
Secondary accession number(s): Q41196
, Q41277, Q41278, Q41279, Q41280, Q41281
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: August 16, 2004
Last modified: October 1, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.