P15316 (HYLP1_BPH44) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hyaluronoglucosaminidase
Short name=Hyaluronidase
EC=3.2.1.35

Gene names

Name:	HYLP1
Synonyms:	HYLP

Organism

Streptococcus pyogenes phage H4489A

Taxonomic identifier

12366 [NCBI]

Taxonomic lineage

Viruses › unclassified phages

Virus host

Streptococcus pyogenes [TaxID: 1314]

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The hyaluronidase of this bacteriophage mediates the penetration of the hyaluronic capsule of Streptococcus pyogenes.
Catalytic activity	Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
Sequence similarities	Belongs to the glycosyl hydrolase 69 family.

Ontologies

Keywords
Molecular function	Glycosidase Hydrolase
Gene Ontology (GO)
Biological_process	capsule polysaccharide biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	hyalurononglucosaminidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Hyaluronoglucosaminidase		PRO_0000057723

Sequences

	Sequence		Length	Mass (Da)
	P15316 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: 09D0DBC5F292B893	FASTA	371	39,519
	10 20 30 40 50 60 MTENIPLRVQ FKRMSADEWA RSDVILLEGE IGFETDTGFA KFGDGQNTFS KLKYLTGPKG 70 80 90 100 110 120 PKGDTGLQGK TGGTGPRGPA GKPGTTDYDQ LQNKPDLGAF AQKEETNSKI TKLESSKADK 130 140 150 160 170 180 SAVYSKAESK IELDKKLSLT GGIVTGQLQF KPNKSGIKPS SSVGGAINID MSKSEGAAMV 190 200 210 220 230 240 MYTNKDTTDG PLMILRSDKD TFDQSAQFVD YSGKTNAVNI VMRQPSAPNF SSALNITSAN 250 260 270 280 290 300 EGGSAMQIRG VEKALGTLKI THENPNVEAK YDENAAALSI DIVKKQKGGK GTAAQGIYIN 310 320 330 340 350 360 STSGTAGKML RIRNKNEDKF YVGPDGGFHS GANSTVAGNL TVKDPTSGKH AATKDYVDEK 370 IAELKKLILK K

References

[1]	"Sequence analysis and expression in Escherichia coli of the hyaluronidase gene of Streptococcus pyogenes bacteriophage H4489A." Hynes W.L., Ferretti J.J. Infect. Immun. 57:533-539(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M19348 Genomic DNA. Translation: AAA98101.1.
PIR	HUBPHA. A30566.
3D structure databases
ProteinModelPortal	P15316.
SMR	P15316. Positions 7-371.
ModBase	Search...
Protein family/group databases
CAZy	PL16. Polysaccharide Lyase Family 16.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR009860. Hyaluronidase_bac. [Graphical view]
Pfam	PF07212. Hyaluronidase_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HYLP1_BPH44

Accession

Primary (citable) accession number: P15316

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program