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Protein

Hyaluronoglucosaminidase

Gene

HYLP1

Organism
Streptococcus pyogenes phage H4489A
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The hyaluronidase of this bacteriophage mediates the penetration of the hyaluronic capsule of Streptococcus pyogenes.

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processDegradation of host capsule during virus entry, Degradation of host cell envelope components during virus entry, Virus entry into host cell

Protein family/group databases

CAZyiPL16 Polysaccharide Lyase Family 16

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronoglucosaminidase (EC:3.2.1.35)
Short name:
Hyaluronidase
Gene namesi
Name:HYLP1
Synonyms:HYLP
OrganismiStreptococcus pyogenes phage H4489A
Taxonomic identifieri12366 [NCBI]
Taxonomic lineageiVirusesunclassified bacterial viruses
Virus hostiStreptococcus pyogenes [TaxID: 1314]

Subcellular locationi

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577231 – 371HyaluronoglucosaminidaseAdd BLAST371

Proteomic databases

PRIDEiP15316

Structurei

3D structure databases

ProteinModelPortaliP15316
SMRiP15316
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 69 family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR009860 Hyaluronidase_bac
PfamiView protein in Pfam
PF07212 Hyaluronidase_1, 1 hit

Sequencei

Sequence statusi: Complete.

P15316-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENIPLRVQ FKRMSADEWA RSDVILLEGE IGFETDTGFA KFGDGQNTFS
60 70 80 90 100
KLKYLTGPKG PKGDTGLQGK TGGTGPRGPA GKPGTTDYDQ LQNKPDLGAF
110 120 130 140 150
AQKEETNSKI TKLESSKADK SAVYSKAESK IELDKKLSLT GGIVTGQLQF
160 170 180 190 200
KPNKSGIKPS SSVGGAINID MSKSEGAAMV MYTNKDTTDG PLMILRSDKD
210 220 230 240 250
TFDQSAQFVD YSGKTNAVNI VMRQPSAPNF SSALNITSAN EGGSAMQIRG
260 270 280 290 300
VEKALGTLKI THENPNVEAK YDENAAALSI DIVKKQKGGK GTAAQGIYIN
310 320 330 340 350
STSGTAGKML RIRNKNEDKF YVGPDGGFHS GANSTVAGNL TVKDPTSGKH
360 370
AATKDYVDEK IAELKKLILK K
Length:371
Mass (Da):39,519
Last modified:April 1, 1990 - v1
Checksum:i09D0DBC5F292B893
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19348 Genomic DNA Translation: AAA98101.1
PIRiA30566 HUBPHA

Similar proteinsi

Entry informationi

Entry nameiHYLP1_BPH44
AccessioniPrimary (citable) accession number: P15316
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

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