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P15316 (HYLP1_BPH44) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hyaluronoglucosaminidase

Short name=Hyaluronidase
EC=3.2.1.35
Gene names
Name:HYLP1
Synonyms:HYLP
OrganismStreptococcus pyogenes phage H4489A
Taxonomic identifier12366 [NCBI]
Taxonomic lineageVirusesunclassified phages
Virus hostStreptococcus pyogenes [TaxID: 1314]

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The hyaluronidase of this bacteriophage mediates the penetration of the hyaluronic capsule of Streptococcus pyogenes.

Catalytic activity

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sequence similarities

Belongs to the glycosyl hydrolase 69 family.

Ontologies

Keywords
   Molecular functionGlycosidase
Hydrolase
Gene Ontology (GO)
   Biological_processcapsule polysaccharide biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionhyalurononglucosaminidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371Hyaluronoglucosaminidase
PRO_0000057723

Sequences

Sequence LengthMass (Da)Tools
P15316 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 09D0DBC5F292B893

FASTA37139,519
        10         20         30         40         50         60 
MTENIPLRVQ FKRMSADEWA RSDVILLEGE IGFETDTGFA KFGDGQNTFS KLKYLTGPKG 

        70         80         90        100        110        120 
PKGDTGLQGK TGGTGPRGPA GKPGTTDYDQ LQNKPDLGAF AQKEETNSKI TKLESSKADK 

       130        140        150        160        170        180 
SAVYSKAESK IELDKKLSLT GGIVTGQLQF KPNKSGIKPS SSVGGAINID MSKSEGAAMV 

       190        200        210        220        230        240 
MYTNKDTTDG PLMILRSDKD TFDQSAQFVD YSGKTNAVNI VMRQPSAPNF SSALNITSAN 

       250        260        270        280        290        300 
EGGSAMQIRG VEKALGTLKI THENPNVEAK YDENAAALSI DIVKKQKGGK GTAAQGIYIN 

       310        320        330        340        350        360 
STSGTAGKML RIRNKNEDKF YVGPDGGFHS GANSTVAGNL TVKDPTSGKH AATKDYVDEK 

       370 
IAELKKLILK K 

« Hide

References

[1]"Sequence analysis and expression in Escherichia coli of the hyaluronidase gene of Streptococcus pyogenes bacteriophage H4489A."
Hynes W.L., Ferretti J.J.
Infect. Immun. 57:533-539(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M19348 Genomic DNA. Translation: AAA98101.1.
PIRHUBPHA. A30566.

3D structure databases

ProteinModelPortalP15316.
SMRP15316. Positions 7-371.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyPL16. Polysaccharide Lyase Family 16.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR009860. Hyaluronidase_bac.
[Graphical view]
PfamPF07212. Hyaluronidase_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHYLP1_BPH44
AccessionPrimary (citable) accession number: P15316
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 16, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries