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P15316

- HYLP1_BPH44

UniProt

P15316 - HYLP1_BPH44

Protein

Hyaluronoglucosaminidase

Gene

HYLP1

Organism
Streptococcus pyogenes phage H4489A
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    The hyaluronidase of this bacteriophage mediates the penetration of the hyaluronic capsule of Streptococcus pyogenes.

    Catalytic activityi

    Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

    GO - Molecular functioni

    1. hyalurononglucosaminidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. capsule polysaccharide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiPL16. Polysaccharide Lyase Family 16.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronoglucosaminidase (EC:3.2.1.35)
    Short name:
    Hyaluronidase
    Gene namesi
    Name:HYLP1
    Synonyms:HYLP
    OrganismiStreptococcus pyogenes phage H4489A
    Taxonomic identifieri12366 [NCBI]
    Taxonomic lineageiVirusesunclassified phages
    Virus hostiStreptococcus pyogenes [TaxID: 1314]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 371371HyaluronoglucosaminidasePRO_0000057723Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP15316.
    SMRiP15316. Positions 7-371.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 69 family.Curated

    Family and domain databases

    InterProiIPR009860. Hyaluronidase_bac.
    [Graphical view]
    PfamiPF07212. Hyaluronidase_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15316-1 [UniParc]FASTAAdd to Basket

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    MTENIPLRVQ FKRMSADEWA RSDVILLEGE IGFETDTGFA KFGDGQNTFS    50
    KLKYLTGPKG PKGDTGLQGK TGGTGPRGPA GKPGTTDYDQ LQNKPDLGAF 100
    AQKEETNSKI TKLESSKADK SAVYSKAESK IELDKKLSLT GGIVTGQLQF 150
    KPNKSGIKPS SSVGGAINID MSKSEGAAMV MYTNKDTTDG PLMILRSDKD 200
    TFDQSAQFVD YSGKTNAVNI VMRQPSAPNF SSALNITSAN EGGSAMQIRG 250
    VEKALGTLKI THENPNVEAK YDENAAALSI DIVKKQKGGK GTAAQGIYIN 300
    STSGTAGKML RIRNKNEDKF YVGPDGGFHS GANSTVAGNL TVKDPTSGKH 350
    AATKDYVDEK IAELKKLILK K 371
    Length:371
    Mass (Da):39,519
    Last modified:April 1, 1990 - v1
    Checksum:i09D0DBC5F292B893
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M19348 Genomic DNA. Translation: AAA98101.1.
    PIRiA30566. HUBPHA.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M19348 Genomic DNA. Translation: AAA98101.1 .
    PIRi A30566. HUBPHA.

    3D structure databases

    ProteinModelPortali P15316.
    SMRi P15316. Positions 7-371.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi PL16. Polysaccharide Lyase Family 16.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR009860. Hyaluronidase_bac.
    [Graphical view ]
    Pfami PF07212. Hyaluronidase_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis and expression in Escherichia coli of the hyaluronidase gene of Streptococcus pyogenes bacteriophage H4489A."
      Hynes W.L., Ferretti J.J.
      Infect. Immun. 57:533-539(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiHYLP1_BPH44
    AccessioniPrimary (citable) accession number: P15316
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3