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P15316

- HYLP1_BPH44

UniProt

P15316 - HYLP1_BPH44

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Protein

Hyaluronoglucosaminidase

Gene

HYLP1

Organism
Streptococcus pyogenes phage H4489A
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The hyaluronidase of this bacteriophage mediates the penetration of the hyaluronic capsule of Streptococcus pyogenes.

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

GO - Molecular functioni

  1. hyalurononglucosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. capsule polysaccharide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiPL16. Polysaccharide Lyase Family 16.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronoglucosaminidase (EC:3.2.1.35)
Short name:
Hyaluronidase
Gene namesi
Name:HYLP1
Synonyms:HYLP
OrganismiStreptococcus pyogenes phage H4489A
Taxonomic identifieri12366 [NCBI]
Taxonomic lineageiVirusesunclassified phages
Virus hostiStreptococcus pyogenes [TaxID: 1314]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371HyaluronoglucosaminidasePRO_0000057723Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP15316.
SMRiP15316. Positions 7-371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 69 family.Curated

Family and domain databases

InterProiIPR009860. Hyaluronidase_bac.
[Graphical view]
PfamiPF07212. Hyaluronidase_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15316 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MTENIPLRVQ FKRMSADEWA RSDVILLEGE IGFETDTGFA KFGDGQNTFS
60 70 80 90 100
KLKYLTGPKG PKGDTGLQGK TGGTGPRGPA GKPGTTDYDQ LQNKPDLGAF
110 120 130 140 150
AQKEETNSKI TKLESSKADK SAVYSKAESK IELDKKLSLT GGIVTGQLQF
160 170 180 190 200
KPNKSGIKPS SSVGGAINID MSKSEGAAMV MYTNKDTTDG PLMILRSDKD
210 220 230 240 250
TFDQSAQFVD YSGKTNAVNI VMRQPSAPNF SSALNITSAN EGGSAMQIRG
260 270 280 290 300
VEKALGTLKI THENPNVEAK YDENAAALSI DIVKKQKGGK GTAAQGIYIN
310 320 330 340 350
STSGTAGKML RIRNKNEDKF YVGPDGGFHS GANSTVAGNL TVKDPTSGKH
360 370
AATKDYVDEK IAELKKLILK K
Length:371
Mass (Da):39,519
Last modified:April 1, 1990 - v1
Checksum:i09D0DBC5F292B893
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19348 Genomic DNA. Translation: AAA98101.1.
PIRiA30566. HUBPHA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19348 Genomic DNA. Translation: AAA98101.1 .
PIRi A30566. HUBPHA.

3D structure databases

ProteinModelPortali P15316.
SMRi P15316. Positions 7-371.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi PL16. Polysaccharide Lyase Family 16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR009860. Hyaluronidase_bac.
[Graphical view ]
Pfami PF07212. Hyaluronidase_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis and expression in Escherichia coli of the hyaluronidase gene of Streptococcus pyogenes bacteriophage H4489A."
    Hynes W.L., Ferretti J.J.
    Infect. Immun. 57:533-539(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHYLP1_BPH44
AccessioniPrimary (citable) accession number: P15316
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 1, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3