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Protein

Hyaluronoglucosaminidase

Gene

HYLP1

Organism
Streptococcus pyogenes phage H4489A
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The hyaluronidase of this bacteriophage mediates the penetration of the hyaluronic capsule of Streptococcus pyogenes.

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Degradation of host capsule during virus entry, Degradation of host cell envelope components during virus entry, Virus entry into host cell

Protein family/group databases

CAZyiPL16. Polysaccharide Lyase Family 16.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronoglucosaminidase (EC:3.2.1.35)
Short name:
Hyaluronidase
Gene namesi
Name:HYLP1
Synonyms:HYLP
OrganismiStreptococcus pyogenes phage H4489A
Taxonomic identifieri12366 [NCBI]
Taxonomic lineageiVirusesunclassified phages
Virus hostiStreptococcus pyogenes [TaxID: 1314]

Subcellular locationi

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371HyaluronoglucosaminidasePRO_0000057723Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP15316.
SMRiP15316. Positions 7-371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 69 family.Curated

Family and domain databases

InterProiIPR009860. Hyaluronidase_bac.
[Graphical view]
PfamiPF07212. Hyaluronidase_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15316-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENIPLRVQ FKRMSADEWA RSDVILLEGE IGFETDTGFA KFGDGQNTFS
60 70 80 90 100
KLKYLTGPKG PKGDTGLQGK TGGTGPRGPA GKPGTTDYDQ LQNKPDLGAF
110 120 130 140 150
AQKEETNSKI TKLESSKADK SAVYSKAESK IELDKKLSLT GGIVTGQLQF
160 170 180 190 200
KPNKSGIKPS SSVGGAINID MSKSEGAAMV MYTNKDTTDG PLMILRSDKD
210 220 230 240 250
TFDQSAQFVD YSGKTNAVNI VMRQPSAPNF SSALNITSAN EGGSAMQIRG
260 270 280 290 300
VEKALGTLKI THENPNVEAK YDENAAALSI DIVKKQKGGK GTAAQGIYIN
310 320 330 340 350
STSGTAGKML RIRNKNEDKF YVGPDGGFHS GANSTVAGNL TVKDPTSGKH
360 370
AATKDYVDEK IAELKKLILK K
Length:371
Mass (Da):39,519
Last modified:April 1, 1990 - v1
Checksum:i09D0DBC5F292B893
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19348 Genomic DNA. Translation: AAA98101.1.
PIRiA30566. HUBPHA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19348 Genomic DNA. Translation: AAA98101.1.
PIRiA30566. HUBPHA.

3D structure databases

ProteinModelPortaliP15316.
SMRiP15316. Positions 7-371.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiPL16. Polysaccharide Lyase Family 16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR009860. Hyaluronidase_bac.
[Graphical view]
PfamiPF07212. Hyaluronidase_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis and expression in Escherichia coli of the hyaluronidase gene of Streptococcus pyogenes bacteriophage H4489A."
    Hynes W.L., Ferretti J.J.
    Infect. Immun. 57:533-539(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHYLP1_BPH44
AccessioniPrimary (citable) accession number: P15316
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 22, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.