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Protein

Thrombomodulin

Gene

Thbd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

GO - Molecular functioni

GO - Biological processi

  • blood coagulation Source: MGI
  • female pregnancy Source: MGI
  • negative regulation of blood coagulation Source: InterPro
  • negative regulation of coagulation Source: MGI
  • response to cAMP Source: Ensembl
  • response to lipopolysaccharide Source: Ensembl
  • response to X-ray Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-MMU-140875. Common Pathway of Fibrin Clot Formation.
R-MMU-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombomodulin
Short name:
TM
Alternative name(s):
Fetomodulin
CD_antigen: CD141
Gene namesi
Name:Thbd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98736. Thbd.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 517ExtracellularSequence analysisAdd BLAST501
Transmembranei518 – 541HelicalSequence analysisAdd BLAST24
Topological domaini542 – 577CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000000777217 – 577ThrombomodulinAdd BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi113N-linked (GlcNAc...)1 Publication1
Disulfide bondi135 ↔ 156By similarity
Glycosylationi243N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi244 ↔ 255By similarity
Disulfide bondi251 ↔ 264By similarity
Glycosylationi256N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi266 ↔ 279By similarity
Disulfide bondi287 ↔ 295By similarity
Disulfide bondi291 ↔ 307By similarity
Disulfide bondi309 ↔ 322By similarity
Disulfide bondi328 ↔ 339By similarity
Disulfide bondi335 ↔ 348By similarity
Disulfide bondi350 ↔ 361By similarity
Disulfide bondi368 ↔ 377By similarity
Disulfide bondi373 ↔ 387By similarity
Disulfide bondi389 ↔ 403By similarity
Disulfide bondi407 ↔ 416By similarity
Glycosylationi408N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi412 ↔ 424By similarity
Disulfide bondi426 ↔ 438By similarity
Disulfide bondi444 ↔ 454By similarity
Disulfide bondi449 ↔ 463By similarity
Disulfide bondi465 ↔ 479By similarity
Glycosylationi494O-linked (Xyl...) (glycosaminoglycan)By similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP15306.
PeptideAtlasiP15306.
PRIDEiP15306.

PTM databases

iPTMnetiP15306.
PhosphoSitePlusiP15306.

Expressioni

Tissue specificityi

Endothelial cells are unique in synthesizing thrombomodulin.

Gene expression databases

BgeeiENSMUSG00000074743.
CleanExiMM_THBD.
ExpressionAtlasiP15306. baseline and differential.
GenevisibleiP15306. MM.

Interactioni

Subunit structurei

Interacts with ITGAL, ITGAM and ITGB2.By similarity

Protein-protein interaction databases

IntActiP15306. 2 interactors.
MINTiMINT-4138449.
STRINGi10090.ENSMUSP00000096877.

Structurei

3D structure databases

ProteinModelPortaliP15306.
SMRiP15306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 167C-type lectinPROSITE-ProRule annotationAdd BLAST137
Domaini240 – 280EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini283 – 323EGF-like 2PROSITE-ProRule annotationAdd BLAST41
Domaini324 – 362EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini364 – 404EGF-like 4PROSITE-ProRule annotationAdd BLAST41
Domaini403 – 439EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini440 – 480EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST41

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 6 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF0T. Eukaryota.
ENOG410Y5JS. LUCA.
GeneTreeiENSGT00810000125382.
HOGENOMiHOG000114624.
HOVERGENiHBG000291.
InParanoidiP15306.
KOiK03907.
OMAiLCGPLCV.
OrthoDBiEOG091G06M1.
PhylomeDBiP15306.
TreeFamiTF330714.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016316. CD141.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR015149. Tme5_EGF-like.
[Graphical view]
PfamiPF07645. EGF_CA. 2 hits.
PF00059. Lectin_C. 1 hit.
PF09064. Tme5_EGF_like. 1 hit.
[Graphical view]
PIRSFiPIRSF001775. CD93/CD141. 1 hit.
SMARTiSM00034. CLECT. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 4 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGIFFLGVL APASLGLSAL AKLQPTGSQC VEHECFALFQ GPATFLDASQ
60 70 80 90 100
ACQRLQGHLM TVRSSVAADV ISLLLSQSSM DLGPWIGLQL PQGCDDPVHL
110 120 130 140 150
GPLRGFQWVT GDNHTSYSRW ARPNDQTAPL CGPLCVTVST ATEAAPGEPA
160 170 180 190 200
WEEKPCETET QGFLCEFYFT ASCRPLTVNT RDPEAAHISS TYNTPFGVSG
210 220 230 240 250
ADFQTLPVGS SAAVEPLGLE LVCRAPPGTS EGHWAWEATG AWNCSVENGG
260 270 280 290 300
CEYLCNRSTN EPRCLCPRDM DLQADGRSCA RPVVQSCNEL CEHFCVSNAE
310 320 330 340 350
VPGSYSCMCE TGYQLAADGH RCEDVDDCKQ GPNPCPQLCV NTKGGFECFC
360 370 380 390 400
YDGYELVDGE CVELLDPCFG SNCEFQCQPV SPTDYRCICA PGFAPKPDEP
410 420 430 440 450
HKCEMFCNET SCPADCDPNS PTVCECPEGF ILDEGSVCTD IDECSQGECF
460 470 480 490 500
TSECRNFPGS YECICGPDTA LAGQISKDCD PIPVREDTKE EEGSGEPPVS
510 520 530 540 550
PTPGSPTGPP SARPVHSGVL IGISIASLSL VVALLALLCH LRKKQGAARA
560 570
ELEYKCASSA KEVVLQHVRT DRTLQKF
Length:577
Mass (Da):61,868
Last modified:April 1, 1990 - v1
Checksum:iB20E50B0FE745014
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14432 mRNA. Translation: CAA32597.1.
BC019154 mRNA. Translation: AAH19154.1.
CCDSiCCDS16838.1.
PIRiS08488. A60501.
RefSeqiNP_033404.1. NM_009378.3.
UniGeneiMm.24096.

Genome annotation databases

EnsembliENSMUST00000099270; ENSMUSP00000096877; ENSMUSG00000074743.
GeneIDi21824.
KEGGimmu:21824.
UCSCiuc008mtd.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Thrombomodulin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14432 mRNA. Translation: CAA32597.1.
BC019154 mRNA. Translation: AAH19154.1.
CCDSiCCDS16838.1.
PIRiS08488. A60501.
RefSeqiNP_033404.1. NM_009378.3.
UniGeneiMm.24096.

3D structure databases

ProteinModelPortaliP15306.
SMRiP15306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP15306. 2 interactors.
MINTiMINT-4138449.
STRINGi10090.ENSMUSP00000096877.

PTM databases

iPTMnetiP15306.
PhosphoSitePlusiP15306.

Proteomic databases

PaxDbiP15306.
PeptideAtlasiP15306.
PRIDEiP15306.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099270; ENSMUSP00000096877; ENSMUSG00000074743.
GeneIDi21824.
KEGGimmu:21824.
UCSCiuc008mtd.2. mouse.

Organism-specific databases

CTDi7056.
MGIiMGI:98736. Thbd.

Phylogenomic databases

eggNOGiENOG410IF0T. Eukaryota.
ENOG410Y5JS. LUCA.
GeneTreeiENSGT00810000125382.
HOGENOMiHOG000114624.
HOVERGENiHBG000291.
InParanoidiP15306.
KOiK03907.
OMAiLCGPLCV.
OrthoDBiEOG091G06M1.
PhylomeDBiP15306.
TreeFamiTF330714.

Enzyme and pathway databases

ReactomeiR-MMU-140875. Common Pathway of Fibrin Clot Formation.
R-MMU-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

PROiP15306.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074743.
CleanExiMM_THBD.
ExpressionAtlasiP15306. baseline and differential.
GenevisibleiP15306. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016316. CD141.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR015149. Tme5_EGF-like.
[Graphical view]
PfamiPF07645. EGF_CA. 2 hits.
PF00059. Lectin_C. 1 hit.
PF09064. Tme5_EGF_like. 1 hit.
[Graphical view]
PIRSFiPIRSF001775. CD93/CD141. 1 hit.
SMARTiSM00034. CLECT. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 4 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRBM_MOUSE
AccessioniPrimary (citable) accession number: P15306
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 162 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.