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P15285

- PSPB_RABIT

UniProt

P15285 - PSPB_RABIT

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Protein
Pulmonary surfactant-associated protein B
Gene
SFTPB, SFTP3
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.

GO - Biological processi

  1. lipid metabolic process Source: InterPro
  2. respiratory gaseous exchange Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Gaseous exchange

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein B
Short name:
SP-B
Alternative name(s):
6 kDa protein
Pulmonary surfactant-associated proteolipid SPL(Phe)
Gene namesi
Name:SFTPB
Synonyms:SFTP3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Propeptidei25 – 184160
PRO_0000031653Add
BLAST
Chaini185 – 26379Pulmonary surfactant-associated protein B
PRO_0000031654Add
BLAST
Propeptidei264 – 370107
PRO_0000031655Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi70 ↔ 144 By similarity
Disulfide bondi73 ↔ 138 By similarity
Disulfide bondi101 ↔ 113 By similarity
Disulfide bondi192 ↔ 261 By similarity
Disulfide bondi195 ↔ 255 By similarity
Disulfide bondi219 ↔ 230 By similarity
Disulfide bondi232 – 232Interchain By similarity
Disulfide bondi288 ↔ 355 By similarity
Disulfide bondi291 ↔ 349 By similarity
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi314 ↔ 324 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000025658.

Structurei

3D structure databases

ProteinModelPortaliP15285.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 6641Saposin A-type
Add
BLAST
Domaini66 – 14883Saposin B-type 1
Add
BLAST
Domaini188 – 26578Saposin B-type 2
Add
BLAST
Domaini284 – 35976Saposin B-type 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG286450.
GeneTreeiENSGT00530000063434.
HOGENOMiHOG000115745.
HOVERGENiHBG006905.
OMAiCWLCRTL.
TreeFamiTF316942.

Family and domain databases

Gene3Di1.10.225.10. 3 hits.
InterProiIPR003119. SapA.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR011001. Saposin-like.
IPR008139. SaposinB.
[Graphical view]
PfamiPF02199. SapA. 1 hit.
PF05184. SapB_1. 1 hit.
PF03489. SapB_2. 2 hits.
[Graphical view]
SMARTiSM00162. SAPA. 1 hit.
SM00741. SapB. 3 hits.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 3 hits.
PROSITEiPS51110. SAP_A. 1 hit.
PS50015. SAP_B. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15285-1 [UniParc]FASTAAdd to Basket

« Hide

MAKSHLPPWL LLLLLPTLCG PGTAVWATSP LACAQGPEFW CQSLEQALQC    50
KALGHCLQEV WGHVGADDLC QECQDIVNIL TKMTKEAIFQ DTIRKFLEHE 100
CDVLPLKLLV PQCHHVLDVY FPLTITYFQS QINAKAICQH LGLCQPGSPE 150
PPLDPLPDKL VLPTLLGALP AKPGPHTQDL SAQRFPIPLP LCWLCRTLLK 200
RIQAMIPKGV LAMAVAQVCH VVPLVVGGIC QCLAERYTVI LLEVLLGHVL 250
PQLVCGLVLR CSSVDSIGQV PPTLEALPGE WLPQDPECRL CMSVTTQARN 300
ISEQTRPQAV YHACLSSQLD KQECEQFVEL HTPQLLSLLS RGWDARAICQ 350
ALGACVATLS PLQCIQSPHF 370
Length:370
Mass (Da):40,610
Last modified:October 1, 1996 - v2
Checksum:i423047A69B12DCB5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151Missing in AAA67934. 1 Publication
Sequence conflicti129 – 1291Q → L in AAB48076. 1 Publication
Sequence conflicti184 – 1841R → P in AAA31466. 1 Publication
Sequence conflicti232 – 2321C → R in AAA67934. 1 Publication
Sequence conflicti289 – 2891R → P in AAB48076. 1 Publication
Sequence conflicti329 – 35527ELHTP…ALGAC → AAHAPAAEPAVQGLGCPRNL PGPEGRV in AAA31466. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24901 mRNA. Translation: AAA31466.1.
U17106 mRNA. Translation: AAA67934.1.
U40853 Genomic DNA. Translation: AAB48076.1.
S80649 Genomic DNA. Translation: AAD14335.1.
PIRiA32421. LNRBB.
I46531.
RefSeqiNP_001075812.1. NM_001082343.1.
UniGeneiOcu.1963.

Genome annotation databases

EnsembliENSOCUT00000021287; ENSOCUP00000025658; ENSOCUG00000020733.
GeneIDi100009194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24901 mRNA. Translation: AAA31466.1 .
U17106 mRNA. Translation: AAA67934.1 .
U40853 Genomic DNA. Translation: AAB48076.1 .
S80649 Genomic DNA. Translation: AAD14335.1 .
PIRi A32421. LNRBB.
I46531.
RefSeqi NP_001075812.1. NM_001082343.1.
UniGenei Ocu.1963.

3D structure databases

ProteinModelPortali P15285.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000025658.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSOCUT00000021287 ; ENSOCUP00000025658 ; ENSOCUG00000020733 .
GeneIDi 100009194.

Organism-specific databases

CTDi 100009194.

Phylogenomic databases

eggNOGi NOG286450.
GeneTreei ENSGT00530000063434.
HOGENOMi HOG000115745.
HOVERGENi HBG006905.
OMAi CWLCRTL.
TreeFami TF316942.

Family and domain databases

Gene3Di 1.10.225.10. 3 hits.
InterProi IPR003119. SapA.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR011001. Saposin-like.
IPR008139. SaposinB.
[Graphical view ]
Pfami PF02199. SapA. 1 hit.
PF05184. SapB_1. 1 hit.
PF03489. SapB_2. 2 hits.
[Graphical view ]
SMARTi SM00162. SAPA. 1 hit.
SM00741. SapB. 3 hits.
[Graphical view ]
SUPFAMi SSF47862. SSF47862. 3 hits.
PROSITEi PS51110. SAP_A. 1 hit.
PS50015. SAP_B. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of the cDNA for pulmonary surfactant-associated protein-B (SP-B) in the rabbit."
    Xu J., Richardson C., Ford C., Spencer T., Li-Juan Y., Mackie G., Hammond G., Possmayer F.
    Biochem. Biophys. Res. Commun. 160:325-332(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Transcription and mRNA stability regulate developmental and hormonal expression of rabbit surfactant protein B gene."
    Margana R.K., Boggaram V.
    Am. J. Physiol. 268:L481-L490(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
  3. "Rabbit surfactant protein B gene: structure and functional characterization of the promoter."
    Margana R.K., Boggaram V.
    Am. J. Physiol. 270:L601-L612(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  4. "The upstream region of the SP-B gene: intrinsic promoter activity and glucocorticoid responsiveness related to a new DNA-binding protein."
    Luzi P., Anceschi M., Strayer D.S.
    Gene 165:285-290(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-34.

Entry informationi

Entry nameiPSPB_RABIT
AccessioniPrimary (citable) accession number: P15285
Secondary accession number(s): P79333
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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