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P15285

- PSPB_RABIT

UniProt

P15285 - PSPB_RABIT

Protein

Pulmonary surfactant-associated protein B

Gene

SFTPB

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.

    GO - Biological processi

    1. lipid metabolic process Source: InterPro
    2. respiratory gaseous exchange Source: UniProtKB-KW

    Keywords - Biological processi

    Gaseous exchange

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pulmonary surfactant-associated protein B
    Short name:
    SP-B
    Alternative name(s):
    6 kDa protein
    Pulmonary surfactant-associated proteolipid SPL(Phe)
    Gene namesi
    Name:SFTPB
    Synonyms:SFTP3
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted, Surface film

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Propeptidei25 – 184160PRO_0000031653Add
    BLAST
    Chaini185 – 26379Pulmonary surfactant-associated protein BPRO_0000031654Add
    BLAST
    Propeptidei264 – 370107PRO_0000031655Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi70 ↔ 144PROSITE-ProRule annotation
    Disulfide bondi73 ↔ 138PROSITE-ProRule annotation
    Disulfide bondi101 ↔ 113PROSITE-ProRule annotation
    Disulfide bondi192 ↔ 261PROSITE-ProRule annotation
    Disulfide bondi195 ↔ 255PROSITE-ProRule annotation
    Disulfide bondi219 ↔ 230PROSITE-ProRule annotation
    Disulfide bondi232 – 232InterchainPROSITE-ProRule annotation
    Disulfide bondi288 ↔ 355PROSITE-ProRule annotation
    Disulfide bondi291 ↔ 349PROSITE-ProRule annotation
    Glycosylationi300 – 3001N-linked (GlcNAc...)PROSITE-ProRule annotation
    Disulfide bondi314 ↔ 324PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000025658.

    Structurei

    3D structure databases

    ProteinModelPortaliP15285.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 6641Saposin A-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini66 – 14883Saposin B-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini188 – 26578Saposin B-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini284 – 35976Saposin B-type 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 saposin A-type domain.PROSITE-ProRule annotation
    Contains 3 saposin B-type domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG286450.
    GeneTreeiENSGT00530000063434.
    HOGENOMiHOG000115745.
    HOVERGENiHBG006905.
    OMAiCWLCRTL.
    TreeFamiTF316942.

    Family and domain databases

    Gene3Di1.10.225.10. 3 hits.
    InterProiIPR003119. SapA.
    IPR007856. SapB_1.
    IPR008138. SapB_2.
    IPR011001. Saposin-like.
    IPR008139. SaposinB.
    [Graphical view]
    PfamiPF02199. SapA. 1 hit.
    PF05184. SapB_1. 1 hit.
    PF03489. SapB_2. 2 hits.
    [Graphical view]
    SMARTiSM00162. SAPA. 1 hit.
    SM00741. SapB. 3 hits.
    [Graphical view]
    SUPFAMiSSF47862. SSF47862. 3 hits.
    PROSITEiPS51110. SAP_A. 1 hit.
    PS50015. SAP_B. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15285-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKSHLPPWL LLLLLPTLCG PGTAVWATSP LACAQGPEFW CQSLEQALQC    50
    KALGHCLQEV WGHVGADDLC QECQDIVNIL TKMTKEAIFQ DTIRKFLEHE 100
    CDVLPLKLLV PQCHHVLDVY FPLTITYFQS QINAKAICQH LGLCQPGSPE 150
    PPLDPLPDKL VLPTLLGALP AKPGPHTQDL SAQRFPIPLP LCWLCRTLLK 200
    RIQAMIPKGV LAMAVAQVCH VVPLVVGGIC QCLAERYTVI LLEVLLGHVL 250
    PQLVCGLVLR CSSVDSIGQV PPTLEALPGE WLPQDPECRL CMSVTTQARN 300
    ISEQTRPQAV YHACLSSQLD KQECEQFVEL HTPQLLSLLS RGWDARAICQ 350
    ALGACVATLS PLQCIQSPHF 370
    Length:370
    Mass (Da):40,610
    Last modified:October 1, 1996 - v2
    Checksum:i423047A69B12DCB5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151Missing in AAA67934. (PubMed:7900830)Curated
    Sequence conflicti129 – 1291Q → L in AAB48076. (PubMed:8928820)Curated
    Sequence conflicti184 – 1841R → P in AAA31466. (PubMed:2469419)Curated
    Sequence conflicti232 – 2321C → R in AAA67934. (PubMed:7900830)Curated
    Sequence conflicti289 – 2891R → P in AAB48076. (PubMed:8928820)Curated
    Sequence conflicti329 – 35527ELHTP…ALGAC → AAHAPAAEPAVQGLGCPRNL PGPEGRV in AAA31466. (PubMed:2469419)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24901 mRNA. Translation: AAA31466.1.
    U17106 mRNA. Translation: AAA67934.1.
    U40853 Genomic DNA. Translation: AAB48076.1.
    S80649 Genomic DNA. Translation: AAD14335.1.
    PIRiA32421. LNRBB.
    I46531.
    RefSeqiNP_001075812.1. NM_001082343.1.
    UniGeneiOcu.1963.

    Genome annotation databases

    EnsembliENSOCUT00000021287; ENSOCUP00000025658; ENSOCUG00000020733.
    GeneIDi100009194.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24901 mRNA. Translation: AAA31466.1 .
    U17106 mRNA. Translation: AAA67934.1 .
    U40853 Genomic DNA. Translation: AAB48076.1 .
    S80649 Genomic DNA. Translation: AAD14335.1 .
    PIRi A32421. LNRBB.
    I46531.
    RefSeqi NP_001075812.1. NM_001082343.1.
    UniGenei Ocu.1963.

    3D structure databases

    ProteinModelPortali P15285.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000025658.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSOCUT00000021287 ; ENSOCUP00000025658 ; ENSOCUG00000020733 .
    GeneIDi 100009194.

    Organism-specific databases

    CTDi 6439.

    Phylogenomic databases

    eggNOGi NOG286450.
    GeneTreei ENSGT00530000063434.
    HOGENOMi HOG000115745.
    HOVERGENi HBG006905.
    OMAi CWLCRTL.
    TreeFami TF316942.

    Family and domain databases

    Gene3Di 1.10.225.10. 3 hits.
    InterProi IPR003119. SapA.
    IPR007856. SapB_1.
    IPR008138. SapB_2.
    IPR011001. Saposin-like.
    IPR008139. SaposinB.
    [Graphical view ]
    Pfami PF02199. SapA. 1 hit.
    PF05184. SapB_1. 1 hit.
    PF03489. SapB_2. 2 hits.
    [Graphical view ]
    SMARTi SM00162. SAPA. 1 hit.
    SM00741. SapB. 3 hits.
    [Graphical view ]
    SUPFAMi SSF47862. SSF47862. 3 hits.
    PROSITEi PS51110. SAP_A. 1 hit.
    PS50015. SAP_B. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the cDNA for pulmonary surfactant-associated protein-B (SP-B) in the rabbit."
      Xu J., Richardson C., Ford C., Spencer T., Li-Juan Y., Mackie G., Hammond G., Possmayer F.
      Biochem. Biophys. Res. Commun. 160:325-332(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "Transcription and mRNA stability regulate developmental and hormonal expression of rabbit surfactant protein B gene."
      Margana R.K., Boggaram V.
      Am. J. Physiol. 268:L481-L490(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: New Zealand white.
    3. "Rabbit surfactant protein B gene: structure and functional characterization of the promoter."
      Margana R.K., Boggaram V.
      Am. J. Physiol. 270:L601-L612(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    4. "The upstream region of the SP-B gene: intrinsic promoter activity and glucocorticoid responsiveness related to a new DNA-binding protein."
      Luzi P., Anceschi M., Strayer D.S.
      Gene 165:285-290(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-34.

    Entry informationi

    Entry nameiPSPB_RABIT
    AccessioniPrimary (citable) accession number: P15285
    Secondary accession number(s): P79333
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3