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Protein

Pulmonary surfactant-associated protein B

Gene

SFTPB

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Gaseous exchange

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein B
Short name:
SP-B
Alternative name(s):
6 kDa protein
Pulmonary surfactant-associated proteolipid SPL(Phe)
Gene namesi
Name:SFTPB
Synonyms:SFTP3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000003165325 – 184Add BLAST160
ChainiPRO_0000031654185 – 263Pulmonary surfactant-associated protein BAdd BLAST79
PropeptideiPRO_0000031655264 – 370Add BLAST107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi70 ↔ 144PROSITE-ProRule annotation
Disulfide bondi73 ↔ 138PROSITE-ProRule annotation
Disulfide bondi101 ↔ 113PROSITE-ProRule annotation
Disulfide bondi192 ↔ 261PROSITE-ProRule annotation
Disulfide bondi195 ↔ 255PROSITE-ProRule annotation
Disulfide bondi219 ↔ 230PROSITE-ProRule annotation
Disulfide bondi232InterchainPROSITE-ProRule annotation
Disulfide bondi288 ↔ 355PROSITE-ProRule annotation
Disulfide bondi291 ↔ 349PROSITE-ProRule annotation
Glycosylationi300N-linked (GlcNAc...)PROSITE-ProRule annotation1
Disulfide bondi314 ↔ 324PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000025658.

Structurei

3D structure databases

ProteinModelPortaliP15285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 66Saposin A-typePROSITE-ProRule annotationAdd BLAST41
Domaini66 – 148Saposin B-type 1PROSITE-ProRule annotationAdd BLAST83
Domaini188 – 265Saposin B-type 2PROSITE-ProRule annotationAdd BLAST78
Domaini284 – 359Saposin B-type 3PROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Contains 1 saposin A-type domain.PROSITE-ProRule annotation
Contains 3 saposin B-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1340. Eukaryota.
ENOG410XSI5. LUCA.
GeneTreeiENSGT00530000063434.
HOGENOMiHOG000115745.
HOVERGENiHBG006905.
InParanoidiP15285.
OMAiVWGHVGA.
OrthoDBiEOG091G0K86.
TreeFamiTF316942.

Family and domain databases

Gene3Di1.10.225.10. 3 hits.
InterProiIPR003119. SAP_A.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR011001. Saposin-like.
IPR008139. SaposinB_dom.
[Graphical view]
PfamiPF02199. SapA. 1 hit.
PF05184. SapB_1. 1 hit.
PF03489. SapB_2. 2 hits.
[Graphical view]
SMARTiSM00162. SAPA. 1 hit.
SM00741. SapB. 3 hits.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 3 hits.
PROSITEiPS51110. SAP_A. 1 hit.
PS50015. SAP_B. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15285-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSHLPPWL LLLLLPTLCG PGTAVWATSP LACAQGPEFW CQSLEQALQC
60 70 80 90 100
KALGHCLQEV WGHVGADDLC QECQDIVNIL TKMTKEAIFQ DTIRKFLEHE
110 120 130 140 150
CDVLPLKLLV PQCHHVLDVY FPLTITYFQS QINAKAICQH LGLCQPGSPE
160 170 180 190 200
PPLDPLPDKL VLPTLLGALP AKPGPHTQDL SAQRFPIPLP LCWLCRTLLK
210 220 230 240 250
RIQAMIPKGV LAMAVAQVCH VVPLVVGGIC QCLAERYTVI LLEVLLGHVL
260 270 280 290 300
PQLVCGLVLR CSSVDSIGQV PPTLEALPGE WLPQDPECRL CMSVTTQARN
310 320 330 340 350
ISEQTRPQAV YHACLSSQLD KQECEQFVEL HTPQLLSLLS RGWDARAICQ
360 370
ALGACVATLS PLQCIQSPHF
Length:370
Mass (Da):40,610
Last modified:October 1, 1996 - v2
Checksum:i423047A69B12DCB5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15Missing in AAA67934 (PubMed:7900830).Curated1
Sequence conflicti129Q → L in AAB48076 (PubMed:8928820).Curated1
Sequence conflicti184R → P in AAA31466 (PubMed:2469419).Curated1
Sequence conflicti232C → R in AAA67934 (PubMed:7900830).Curated1
Sequence conflicti289R → P in AAB48076 (PubMed:8928820).Curated1
Sequence conflicti329 – 355ELHTP…ALGAC → AAHAPAAEPAVQGLGCPRNL PGPEGRV in AAA31466 (PubMed:2469419).CuratedAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24901 mRNA. Translation: AAA31466.1.
U17106 mRNA. Translation: AAA67934.1.
U40853 Genomic DNA. Translation: AAB48076.1.
S80649 Genomic DNA. Translation: AAD14335.1.
PIRiA32421. LNRBB.
I46531.
RefSeqiNP_001075812.1. NM_001082343.1.
XP_008250836.1. XM_008252614.2.
XP_008250841.1. XM_008252619.2.
XP_008250852.1. XM_008252630.2.
UniGeneiOcu.1963.

Genome annotation databases

EnsembliENSOCUT00000021287; ENSOCUP00000025658; ENSOCUG00000020733.
GeneIDi100009194.
KEGGiocu:100009194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24901 mRNA. Translation: AAA31466.1.
U17106 mRNA. Translation: AAA67934.1.
U40853 Genomic DNA. Translation: AAB48076.1.
S80649 Genomic DNA. Translation: AAD14335.1.
PIRiA32421. LNRBB.
I46531.
RefSeqiNP_001075812.1. NM_001082343.1.
XP_008250836.1. XM_008252614.2.
XP_008250841.1. XM_008252619.2.
XP_008250852.1. XM_008252630.2.
UniGeneiOcu.1963.

3D structure databases

ProteinModelPortaliP15285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000025658.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000021287; ENSOCUP00000025658; ENSOCUG00000020733.
GeneIDi100009194.
KEGGiocu:100009194.

Organism-specific databases

CTDi6439.

Phylogenomic databases

eggNOGiKOG1340. Eukaryota.
ENOG410XSI5. LUCA.
GeneTreeiENSGT00530000063434.
HOGENOMiHOG000115745.
HOVERGENiHBG006905.
InParanoidiP15285.
OMAiVWGHVGA.
OrthoDBiEOG091G0K86.
TreeFamiTF316942.

Family and domain databases

Gene3Di1.10.225.10. 3 hits.
InterProiIPR003119. SAP_A.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR011001. Saposin-like.
IPR008139. SaposinB_dom.
[Graphical view]
PfamiPF02199. SapA. 1 hit.
PF05184. SapB_1. 1 hit.
PF03489. SapB_2. 2 hits.
[Graphical view]
SMARTiSM00162. SAPA. 1 hit.
SM00741. SapB. 3 hits.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 3 hits.
PROSITEiPS51110. SAP_A. 1 hit.
PS50015. SAP_B. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSPB_RABIT
AccessioniPrimary (citable) accession number: P15285
Secondary accession number(s): P79333
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 1, 1996
Last modified: October 5, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.