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Protein

Tyrosine-protein phosphatase YopH

Gene

yopH

Organism
Yersinia enterocolitica
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to resist phagocytosis by peritoneal macrophages.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei403Phosphocysteine intermediate1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BRENDAi3.1.3.48. 6741.
SABIO-RKP15273.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase YopH (EC:3.1.3.48)
Alternative name(s):
Virulence protein
Gene namesi
Name:yopH
Synonyms:yop51
Encoded oniPlasmid pYV0 Publication
OrganismiYersinia enterocolitica
Taxonomic identifieri630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia

Subcellular locationi

  • Secreted

  • Note: Secreted via type III secretion system.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4404.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948611 – 468Tyrosine-protein phosphatase YopHAdd BLAST468

Proteomic databases

PRIDEiP15273.

Expressioni

Inductioni

At 37 degrees Celsius in the absence of calcium.

Interactioni

Subunit structurei

Monomer.

Chemistry databases

BindingDBiP15273.

Structurei

Secondary structure

1468
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 39Combined sources3
Beta strandi42 – 46Combined sources5
Helixi50 – 62Combined sources13
Helixi191 – 208Combined sources18
Beta strandi221 – 224Combined sources4
Helixi236 – 238Combined sources3
Beta strandi239 – 241Combined sources3
Beta strandi246 – 251Combined sources6
Beta strandi254 – 259Combined sources6
Helixi264 – 266Combined sources3
Helixi267 – 276Combined sources10
Beta strandi282 – 284Combined sources3
Helixi288 – 292Combined sources5
Helixi294 – 296Combined sources3
Beta strandi302 – 304Combined sources3
Beta strandi306 – 308Combined sources3
Beta strandi311 – 324Combined sources14
Beta strandi327 – 338Combined sources12
Beta strandi344 – 351Combined sources8
Beta strandi356 – 358Combined sources3
Helixi362 – 385Combined sources24
Helixi389 – 392Combined sources4
Beta strandi394 – 397Combined sources4
Beta strandi400 – 408Combined sources9
Helixi409 – 419Combined sources11
Helixi422 – 424Combined sources3
Helixi429 – 439Combined sources11
Helixi448 – 460Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LYVX-ray1.36A163-468[»]
1PA9X-ray2.00A185-468[»]
1XXPX-ray3.00A/B163-468[»]
1XXVX-ray2.50A/B163-468[»]
1YPTX-ray2.50A/B164-468[»]
1YTNX-ray2.40A164-468[»]
1YTSX-ray2.50A191-468[»]
1YTWX-ray2.40A164-468[»]
2I42X-ray2.20A164-468[»]
3BLTX-ray2.20A164-468[»]
3BLUX-ray2.00A164-468[»]
3BM8X-ray2.70A164-468[»]
3F99X-ray1.65A164-468[»]
3F9AX-ray1.69A164-468[»]
3F9BX-ray1.42A164-468[»]
3U96X-ray1.80A/B163-468[»]
4GF3X-ray1.90B21-63[»]
4YAAX-ray1.05A164-468[»]
4Z6BX-ray1.20A164-468[»]
4ZI4X-ray1.12A164-468[»]
4ZN5X-ray1.12A164-468[»]
ProteinModelPortaliP15273.
SMRiP15273.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15273.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini152 – 461Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST310

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.30.1570.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR015103. ProtTyrPase_YopH_N.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR003546. Tyr_Pase_SptP/YopH.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
PF09013. YopH_N. 1 hit.
[Graphical view]
PRINTSiPR01371. BACYPHPHTASE.
PR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF64449. SSF64449. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLSLSDLHR QVSRLVQQES GDCTGKLRGN VAANKETTFQ GLTIASGARE
60 70 80 90 100
SEKVFAQTVL SHVANIVLTQ EDTAKLLQST VKHNLNNYEL RSVGNGNSVL
110 120 130 140 150
VSLRSDQMTL QDAKVLLEAA LRQESGARGH VSSHSHSVLH APGTPVREGL
160 170 180 190 200
RSHLDPRTPP LPPRERPHTS GHHGAGEARA TAPSTVSPYG PEARAELSSR
210 220 230 240 250
LTTLRNTLAP ATNDPRYLQA CGGEKLNRFR DIQCCRQTAV RADLNANYIQ
260 270 280 290 300
VGNTRTIACQ YPLQSQLESH FRMLAENRTP VLAVLASSSE IANQRFGMPD
310 320 330 340 350
YFRQSGTYGS ITVESKMTQQ VGLGDGIMAD MYTLTIREAG QKTISVPVVH
360 370 380 390 400
VGNWPDQTAV SSEVTKALAS LVDQTAETKR NMYESKGSSA VADDSKLRPV
410 420 430 440 450
IHCRAGVGRT AQLIGAMCMN DSRNSQLSVE DMVSQMRVQR NGIMVQKDEQ
460
LDVLIKLAEG QGRPLLNS
Length:468
Mass (Da):50,939
Last modified:April 1, 1990 - v1
Checksum:iB207D0B1AC830AF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30457 Unassigned DNA. Translation: AAA19860.1.
PIRiA53889.
RefSeqiNP_052424.1. NC_002120.1.
WP_010891234.1. NZ_KN150737.1.

Genome annotation databases

GeneIDi1239155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30457 Unassigned DNA. Translation: AAA19860.1.
PIRiA53889.
RefSeqiNP_052424.1. NC_002120.1.
WP_010891234.1. NZ_KN150737.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LYVX-ray1.36A163-468[»]
1PA9X-ray2.00A185-468[»]
1XXPX-ray3.00A/B163-468[»]
1XXVX-ray2.50A/B163-468[»]
1YPTX-ray2.50A/B164-468[»]
1YTNX-ray2.40A164-468[»]
1YTSX-ray2.50A191-468[»]
1YTWX-ray2.40A164-468[»]
2I42X-ray2.20A164-468[»]
3BLTX-ray2.20A164-468[»]
3BLUX-ray2.00A164-468[»]
3BM8X-ray2.70A164-468[»]
3F99X-ray1.65A164-468[»]
3F9AX-ray1.69A164-468[»]
3F9BX-ray1.42A164-468[»]
3U96X-ray1.80A/B163-468[»]
4GF3X-ray1.90B21-63[»]
4YAAX-ray1.05A164-468[»]
4Z6BX-ray1.20A164-468[»]
4ZI4X-ray1.12A164-468[»]
4ZN5X-ray1.12A164-468[»]
ProteinModelPortaliP15273.
SMRiP15273.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP15273.
ChEMBLiCHEMBL4404.

Proteomic databases

PRIDEiP15273.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1239155.

Enzyme and pathway databases

BRENDAi3.1.3.48. 6741.
SABIO-RKP15273.

Miscellaneous databases

EvolutionaryTraceiP15273.
PROiP15273.

Family and domain databases

Gene3Di3.30.1570.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR015103. ProtTyrPase_YopH_N.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR003546. Tyr_Pase_SptP/YopH.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
PF09013. YopH_N. 1 hit.
[Graphical view]
PRINTSiPR01371. BACYPHPHTASE.
PR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF64449. SSF64449. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYOPH_YEREN
AccessioniPrimary (citable) accession number: P15273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.