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Protein

Interferon gamma receptor 1

Gene

Ifngr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:2530582, PubMed:2532365, PubMed:2137461, PubMed:2531896, PubMed:2530216). Ligand binding stimulates activation of the JAK/STAT signaling pathway (By similarity).By similarity5 Publications

GO - Molecular functioni

GO - Biological processi

  • cytokine-mediated signaling pathway Source: GO_Central
  • defense response to virus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-877300. Interferon gamma signaling.
R-MMU-877312. Regulation of IFNG signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma receptor 1Imported
Short name:
IFN-gamma receptor 1
Short name:
IFN-gamma-R1
Alternative name(s):
Interferon gamma receptor alpha-chainBy similarity
Short name:
IFN-gamma-R-alphaBy similarity
CD_antigen: CD119
Gene namesi
Name:Ifngr1Imported
Synonyms:Ifngr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:107655. Ifngr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 254ExtracellularSequence analysisAdd BLAST229
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 477CytoplasmicSequence analysisAdd BLAST202

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001101026 – 477Interferon gamma receptor 11 PublicationAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi83 ↔ 91By similarity
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi128 ↔ 174By similarity
Disulfide bondi203 ↔ 208By similarity
Disulfide bondi222 ↔ 243By similarity
Modified residuei362PhosphoserineCombined sources1
Modified residuei367PhosphothreonineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Modified residuei373PhosphothreonineCombined sources1
Modified residuei375PhosphothreonineCombined sources1
Modified residuei379PhosphoserineCombined sources1
Modified residuei402PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated at Ser/Thr residues.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP15261.
MaxQBiP15261.
PaxDbiP15261.
PeptideAtlasiP15261.
PRIDEiP15261.

PTM databases

iPTMnetiP15261.
PhosphoSitePlusiP15261.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020009.
CleanExiMM_IFNGR1.
ExpressionAtlasiP15261. baseline and differential.
GenevisibleiP15261. MM.

Interactioni

Subunit structurei

Monomer. Heterodimer with IFNGR2, to form the IFNG receptor complex. Interacts with JAK1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200542. 3 interactors.
STRINGi10090.ENSMUSP00000020188.

Structurei

3D structure databases

ProteinModelPortaliP15261.
SMRiP15261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 2 fibronectin type-III domains.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG11. Eukaryota.
ENOG411218K. LUCA.
GeneTreeiENSGT00510000048929.
HOGENOMiHOG000113074.
HOVERGENiHBG052128.
InParanoidiP15261.
KOiK05132.
OMAiNSYHSRN.
OrthoDBiEOG091G08ZD.
TreeFamiTF338358.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR021126. Interferon_gamma_pox/mammal.
IPR008355. Interferon_gamma_rcpt_asu.
[Graphical view]
PANTHERiPTHR20859:SF5. PTHR20859:SF5. 1 hit.
PfamiPF07140. IFNGR1. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
PRINTSiPR01777. INTERFERONGR.
SUPFAMiSSF49265. SSF49265. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPQAAAGRM ILLVVLMLSA KVGSGALTST EDPEPPSVPV PTNVLIKSYN
60 70 80 90 100
LNPVVCWEYQ NMSQTPIFTV QVKVYSGSWT DSCTNISDHC CNIYEQIMYP
110 120 130 140 150
DVSAWARVKA KVGQKESDYA RSKEFLMCLK GKVGPPGLEI RRKKEEQLSV
160 170 180 190 200
LVFHPEVVVN GESQGTMFGD GSTCYTFDYT VYVEHNRSGE ILHTKHTVEK
210 220 230 240 250
EECNETLCEL NISVSTLDSR YCISVDGISS FWQVRTEKSK DVCIPPFHDD
260 270 280 290 300
RKDSIWILVV APLTVFTVVI LVFAYWYTKK NSFKRKSIML PKSLLSVVKS
310 320 330 340 350
ATLETKPESK YSLVTPHQPA VLESETVICE EPLSTVTAPD SPEAAEQEEL
360 370 380 390 400
SKETKALEAG GSTSAMTPDS PPTPTQRRSF SLLSSNQSGP CSLTAYHSRN
410 420 430 440 450
GSDSGLVGSG SSISDLESLP NNNSETKMAE HDPPPVRKAP MASGYDKPHM
460 470
LVDVLVDVGG KESLMGYRLT GEAQELS
Length:477
Mass (Da):52,343
Last modified:July 27, 2011 - v3
Checksum:i2216663F5B9C5256
GO

Sequence cautioni

The sequence AAA37895 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30Missing AA sequence (PubMed:2137461).Curated1
Sequence conflicti95E → G in AAA37895 (PubMed:2531896).Curated1
Sequence conflicti95E → G in AAA39177 (PubMed:2530216).Curated1
Sequence conflicti95E → G in AAA39178 (PubMed:2137461).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28995 mRNA. Translation: AAA37895.1. Different initiation.
M26711 mRNA. Translation: AAA37896.1.
M28233 mRNA. Translation: AAA37898.1.
M25764 mRNA. Translation: AAA39177.1.
J05265 mRNA. Translation: AAA39178.1.
AF128216 mRNA. Translation: AAF22557.1.
AK151079 mRNA. Translation: BAE30094.1.
AK153347 mRNA. Translation: BAE31923.1.
AK159359 mRNA. Translation: BAE35017.1.
AK169593 mRNA. Translation: BAE41245.1.
CH466562 Genomic DNA. Translation: EDL03452.1.
U05960 Genomic DNA. Translation: AAA80980.1.
CCDSiCCDS35856.1.
PIRiA34368.
RefSeqiNP_034641.1. NM_010511.3.
UniGeneiMm.549.

Genome annotation databases

EnsembliENSMUST00000020188; ENSMUSP00000020188; ENSMUSG00000020009.
GeneIDi15979.
KEGGimmu:15979.
UCSCiuc007eng.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28995 mRNA. Translation: AAA37895.1. Different initiation.
M26711 mRNA. Translation: AAA37896.1.
M28233 mRNA. Translation: AAA37898.1.
M25764 mRNA. Translation: AAA39177.1.
J05265 mRNA. Translation: AAA39178.1.
AF128216 mRNA. Translation: AAF22557.1.
AK151079 mRNA. Translation: BAE30094.1.
AK153347 mRNA. Translation: BAE31923.1.
AK159359 mRNA. Translation: BAE35017.1.
AK169593 mRNA. Translation: BAE41245.1.
CH466562 Genomic DNA. Translation: EDL03452.1.
U05960 Genomic DNA. Translation: AAA80980.1.
CCDSiCCDS35856.1.
PIRiA34368.
RefSeqiNP_034641.1. NM_010511.3.
UniGeneiMm.549.

3D structure databases

ProteinModelPortaliP15261.
SMRiP15261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200542. 3 interactors.
STRINGi10090.ENSMUSP00000020188.

PTM databases

iPTMnetiP15261.
PhosphoSitePlusiP15261.

Proteomic databases

EPDiP15261.
MaxQBiP15261.
PaxDbiP15261.
PeptideAtlasiP15261.
PRIDEiP15261.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020188; ENSMUSP00000020188; ENSMUSG00000020009.
GeneIDi15979.
KEGGimmu:15979.
UCSCiuc007eng.1. mouse.

Organism-specific databases

CTDi3459.
MGIiMGI:107655. Ifngr1.

Phylogenomic databases

eggNOGiENOG410IG11. Eukaryota.
ENOG411218K. LUCA.
GeneTreeiENSGT00510000048929.
HOGENOMiHOG000113074.
HOVERGENiHBG052128.
InParanoidiP15261.
KOiK05132.
OMAiNSYHSRN.
OrthoDBiEOG091G08ZD.
TreeFamiTF338358.

Enzyme and pathway databases

ReactomeiR-MMU-877300. Interferon gamma signaling.
R-MMU-877312. Regulation of IFNG signaling.

Miscellaneous databases

ChiTaRSiIfngr1. mouse.
PROiP15261.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020009.
CleanExiMM_IFNGR1.
ExpressionAtlasiP15261. baseline and differential.
GenevisibleiP15261. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR021126. Interferon_gamma_pox/mammal.
IPR008355. Interferon_gamma_rcpt_asu.
[Graphical view]
PANTHERiPTHR20859:SF5. PTHR20859:SF5. 1 hit.
PfamiPF07140. IFNGR1. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
PRINTSiPR01777. INTERFERONGR.
SUPFAMiSSF49265. SSF49265. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiINGR1_MOUSE
AccessioniPrimary (citable) accession number: P15261
Secondary accession number(s): Q91Y85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.