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P15260

- INGR1_HUMAN

UniProt

P15260 - INGR1_HUMAN

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Protein

Interferon gamma receptor 1

Gene

IFNGR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for interferon gamma. Two receptors bind one interferon gamma dimer.

GO - Molecular functioni

  1. interferon-gamma receptor activity Source: ProtInc

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: Reactome
  2. interferon-gamma-mediated signaling pathway Source: Reactome
  3. regulation of interferon-gamma-mediated signaling pathway Source: Reactome
  4. response to virus Source: ProtInc
  5. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_24980. Regulation of IFNG signaling.
REACT_25078. Interferon gamma signaling.
SignaLinkiP15260.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma receptor 1
Short name:
IFN-gamma receptor 1
Short name:
IFN-gamma-R1
Alternative name(s):
CDw119
CD_antigen: CD119
Gene namesi
Name:IFNGR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:5439. IFNGR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 245228ExtracellularSequence AnalysisAdd
BLAST
Transmembranei246 – 26621HelicalSequence AnalysisAdd
BLAST
Topological domaini267 – 489223CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. endoplasmic reticulum Source: Ensembl
  3. integral component of plasma membrane Source: ProtInc
  4. plasma membrane Source: Reactome
  5. postsynaptic density Source: Ensembl
  6. vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency 27A (IMD27A) [MIM:209950]: A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771C → Y in IMD27A; fails to bind IFN-gamma. 1 Publication
VAR_017577
Natural varianti87 – 871I → T in IMD27A; impaired response to IFN-gamma. 1 Publication
VAR_017578
Natural varianti99 – 1024Missing in IMD27A; fails to bind IFN-gamma. 1 Publication
VAR_017579

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi209950. phenotype.
600263. phenotype.
Orphaneti319581. Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial IFNgammaR1 deficiency.
319569. Autosomal recessive mendelian susceptibility to mycobacterial diseases due to partial IFNgammaR1 deficiency.
99898. Mendelian susceptibility to mycobacterial diseases due to complete IFNgammaR1 deficiency.
PharmGKBiPA29675.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Add
BLAST
Chaini18 – 489472Interferon gamma receptor 1PRO_0000011009Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi77 ↔ 851 Publication
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi122 ↔ 1671 Publication
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi195 ↔ 2001 Publication
Disulfide bondi214 ↔ 2351 Publication
Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
Modified residuei369 – 3691PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated at Ser/Thr residues.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP15260.
PaxDbiP15260.
PRIDEiP15260.

PTM databases

PhosphoSiteiP15260.
UniCarbKBiP15260.

Expressioni

Gene expression databases

BgeeiP15260.
CleanExiHS_IFNGR1.
ExpressionAtlasiP15260. baseline and differential.
GenevestigatoriP15260.

Organism-specific databases

HPAiCAB004444.
HPA029213.

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
STAT1P422244EBI-1030755,EBI-1057697

Protein-protein interaction databases

BioGridi109681. 12 interactions.
DIPiDIP-47N.
IntActiP15260. 6 interactions.
MINTiMINT-8013365.
STRINGi9606.ENSP00000356713.

Structurei

Secondary structure

1
489
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 386Combined sources
Beta strandi40 – 423Combined sources
Beta strandi45 – 495Combined sources
Beta strandi58 – 658Combined sources
Beta strandi69 – 713Combined sources
Beta strandi74 – 8613Combined sources
Helixi88 – 903Combined sources
Beta strandi98 – 1069Combined sources
Helixi121 – 1244Combined sources
Beta strandi131 – 1366Combined sources
Beta strandi138 – 1469Combined sources
Helixi149 – 1513Combined sources
Beta strandi168 – 17811Combined sources
Beta strandi181 – 19111Combined sources
Beta strandi197 – 2059Combined sources
Beta strandi212 – 22110Combined sources
Turni222 – 2243Combined sources
Beta strandi234 – 2374Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FG9X-ray2.90C/D/E18-262[»]
1FYHX-ray2.04B/E18-246[»]
1JRHX-ray2.80I18-125[»]
ProteinModelPortaliP15260.
SMRiP15260. Positions 28-241.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15260.

Family & Domainsi

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 2 fibronectin type-III domains.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45077.
GeneTreeiENSGT00510000048929.
HOGENOMiHOG000113074.
HOVERGENiHBG052128.
InParanoidiP15260.
KOiK05132.
OMAiNSYHSRN.
PhylomeDBiP15260.
TreeFamiTF338358.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR021126. Interferon_gamma_pox/mammal.
IPR008355. Interferon_gamma_rcpt_asu.
[Graphical view]
PANTHERiPTHR20859:SF5. PTHR20859:SF5. 1 hit.
PfamiPF07140. IFNGR1. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
PRINTSiPR01777. INTERFERONGR.
SUPFAMiSSF49265. SSF49265. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P15260-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALLFLLPLV MQGVSRAEMG TADLGPSSVP TPTNVTIESY NMNPIVYWEY
60 70 80 90 100
QIMPQVPVFT VEVKNYGVKN SEWIDACINI SHHYCNISDH VGDPSNSLWV
110 120 130 140 150
RVKARVGQKE SAYAKSEEFA VCRDGKIGPP KLDIRKEEKQ IMIDIFHPSV
160 170 180 190 200
FVNGDEQEVD YDPETTCYIR VYNVYVRMNG SEIQYKILTQ KEDDCDEIQC
210 220 230 240 250
QLAIPVSSLN SQYCVSAEGV LHVWGVTTEK SKEVCITIFN SSIKGSLWIP
260 270 280 290 300
VVAALLLFLV LSLVFICFYI KKINPLKEKS IILPKSLISV VRSATLETKP
310 320 330 340 350
ESKYVSLITS YQPFSLEKEV VCEEPLSPAT VPGMHTEDNP GKVEHTEELS
360 370 380 390 400
SITEVVTTEE NIPDVVPGSH LTPIERESSS PLSSNQSEPG SIALNSYHSR
410 420 430 440 450
NCSESDHSRN GFDTDSSCLE SHSSLSDSEF PPNNKGEIKT EGQELITVIK
460 470 480
APTSFGYDKP HVLVDLLVDD SGKESLIGYR PTEDSKEFS
Length:489
Mass (Da):54,405
Last modified:April 1, 1990 - v1
Checksum:iDCF9E574D8F47400
GO
Isoform 2 (identifier: P15260-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MALLFLLPLVMQGVSRAEMGTADLGPSS → MLLKSPENSLLQFQFKYG
     184-196: QYKILTQKEDDCD → KRSCAFSLFSFFI
     197-489: Missing.

Note: No experimental confirmation available.

Show »
Length:186
Mass (Da):21,542
Checksum:i13C30A3C31EF0107
GO

Polymorphismi

A genetic variation in the IFNGR1 gene is associated with susceptibility to Helicobacter pylori infection [MIMi:600263].

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611V → I.1 Publication
Corresponds to variant rs17175322 [ dbSNP | Ensembl ].
VAR_019281
Natural varianti77 – 771C → Y in IMD27A; fails to bind IFN-gamma. 1 Publication
VAR_017577
Natural varianti87 – 871I → T in IMD27A; impaired response to IFN-gamma. 1 Publication
VAR_017578
Natural varianti99 – 1024Missing in IMD27A; fails to bind IFN-gamma. 1 Publication
VAR_017579
Natural varianti335 – 3351H → P.2 Publications
Corresponds to variant rs17175350 [ dbSNP | Ensembl ].
VAR_019282
Natural varianti467 – 4671L → P.2 Publications
Corresponds to variant rs1887415 [ dbSNP | Ensembl ].
VAR_019283

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2828MALLF…LGPSS → MLLKSPENSLLQFQFKYG in isoform 2. 1 PublicationVSP_055589Add
BLAST
Alternative sequencei184 – 19613QYKIL…EDDCD → KRSCAFSLFSFFI in isoform 2. 1 PublicationVSP_055590Add
BLAST
Alternative sequencei197 – 489293Missing in isoform 2. 1 PublicationVSP_055591Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03143 mRNA. Translation: AAA52731.1.
AY594694 Genomic DNA. Translation: AAS89302.1.
BT006814 mRNA. Translation: AAP35460.1.
AK294252 mRNA. Translation: BAG57548.1.
AL050337 Genomic DNA. Translation: CAB53062.1.
CH471051 Genomic DNA. Translation: EAW47931.1.
CH471051 Genomic DNA. Translation: EAW47932.1.
BC005333 mRNA. Translation: AAH05333.1.
CCDSiCCDS5185.1. [P15260-1]
PIRiA31555.
RefSeqiNP_000407.1. NM_000416.2. [P15260-1]
UniGeneiHs.520414.

Genome annotation databases

EnsembliENST00000367739; ENSP00000356713; ENSG00000027697. [P15260-1]
GeneIDi3459.
KEGGihsa:3459.
UCSCiuc003qho.2. human. [P15260-1]

Polymorphism databases

DMDMi124474.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

IFNGR1base

IFNGR1 mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03143 mRNA. Translation: AAA52731.1 .
AY594694 Genomic DNA. Translation: AAS89302.1 .
BT006814 mRNA. Translation: AAP35460.1 .
AK294252 mRNA. Translation: BAG57548.1 .
AL050337 Genomic DNA. Translation: CAB53062.1 .
CH471051 Genomic DNA. Translation: EAW47931.1 .
CH471051 Genomic DNA. Translation: EAW47932.1 .
BC005333 mRNA. Translation: AAH05333.1 .
CCDSi CCDS5185.1. [P15260-1 ]
PIRi A31555.
RefSeqi NP_000407.1. NM_000416.2. [P15260-1 ]
UniGenei Hs.520414.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FG9 X-ray 2.90 C/D/E 18-262 [» ]
1FYH X-ray 2.04 B/E 18-246 [» ]
1JRH X-ray 2.80 I 18-125 [» ]
ProteinModelPortali P15260.
SMRi P15260. Positions 28-241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109681. 12 interactions.
DIPi DIP-47N.
IntActi P15260. 6 interactions.
MINTi MINT-8013365.
STRINGi 9606.ENSP00000356713.

Chemistry

ChEMBLi CHEMBL2364171.
DrugBanki DB00033. Interferon gamma-1b.

PTM databases

PhosphoSitei P15260.
UniCarbKBi P15260.

Polymorphism databases

DMDMi 124474.

Proteomic databases

MaxQBi P15260.
PaxDbi P15260.
PRIDEi P15260.

Protocols and materials databases

DNASUi 3459.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367739 ; ENSP00000356713 ; ENSG00000027697 . [P15260-1 ]
GeneIDi 3459.
KEGGi hsa:3459.
UCSCi uc003qho.2. human. [P15260-1 ]

Organism-specific databases

CTDi 3459.
GeneCardsi GC06M137518.
HGNCi HGNC:5439. IFNGR1.
HPAi CAB004444.
HPA029213.
MIMi 107470. gene.
209950. phenotype.
600263. phenotype.
neXtProti NX_P15260.
Orphaneti 319581. Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial IFNgammaR1 deficiency.
319569. Autosomal recessive mendelian susceptibility to mycobacterial diseases due to partial IFNgammaR1 deficiency.
99898. Mendelian susceptibility to mycobacterial diseases due to complete IFNgammaR1 deficiency.
PharmGKBi PA29675.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45077.
GeneTreei ENSGT00510000048929.
HOGENOMi HOG000113074.
HOVERGENi HBG052128.
InParanoidi P15260.
KOi K05132.
OMAi NSYHSRN.
PhylomeDBi P15260.
TreeFami TF338358.

Enzyme and pathway databases

Reactomei REACT_24980. Regulation of IFNG signaling.
REACT_25078. Interferon gamma signaling.
SignaLinki P15260.

Miscellaneous databases

ChiTaRSi IFNGR1. human.
EvolutionaryTracei P15260.
GeneWikii Interferon_gamma_receptor_1.
GenomeRNAii 3459.
NextBioi 13628.
PROi P15260.
SOURCEi Search...

Gene expression databases

Bgeei P15260.
CleanExi HS_IFNGR1.
ExpressionAtlasi P15260. baseline and differential.
Genevestigatori P15260.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR021126. Interferon_gamma_pox/mammal.
IPR008355. Interferon_gamma_rcpt_asu.
[Graphical view ]
PANTHERi PTHR20859:SF5. PTHR20859:SF5. 1 hit.
Pfami PF07140. IFNGR1. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view ]
PRINTSi PR01777. INTERFERONGR.
SUPFAMi SSF49265. SSF49265. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of the human interferon-gamma receptor."
    Aguet M., Dembic Z., Merlin G.
    Cell 55:273-280(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. SeattleSNPs variation discovery resource
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-61; PRO-335 AND PRO-467.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Amygdala.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Prostate.
  8. "Alignment of disulfide bonds of the extracellular domain of the interferon gamma receptor and investigation of their role in biological activity."
    Stueber D., Friedlein A., Fountoulakis M., Lahm H.-W., Garotta G.
    Biochemistry 32:2423-2430(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS, PARTIAL PROTEIN SEQUENCE, MUTAGENESIS.
  9. "Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor."
    Walter M.R., Windsor W.T., Nagabhushan T.L., Lundell D.J., Lunn C.A., Zauodny P.J., Narula S.K.
    Nature 376:230-235(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 26-248.
  10. "Neutralizing epitopes on the extracellular interferon gamma receptor (IFNgammaR) alpha-chain characterized by homolog scanning mutagenesis and X-ray crystal structure of the A6 fab-IFNgammaR1-108 complex."
    Sogabe S., Stuart F., Henke C., Bridges A., Williams G., Birch A., Winkler F.K., Robinson J.A.
    J. Mol. Biol. 273:882-897(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 28-122 IN COMPLEX WITH ANTIBODY.
  11. "Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex."
    Thiel D.J., le Du M.-H., Walter R.L., D'Arcy A., Chene C., Fountoulakis M., Garotta G., Winkler F.K., Ealick S.E.
    Structure 8:927-936(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF COMPLEX WITH ING.
  12. "Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guerin infection and a sibling with clinical tuberculosis."
    Jouanguy E., Lamhamedi-Cherradi S.-E., Altare F., Fondaneche M.-C., Tuerlinckx D., Blanche S., Emile J.-F., Gaillard J.-L., Schreiber R., Levin M., Fischer A., Hivroz C., Casanova J.-L.
    J. Clin. Invest. 100:2658-2664(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT IMD27A THR-87.
  13. Cited for: VARIANTS IMD27A TYR-77 AND 99-TRP--VAL-102 DEL.
  14. "Genomewide linkage analysis identifies polymorphism in the human interferon-gamma receptor affecting Helicobacter pylori infection."
    Thye T., Burchard G.D., Nilius M., Mueller-Myhsok B., Horstmann R.D.
    Am. J. Hum. Genet. 72:448-453(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO HELICOBACTER PYLORI INFECTION, VARIANTS PRO-335 AND PRO-467.

Entry informationi

Entry nameiINGR1_HUMAN
AccessioniPrimary (citable) accession number: P15260
Secondary accession number(s): B4DFT7, E1P587, Q53Y96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 26, 2014
This is version 172 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3