IFNGR1

Functionⁱ

Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114).5 Publications

GO - Molecular functionⁱ

cytokine binding Source: InterPro
interferon-gamma receptor activity
Source: ProtInc
Traceable author statementⁱ
- 2971451

Complete GO annotation...

GO - Biological processⁱ

defense response to virus Source: Ensembl
interferon-gamma-mediated signaling pathway Source: Reactome
regulation of interferon-gamma-mediated signaling pathway Source: Reactome
response to virus
Source: ProtInc
Traceable author statementⁱ
- 2954953
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 2971451

Complete GO annotation...

Keywordsⁱ

Molecular function	Receptor

Molecular function

Receptor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-877300. Interferon gamma signaling. R-HSA-877312. Regulation of IFNG signaling.
SignaLinkⁱ	P15260.
SIGNORⁱ	P15260.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interferon gamma receptor 1Imported Short name: IFN-gamma receptor 1 Short name: IFN-gamma-R1 Alternative name(s): CDw119 Interferon gamma receptor alpha-chain2 Publications Short name: IFN-gamma-R-alpha1 Publication CD_antigen: CD119
Gene namesⁱ	Name:IFNGR1Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000027697.12.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5439. IFNGR1.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	18 – 245	ExtracellularSequence analysisAdd BLAST	228
Transmembraneⁱ	246 – 266	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	267 – 489	CytoplasmicSequence analysisAdd BLAST	223

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Immunodeficiency 27A (IMD27A)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_017577	77	C → Y in IMD27A; fails to bind IFN-gamma. 1 PublicationCorresponds to variant dbSNP:rs104893974Ensembl.	1
Natural variantⁱVAR_017578	87	I → T in IMD27A; impaired response to IFN-gamma. 1 PublicationCorresponds to variant dbSNP:rs104893973Ensembl.	1
Natural variantⁱVAR_017579	99 – 102	Missing in IMD27A; fails to bind IFN-gamma. 1 Publication	4

Immunodeficiency 27B (IMD27B)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. IMD27B commonly presents with recurrent, moderately severe infections with environmental mycobacteria or BCG. Salmonellosis is present in about 5% of patients.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3459.
MalaCards human disease database More...MalaCardsⁱ	IFNGR1.
MIMⁱ	209950. phenotype. 600263. phenotype. 615978. phenotype.
Open Targets More...OpenTargetsⁱ	ENSG00000027697.
Orphanetⁱ	319581. Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial IFNgammaR1 deficiency. 319569. Autosomal recessive mendelian susceptibility to mycobacterial diseases due to partial IFNgammaR1 deficiency. 99898. Mendelian susceptibility to mycobacterial diseases due to complete IFNgammaR1 deficiency.
PharmGKBⁱ	PA29675.

Chemistry databases

ChEMBLⁱ	CHEMBL2364171.
Drug and drug target database More...DrugBankⁱ	DB00033. Interferon gamma-1b.

Polymorphism and mutation databases

BioMutaⁱ	IFNGR1.
DMDMⁱ	124474.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Add BLAST		17
ChainⁱPRO_0000011009	18 – 489	Interferon gamma receptor 1Add BLAST		472

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	34	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	77 ↔ 85	1 Publication
Glycosylationⁱ	79	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	86	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	122 ↔ 167	1 Publication
Glycosylationⁱ	179	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	195 ↔ 200	1 Publication
Disulfide bondⁱ	214 ↔ 235	1 Publication
Glycosylationⁱ	240	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	369	PhosphoserineBy similarity	1
Modified residueⁱ	372	PhosphothreonineBy similarity	1
Modified residueⁱ	378	PhosphoserineBy similarity	1
Modified residueⁱ	403	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated at Ser/Thr residues.2 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P15260.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P15260.
PaxDbⁱ	P15260.
PeptideAtlas More...PeptideAtlasⁱ	P15260.
PRIDEⁱ	P15260.

PTM databases

iPTMnetⁱ	P15260.
PhosphoSitePlusⁱ	P15260.
SwissPalmⁱ	P15260.
UniCarbKBⁱ	P15260.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000027697.
CleanExⁱ	HS_IFNGR1.
ExpressionAtlasⁱ	P15260. baseline and differential.
Genevisibleⁱ	P15260. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA029213. HPA063871.

HPAⁱ

HPA029213.
HPA063871.

Interactionⁱ

Subunit structureⁱ

Monomer (PubMed:9367779). Heterodimer with IFNGR2, to form the IFNG receptor complex (PubMed:7615558). Interacts with JAK1 (PubMed:7615558).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
STAT1	P42224	4	EBI-1030755,EBI-1057697

With

Entry

#Exp.

IntAct

Notes

STAT1

P42224

4

EBI-1030755,EBI-1057697

GO - Molecular functionⁱ

cytokine binding Source: InterPro

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	109681. 31 interactors.
Database of interacting proteins More...DIPⁱ	DIP-47N.
IntActⁱ	P15260. 7 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-8013365.
STRINGⁱ	9606.ENSP00000356713.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	33 – 38	Combined sources	6
Beta strandⁱ	40 – 42	Combined sources	3
Beta strandⁱ	45 – 49	Combined sources	5
Beta strandⁱ	58 – 65	Combined sources	8
Beta strandⁱ	69 – 71	Combined sources	3
Beta strandⁱ	74 – 86	Combined sources	13
Helixⁱ	88 – 90	Combined sources	3
Beta strandⁱ	98 – 106	Combined sources	9
Helixⁱ	121 – 124	Combined sources	4
Beta strandⁱ	131 – 136	Combined sources	6
Beta strandⁱ	138 – 146	Combined sources	9
Helixⁱ	149 – 151	Combined sources	3
Beta strandⁱ	168 – 178	Combined sources	11
Beta strandⁱ	181 – 191	Combined sources	11
Beta strandⁱ	197 – 205	Combined sources	9
Beta strandⁱ	212 – 221	Combined sources	10
Turnⁱ	222 – 224	Combined sources	3
Beta strandⁱ	234 – 237	Combined sources	4

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1FG9	X-ray	2.90	C/D/E	18-262	[»]
	1FYH	X-ray	2.04	B/E	18-246	[»]
	1JRH	X-ray	2.80	I	18-125	[»]
ProteinModelPortalⁱ	P15260.
SMRⁱ	P15260.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P15260.

EvolutionaryTraceⁱ

P15260.

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the type II cytokine receptor family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IG11. Eukaryota. ENOG411218K. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048929.
HOGENOMⁱ	HOG000113074.
HOVERGENⁱ	HBG052128.
InParanoidⁱ	P15260.
KEGG Orthology (KO) More...KOⁱ	K05132.
OMAⁱ	NSYHSRN.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08ZD.
PhylomeDBⁱ	P15260.
TreeFamⁱ	TF338358.

Family and domain databases

Gene3Dⁱ	2.60.40.10. 2 hits.
InterProⁱ	View protein in InterPro IPR003961. FN3_dom. IPR013783. Ig-like_fold. IPR021126. Interferon_gamma_pox/mammal. IPR008355. Interferon_gamma_rcpt_asu.
PANTHERⁱ	PTHR20859:SF62. PTHR20859:SF62. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07140. IFNGR1. 1 hit. PF01108. Tissue_fac. 1 hit.
PRINTSⁱ	PR01777. INTERFERONGR.
SUPFAMⁱ	SSF49265. SSF49265. 2 hits.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: P15260-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALLFLLPLV MQGVSRAEMG TADLGPSSVP TPTNVTIESY NMNPIVYWEY 
        60         70         80         90        100
QIMPQVPVFT VEVKNYGVKN SEWIDACINI SHHYCNISDH VGDPSNSLWV 
       110        120        130        140        150
RVKARVGQKE SAYAKSEEFA VCRDGKIGPP KLDIRKEEKQ IMIDIFHPSV 
       160        170        180        190        200
FVNGDEQEVD YDPETTCYIR VYNVYVRMNG SEIQYKILTQ KEDDCDEIQC 
       210        220        230        240        250
QLAIPVSSLN SQYCVSAEGV LHVWGVTTEK SKEVCITIFN SSIKGSLWIP 
       260        270        280        290        300
VVAALLLFLV LSLVFICFYI KKINPLKEKS IILPKSLISV VRSATLETKP 
       310        320        330        340        350
ESKYVSLITS YQPFSLEKEV VCEEPLSPAT VPGMHTEDNP GKVEHTEELS 
       360        370        380        390        400
SITEVVTTEE NIPDVVPGSH LTPIERESSS PLSSNQSEPG SIALNSYHSR 
       410        420        430        440        450
NCSESDHSRN GFDTDSSCLE SHSSLSDSEF PPNNKGEIKT EGQELITVIK 
       460        470        480 
APTSFGYDKP HVLVDLLVDD SGKESLIGYR PTEDSKEFS

Length:489

Mass (Da):54,405

Last modified:April 1, 1990 - v1

Checksum:ⁱDCF9E574D8F47400

GO

Isoform 2 (identifier: P15260-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MALLFLLPLVMQGVSRAEMGTADLGPSS → MLLKSPENSLLQFQFKYG
     184-196: QYKILTQKEDDCD → KRSCAFSLFSFFI
     197-489: Missing.

« Hide

        10         20         30         40         50
MLLKSPENSL LQFQFKYGVP TPTNVTIESY NMNPIVYWEY QIMPQVPVFT 
        60         70         80         90        100
VEVKNYGVKN SEWIDACINI SHHYCNISDH VGDPSNSLWV RVKARVGQKE 
       110        120        130        140        150
SAYAKSEEFA VCRDGKIGPP KLDIRKEEKQ IMIDIFHPSV FVNGDEQEVD 
       160        170        180 
YDPETTCYIR VYNVYVRMNG SEIKRSCAFS LFSFFI

Note: No experimental confirmation available.

Show »

Length:186

Mass (Da):21,542

Checksum:ⁱ13C30A3C31EF0107

GO

Polymorphismⁱ

A genetic variation in the IFNGR1 gene is associated with susceptibility to Helicobacter pylori infection [MIMⁱ:600263].

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_019281	61	V → I1 PublicationCorresponds to variant dbSNP:rs17175322Ensembl.	1
Natural variantⁱVAR_017577	77	C → Y in IMD27A; fails to bind IFN-gamma. 1 PublicationCorresponds to variant dbSNP:rs104893974Ensembl.	1
Natural variantⁱVAR_017578	87	I → T in IMD27A; impaired response to IFN-gamma. 1 PublicationCorresponds to variant dbSNP:rs104893973Ensembl.	1
Natural variantⁱVAR_017579	99 – 102	Missing in IMD27A; fails to bind IFN-gamma. 1 Publication	4
Natural variantⁱVAR_019282	335	H → P2 PublicationsCorresponds to variant dbSNP:rs17175350Ensembl.	1
Natural variantⁱVAR_019283	467	L → P2 PublicationsCorresponds to variant dbSNP:rs1887415Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_055589	1 – 28	MALLF…LGPSS → MLLKSPENSLLQFQFKYG in isoform 2. 1 PublicationAdd BLAST	28
Alternative sequenceⁱVSP_055590	184 – 196	QYKIL…EDDCD → KRSCAFSLFSFFI in isoform 2. 1 PublicationAdd BLAST	13
Alternative sequenceⁱVSP_055591	197 – 489	Missing in isoform 2. 1 PublicationAdd BLAST	293

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03143 mRNA. Translation: AAA52731.1. AY594694 Genomic DNA. Translation: AAS89302.1. BT006814 mRNA. Translation: AAP35460.1. AK294252 mRNA. Translation: BAG57548.1. AL050337 Genomic DNA. Translation: CAB53062.1. CH471051 Genomic DNA. Translation: EAW47931.1. CH471051 Genomic DNA. Translation: EAW47932.1. BC005333 mRNA. Translation: AAH05333.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5185.1. [P15260-1]
PIRⁱ	A31555.
NCBI Reference Sequences More...RefSeqⁱ	NP_000407.1. NM_000416.2. [P15260-1]
UniGeneⁱ	Hs.520414.

Genome annotation databases

Ensemblⁱ	ENST00000367739; ENSP00000356713; ENSG00000027697. [P15260-1]
GeneIDⁱ	3459.
KEGGⁱ	hsa:3459.
UCSC genome browser More...UCSCⁱ	uc003qho.3. human. [P15260-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P15260	A0A0S2Z3Y2 Q7Z687 UPI00001117F8 UPI000011163B E5QBZ2 UPI00004DF88F A1Z2M9	Homo sapiens (Human)	489	UniRef100_P15260	Cluster: Interferon gamma receptor 1	8

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P15260	A0A0S2Z3Y2 Q7Z687 UPI00001117F8 UPI000011163B E5QBZ2 UPI00004DF88F A1Z2M9 UPI0005F37BCB UPI0005F3B2A2 UPI0005F3F62A +42	Homo sapiens (Human) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Pan paniscus (Pygmy chimpanzee) (Bonobo) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Gorilla gorilla gorilla (Western lowland gorilla) Colobus angolensis palliatus (Peters' Angolan colobus) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Pan troglodytes (Chimpanzee) And more	489	UniRef90_P15260	Cluster: Interferon gamma receptor 1	53

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P15260	A0A0S2Z3Y2 Q7Z687 UPI00001117F8 UPI000011163B E5QBZ2 UPI00004DF88F A1Z2M9 UPI0005F37BCB UPI0005F3B2A2 UPI0005F3F62A +72	Homo sapiens (Human) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Pan troglodytes (Chimpanzee) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Pan paniscus (Pygmy chimpanzee) (Bonobo) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Gorilla gorilla gorilla (Western lowland gorilla) And more	489	UniRef50_P15260	Cluster: Interferon gamma receptor 1	83
P15260-2	Q5TFC9	Homo sapiens (Human)	186	UniRef50_P15260-2	Cluster: Isoform 2 of Interferon gamma receptor 1	2

Cross-referencesⁱ

Web resourcesⁱ

IFNGR1base

IFNGR1 mutation db

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03143 mRNA. Translation: AAA52731.1. AY594694 Genomic DNA. Translation: AAS89302.1. BT006814 mRNA. Translation: AAP35460.1. AK294252 mRNA. Translation: BAG57548.1. AL050337 Genomic DNA. Translation: CAB53062.1. CH471051 Genomic DNA. Translation: EAW47931.1. CH471051 Genomic DNA. Translation: EAW47932.1. BC005333 mRNA. Translation: AAH05333.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5185.1. [P15260-1]
PIRⁱ	A31555.
NCBI Reference Sequences More...RefSeqⁱ	NP_000407.1. NM_000416.2. [P15260-1]
UniGeneⁱ	Hs.520414.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1FG9	X-ray	2.90	C/D/E	18-262	[»]
	1FYH	X-ray	2.04	B/E	18-246	[»]
	1JRH	X-ray	2.80	I	18-125	[»]
ProteinModelPortalⁱ	P15260.
SMRⁱ	P15260.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109681. 31 interactors.
Database of interacting proteins More...DIPⁱ	DIP-47N.
IntActⁱ	P15260. 7 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-8013365.
STRINGⁱ	9606.ENSP00000356713.

Chemistry databases

ChEMBLⁱ	CHEMBL2364171.
Drug and drug target database More...DrugBankⁱ	DB00033. Interferon gamma-1b.

PTM databases

iPTMnetⁱ	P15260.
PhosphoSitePlusⁱ	P15260.
SwissPalmⁱ	P15260.
UniCarbKBⁱ	P15260.

Polymorphism and mutation databases

BioMutaⁱ	IFNGR1.
DMDMⁱ	124474.

Proteomic databases

EPDⁱ	P15260.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P15260.
PaxDbⁱ	P15260.
PeptideAtlas More...PeptideAtlasⁱ	P15260.
PRIDEⁱ	P15260.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3459.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000367739; ENSP00000356713; ENSG00000027697. [P15260-1]
GeneIDⁱ	3459.
KEGGⁱ	hsa:3459.
UCSC genome browser More...UCSCⁱ	uc003qho.3. human. [P15260-1]

Organism-specific databases

CTDⁱ	3459.
DisGeNET More...DisGeNETⁱ	3459.
EuPathDBⁱ	HostDB:ENSG00000027697.12.
GeneCardsⁱ	IFNGR1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5439. IFNGR1.
Human Protein Atlas More...HPAⁱ	HPA029213. HPA063871.
MalaCards human disease database More...MalaCardsⁱ	IFNGR1.
MIMⁱ	107470. gene. 209950. phenotype. 600263. phenotype. 615978. phenotype.
neXtProtⁱ	NX_P15260.
Open Targets More...OpenTargetsⁱ	ENSG00000027697.
Orphanetⁱ	319581. Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial IFNgammaR1 deficiency. 319569. Autosomal recessive mendelian susceptibility to mycobacterial diseases due to partial IFNgammaR1 deficiency. 99898. Mendelian susceptibility to mycobacterial diseases due to complete IFNgammaR1 deficiency.
PharmGKBⁱ	PA29675.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IG11. Eukaryota. ENOG411218K. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048929.
HOGENOMⁱ	HOG000113074.
HOVERGENⁱ	HBG052128.
InParanoidⁱ	P15260.
KEGG Orthology (KO) More...KOⁱ	K05132.
OMAⁱ	NSYHSRN.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08ZD.
PhylomeDBⁱ	P15260.
TreeFamⁱ	TF338358.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-877300. Interferon gamma signaling. R-HSA-877312. Regulation of IFNG signaling.
SignaLinkⁱ	P15260.
SIGNORⁱ	P15260.

Miscellaneous databases

ChiTaRSⁱ	IFNGR1. human.
EvolutionaryTraceⁱ	P15260.
GeneWikiⁱ	Interferon_gamma_receptor_1.
GenomeRNAiⁱ	3459.
Protein Ontology More...PROⁱ	PR:P15260.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000027697.
CleanExⁱ	HS_IFNGR1.
ExpressionAtlasⁱ	P15260. baseline and differential.
Genevisibleⁱ	P15260. HS.

Family and domain databases

Gene3Dⁱ	2.60.40.10. 2 hits.
InterProⁱ	View protein in InterPro IPR003961. FN3_dom. IPR013783. Ig-like_fold. IPR021126. Interferon_gamma_pox/mammal. IPR008355. Interferon_gamma_rcpt_asu.
PANTHERⁱ	PTHR20859:SF62. PTHR20859:SF62. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07140. IFNGR1. 1 hit. PF01108. Tissue_fac. 1 hit.
PRINTSⁱ	PR01777. INTERFERONGR.
SUPFAMⁱ	SSF49265. SSF49265. 2 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	INGR1_HUMAN
Accessionⁱ	P15260Primary (citable) accession number: P15260 Secondary accession number(s): B4DFT7, E1P587, Q53Y96
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	April 1, 1990
	Last modified:	September 27, 2017
	This is version 196 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P15260 (INGR1_HUMAN)

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Interferon gamma receptor 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ